JP2018194374A5 - - Google Patents
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- JP2018194374A5 JP2018194374A5 JP2017096857A JP2017096857A JP2018194374A5 JP 2018194374 A5 JP2018194374 A5 JP 2018194374A5 JP 2017096857 A JP2017096857 A JP 2017096857A JP 2017096857 A JP2017096857 A JP 2017096857A JP 2018194374 A5 JP2018194374 A5 JP 2018194374A5
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- JP
- Japan
- Prior art keywords
- antibody
- app
- peptide
- terminal side
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 description 17
- 238000001114 immunoprecipitation Methods 0.000 description 13
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 210000004899 c-terminal region Anatomy 0.000 description 6
- 238000004949 mass spectrometry Methods 0.000 description 6
- 238000003776 cleavage reaction Methods 0.000 description 5
- 230000007017 scission Effects 0.000 description 5
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 description 4
- 239000012634 fragment Substances 0.000 description 3
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 description 2
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 description 2
- 108010033276 Peptide Fragments Proteins 0.000 description 2
- 102000007079 Peptide Fragments Human genes 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 108010032595 Antibody Binding Sites Proteins 0.000 description 1
- 101001018085 Lysobacter enzymogenes Lysyl endopeptidase Proteins 0.000 description 1
- 101800000021 N-terminal protease Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Images
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017096857A JP6870468B2 (ja) | 2017-05-15 | 2017-05-15 | ペプチドの分析方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017096857A JP6870468B2 (ja) | 2017-05-15 | 2017-05-15 | ペプチドの分析方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018194374A JP2018194374A (ja) | 2018-12-06 |
| JP2018194374A5 true JP2018194374A5 (enExample) | 2020-01-09 |
| JP6870468B2 JP6870468B2 (ja) | 2021-05-12 |
Family
ID=64571263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017096857A Active JP6870468B2 (ja) | 2017-05-15 | 2017-05-15 | ペプチドの分析方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6870468B2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3932942A4 (en) * | 2019-03-01 | 2022-12-07 | Shimadzu Corporation | APP669-711 MEASUREMENT METHOD AND KIT |
| JP7478040B2 (ja) | 2020-06-25 | 2024-05-02 | シスメックス株式会社 | Ａβペプチドの測定方法及びその方法に用いられる試薬組成物 |
| CN112255061A (zh) * | 2020-10-13 | 2021-01-22 | 南开大学 | 一种通过免疫沉淀分离和检测蛋白质的方法 |
| US20240230682A1 (en) * | 2021-05-14 | 2024-07-11 | Shimadzu Corporation | Method for analyzing neurogranin-related peptide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110294138A1 (en) * | 2008-11-12 | 2011-12-01 | The Washington University | Methods for simultaneously measuring the in vivo metabolism of two or more isoforms of a biomolecule |
| WO2014160647A1 (en) * | 2013-03-24 | 2014-10-02 | The Washington University | Method for amyloid beta sample processing |
| JP6152908B2 (ja) * | 2016-04-07 | 2017-06-28 | 株式会社島津製作所 | ペプチド断片の調製方法および分析方法 |
-
2017
- 2017-05-15 JP JP2017096857A patent/JP6870468B2/ja active Active
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