JP2018501281A5 - - Google Patents
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- JP2018501281A5 JP2018501281A5 JP2017535831A JP2017535831A JP2018501281A5 JP 2018501281 A5 JP2018501281 A5 JP 2018501281A5 JP 2017535831 A JP2017535831 A JP 2017535831A JP 2017535831 A JP2017535831 A JP 2017535831A JP 2018501281 A5 JP2018501281 A5 JP 2018501281A5
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- JP
- Japan
- Prior art keywords
- cells
- pharmaceutical composition
- use according
- retinal
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims description 142
- 239000008194 pharmaceutical composition Substances 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 53
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims description 19
- 101710130208 Melanocyte protein PMEL Proteins 0.000 claims description 18
- 102100028001 Retinaldehyde-binding protein 1 Human genes 0.000 claims description 18
- 101710101931 Retinaldehyde-binding protein 1 Proteins 0.000 claims description 18
- 102100031248 Patatin-like phospholipase domain-containing protein 2 Human genes 0.000 claims description 17
- 208000017442 Retinal disease Diseases 0.000 claims description 17
- 108090000102 pigment epithelium-derived factor Proteins 0.000 claims description 17
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 16
- 208000002780 macular degeneration Diseases 0.000 claims description 15
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 14
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 14
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 14
- 230000028327 secretion Effects 0.000 claims description 14
- 210000001525 retina Anatomy 0.000 claims description 12
- 230000005856 abnormality Effects 0.000 claims description 11
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 11
- 238000012258 culturing Methods 0.000 claims description 11
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 11
- 102000007354 PAX6 Transcription Factor Human genes 0.000 claims description 10
- 108010032788 PAX6 Transcription Factor Proteins 0.000 claims description 10
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 9
- 238000011534 incubation Methods 0.000 claims description 9
- 235000020945 retinal Nutrition 0.000 claims description 9
- 239000011604 retinal Substances 0.000 claims description 9
- 230000002207 retinal effect Effects 0.000 claims description 9
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims description 9
- 208000011325 dry age related macular degeneration Diseases 0.000 claims description 8
- 229960003966 nicotinamide Drugs 0.000 claims description 8
- 235000005152 nicotinamide Nutrition 0.000 claims description 8
- 239000011570 nicotinamide Substances 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 239000001301 oxygen Substances 0.000 claims description 7
- 208000034461 Progressive cone dystrophy Diseases 0.000 claims description 6
- 241000700159 Rattus Species 0.000 claims description 6
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims description 6
- 108010023082 activin A Proteins 0.000 claims description 6
- 201000008615 cone dystrophy Diseases 0.000 claims description 6
- 238000012744 immunostaining Methods 0.000 claims description 6
- 230000004069 differentiation Effects 0.000 claims description 5
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 5
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 5
- 206010002091 Anaesthesia Diseases 0.000 claims description 3
- 206010003694 Atrophy Diseases 0.000 claims description 3
- 208000016615 Central areolar choroidal dystrophy Diseases 0.000 claims description 3
- 208000033810 Choroidal dystrophy Diseases 0.000 claims description 3
- 201000001353 Doyne honeycomb retinal dystrophy Diseases 0.000 claims description 3
- 208000037312 Familial drusen Diseases 0.000 claims description 3
- 206010025421 Macule Diseases 0.000 claims description 3
- 208000035719 Maculopathy Diseases 0.000 claims description 3
- 208000004453 Retinal Dysplasia Diseases 0.000 claims description 3
- 201000007737 Retinal degeneration Diseases 0.000 claims description 3
- 206010038848 Retinal detachment Diseases 0.000 claims description 3
- 206010038923 Retinopathy Diseases 0.000 claims description 3
- 208000027073 Stargardt disease Diseases 0.000 claims description 3
- 230000037005 anaesthesia Effects 0.000 claims description 3
- 230000037444 atrophy Effects 0.000 claims description 3
- 208000001309 degenerative myopia Diseases 0.000 claims description 3
- 230000004340 degenerative myopia Effects 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 210000002950 fibroblast Anatomy 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 208000038015 macular disease Diseases 0.000 claims description 3
- 108091008695 photoreceptors Proteins 0.000 claims description 3
- 230000004264 retinal detachment Effects 0.000 claims description 3
- 239000000790 retinal pigment Substances 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 231100000331 toxic Toxicity 0.000 claims description 3
- 230000002588 toxic effect Effects 0.000 claims description 3
- 201000007790 vitelliform macular dystrophy Diseases 0.000 claims description 3
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 2
- 208000009795 Microphthalmos Diseases 0.000 claims description 2
- 102000040945 Transcription factor Human genes 0.000 claims description 2
- 108091023040 Transcription factor Proteins 0.000 claims description 2
- 230000007813 immunodeficiency Effects 0.000 claims description 2
- 201000010478 microphthalmia Diseases 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 230000004304 visual acuity Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 20
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 20
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 4
- 102000013760 Microphthalmia-Associated Transcription Factor Human genes 0.000 claims 3
- 108010050345 Microphthalmia-Associated Transcription Factor Proteins 0.000 claims 3
- 208000002352 blister Diseases 0.000 claims 2
- 210000003161 choroid Anatomy 0.000 claims 2
- 238000007726 management method Methods 0.000 claims 2
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 1
- 230000004438 eyesight Effects 0.000 claims 1
- 208000023678 immunodeficiency 70 Diseases 0.000 claims 1
- 230000010287 polarization Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 108060007030 Ribulose-phosphate 3-epimerase Proteins 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 101000670189 Homo sapiens Ribulose-phosphate 3-epimerase Proteins 0.000 description 2
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
- 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462097753P | 2014-12-30 | 2014-12-30 | |
| US62/097,753 | 2014-12-30 | ||
| US201562116980P | 2015-02-17 | 2015-02-17 | |
| US201562116972P | 2015-02-17 | 2015-02-17 | |
| US62/116,972 | 2015-02-17 | ||
| US62/116,980 | 2015-02-17 | ||
| PCT/IL2015/050456 WO2016108219A1 (en) | 2014-12-30 | 2015-04-30 | Methods of treating retinal diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020092030A Division JP2020143137A (ja) | 2014-12-30 | 2020-05-27 | 網膜疾患を治療する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018501281A JP2018501281A (ja) | 2018-01-18 |
| JP2018501281A5 true JP2018501281A5 (enExample) | 2019-03-07 |
Family
ID=56284392
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017535831A Pending JP2018501281A (ja) | 2014-12-30 | 2015-04-30 | 網膜疾患を治療する方法 |
| JP2020092030A Withdrawn JP2020143137A (ja) | 2014-12-30 | 2020-05-27 | 網膜疾患を治療する方法 |
| JP2022107516A Pending JP2022125160A (ja) | 2014-12-30 | 2022-07-04 | 網膜疾患を治療する方法 |
| JP2023208119A Pending JP2024023611A (ja) | 2014-12-30 | 2023-12-11 | 網膜疾患を治療する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020092030A Withdrawn JP2020143137A (ja) | 2014-12-30 | 2020-05-27 | 網膜疾患を治療する方法 |
| JP2022107516A Pending JP2022125160A (ja) | 2014-12-30 | 2022-07-04 | 網膜疾患を治療する方法 |
| JP2023208119A Pending JP2024023611A (ja) | 2014-12-30 | 2023-12-11 | 網膜疾患を治療する方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20180008458A1 (enExample) |
| EP (1) | EP3240612B1 (enExample) |
| JP (4) | JP2018501281A (enExample) |
| KR (2) | KR102359257B1 (enExample) |
| CN (3) | CN107427534A (enExample) |
| AU (3) | AU2015373111B2 (enExample) |
| BR (1) | BR112017014332A2 (enExample) |
| CA (2) | CA2972700A1 (enExample) |
| DK (1) | DK3240612T3 (enExample) |
| EA (1) | EA201791518A1 (enExample) |
| ES (1) | ES2843626T3 (enExample) |
| HK (1) | HK1246179A1 (enExample) |
| IL (1) | IL253244B2 (enExample) |
| MX (1) | MX2017008818A (enExample) |
| PH (1) | PH12017501217A1 (enExample) |
| SG (1) | SG11201705378RA (enExample) |
| WO (1) | WO2016108219A1 (enExample) |
| ZA (1) | ZA201704359B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011063005A2 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| MX2017008737A (es) | 2014-12-30 | 2018-01-25 | Cell Cure Neurosciences Ltd | Poblaciones de celulas rpe y metodos para generar las mismas. |
| US20180011092A1 (en) | 2014-12-30 | 2018-01-11 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
| EA201791518A1 (ru) * | 2014-12-30 | 2017-10-31 | Селл Кьюр Нейросайансес Лтд. | Способы лечения заболеваний сетчатки |
| US11230696B2 (en) | 2015-07-29 | 2022-01-25 | Hadasit Medical Research Services And Development Ltd. | Large scale production of retinal pigment epithelial cells |
| PL3331994T3 (pl) | 2015-08-05 | 2023-01-30 | Cell Cure Neurosciences Ltd. | Wytwarzanie komórek nabłonka barwnikowego siatkówki |
| AU2016303631B2 (en) | 2015-08-05 | 2022-07-28 | Cell Cure Neurosciences Ltd. | Preparation of photoreceptors for the treatment of retinal diseases |
| CN110913874A (zh) * | 2017-03-16 | 2020-03-24 | 谱系细胞疗法公司 | 用于测量视网膜疾病疗法的疗效的方法 |
| WO2019028088A1 (en) | 2017-07-31 | 2019-02-07 | Biotime, Inc. | COMPOSITIONS AND METHODS FOR RESTORING OR PREVENTING LOSS OF VISION CAUSED BY TRAUMATIC DISEASE OR INJURY |
| SG11202005795TA (en) * | 2017-12-29 | 2020-07-29 | Cell Cure Neurosciences Ltd | Retinal pigment epithelium cell compositions |
| AU2019256723B2 (en) | 2018-04-20 | 2025-09-04 | FUJIFILM Cellular Dynamics, Inc. | Method for differentiation of ocular cells and use thereof |
| CN108795864B (zh) * | 2018-05-24 | 2021-08-24 | 中山大学中山眼科中心 | 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法 |
| US10264436B1 (en) * | 2018-05-29 | 2019-04-16 | Link Labs, Inc. | BLE networking systems and methods providing central and peripheral role reversal with independent peripheral network connectivity |
| WO2020047476A1 (en) * | 2018-08-31 | 2020-03-05 | University Of Florida Research Foundation, Incorporated | Adeno-associated viral vectors for the treatment of best disease |
| WO2020229628A1 (en) * | 2019-05-15 | 2020-11-19 | Novo Nordisk A/S | Methods for obtaining eye field progenitor cells from human pluripotent stem cells |
| JP2023528362A (ja) * | 2020-05-25 | 2023-07-04 | リネージ セル セラピューティクス インコーポレイテッド | 網膜の疾患及び症状を処置するための方法及び組成物 |
| IL301042A (en) * | 2020-09-03 | 2023-05-01 | Curebiotec Gmbh | Pigment epithelium-derived factor (pedf) for use in treatment of macular degeneration or choroidal neovascularisation |
| EP3964227A1 (en) * | 2020-09-08 | 2022-03-09 | Curebiotec GmbH | Method for the treatment of a disease using pigment epithelium-derived factor (pedf) |
| KR102633321B1 (ko) * | 2021-05-11 | 2024-02-05 | 연세대학교 산학협력단 | 노인성 황반변성의 예방 또는 치료를 위한 약학 조성물 |
| CN115137553A (zh) * | 2022-07-11 | 2022-10-04 | 上海市同济医院 | 一种免造孔视网膜下液排出装置 |
| CN115212233B (zh) * | 2022-08-26 | 2024-05-28 | 北京市眼科研究所 | 用于治疗视网膜相关疾病的组合物、试剂盒及其应用 |
| WO2024110625A1 (en) * | 2022-11-24 | 2024-05-30 | Universität Bern | Cralbp based therapeutics for retinal disorders |
| KR102531735B1 (ko) * | 2022-12-27 | 2023-05-12 | 주식회사 셀리코 | 초소형 자극기 및 이의 제조방법 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| ES2530370T5 (es) | 2007-04-18 | 2018-05-28 | Hadasit Medical Research Services & Development Limited | Células del epitelio pigmentario de la retina derivadas de células madre |
| ES2764473T3 (es) * | 2007-10-12 | 2020-06-03 | Astellas Inst For Regenerative Medicine | Métodos mejorados para producir células RPE y composiciones de células RPE |
| KR101025880B1 (ko) * | 2008-10-23 | 2011-03-30 | 공희숙 | 성체 줄기세포를 이용한 인슐린 분비세포로의 분화 유도방법 |
| WO2011063005A2 (en) * | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| CA2855941A1 (en) | 2011-11-14 | 2013-05-23 | Advanced Cell Technology, Inc. | Pharmaceutical preparations of human rpe cells and uses thereof |
| US9850463B2 (en) * | 2012-02-01 | 2017-12-26 | The Regents Of The University Of California | Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation |
| WO2013154336A1 (ko) * | 2012-04-09 | 2013-10-17 | 연세대학교 산학협력단 | 망막하 주사 또는 추출용 중공형 마이크로니들 및 망막하 주사기 |
| US20150368713A1 (en) * | 2013-02-01 | 2015-12-24 | THE UNITED STATES OF AMERICAN, as represented by the Secretary, Department of Health and Human Serv | METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs) |
| EP3080248A1 (en) * | 2013-12-11 | 2016-10-19 | Pfizer Limited | Method for producing retinal pigment epithelial cells |
| US20180011092A1 (en) | 2014-12-30 | 2018-01-11 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
| EA201791518A1 (ru) | 2014-12-30 | 2017-10-31 | Селл Кьюр Нейросайансес Лтд. | Способы лечения заболеваний сетчатки |
| MX2017008737A (es) | 2014-12-30 | 2018-01-25 | Cell Cure Neurosciences Ltd | Poblaciones de celulas rpe y metodos para generar las mismas. |
| KR101982801B1 (ko) * | 2015-10-28 | 2019-05-30 | 서울대학교 산학협력단 | 망막색소상피 분화 유도용 조성물 |
-
2015
- 2015-04-30 EA EA201791518A patent/EA201791518A1/ru unknown
- 2015-04-30 JP JP2017535831A patent/JP2018501281A/ja active Pending
- 2015-04-30 CN CN201580076318.0A patent/CN107427534A/zh active Pending
- 2015-04-30 US US15/539,565 patent/US20180008458A1/en not_active Abandoned
- 2015-04-30 CA CA2972700A patent/CA2972700A1/en not_active Abandoned
- 2015-04-30 KR KR1020177021263A patent/KR102359257B1/ko active Active
- 2015-04-30 KR KR1020227003550A patent/KR102514912B1/ko active Active
- 2015-04-30 CN CN202210141757.7A patent/CN114533761A/zh active Pending
- 2015-04-30 CN CN202210144880.4A patent/CN114469998A/zh active Pending
- 2015-04-30 CA CA3175175A patent/CA3175175A1/en active Pending
- 2015-04-30 DK DK15875361.6T patent/DK3240612T3/da active
- 2015-04-30 MX MX2017008818A patent/MX2017008818A/es unknown
- 2015-04-30 WO PCT/IL2015/050456 patent/WO2016108219A1/en not_active Ceased
- 2015-04-30 SG SG11201705378RA patent/SG11201705378RA/en unknown
- 2015-04-30 AU AU2015373111A patent/AU2015373111B2/en active Active
- 2015-04-30 EP EP15875361.6A patent/EP3240612B1/en not_active Revoked
- 2015-04-30 IL IL253244A patent/IL253244B2/en unknown
- 2015-04-30 HK HK18105715.3A patent/HK1246179A1/zh unknown
- 2015-04-30 ES ES15875361T patent/ES2843626T3/es active Active
- 2015-04-30 BR BR112017014332A patent/BR112017014332A2/pt not_active Application Discontinuation
-
2017
- 2017-06-27 ZA ZA2017/04359A patent/ZA201704359B/en unknown
- 2017-06-29 PH PH12017501217A patent/PH12017501217A1/en unknown
-
2020
- 2020-05-27 JP JP2020092030A patent/JP2020143137A/ja not_active Withdrawn
-
2021
- 2021-09-08 AU AU2021229196A patent/AU2021229196A1/en not_active Abandoned
-
2022
- 2022-07-04 JP JP2022107516A patent/JP2022125160A/ja active Pending
- 2022-09-13 US US17/943,462 patent/US20230028133A1/en not_active Abandoned
-
2023
- 2023-10-27 AU AU2023255009A patent/AU2023255009A1/en not_active Abandoned
- 2023-12-11 JP JP2023208119A patent/JP2024023611A/ja active Pending
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