JP2018502286A5 - - Google Patents
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- JP2018502286A5 JP2018502286A5 JP2017526884A JP2017526884A JP2018502286A5 JP 2018502286 A5 JP2018502286 A5 JP 2018502286A5 JP 2017526884 A JP2017526884 A JP 2017526884A JP 2017526884 A JP2017526884 A JP 2017526884A JP 2018502286 A5 JP2018502286 A5 JP 2018502286A5
- Authority
- JP
- Japan
- Prior art keywords
- biomarkers
- subject
- level
- sample
- liver disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081903P | 2014-11-19 | 2014-11-19 | |
| US62/081,903 | 2014-11-19 | ||
| US201562141494P | 2015-04-01 | 2015-04-01 | |
| US62/141,494 | 2015-04-01 | ||
| PCT/US2015/061215 WO2016081534A1 (en) | 2014-11-19 | 2015-11-18 | Biomarkers for fatty liver disease and methods using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502286A JP2018502286A (ja) | 2018-01-25 |
| JP2018502286A5 true JP2018502286A5 (enExample) | 2018-12-27 |
Family
ID=56014479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526884A Pending JP2018502286A (ja) | 2014-11-19 | 2015-11-18 | 脂肪肝疾患のバイオマーカーおよびその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170370954A1 (enExample) |
| EP (1) | EP3221463A4 (enExample) |
| JP (1) | JP2018502286A (enExample) |
| CN (1) | CN107002113A (enExample) |
| WO (1) | WO2016081534A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170193810A1 (en) * | 2016-01-05 | 2017-07-06 | Wizr Llc | Video event detection and notification |
| CN108990420B (zh) | 2016-05-29 | 2022-06-24 | 深圳市绘云生物科技有限公司 | 肝病相关生物标志物和其使用方法 |
| EP3465202B1 (en) | 2016-06-02 | 2023-07-05 | Metabolon, Inc. | Mass spectrometry method for detection and quantitation of metabolites |
| WO2018007422A1 (en) * | 2016-07-05 | 2018-01-11 | One Way Liver,S.L. | Identification of human non-alcoholic fatty liver disease (nafld) subtypes |
| EP3267199A1 (en) * | 2016-07-06 | 2018-01-10 | One Way Liver S.L. | Diagnostic methods based on lipid profiles |
| EP3714273A1 (en) | 2017-11-20 | 2020-09-30 | Zora Biosciences OY | Methods for prediction and early detection of diabetes |
| EP3502703A1 (en) | 2017-12-22 | 2019-06-26 | Metanomics Health GmbH | Method for the assessment of nafld |
| US11536726B2 (en) | 2018-04-04 | 2022-12-27 | Metabolon, Inc. | Mass spectrometry assay method for detection and quantitation of liver function metabolites |
| US20210349103A1 (en) * | 2018-06-18 | 2021-11-11 | Duke University | Metabolic biomarkers of nafld/nash and related disease phenotypes and methods of using same |
| JP7029139B2 (ja) | 2018-08-23 | 2022-03-03 | デンカ株式会社 | 非アルコール性脂肪性肝炎の検出を補助する方法 |
| WO2020044497A1 (ja) * | 2018-08-30 | 2020-03-05 | 国立大学法人 東京大学 | Ｎａｆｌｄ又はｎａｓｈの検出又はリスクの予測方法、ｎａｆｌｄ又はｎａｓｈを検出するための診断薬キット、対象における肝線維化の進行度の判定方法、及び対象における肝線維化の進行度を判定するための診断薬キット |
| JP6592638B1 (ja) * | 2018-08-30 | 2019-10-16 | 国立大学法人 東京大学 | 脂肪性肝疾患の検出又はリスクの予測方法、脂肪性肝疾患を検出するための診断薬キット及びバイオマーカー、対象の肝線維化の進行度の判定方法、並びに対象の肝線維化の進行度を判定するためのバイオマーカー |
| WO2020066162A1 (ja) * | 2018-09-26 | 2020-04-02 | 株式会社島津製作所 | 非アルコール性脂肪肝疾患の検出方法、非アルコール性脂肪肝疾患検出用キットおよび非アルコール性脂肪肝疾患検出用バイオマーカー |
| KR102105880B1 (ko) * | 2018-10-26 | 2020-04-29 | 서울대학교병원 | 비알코올 지방간 질환의 조직학적 중증도 진단 또는 예후 측정에 관한 정보 제공 방법 |
| EP3899015A1 (en) * | 2018-12-19 | 2021-10-27 | Astrazeneca AB | Biomarker of pnpla3 expression |
| JP6592627B1 (ja) * | 2019-03-12 | 2019-10-16 | 国立大学法人 東京大学 | Ｎａｆｌｄ又はｎａｓｈの検出又はリスクの予測方法、ｎａｆｌｄ又はｎａｓｈを検出するための診断薬キット、対象における肝線維化の進行度の判定方法、及び対象における肝線維化の進行度を判定するための診断薬キット |
| JP6592628B1 (ja) * | 2019-03-12 | 2019-10-16 | 国立大学法人 東京大学 | 脂肪性肝疾患の検出又はリスクの予測方法、脂肪性肝疾患を検出するための診断薬キット及びバイオマーカー、対象の肝線維化の進行度の判定方法、並びに対象の肝線維化の進行度を判定するためのバイオマーカー |
| KR102280261B1 (ko) * | 2019-07-16 | 2021-07-20 | 이화여자대학교 산학협력단 | 대사체 분석을 이용한 간질환의 진단 방법 |
| CN110507670B (zh) * | 2019-09-24 | 2023-04-07 | 江西天元药业有限公司 | 精制熊胆粉及预防治疗肝病肝纤维化改善肝功能的用途 |
| WO2021092265A1 (en) * | 2019-11-05 | 2021-05-14 | Beth Israel Deaconess Medical Center, Inc. | Diagnosis and treatment of nafld and liver fibrosis |
| EP4080221A4 (en) * | 2020-02-04 | 2023-06-28 | Denka Company Limited | Method for assisting detection of non-alcoholic steatohepatitis |
| CN111562321B (zh) * | 2020-04-16 | 2022-10-28 | 广东省结核病控制中心 | 用于检测活动性肺结核的粪便代谢物及其检测系统 |
| US12540946B2 (en) | 2021-03-18 | 2026-02-03 | Complete Omics Inc. | Methods and systems for detecting and quantifying large number of molecule biomarkers from a body fluid sample |
| CN112712896B (zh) * | 2021-03-26 | 2023-03-07 | 深圳市绘云生物科技有限公司 | 用于受试体检测非酒精性脂肪性肝病状态的诊断装置及计算机系统 |
| CN113160983A (zh) * | 2021-04-09 | 2021-07-23 | 南京医科大学附属逸夫医院 | 一种代谢相关脂肪性肝病临床预测模型 |
| CN117741023A (zh) * | 2021-11-30 | 2024-03-22 | 江苏品生医疗科技集团有限公司 | 预测受试者患有糖尿病的可能性的标记物及其应用 |
| EP4553503A1 (en) * | 2022-06-07 | 2025-05-14 | Nitto Denko Corporation | Marker for diagnosing non-alcoholic fatty liver disease (nafld) or non-alcoholic steatohepatitis (nash) |
| CN121195170A (zh) * | 2023-05-17 | 2025-12-23 | 株式会社岛津制作所 | 非酒精性脂肪性肝病的识别方法和生物标志物 |
| WO2024237259A1 (ja) * | 2023-05-17 | 2024-11-21 | 株式会社島津製作所 | 非アルコール性脂肪肝疾患の発症リスク評価方法、および、バイオマーカー |
| EP4740020A2 (en) | 2023-07-06 | 2026-05-13 | Numares AG | Use of a marker or a marker set for determining the risk of an individual to have ascites |
| WO2025008465A2 (en) | 2023-07-06 | 2025-01-09 | Numares Ag | Use of a biomarker for determining the child-pugh class into which an individual is to be classified |
| WO2025008466A1 (en) | 2023-07-06 | 2025-01-09 | Numares Ag | Use of a biomarker for determining the risk of an individual to have hepatic encephalopathy |
| WO2025008467A2 (en) | 2023-07-06 | 2025-01-09 | Numares Ag | Use of a marker or a marker set for determining the risk of an individual to have a reduced liver function |
| EP4653872A1 (en) * | 2024-05-22 | 2025-11-26 | Cristóbal Manuel Richart Jurado | A set of biomarkers and an in vitro method for the diagnosis of metabolic dysfunction-associated steatohepatitis (mash) |
| WO2026083345A1 (en) * | 2024-10-18 | 2026-04-23 | Universita' Degli Studi Di Torino | A new model for the diagnosis of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease |
| CN119506412B (zh) * | 2024-11-01 | 2026-02-24 | 上海爱谱蒂康生物科技有限公司 | 一种生物标志物组合及其在预测帕金森病中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001078652A2 (en) | 2000-04-14 | 2001-10-25 | Metabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| WO2005052575A1 (en) * | 2003-11-28 | 2005-06-09 | Pfizer Limited | Molecular markers of oxidative stress |
| US7856319B2 (en) * | 2005-02-03 | 2010-12-21 | Assistance Publique-Hopitaux De Paris (Ap-Hp) | Diagnosis method of alcoholic steato-hepatitis using biochemical markers |
| EP1997049B1 (en) | 2006-03-21 | 2019-03-13 | Metabolon Inc. | A system, method, and computer program product for analyzing spectrometry data to indentify and quantify individual components in a sample |
| WO2007136674A1 (en) * | 2006-05-19 | 2007-11-29 | The Cleveland Clinic Foundation | Detection and monitoring of liver damage |
| EP2930512B1 (en) * | 2007-11-02 | 2018-01-31 | Metabolon, Inc. | Biomarkers for fatty liver disease and methods using the same |
| EP2393946B1 (en) * | 2009-02-06 | 2013-12-04 | Metabolon Inc. | Determination of the liver toxicity of an agent |
| EP2309276A1 (en) * | 2009-09-22 | 2011-04-13 | One Way Liver Genomics, S.L. | Method for the diagnosis of non-alcoholic steatohepatitis based on a metabolomic profile |
| CA2778226A1 (en) * | 2009-10-09 | 2011-04-14 | Carolyn Slupsky | Methods for diagnosis, treatment and monitoring of patient health using metabolomics |
| EP2863227B1 (en) * | 2010-06-10 | 2017-09-27 | Metanomics Health GmbH | Means and methods for metabolic differentiation of non-alcoholic steatohepatitis from liver disease |
| US20130276513A1 (en) * | 2010-10-14 | 2013-10-24 | The Regents Of The University Of California | Methods for diagnosing and assessing kidney disease |
| US20150065366A1 (en) * | 2011-11-11 | 2015-03-05 | Metabolon, Inc. | Biomarkers for Bladder Cancer and Methods Using the Same |
| WO2015042602A1 (en) * | 2013-09-23 | 2015-03-26 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Biomarkers related to organ function |
| CN106537145B (zh) * | 2014-04-08 | 2020-08-25 | 麦特博隆股份有限公司 | 用于疾病诊断和健康评估的个体受试者的小分子生物化学特征分析 |
-
2015
- 2015-11-18 US US15/527,362 patent/US20170370954A1/en not_active Abandoned
- 2015-11-18 WO PCT/US2015/061215 patent/WO2016081534A1/en not_active Ceased
- 2015-11-18 CN CN201580063349.2A patent/CN107002113A/zh active Pending
- 2015-11-18 JP JP2017526884A patent/JP2018502286A/ja active Pending
- 2015-11-18 EP EP15860608.7A patent/EP3221463A4/en not_active Withdrawn
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