JP2018500317A5 - - Google Patents
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- Publication number
- JP2018500317A5 JP2018500317A5 JP2017531893A JP2017531893A JP2018500317A5 JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5 JP 2017531893 A JP2017531893 A JP 2017531893A JP 2017531893 A JP2017531893 A JP 2017531893A JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5
- Authority
- JP
- Japan
- Prior art keywords
- trolox
- item
- salt
- resolving agent
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462092743P | 2014-12-16 | 2014-12-16 | |
| US62/092,743 | 2014-12-16 | ||
| US201562133276P | 2015-03-13 | 2015-03-13 | |
| US62/133,276 | 2015-03-13 | ||
| PCT/US2015/066208 WO2016100576A1 (en) | 2014-12-16 | 2015-12-16 | Methods for chiral resolution of trolox |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018500317A JP2018500317A (ja) | 2018-01-11 |
| JP2018500317A5 true JP2018500317A5 (cg-RX-API-DMAC7.html) | 2019-01-31 |
Family
ID=56684375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531893A Withdrawn JP2018500317A (ja) | 2014-12-16 | 2015-12-16 | トロロックスのキラル分割のための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20180002247A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3233819A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018500317A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016100576A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2619303T3 (es) | 2005-06-01 | 2017-06-26 | Edison Pharmaceuticals, Inc. | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
| EA038941B1 (ru) | 2007-11-06 | 2021-11-12 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ |
| ES2553557T3 (es) | 2008-10-28 | 2015-12-10 | Edison Pharmaceuticals, Inc. | Proceso para la producción de alfa-tocotrienol y derivados |
| EP2734512B1 (en) | 2011-07-19 | 2019-11-20 | Bioelectron Technology Corporation | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| DK3233786T3 (da) | 2014-12-16 | 2022-05-09 | Ptc Therapeutics Inc | Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid |
| WO2017106786A1 (en) | 2015-12-16 | 2017-06-22 | Bioelectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| WO2021097249A1 (en) * | 2019-11-14 | 2021-05-20 | Senseonics, Incorporated | Mediation of in vivo analyte signal degradation |
| EP4108658A4 (en) * | 2020-02-21 | 2024-05-22 | Sumitomo Pharma Co., Ltd. | OPTICALLY RESOLVED TROLOX INTERMEDIATE AND PRODUCTION METHOD THEREFOR |
| JP7223738B2 (ja) | 2020-11-12 | 2023-02-16 | 株式会社アルバック | スパッタリング装置 |
| AU2023352262A1 (en) * | 2022-09-30 | 2025-04-24 | Ptc Therapeutics, Inc. | Oxidative cleavage method of trolox amide |
| CN118126011A (zh) * | 2024-01-22 | 2024-06-04 | 辽宁大学 | 一种手性拆分Trolox及Trolox酯类化合物对映异构体的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947473A (en) | 1972-12-22 | 1976-03-30 | Hoffman-La Roche Inc. | Antioxidant chroman compounds |
| US4018799A (en) * | 1973-11-19 | 1977-04-19 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| US4026907A (en) | 1973-11-19 | 1977-05-31 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| US4003919A (en) | 1973-11-19 | 1977-01-18 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| US5348973A (en) * | 1990-10-09 | 1994-09-20 | Rhone-Poulenc Chimie | Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis |
| JP3913329B2 (ja) * | 1997-09-11 | 2007-05-09 | 株式会社クラレ | （±）−クロマンカルボン酸の光学分割法 |
| WO2002012221A1 (en) * | 2000-08-03 | 2002-02-14 | Kuraray Co., Ltd. | Method for optical resolution of (±)-6-hydroxy-2,5,7,8-tetramethylcoumarone-2-carboxylic acid |
| ES2619303T3 (es) | 2005-06-01 | 2017-06-26 | Edison Pharmaceuticals, Inc. | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
| US8080676B2 (en) * | 2006-10-26 | 2011-12-20 | Mitsubishi Gas Chemical Company, Inc. | Method of producing S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid and product obtained by the method |
| EA038941B1 (ru) * | 2007-11-06 | 2021-11-12 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ |
| JP5266875B2 (ja) * | 2008-05-23 | 2013-08-21 | 三菱瓦斯化学株式会社 | 有機カルボン酸エステルからの光学活性有機カルボン酸の製造方法 |
| JP5598330B2 (ja) | 2008-10-29 | 2014-10-01 | 三菱瓦斯化学株式会社 | 光学活性有機カルボン酸の製造方法 |
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2015
- 2015-12-16 EP EP15820772.0A patent/EP3233819A1/en not_active Withdrawn
- 2015-12-16 WO PCT/US2015/066208 patent/WO2016100576A1/en not_active Ceased
- 2015-12-16 JP JP2017531893A patent/JP2018500317A/ja not_active Withdrawn
- 2015-12-16 US US15/536,514 patent/US20180002247A1/en not_active Abandoned