JP2018139539A - Food-and-drink composition for alcohol concentration reduction in expiration - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a food-and-drink composition for alcohol concentration reduction in expiration.SOLUTION: A food-and-drink composition for alcohol concentration reduction in expiration after drinking in a subject includes Andrographis paniculata extract, and the food-and-drink composition causes that the subject is ND type in an alcohol patch test.SELECTED DRAWING: None

Description

  The present invention relates to a food and beverage composition for reducing alcohol concentration in breath.

  Senshinren is a plant belonging to the foxglove family. Senshinren extract powder is used as a raw material for health foods and is also known as Amphis (registered trademark).

  It is commonly said that “prevents colds,” “good for allergies,” and “good for HIV / AIDS.” However, there is no reliable enough information on the effectiveness of taking sensinren alone (non-patent literature). 1). Moreover, the DNA damage suppression food / beverage which uses sensinren extract as an active ingredient is also reported (patent document 1). However, the effect of sensinren on the alcohol concentration in the breath was not known.

JP 2013-209299 A

National Research and Development Institute National Institute of Health, Nutrition and Nutrition National Institute of Health and Nutrition, “Health Foods” Material Information Database, Senshinren, [Search on December 27, 2016], Internet <URL: http: / /hfnet.nih.go.jp/contents/detail1685.html>

  This invention makes it a subject to provide the food-drinks composition for alcohol concentration reduction in breath.

  The present inventor has found that sensinren has an action of reducing the alcohol concentration in breath, and has completed the present invention.

That is, the present invention is as follows.
[1] A food / beverage composition for reducing alcohol concentration in breath after drinking in a subject, comprising sensinren,
[2] The food / beverage product composition according to [1], wherein the subject is ND type in an alcohol patch test.

  The present invention can reduce the alcohol concentration in exhaled breath.

  The raw material, senshinren, is Andrographis panicu / Lata, an annual plant belonging to the family Vulgaridae. Add white or pink bell-shaped flowers.

  As a specific extraction / purification method for obtaining the extract from this sensine, any conventionally known method in this technical field can be used, but the dried perforated lotus is pulverized, and the obtained pulverized product is obtained. A method of extracting with an appropriate extraction solvent and purifying the obtained extract by chromatography such as a column can be exemplified.

  Although it does not specifically limit as said extraction solvent, 1 type, or 2 or more types, such as water; Alcohols; Ketones, such as acetone; Ethers, such as ethyl ether; Esters, such as ethyl acetate, can be used. Examples of the alcohols include lower monohydric alcohols such as methanol and ethanol; liquid polyhydric alcohols such as glycerin, propylene glycol, and butanediol.

  The form of the food / beverage composition of the present invention is not particularly limited. For example, confectionery such as chewing gum, chocolate, candy, jelly, biscuits and crackers mixed with food and drink materials; frozen confectionery such as ice cream and ice confectionery; Beverages such as tea, soft drinks, energy drinks and beauty drinks; noodles such as udon, Chinese noodles, spaghetti and instant noodles; kneaded products such as crab; seasonings such as dressings, mayonnaise, sauces; Kinds: Can be used for all common foods and drinks such as bread, ham, soup, retort food, frozen food, etc., and can be formulated into health foods and supplements. When these foods and beverages are ingested, the intake is converted to the amount of the active ingredient per adult day, preferably 0.01 to 1000 mg / Kg body weight, more preferably 0.1 to 300 mg / Kg body weight, most preferably Is preferably taken so as to be 5 to 25 mg / Kg body weight.

  Furthermore, when used as cosmetics or pharmaceuticals, the dosage form is not particularly limited, and examples thereof include capsules, tablets, granules, injections, suppositories, and patches. In formulation, other pharmaceutically acceptable formulation materials such as excipients, disintegrants, lubricants, binders, antioxidants, colorants, anti-aggregation agents, absorption enhancers, solubilizers An agent, a stabilizer and the like can be added as appropriate. The dose is preferably 0.01 to 1000 mg / Kg body weight, more preferably 0.1 to 100 mg / Kg body weight per adult day in terms of the amount of the active ingredient, divided into 1 to several times. Can be administered.

  The alcohol concentration in the breath can be stimulated using a commercially available alcohol detector or the like. The alcohol patch test classifies the acetaldehyde dehydrogenase (ALDH2) genotype into three types, NN, ND, and DD. The NN type (ALDH2 active type) decomposes acetaldehyde quickly, and the DD type (ALDH2). Inactive type) is known to be unable to degrade acetaldehyde. The ND type (ALDH2 low activity type) is a type having a weak ability to decompose alcohol. A commercially available alcohol patch test can be used.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples.

  We studied the effects of sensinren-containing foods on alcohol metabolism and physical discomfort after drinking, taking a single dose of sensinelen-containing foods for 20 healthy adult men with drinking habits and using placebo as a control.

The composition of the sensinlen-containing food used is as follows.
Senshinren extract powder 700mg,
Beer yeast (containing manganese),
Beer yeast (containing selenium),
Vitamin C,
Vitamin E,
Vitamin B1 group Sensinlen extract powder was produced by mixing and adjusting an ethanol extract of Andrographis paniculata and a residual water extract, followed by supercritical extraction.

  Area under blood alcohol concentration time curve (blood alcohol AUC), blood alcohol concentration (blood alcohol Cmax), peak value of breath alcohol concentration (exhaled alcohol Cmax), area under breath alcohol concentration time curve (expiration) Middle alcohol (AUC), and blood alcohol and breath alcohol concentrations at 30 minutes, 60 minutes, 120 minutes, and 180 minutes after alcohol loading.

  There was no significant difference in blood alcohol AUC (when ingesting sensinren-containing food: 70.28 ± 10.04 mg / mL · min, when ingesting placebo 69.45 ± 11.11 mg / mL · min). Sensyllene-containing food at 120 minutes after loading, with alcohol concentration in breath (when ingesting sensinelen-containing food: 0.099 ± 0.019 mg / L, when taking placebo, 0.108 ± 0.017 mg / L, p = 0.081) However, there was a trend toward lower prices compared to placebo.

  We investigated the effectiveness of sensine-containing foods in alcohol-sensitive subjects. As a result of analysis using 18 subjects whose alcohol patch test is ND type and ALDH2 gene is presumed to be heterozygous as a control, in the alcohol concentration in breath, 120 minutes after loading (when ingesting sensine-lens-containing food: 0.098 ± 0 019 mg / L, placebo ingestion: 0.111 ± 0.016 mg / L, p = 0.006), sensine-lens-containing food was significantly lower than placebo, 180 minutes after loading (sensin-lens-containing food At the time of ingestion: 0.072 ± 0.014 mg / L, at the time of placebo ingestion: 0.079 ± 0.022 mg / L, p = 0.082), the sensine-lens-containing food tended to be lower than the placebo.

  Furthermore, as a result of analyzing as a control an ND type test subject who developed “redness of the face, hot flashes” after drinking, the alcohol concentration in breath was 120 minutes after loading (at the time of ingestion of sensinren-containing food: 0.099 ± 0.020 mg). / L, placebo ingestion: 0.114 ± 0.015 mg / L, p = 0.015), 180 minutes after loading (ingestion of sensinren-containing food: 0.074 ± 0.014 mg / L, placebo ingestion: 0 0.084 ± 0.015 mg / L, p = 0.040), the food containing sensinren was significantly lower than the placebo. Similar results were obtained in subjects of ND type who were “feeling cheerful” after drinking.

  Ingestion of sensinlen-containing foods before drinking led to a tendency for alcohol concentration in breathing to decrease. In addition, ALDH2 gene heterotype accounts for about 40% of Japanese people, but sensine-containing foods are particularly effective against such subjects who are vulnerable to alcohol.

  INDUSTRIAL APPLICATION This invention can be utilized as a food-drinks composition for reducing the alcohol concentration in the breath after drinking in a subject.

Claims (2)

  The food-drinks composition for reducing the alcohol concentration in the breath after drinking in the object containing senshinren.   The food-drinks composition of Claim 1 whose object is a ND type | mold by an alcohol patch test.