JP2018502087A - Ｒａｆ阻害剤及びタキサンの組み合わせ - Google Patents

Ｒａｆ阻害剤及びタキサンの組み合わせ Download PDF

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Publication number
JP2018502087A
JP2018502087A JP2017533810A JP2017533810A JP2018502087A JP 2018502087 A JP2018502087 A JP 2018502087A JP 2017533810 A JP2017533810 A JP 2017533810A JP 2017533810 A JP2017533810 A JP 2017533810A JP 2018502087 A JP2018502087 A JP 2018502087A
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Prior art keywords
cancer
raf
pharmaceutically acceptable
compound
acceptable salt
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JP2017533810A
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English (en)
Japanese (ja)
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JP2018502087A5 (https=
Inventor
ヴィヴィアーナ ボゾン，
ヴィヴィアーナ ボゾン，
キャサリン エム． ガルビン，
キャサリン エム． ガルビン，
レイチェル エル． ブレイク，
レイチェル エル． ブレイク，
チュンリ シュー，
チュンリ シュー，
カルッピア カナン，
カルッピア カナン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of JP2018502087A publication Critical patent/JP2018502087A/ja
Publication of JP2018502087A5 publication Critical patent/JP2018502087A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017533810A 2014-12-23 2015-12-22 Ｒａｆ阻害剤及びタキサンの組み合わせ Pending JP2018502087A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462096020P 2014-12-23 2014-12-23
US62/096,020 2014-12-23
US201562242629P 2015-10-16 2015-10-16
US62/242,629 2015-10-16
PCT/US2015/067462 WO2016106359A1 (en) 2014-12-23 2015-12-22 Combination of raf inhibitors and taxanes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020065763A Division JP2020114857A (ja) 2014-12-23 2020-04-01 Ｒａｆ阻害剤及びタキサンの組み合わせ

Publications (2)

Publication Number Publication Date
JP2018502087A true JP2018502087A (ja) 2018-01-25
JP2018502087A5 JP2018502087A5 (https=) 2019-02-07

Family

ID=56151531

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017533810A Pending JP2018502087A (ja) 2014-12-23 2015-12-22 Ｒａｆ阻害剤及びタキサンの組み合わせ
JP2020065763A Pending JP2020114857A (ja) 2014-12-23 2020-04-01 Ｒａｆ阻害剤及びタキサンの組み合わせ

Family Applications After (1)

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JP2020065763A Pending JP2020114857A (ja) 2014-12-23 2020-04-01 Ｒａｆ阻害剤及びタキサンの組み合わせ

Country Status (7)

Country Link
US (2) US20190117652A1 (https=)
EP (1) EP3236966B1 (https=)
JP (2) JP2018502087A (https=)
CN (1) CN107405348B (https=)
CA (1) CA2972189A1 (https=)
ES (1) ES2827024T3 (https=)
WO (1) WO2016106359A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021108616A1 (en) * 2019-11-27 2021-06-03 Dot Therapeutics-1, Inc. Solid dispersion of pan-raf kinase inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532380A (ja) * 2007-06-29 2010-10-07 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用な化合物
WO2013144923A1 (en) * 2012-03-30 2013-10-03 Takeda Pharmaceutical Company Limited Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma
WO2014138279A1 (en) * 2013-03-05 2014-09-12 University Of Tennessee Research Foundation Compounds for treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA99731C2 (ru) * 2007-07-30 2012-09-25 Ардеа Биосайенсис, Инк Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение
JO3101B1 (ar) * 2008-12-02 2017-09-20 Takeda Pharmaceuticals Co مشتقات بنزوثيازول كعوامل مضادة للسرطان
CN102317293A (zh) * 2008-12-05 2012-01-11 艾科尔公司 Raf抑制剂及其用途
IN2012DN01403A (https=) * 2009-08-24 2015-06-05 Genentech Inc
UY36046A (es) * 2014-03-26 2015-10-30 Millennium Pharm Inc Formulaciones farmacéuticas, procesos para la preparación y métodos de uso

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532380A (ja) * 2007-06-29 2010-10-07 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用な化合物
WO2013144923A1 (en) * 2012-03-30 2013-10-03 Takeda Pharmaceutical Company Limited Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma
WO2014138279A1 (en) * 2013-03-05 2014-09-12 University Of Tennessee Research Foundation Compounds for treatment of cancer

Also Published As

Publication number Publication date
EP3236966A1 (en) 2017-11-01
ES2827024T3 (es) 2021-05-19
CA2972189A1 (en) 2016-06-30
CN107405348B (zh) 2021-06-11
EP3236966A4 (en) 2018-10-03
US20200316067A1 (en) 2020-10-08
JP2020114857A (ja) 2020-07-30
WO2016106359A1 (en) 2016-06-30
CN107405348A (zh) 2017-11-28
US20190117652A1 (en) 2019-04-25
EP3236966B1 (en) 2020-08-12

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