JP2018500317A5 - - Google Patents

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Publication number
JP2018500317A5
JP2018500317A5 JP2017531893A JP2017531893A JP2018500317A5 JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5 JP 2017531893 A JP2017531893 A JP 2017531893A JP 2017531893 A JP2017531893 A JP 2017531893A JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5
Authority
JP
Japan
Prior art keywords
trolox
item
salt
resolving agent
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2017531893A
Other languages
English (en)
Japanese (ja)
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JP2018500317A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/066208 external-priority patent/WO2016100576A1/en
Publication of JP2018500317A publication Critical patent/JP2018500317A/ja
Publication of JP2018500317A5 publication Critical patent/JP2018500317A5/ja
Withdrawn legal-status Critical Current

Links

JP2017531893A 2014-12-16 2015-12-16 トロロックスのキラル分割のための方法 Withdrawn JP2018500317A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462092743P 2014-12-16 2014-12-16
US62/092,743 2014-12-16
US201562133276P 2015-03-13 2015-03-13
US62/133,276 2015-03-13
PCT/US2015/066208 WO2016100576A1 (en) 2014-12-16 2015-12-16 Methods for chiral resolution of trolox

Publications (2)

Publication Number Publication Date
JP2018500317A JP2018500317A (ja) 2018-01-11
JP2018500317A5 true JP2018500317A5 (enExample) 2019-01-31

Family

ID=56684375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017531893A Withdrawn JP2018500317A (ja) 2014-12-16 2015-12-16 トロロックスのキラル分割のための方法

Country Status (4)

Country Link
US (1) US20180002247A1 (enExample)
EP (1) EP3233819A1 (enExample)
JP (1) JP2018500317A (enExample)
WO (1) WO2016100576A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA035619B1 (ru) 2005-06-01 2020-07-16 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Композиции для использования в способе лечения митохондриальных нарушений
PL2220030T3 (pl) 2007-11-06 2016-07-29 Bioelectron Tech Corp Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych
WO2010051277A1 (en) 2008-10-28 2010-05-06 Edison Pharmaceuticals, Inc. Process for the production of alpha-tocotrienol and derivatives
CA2842486C (en) 2011-07-19 2022-09-06 Edison Pharmaceuticals, Inc. Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
HUE058877T2 (hu) 2014-12-16 2022-09-28 Ptc Therapeutics Inc (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociklohexa-1,4-dienil)butánamid polimorf és amorf alakjai
JP7117241B2 (ja) 2015-12-16 2022-08-12 ピーティーシー セラピューティクス， インコーポレイテッド 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法
EP3389646A1 (en) 2015-12-17 2018-10-24 BioElectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
WO2021097249A1 (en) * 2019-11-14 2021-05-20 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
EP4108658A4 (en) * 2020-02-21 2024-05-22 Sumitomo Pharma Co., Ltd. OPTICALLY RESOLVED TROLOX INTERMEDIATE AND PRODUCTION METHOD THEREFOR
JP7241238B2 (ja) 2020-03-26 2023-03-16 三菱電機株式会社 衛星コンステレーション形成システム、メガコンステレーション事業装置、および地上設備
JP7223738B2 (ja) 2020-11-12 2023-02-16 株式会社アルバック スパッタリング装置
IL319633A (en) * 2022-09-30 2025-05-01 Ptc Therapeutics Inc Oxygen cleavage method of trolox amide
CN118126011A (zh) * 2024-01-22 2024-06-04 辽宁大学 一种手性拆分Trolox及Trolox酯类化合物对映异构体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947473A (en) 1972-12-22 1976-03-30 Hoffman-La Roche Inc. Antioxidant chroman compounds
US4003919A (en) 1973-11-19 1977-01-18 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US4018799A (en) * 1973-11-19 1977-04-19 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US4026907A (en) 1973-11-19 1977-05-31 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US5348973A (en) * 1990-10-09 1994-09-20 Rhone-Poulenc Chimie Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis
JP3913329B2 (ja) * 1997-09-11 2007-05-09 株式会社クラレ （±）−クロマンカルボン酸の光学分割法
WO2002012221A1 (en) * 2000-08-03 2002-02-14 Kuraray Co., Ltd. Method for optical resolution of (±)-6-hydroxy-2,5,7,8-tetramethylcoumarone-2-carboxylic acid
EA035619B1 (ru) 2005-06-01 2020-07-16 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Композиции для использования в способе лечения митохондриальных нарушений
ATE539071T1 (de) * 2006-10-26 2012-01-15 Mitsubishi Gas Chemical Co Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure
PL2220030T3 (pl) * 2007-11-06 2016-07-29 Bioelectron Tech Corp Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych
JP5266875B2 (ja) * 2008-05-23 2013-08-21 三菱瓦斯化学株式会社 有機カルボン酸エステルからの光学活性有機カルボン酸の製造方法
US20110251407A1 (en) 2008-10-29 2011-10-13 Mitsubishi Gas Chemical Company, Inc. Process for production of optically active organic carboxylic acid

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