JP2018203763A5 - - Google Patents
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- JP2018203763A5 JP2018203763A5 JP2018164332A JP2018164332A JP2018203763A5 JP 2018203763 A5 JP2018203763 A5 JP 2018203763A5 JP 2018164332 A JP2018164332 A JP 2018164332A JP 2018164332 A JP2018164332 A JP 2018164332A JP 2018203763 A5 JP2018203763 A5 JP 2018203763A5
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- JP
- Japan
- Prior art keywords
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020083208A JP7396960B2 (ja) | 2013-08-14 | 2020-05-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13004050.4 | 2013-08-14 | ||
| EP13004050.4A EP2837631A1 (en) | 2013-08-14 | 2013-08-14 | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533926A Division JP6617104B2 (ja) | 2013-08-14 | 2014-08-14 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020083208A Division JP7396960B2 (ja) | 2013-08-14 | 2020-05-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018203763A JP2018203763A (ja) | 2018-12-27 |
| JP2018203763A5 true JP2018203763A5 (enExample) | 2020-01-09 |
| JP6735321B2 JP6735321B2 (ja) | 2020-08-05 |
Family
ID=48998397
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533926A Active JP6617104B2 (ja) | 2013-08-14 | 2014-08-14 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2018164332A Active JP6735321B2 (ja) | 2013-08-14 | 2018-09-03 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2019070293A Active JP6764501B2 (ja) | 2013-08-14 | 2019-04-02 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2020083208A Active JP7396960B2 (ja) | 2013-08-14 | 2020-05-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2021183793A Active JP7710356B2 (ja) | 2013-08-14 | 2021-11-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533926A Active JP6617104B2 (ja) | 2013-08-14 | 2014-08-14 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019070293A Active JP6764501B2 (ja) | 2013-08-14 | 2019-04-02 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2020083208A Active JP7396960B2 (ja) | 2013-08-14 | 2020-05-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2021183793A Active JP7710356B2 (ja) | 2013-08-14 | 2021-11-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US20160185787A1 (enExample) |
| EP (3) | EP2837631A1 (enExample) |
| JP (5) | JP6617104B2 (enExample) |
| KR (2) | KR102439605B1 (enExample) |
| CN (2) | CN105452250B (enExample) |
| AU (2) | AU2014307872B2 (enExample) |
| BR (2) | BR112016002770B1 (enExample) |
| CA (1) | CA2921178C (enExample) |
| CY (2) | CY1119694T1 (enExample) |
| DK (2) | DK3287460T3 (enExample) |
| EA (3) | EA032179B1 (enExample) |
| ES (2) | ES2654474T3 (enExample) |
| HK (1) | HK1256262A1 (enExample) |
| HR (2) | HRP20171895T1 (enExample) |
| HU (2) | HUE037615T2 (enExample) |
| IL (2) | IL244069B (enExample) |
| LT (2) | LT3287460T (enExample) |
| MX (2) | MX382578B (enExample) |
| NO (1) | NO3033344T3 (enExample) |
| NZ (2) | NZ745811A (enExample) |
| PL (2) | PL3033344T3 (enExample) |
| PT (2) | PT3033344T (enExample) |
| RS (2) | RS61986B1 (enExample) |
| SG (2) | SG10201801179VA (enExample) |
| SI (2) | SI3287460T1 (enExample) |
| WO (1) | WO2015022407A1 (enExample) |
| ZA (1) | ZA201509204B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| US10059710B2 (en) | 2016-02-17 | 2018-08-28 | Merck & Cie | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid |
| EP3446704A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| EP3446703A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | 6r]-mthf multiple bolus administration in 5-fluorouracil based chemotherapy |
| EP3668516B1 (en) | 2017-08-16 | 2021-09-22 | Merck Patent GmbH | Stable lyophilisates comprising 5,10-methylene-(6r)-tetrahydrofolic acid and a dicarboxylic acid |
| KR20200107988A (ko) * | 2018-01-05 | 2020-09-16 | 이소폴 메디컬 에이비 | 결장직장암 및 전이성 결장직장암의 치료 방법 |
| KR20220152385A (ko) * | 2020-03-30 | 2022-11-15 | 수미토모 케미칼 컴퍼니 리미티드 | 적층체 |
| IL317418A (en) | 2022-06-08 | 2025-02-01 | Merck Patent Gmbh | Stable pharmaceutical preparations comprising 5,10-methylene-(6R)-tetrahydrofolic acid and NaCl |
| EP4536184A1 (en) | 2022-06-08 | 2025-04-16 | Merck Patent GmbH | Concentrated solutions comprising sodium 5,10-methylene-(6r)- tetrahydrofolate |
| WO2023237484A1 (en) | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Compositions comprising disodium 5,10-methylene-(6r)-tetrahydrofolate |
| CN119325374A (zh) | 2022-06-08 | 2025-01-17 | 默克专利股份有限公司 | 包含5,10-亚甲基-(6r)-四氢叶酸的稳定的冻干物 |
| EP4536186A1 (en) | 2022-06-08 | 2025-04-16 | Merck Patent GmbH | Concentrated solutions comprising 5,10-methylene-(6r)-tetrahydrofolic acid |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2300505A (en) * | 1940-10-31 | 1942-11-03 | Bell Telephone Labor Inc | Selective system |
| EP0165926B1 (en) | 1983-05-20 | 1990-10-24 | Bengt Gustavsson | A device for transferring a substance |
| DE3821875C1 (enExample) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
| CH682664A5 (en) * | 1991-10-15 | 1993-10-29 | Eprova Ag | Stable salts of 5,10-methylene tetrahydrofolate. |
| CH684644A5 (de) | 1992-07-13 | 1994-11-15 | Eprova Ag | 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen. |
| HU226998B1 (en) | 2000-11-23 | 2010-04-28 | Richter Gedeon Nyrt | Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same |
| CH696628A5 (de) * | 2002-02-26 | 2007-08-31 | Eprova Ag | Verwendung von Folaten zur Herstellung einer Zubereitung geeignet zur Vorbeugung und Behandlung von Entzündungen und entzündungsassoziierter Krankheiten, im Speziellen zur Beeinflussung der |
| CH697021A5 (de) | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
| KR20080074201A (ko) | 2005-12-02 | 2008-08-12 | 어드벤트륵스 파마슈티칼스, 인크. | 5,10 메틸렌테트라히드로폴레이트의 안정한 약학 조성물 |
| PT2125779T (pt) | 2006-12-21 | 2016-07-19 | Hoffmann La Roche | Polimorfos de um antagonista de um recetor de mglur5 |
| JP5294968B2 (ja) | 2009-05-01 | 2013-09-18 | 三星ダイヤモンド工業株式会社 | スクライブヘッド及び該スクライブヘッドを用いたスクライブ装置 |
| AU2012325801B2 (en) * | 2011-10-19 | 2016-05-12 | Mercator Medsystems, Inc. | Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation |
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| EP2837766A1 (de) * | 2013-08-14 | 2015-02-18 | Sika Technology AG | Verfahren zum Ausfüllen einer Fuge mit einem Kleb- und/oder Dichtstoff sowie System zum Ausfüllen einer Fuge mit einem Kleb- und/oder Dichtstoff |
| JP6971761B2 (ja) * | 2017-10-11 | 2021-11-24 | 株式会社Ｉｈｉプラント | タンクの構築方法 |
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2013
- 2013-08-14 EP EP13004050.4A patent/EP2837631A1/en not_active Withdrawn
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2014
- 2014-08-14 PL PL14758102T patent/PL3033344T3/pl unknown
- 2014-08-14 AU AU2014307872A patent/AU2014307872B2/en active Active
- 2014-08-14 EP EP14758102.9A patent/EP3033344B1/en active Active
- 2014-08-14 BR BR112016002770-1A patent/BR112016002770B1/pt active IP Right Grant
- 2014-08-14 KR KR1020167006595A patent/KR102439605B1/ko active Active
- 2014-08-14 HR HRP20171895TT patent/HRP20171895T1/hr unknown
- 2014-08-14 EP EP17190279.4A patent/EP3287460B1/en active Active
- 2014-08-14 NZ NZ745811A patent/NZ745811A/en unknown
- 2014-08-14 SG SG10201801179VA patent/SG10201801179VA/en unknown
- 2014-08-14 CN CN201480044477.8A patent/CN105452250B/zh active Active
- 2014-08-14 HU HUE14758102A patent/HUE037615T2/hu unknown
- 2014-08-14 MX MX2018013134A patent/MX382578B/es unknown
- 2014-08-14 MX MX2016001834A patent/MX360355B/es active IP Right Grant
- 2014-08-14 HU HUE17190279A patent/HUE054504T2/hu unknown
- 2014-08-14 JP JP2016533926A patent/JP6617104B2/ja active Active
- 2014-08-14 EA EA201600172A patent/EA032179B1/ru not_active IP Right Cessation
- 2014-08-14 US US14/912,328 patent/US20160185787A1/en not_active Abandoned
- 2014-08-14 PL PL17190279T patent/PL3287460T3/pl unknown
- 2014-08-14 NZ NZ71782514A patent/NZ717825A/en unknown
- 2014-08-14 RS RS20210630A patent/RS61986B1/sr unknown
- 2014-08-14 WO PCT/EP2014/067447 patent/WO2015022407A1/en not_active Ceased
- 2014-08-14 ES ES14758102.9T patent/ES2654474T3/es active Active
- 2014-08-14 PT PT147581029T patent/PT3033344T/pt unknown
- 2014-08-14 SI SI201431825T patent/SI3287460T1/sl unknown
- 2014-08-14 KR KR1020217009189A patent/KR102410373B1/ko active Active
- 2014-08-14 BR BR122020002802-5A patent/BR122020002802B1/pt active IP Right Grant
- 2014-08-14 SG SG11201601016PA patent/SG11201601016PA/en unknown
- 2014-08-14 PT PT171902794T patent/PT3287460T/pt unknown
- 2014-08-14 DK DK17190279.4T patent/DK3287460T3/da active
- 2014-08-14 ES ES17190279T patent/ES2871483T3/es active Active
- 2014-08-14 CN CN201810160334.3A patent/CN108096200A/zh active Pending
- 2014-08-14 DK DK14758102.9T patent/DK3033344T3/en active
- 2014-08-14 CA CA2921178A patent/CA2921178C/en active Active
- 2014-08-14 RS RS20171337A patent/RS56910B1/sr unknown
- 2014-08-14 SI SI201430529T patent/SI3033344T1/en unknown
- 2014-08-14 LT LTEP17190279.4T patent/LT3287460T/lt unknown
- 2014-08-14 EA EA201892729A patent/EA201892729A1/ru unknown
- 2014-08-14 EA EA202091271A patent/EA202091271A3/ru unknown
- 2014-08-14 LT LTEP14758102.9T patent/LT3033344T/lt unknown
- 2014-08-14 NO NO14758102A patent/NO3033344T3/no unknown
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2015
- 2015-12-17 ZA ZA2015/09204A patent/ZA201509204B/en unknown
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2016
- 2016-02-11 IL IL244069A patent/IL244069B/en active IP Right Grant
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2017
- 2017-12-12 CY CY20171101298T patent/CY1119694T1/el unknown
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2018
- 2018-09-03 JP JP2018164332A patent/JP6735321B2/ja active Active
- 2018-11-29 HK HK18115320.9A patent/HK1256262A1/zh unknown
- 2018-12-06 US US16/212,056 patent/US20190106431A1/en not_active Abandoned
- 2018-12-13 AU AU2018278943A patent/AU2018278943B2/en active Active
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2019
- 2019-04-02 JP JP2019070293A patent/JP6764501B2/ja active Active
- 2019-09-08 IL IL269170A patent/IL269170B/en active IP Right Grant
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2020
- 2020-05-11 JP JP2020083208A patent/JP7396960B2/ja active Active
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2021
- 2021-04-27 CY CY20211100364T patent/CY1124076T1/el unknown
- 2021-05-12 HR HRP20210743TT patent/HRP20210743T1/hr unknown
- 2021-10-08 US US17/496,939 patent/US12122783B2/en active Active
- 2021-11-11 JP JP2021183793A patent/JP7710356B2/ja active Active
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2024
- 2024-08-09 US US18/799,606 patent/US20240400574A1/en active Pending