JP2018501217A - 統合失調症を治療するための２−（（１−（２（４−フルオロフェニル）−２−オキソエチル）ピペリジン−４−イル）メチル）イソインドリン−１−オン - Google Patents

統合失調症を治療するための２−（（１−（２（４−フルオロフェニル）−２−オキソエチル）ピペリジン−４−イル）メチル）イソインドリン−１−オン Download PDF

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JP2018501217A
JP2018501217A JP2017529388A JP2017529388A JP2018501217A JP 2018501217 A JP2018501217 A JP 2018501217A JP 2017529388 A JP2017529388 A JP 2017529388A JP 2017529388 A JP2017529388 A JP 2017529388A JP 2018501217 A JP2018501217 A JP 2018501217A
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compound
hcl
formulation
pharmaceutical formulation
sleep
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JP2018501217A5 (OSRAM
Inventor
レミー・ルースリンガー
昌弘 奥山
昌弘 奥山
ナディネ・ノエル
サンドラ・ウェルネ
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Mitsubishi Tanabe Pharma Corp
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Mitsubishi Tanabe Pharma Corp
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Publication of JP2018501217A5 publication Critical patent/JP2018501217A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2017529388A 2014-12-02 2015-11-30 統合失調症を治療するための２−（（１−（２（４−フルオロフェニル）−２−オキソエチル）ピペリジン−４−イル）メチル）イソインドリン−１−オン Pending JP2018501217A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462086691P 2014-12-02 2014-12-02
US62/086,691 2014-12-02
US201562248071P 2015-10-29 2015-10-29
US62/248,071 2015-10-29
PCT/US2015/062985 WO2016089766A1 (en) 2014-12-02 2015-11-30 Compositions comprising 2-((1-(2(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia

Related Child Applications (1)

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JP2020116157A Division JP7069253B2 (ja) 2014-12-02 2020-07-06 統合失調症を治療するための２－（（１－（２（４－フルオロフェニル）－２－オキソエチル）ピペリジン－４－イル）メチル）イソインドリン－１－オン

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JP2018501217A true JP2018501217A (ja) 2018-01-18
JP2018501217A5 JP2018501217A5 (OSRAM) 2018-12-13

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JP2017529388A Pending JP2018501217A (ja) 2014-12-02 2015-11-30 統合失調症を治療するための２−（（１−（２（４−フルオロフェニル）−２−オキソエチル）ピペリジン−４−イル）メチル）イソインドリン−１−オン
JP2020116157A Active JP7069253B2 (ja) 2014-12-02 2020-07-06 統合失調症を治療するための２－（（１－（２（４－フルオロフェニル）－２－オキソエチル）ピペリジン－４－イル）メチル）イソインドリン－１－オン
JP2022076280A Pending JP2022105159A (ja) 2014-12-02 2022-05-02 統合失調症を治療するための２－（（１－（２（４－フルオロフェニル）－２－オキソエチル）ピペリジン－４－イル）メチル）イソインドリン－１－オン
JP2024173051A Pending JP2025004090A (ja) 2014-12-02 2024-10-02 統合失調症を治療するための２－（（１－（２（４－フルオロフェニル）－２－オキソエチル）ピペリジン－４－イル）メチル）イソインドリン－１－オン

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JP2020116157A Active JP7069253B2 (ja) 2014-12-02 2020-07-06 統合失調症を治療するための２－（（１－（２（４－フルオロフェニル）－２－オキソエチル）ピペリジン－４－イル）メチル）イソインドリン－１－オン
JP2022076280A Pending JP2022105159A (ja) 2014-12-02 2022-05-02 統合失調症を治療するための２－（（１－（２（４－フルオロフェニル）－２－オキソエチル）ピペリジン－４－イル）メチル）イソインドリン－１－オン
JP2024173051A Pending JP2025004090A (ja) 2014-12-02 2024-10-02 統合失調症を治療するための２－（（１－（２（４－フルオロフェニル）－２－オキソエチル）ピペリジン－４－イル）メチル）イソインドリン－１－オン

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US (7) US9458130B2 (OSRAM)
EP (2) EP4063357B1 (OSRAM)
JP (4) JP2018501217A (OSRAM)
KR (1) KR102620681B1 (OSRAM)
CN (2) CN107567444A (OSRAM)
AU (4) AU2015355226B2 (OSRAM)
BR (1) BR112017011555B1 (OSRAM)
CA (1) CA2968977A1 (OSRAM)
CL (2) CL2017001376A1 (OSRAM)
CO (1) CO2017005498A2 (OSRAM)
DK (1) DK3227273T3 (OSRAM)
EA (1) EA201791226A1 (OSRAM)
ES (1) ES2910528T3 (OSRAM)
HU (1) HUE058212T2 (OSRAM)
IL (4) IL313572A (OSRAM)
MX (1) MX385586B (OSRAM)
MY (1) MY185516A (OSRAM)
PE (1) PE20171646A1 (OSRAM)
PH (1) PH12017501007B1 (OSRAM)
PL (1) PL3227273T3 (OSRAM)
PT (1) PT3227273T (OSRAM)
SG (1) SG11201704332YA (OSRAM)
TW (1) TWI694069B (OSRAM)
UA (1) UA122780C2 (OSRAM)
WO (1) WO2016089766A1 (OSRAM)
ZA (1) ZA201703481B (OSRAM)

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JP2018501217A (ja) * 2014-12-02 2018-01-18 田辺三菱製薬株式会社 統合失調症を治療するための２−（（１−（２（４−フルオロフェニル）−２−オキソエチル）ピペリジン−４−イル）メチル）イソインドリン−１−オン
WO2017205393A1 (en) * 2016-05-25 2017-11-30 Minerva Neurosciences, Inc. Compositions and methods for treating negative symptoms in non-schizophrenic patients
PE20200732A1 (es) * 2017-06-21 2020-07-23 Minerva Neurosciences Inc Formas de dosificacion oral y de liberacion controlada gastrorresistentes
CN107721988A (zh) * 2017-10-31 2018-02-23 无锡福祈制药有限公司 具有抗炎活性的异吲哚‑1‑酮类化合物
GB2591667A (en) 2018-08-21 2021-08-04 Minerva Neurosciences Inc Use of roluperidone to treat negative symptoms and disorders, increase neuroplasticity, and promote neuroprotection
TWI841545B (zh) * 2018-12-12 2024-05-11 日商田邊三菱製藥股份有限公司 耐胃性控制釋放經口劑型
WO2020264486A1 (en) 2019-06-28 2020-12-30 Teva Czech Industries S.R.O Solid state forms of roluperidone and salts thereof
WO2021236879A1 (en) 2020-05-20 2021-11-25 The Board Of Trustees Of The University Of Illinois Method for treating lysosomal storage diseases with histatin peptides
CN116251078B (zh) * 2021-12-09 2025-12-19 河北以岭医药研究院有限公司 一种盐酸度洛西汀肠溶胶囊及其制备方法
EP4479049B1 (en) 2022-02-14 2025-12-17 Minerva Neurosciences, Inc. Use of roluperidone in preventing relapse in schizophrenia patients
WO2025090588A1 (en) 2023-10-24 2025-05-01 Minerva Neurosciences, Inc. Roluperidone for the treatment of lysosomal storage disorders and their symptoms

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WO2017205393A1 (en) 2016-05-25 2017-11-30 Minerva Neurosciences, Inc. Compositions and methods for treating negative symptoms in non-schizophrenic patients
PE20200732A1 (es) 2017-06-21 2020-07-23 Minerva Neurosciences Inc Formas de dosificacion oral y de liberacion controlada gastrorresistentes
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JP2013531072A (ja) * 2010-07-20 2013-08-01 キレナイク・ファーマシューティカルズ，インコーポレーテッド 統合失調症を処置するための環状アミド誘導体の使用の方法
WO2012123922A1 (en) * 2011-03-17 2012-09-20 Lupin Limited Controlled release pharmaceutical compositions of selective serotonin reuptake inhibitor
US20140018348A1 (en) * 2012-07-12 2014-01-16 Daniel C. Javitt Composition and Method for Treatment of Depression and Psychosis in Humans

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AU2015355226B2 (en) 2020-04-02
US9730920B2 (en) 2017-08-15
PT3227273T (pt) 2022-04-06
KR102620681B1 (ko) 2024-01-04
US20250195494A1 (en) 2025-06-19
BR112017011555A2 (pt) 2018-01-09
EP4063357A1 (en) 2022-09-28
IL301320A (en) 2023-05-01
AU2023258386B2 (en) 2025-10-23
SG11201704332YA (en) 2017-06-29
PL3227273T3 (pl) 2022-05-30
EP3227273A1 (en) 2017-10-11
EA201791226A1 (ru) 2017-09-29
HUE058212T2 (hu) 2022-07-28
CN107567444A (zh) 2018-01-09
CN111110677A (zh) 2020-05-08
CL2017001376A1 (es) 2018-02-16
KR20170106310A (ko) 2017-09-20
TWI694069B (zh) 2020-05-21
JP2025004090A (ja) 2025-01-14
EP3227273B1 (en) 2022-02-09
US20160152597A1 (en) 2016-06-02
ZA201703481B (en) 2023-12-20
IL252347A0 (en) 2017-07-31
AU2021229240A1 (en) 2021-10-07
IL280052B2 (en) 2023-09-01
UA122780C2 (uk) 2021-01-06
CA2968977A1 (en) 2016-06-09
IL280052B1 (en) 2023-05-01
MY185516A (en) 2021-05-19
DK3227273T3 (da) 2022-05-02
WO2016089766A1 (en) 2016-06-09
US10799493B2 (en) 2020-10-13
US20200022968A1 (en) 2020-01-23
AU2020204286B2 (en) 2021-06-17
AU2015355226A1 (en) 2017-06-08
AU2020204286A1 (en) 2020-07-16
US20210228561A1 (en) 2021-07-29
JP7069253B2 (ja) 2022-05-17
ES2910528T3 (es) 2022-05-12
BR112017011555B1 (pt) 2023-10-03
EP4063357B1 (en) 2025-12-31
IL280052A (en) 2021-03-01
IL301320B1 (en) 2024-07-01
IL301320B2 (en) 2024-11-01
NZ732033A (en) 2023-10-27
CO2017005498A2 (es) 2017-09-20
AU2021229240B2 (en) 2023-08-24
IL313572A (en) 2024-08-01
JP2022105159A (ja) 2022-07-12
CL2021000044A1 (es) 2021-06-04
PH12017501007A1 (en) 2017-12-18
US20170042877A1 (en) 2017-02-16
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NZ770365A (en) 2023-10-27
TW201632511A (zh) 2016-09-16
IL252347B (en) 2021-01-31
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US20180153871A1 (en) 2018-06-07
MX385586B (es) 2025-03-18
US20230201184A1 (en) 2023-06-29
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