JP5572775B1 - Low moisture composition containing useful ingredients in turmeric - Google Patents

Abstract

An object of the present invention is to provide a composition capable of suppressing the symptoms of hangover, comprising as an active ingredient a natural compound obtained from a highly safe food material rich in food experience.
A composition containing 0.15 mg or more of bisaclone per oral intake, having a water content of 7% by weight or less and / or a water activity (Aw) of 0.7 or less. A composition as described above.
[Selection figure] None

Description

  The present invention relates to a low moisture composition containing bisaclone that can suppress the symptoms of hangover.

  Turmeric (Curcuma longa LINEN) is a medicinal plant belonging to the genus Turmeric belonging to the genus Turmeric, which is cultivated in tropical and subtropical regions around the world, mainly in Southeast Asia.

  Turmeric rhizomes contain 3-5% curcumin (yellow pigment). Various utilities are known for turmeric extract and curcumin. For example, Non-Patent Document 1 suggests that a turmeric extract-containing beverage has an action of preventing sickness while appropriately expressing the “sickness” inherent in alcohol by ingesting together with alcohol.

  Patent Document 1 discloses a pharmaceutical composition for the prevention and treatment of hangover, comprising turmeric or an extract thereof in combination with duck or an extract thereof, oren or an extract thereof and ginger or an extract thereof. Has been.

  Patent Document 2 discloses a pharmaceutical composition containing turmeric together with a processed garlic product and having an action of improving unpleasant symptoms such as irritations after drinking alcohol, nausea, and hangover.

  On the other hand, there is still a need for an effective therapeutic agent and preventive agent for hangover symptoms, and there is a need for a therapeutic agent and prophylactic agent that has abundant dietary experience and a highly safe naturally-derived component as an active ingredient. Yes.

JP 2003-226650 A WO 2005/032569

Takuya Hamano et al. “Examination of the effect of turmeric extract on alcohol metabolism in healthy adults”, Applied Pharmacology, 72 (1/2), 31-38 (2007)

  An object of this invention is to provide the composition which can suppress the symptom of a hangover which uses the natural compound obtained from the food material with abundant food experience with high safety as an active ingredient.

As a result of intensive studies to solve the above problems, the present inventors have found that bisaclone contained in the turmeric extract has an action of suppressing hangover symptoms.
Further, it has been found that by using bisaclone as a low moisture composition, a composition with high storage stability of bisaclone and easy to be taken orally can be obtained.
The present invention is based on these findings.

That is, the present invention has the following features.
[1] A composition containing 0.15 mg or more of bisaclone per oral intake, having a water content of 7% by weight or less and / or a water activity (Aw) of 0.7 or less. , The above composition.
[2] The composition according to [1], wherein bisaclone is derived from a turmeric extract.
[3] The composition of [1] or [2], further comprising curcumin.
[4] The composition according to any one of [1] to [3], wherein the composition has the form of a granule, a chewable tablet, or a powdered beverage.
[5] The composition according to any one of [1] to [4], which is a food or a medicine.
[6] An inhibitor of a hangover symptom, comprising the composition according to any one of [1] to [4].
[7] The inhibitor of [6], wherein the symptoms of hangover are head sensation, nausea, malaise, a feeling of remaining alcohol, and / or stomach discomfort.
[8] A bisaclone-containing composition comprising a step of mixing bisaclone and an edible raw material to obtain a composition having a water content of 7% by weight or less and / or a water activity (Aw) of 0.7 or less. Production method.
[9] The method according to [8], wherein bisaclone is derived from a turmeric extract.
[10] The method according to [8] or [9], wherein bisaclone is mixed with an edible raw material in an amount of 0.15 mg or more per oral intake.
[11] The stability of bisaclone in the composition, comprising mixing bisaclone and an edible raw material so that the water content is 7% by weight or less and / or the water activity (Aw) is 0.7 or less. How to improve.

  ADVANTAGE OF THE INVENTION According to this invention, the low moisture type composition which can suppress the symptom of a hangover which uses a natural compound as an active ingredient can be provided.

FIG. 1 shows the effect of bisaclone on blood ethanol concentration. FIG. 2 shows the effect of bisaclone and curcumin on blood ethanol concentration. FIG. 3 shows the effect of suppressing hangover symptoms by ingesting bisaclone (0.15 mg). FIG. 4 shows the results of a storage test for bisaclone in a beverage composition and bisaclone in a granular composition.

1. Bisacron In the present invention, “bisaclone” is a compound classified as a bisaborane-type sesquiterpene, and means a compound having the following planar structural formula or a salt thereof. Bisaclone has an asymmetric carbon at the position indicated by * in the planar structural formula, and therefore there are several kinds of optical isomers. Bisaclone in this specification is a concept that includes any optical isomers. is there.

  Bisacron may be extracted or purified from plant materials or artificially synthesized, but from the viewpoint of safety, it may be extracted or separated / purified from plant materials. preferable.

  The plant material is preferably a ginger family plant, and in particular, Curcuma longa (curcuma), Curcuma aromatica, Curcuma zedoaria, Curcuma phaeocaulis, Curcuma kwangsiensis, and Curcumacurx are preferred. Appropriate parts such as rhizomes of plant raw materials can be used as raw materials for the manufacture of bisaclone in the original form, in a form cut into an appropriate size or shape, or in the form of a pulverized product. These raw materials may be appropriately dried.

  The extraction method of bisaclone from plant materials is not particularly limited. For example, a solvent capable of dissolving bisaclone such as water, ethanol, methanol, isopropanol, propylene glycol, diethyl ether, petroleum ether, hexane, acetone, acetonitrile, ethyl acetate, animal and vegetable fats and oils, or a mixture of two or more thereof. Is used to extract solvent-soluble components from plant materials. The extraction solvent is preferably a hydrophilic extraction solvent such as alcohol and / or water. Ethanol is preferred as the alcohol. The mixing ratio in the case of using a mixture of alcohol and water is not particularly limited. For example, the weight ratio is preferably in the range of 10:90 to 90:10, and more preferably in the range of 20:80 to 50:50.

  The obtained plant raw material extract is further subjected to purification means such as solvent fractionation, chromatography (column chromatography, high performance liquid chromatography (HPLC), etc.) and / or recrystallization, if necessary, and bisaclone May be separated or purified. For example, bisaclone obtains a methanol extract of turmeric as a plant raw material, and elutes the extract with a silica gel column using methanol and chloroform, rather than curcuminoid (mixture of curcumin, demethoxycurcumin, bisdemethoxycurcumin) It can be separated or purified from the highly polar fraction using a preparative HPLC column.

  In the composition of the present invention or the inhibitor of hangover symptoms (hereinafter referred to as “the composition or the inhibitor of the present invention”), preferably 0.15 mg or more of bisaclone per oral intake. Blend. Bisaclone may be in the form of an extract of plant material. That is, in the composition or inhibitor of the present invention, an extract of a plant raw material obtained using the above extraction solvent containing 0.15 mg or more of bisaclone per oral intake can be included. . Alternatively, bisaclone may be in a form separated / purified from an extract of plant material.

  The amount of bisaclone in the composition or inhibitor of the present invention is determined by dissolving ethyl acetate in vacuo from the supernatant obtained by dissolving the composition or inhibitor of the present invention in ethyl acetate and centrifuging. It can be determined by subjecting a solution dissolved in acetonitrile to high performance liquid chromatography (HPLC) as an analysis sample.

  In the present invention, the term “single oral intake” means an amount at which the composition or inhibitor of the present invention is taken orally at a time, or a short time interval (for example, 10 minutes or less, preferably 5 minutes or less). It means the total amount that is taken orally continuously multiple times. The single oral intake of the composition or inhibitor of the present invention is, for example, 200 mg to 2500 mg, preferably 1000 mg to 2000 mg (typically 200 mg, 300 mg, 400 mg, 500 mg, 600 mg, 700 mg, 800 mg, 900 mg, 1000 mg, 1100 mg, 1200 mg, 1300 mg, 1400 mg, 1500 mg, 1600 mg, 1700 mg, 1800 mg, 1900 mg, 2000 mg, 2100 mg, 2200 mg, 2300 mg, 2400 mg, or 2500 mg). Hereinafter, “single oral intake” is used in this sense.

  In the present invention, the term “bisaclone is 0.15 mg or more” is not particularly limited as long as 0.15 mg or more of bisaclone is contained per one oral intake of the composition or inhibitor of the present invention. Specifically, 0.15 mg or more, 0.2 mg or more, 0.3 mg or more, 0.4 mg or more, 0.5 mg or more, 0.6 mg or more, 0.7 mg or more, 0.8 mg or more, 0.9 mg or more. It means containing 0 mg or more of bisaclone.

2. Turmeric Dye The composition or inhibitor of the present invention can include a turmeric dye.
Turmeric pigment is obtained by extracting from the rhizome part of turmeric with hot ethanol, hot oil or propylene glycol, or room temperature to hot hexane or acetone. The pigment mainly contains curcumin. The amount of turmeric pigment in the composition or inhibitor of the present invention is 3 mg to 100 mg, more preferably 5 mg to 70 mg, more preferably 20 to 45 mg, typically 5 mg, 10 mg, The amount of turmeric pigments to be 15 mg, 20 mg, 25 mg, 30 mg, 35 mg, or 40 mg is preferably blended.

  Turmeric pigments may be finely divided. Turmeric pigments can be microparticulated by, for example, pulverization (micronization) so as to obtain a desired microparticle size by the following method.

  As the fine particle treatment method, a known method can be used as a fine particle treatment method for a poorly water-soluble substance. For example, a method in which a solution obtained by dissolving a turmeric dye in a hydrophilic organic solvent is dispersed in an aqueous solvent to form fine particles, a mixture obtained by mixing a turmeric dye with an emulsifier is pulverized, or a turmeric dye is used as an emulsifier. And a method of pulverizing a dispersion obtained by dispersing in a water-based solvent containing a polysaccharide or the like (Japanese Patent Laid-Open No. 2005-328839, Japanese Patent Laid-Open No. 2004-208555, and Japanese Patent Laid-Open No. 2004-208555). 2009-201371, JP2009-263638).

3. Acidulant The composition or inhibitor of the present invention can include an acidulant that is acceptable in a final form such as a food or pharmaceutical product. Examples of the acidulant include citric acid, malic acid, gluconic acid, tartaric acid, lactic acid, phosphoric acid, and salts thereof, and one or more of these can be used.

  By including the acidulant, when the composition or inhibitor of the present invention is eaten, the acidulant touches the tongue to promote saliva secretion, and the solidified base material disintegrates, disperses, and dissolves rapidly in the oral cavity. However, it can be taken in with saliva as it is. That is, the composition or inhibitor of the present invention can be taken without drinking water.

  The amount of the sour agent is not particularly limited, but it is desirable to include it in the following manner. That is, when 100 ml of water at 20 ° C. placed in a beaker contains a single oral intake of the composition or inhibitor of the present invention, the pH of the water is 2.0 to 5.0, preferably 2.5. -4.5 (typically 2.5 or more, 2.6 or more, 2.7 or more, 2.8 or more, 2.9 or more, 3.0 or more, 3.1 or more, 3.2 or more, 3.3 or more, 3.4 or more, 3.5 or more, 3.6 or more, 3.7 or more, 3.8 or more, 3.9 or more, and 4.0 or less, 4.5 or less, 5.0 It is desirable to include it in the following amount. Thereby, when the composition or inhibitor of the present invention is put in the mouth, saliva secretion is promoted by the action of the sour agent, and the solidified base material can be easily disintegrated, dispersed, dissolved, and eaten. At the same time, it is possible to achieve an acidity suitable for eating, or an acidity that can suppress unpleasant taste such as “bitterness” and “astringency” due to the turmeric extract and / or the turmeric pigment. When citric acid is used as a sour agent, the composition should contain 1 to 20% by weight as a solid content.

4). Other Ingredients The composition or inhibitor of the present invention can contain ingredients that are acceptable in the final form such as foods and pharmaceuticals and can be taken orally.

  Examples of such components include solidified base materials, sweeteners, vitamins, minerals, antioxidants and the like. Moreover, you may add a pigment | dye, a fragrance | flavor, a preservative, an antiseptic | preservative, a fungicide, etc. as needed.

  As the solidified base material, any material can be used as long as it functions as a binder for solidifying the above components and has a property of being easily dispersed in water. For example, sugar, sugar alcohol, starch, and various starches. , Dextrin, amino acid and the like, and one or more of these can be used. Further, the solidified substrate can be used in combination with starch syrup, crystalline cellulose, various gums, and dextrin, which are generally used as a binder.

  Sweeteners include monosaccharides and disaccharides such as glucose, fructose, sucrose, lactose, maltose, palatinose, trehalose, and xylose, isomerized sugar (glucose fructose liquid sugar, fructose glucose liquid sugar, sugar mixed isomerized sugar, etc.) , Sugar alcohols (erythritol, xylitol, lactitol, palatinit, sorbitol, reduced starch syrup, etc.), honey, high intensity sweeteners (sucralose, acesulfame potassium, thaumatin, stevia, aspartame, etc.).

  Examples of vitamins include vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin E, niacin, inositol, and the like.

  Examples of minerals include sodium, calcium, magnesium, zinc, iron and the like.

  Examples of the antioxidant include vitamin C, tocopherol (vitamin E), enzyme-treated rutin, catechin and the like.

  Each of these components can be appropriately blended in an amount within the range normally employed by those skilled in the art in foods and pharmaceuticals.

5). Method for Producing Composition The composition or inhibitor of the present invention can be produced using a technique generally used for producing a low moisture composition.

  Although not particularly limited, for example, a raw material containing the above components is mixed with an appropriate amount of water and granulated (spray granulation, extrusion granulation, stirring granulation, fluidized bed granulation, rolling granulation, compression granulation, etc.) It can be produced by processing one or a plurality of processes such as sizing, compression molding and tableting. As the granulation treatment, extrusion granulation is particularly preferable. In the granular composition produced by the extrusion granulation treatment, uniform granules can be obtained with no component bias.

  The form of the composition of the present invention is not particularly limited and may be in the form of granules, pills, tablets, powders, chewable tablets, etc., but preferably granules that can be taken without drinking water It is in the form of drugs, chewable tablets, or powdered beverages.

  The composition of the present invention has a water content of 7 wt% or less, typically 7 wt% or less, 6 wt% or less, 5 wt% or less, 4 wt% or less, or less, based on the total weight of the composition. It is characterized by being. The lower limit of the moisture content is not particularly limited, but is desirably 3% by weight or more based on the total weight of the composition. The moisture content can be measured using a known method. For example, it can be measured by the drying aid method (at 105 ° C. for 16 hours) after using the atmospheric pressure heating drying method. The composition of the present invention has a water activity (Aw) of 0.7 or less, typically 0.7 or less, 0.6 or less, 0.5 or less, 0.4 or less, or less. It is characterized by. The value of water activity can be adjusted by adjusting the amount of sugar, salt, etc. contained in the composition. The water activity can be measured using a known water activity measuring device, for example, using a water activity measuring device manufactured by Nova Cina. In the composition of the present invention, by setting the water content and / or water activity to the above values, attenuation of bisaclone in the composition can be suppressed, and storage stability can be improved.

6). Composition and use thereof The composition of the present invention is a food composition having an action of alleviating so-called hangover symptoms (particularly head sensation, nausea, malaise, feeling of remaining alcohol, stomach discomfort) upon waking up after ingesting alcohol. Or it can be used as a pharmaceutical composition.

  The composition of the present invention may be provided as a food or a pharmaceutical product for oral administration, but is preferably a food. Such a composition can be contained in a container or bag used as a container or bag for food or medicine, and examples thereof include paper, plastic, glass, metal containers and bags. The composition of the present invention can be packaged for each oral intake. The means for storing the composition in a container or bag is arbitrary.

I. Effect of bisaclone on blood ethanol concentration The effect of bisaclone on blood ethanol concentration was tested as follows.

1. Test animals For each test object, 7-week-old male SD rats (7 animals) were used.

2. Test object control: Dextrin (Matsuya Chemical Co., Ltd.)
Bisaclon: The rhizome part of curcuma longa was extracted with water, the obtained aqueous extract was re-extracted with methanol, and purified from the resulting methanol extract with a preparative column. I used something.
Bisaclone was dissolved in 0.5 w / v% methylcellulose (Wako Pure Chemical Industries).

3. Test Method Preliminary breeding was carried out for one week from the arrival of the test animals to the day before the start of this breeding to acclimatize.
The test object was forcibly administered intragastrically using a gastric sonde to the following dosage. Ethanol was administered by the same route at the same time so that the following dose was obtained.
Dextrin (control): dextrin 2010mg / kg
Bisaclone: Bisaclone 250 mg / kg + dextrin 1760 mg / kg
Ethanol: 2g / kg
After ethanol administration, heparinized blood was collected from the tail vein at 10, 30, 60, 120, 180, and 240 minutes, and blood at each time point was obtained using F-kit ethanol (JK International) according to the manufacturer's instructions. The medium ethanol concentration was measured.

4). Test results The results are shown in FIG. Each result shows the total area under the blood concentration-time curve (AUC) at each time point. It was confirmed that blood ethanol concentration can be reduced by administering bisaclone.

II. Effect of bisaclone and curcumin on blood ethanol concentration The effect of bisaclone and curcumin on blood ethanol concentration was tested as follows.

1. Test animals For each test object, 7-week-old male SD rats (8 animals) were used.

2. Test object control: Dextrin (Matsuya Chemical Co., Ltd.)
Curcumin: Turmeric Color HJK (Inabata Fragrance Co., Ltd.)
Bisaclon: The rhizome part of curcuma longa was extracted with water, the obtained aqueous extract was re-extracted with methanol, and purified from the resulting methanol extract with a preparative column. I used something.
Curcumin and bisaclone were dissolved in 0.5 w / v% methylcellulose (Wako Pure Chemical Industries) (hereinafter referred to as “0.5% MC”).

3. Test Method Preliminary breeding was carried out for one week from the arrival of the test animals to the day before the start of this breeding to acclimatize.
The test object was forcibly administered intragastrically using a gastric sonde to the following dosage. Ethanol was administered by the same route at the same time so that the following dose was obtained.
Curcumin only: 125mg / kg
Curcumin + Bisaclone: Curcumin 125mg / kg + Bisaclone 20mg / kg
Ethanol: 2g / kg
After ethanol administration, heparinized blood was collected from the tail vein at 10, 30, 60, 120, 180, and 240 minutes, and blood at each time point was obtained using F-kit ethanol (JK International) according to the manufacturer's instructions. The medium ethanol concentration was measured.

4). Test results The results are shown in FIG. Each result shows the total area under the blood concentration-time curve (AUC) at each time point. It was shown that blood ethanol concentration can be further reduced by administering a mixture of curcumin and bisaclone rather than curcumin alone, and it was confirmed that bisaclone has an effect of lowering blood ethanol concentration.

III. Effect on hangover symptoms The effect of bisaclone on hangover symptoms was tested as follows.

1. Test composition (beverage)
The bisaclone-containing composition (Example A) was prepared by mixing components other than water (powder raw material), adding and dissolving in water to make a 100 mL aqueous solution, and hot-packing the product heated to 93 ° C. into a metal can did. Comparative Example a was prepared in the same manner as in Example A except that it was hot-packed and further stored at 40 ° C. for one week. The pH value of each test beverage was 3.1. By storing bisaclone in an acidic aqueous solution at 40 ° C., decomposition is accelerated, and bisaclone in the test beverage can be reduced.

  The turmeric pigment is obtained by extracting a rhizome part of turmeric (Curcuma longa) with acetone and reducing the pressure to volatilize the acetone. This turmeric pigment contained 30% by weight of curcumin, and each composition contained 30 mg of curcumin.

Bisaclone was used in the form of turmeric extract. That is, a turmeric extract containing a predetermined amount of bisaclone was blended in each composition. The turmeric extract is obtained by extracting the rhizome part of the rhizome part of turmeric (Curcuma longa) using water. The amount of bisaclone in each composition is determined by high-performance liquid chromatography using a solution obtained by mixing the composition with ethyl acetate and centrifuging and then evaporating ethyl acetate under reduced pressure from the supernatant and dissolving in acetonitrile. It was determined by attaching to a graphic (HPLC). HPLC was performed under the following conditions.

  Example A and Comparative Example a had the following compositions. Example A contained 0.15 mg of bisaclone, and no bisaclone was detected in Comparative Example a.

2. Test subjects The test subjects were 13 selected from men and women aged 20 to 65 who can drink alcoholic beverages. Those who could not drink alcoholic beverages (self-reported), those who were in the hospital, those who were taking medication, those who were ill with kidney / liver disease, and those with various types of hypersensitivity were excluded from the study subjects.

3. Test Method The hangover suppression effect of Example A and Comparative Example a was confirmed by the following procedure.
The test with the following contents was carried out twice in one week.

  After ingesting the above Example A or Comparative Example a on the day before the test, alcohol was drunk while eating for 2 hours. The amount of alcohol and meal menu and amount were managed for each individual so that the alcohol and diet conditions were almost the same in the two tests.

  I went to bed after drinking and took a sleep of 7 hours as a guide. The amount of water that can be ingested after drinking was up to 200 mL. After getting up, a questionnaire about hangover was conducted.

The following matters were prohibited:
Ingestion of medicines and foods to improve hangover

4). Test Schedule The test (first test) was performed on Example A for five test subjects, and then the test (second test) was performed on Comparative Example a. Moreover, the said test (1st test) was performed about the comparative example a with respect to the remaining 8 test subjects, and the said test (2nd test) was then performed about Example A.

5. Evaluation Items by Questionnaire In the questionnaire, each test subject was asked to fill in the self-assessment results by the VAS method for six items of headache, head feeling, nausea, malaise, feeling of remaining alcohol, and stomach discomfort.

  The VAS (Visual Analog Scale) method is a test that evaluates the degree of subjective symptoms by quantification. In this method, the highest possible state is set to the right end and the lowest is set to the left end in a straight line. It is also widely used in clinical medicine for subjective evaluation, and is used especially for comparison of the condition before and after administration between subjects.

6). Test result For each evaluation item in the test ingesting each test beverage, an average value obtained by summing up the VAS entry values of all the subjects was obtained. The results are shown in FIG.

  In Example A containing 0.15 mg of bisaclone, all items of hangover symptoms, headache, head feeling, nausea, malaise, feeling of residual alcohol, and stomach discomfort, compared to Comparative Example a without bisaclone In particular, it was confirmed that the effect of suppressing “head feeling” and “stomach discomfort” was significantly high.

  From the above results, it was revealed that hangover symptoms can be suppressed by ingesting at least 0.15 mg of bisaclone.

IV. Storage test The storage stability of bisaclone according to the form of the composition was tested as follows.
In the test, Example 1 (Table 2) which is in the form of a granular composition and Comparative Example 1-5 (Table 3) which is in the form of a beverage composition were used.
The granular composition was produced by the following method.

  The turmeric pigment used was obtained by the method described in “III. Effect on hangover symptoms”.

  Bisaclone was used in the form of turmeric extract. The turmeric extract used was obtained by the method described in “III. Effect on hangover symptoms”. The amount of bisaclone in the turmeric extract was determined by mixing the extract with ethyl acetate, centrifuging the ethyl acetate from the supernatant obtained by centrifugation, and then using the solution dissolved in acetonitrile as the analysis sample. In the same manner as the method for measuring the amount of bisaclone in the composition described in “Effect on hangover symptoms”, the measurement was performed using high performance liquid chromatography (HPLC).

(1) According to the composition of Table 1 above, turmeric pigment, turmeric extract containing bisaclone, reduced maltose, corn starch, citric acid, vitamin E, vitamin C, niacin and sweetener are mixed, and "powder blend" Manufactured.
(2) Water and Vitamin B were mixed to produce “Hydro Compound”.
(3) In the mixer, the water blend was added dropwise to the powder blend and sufficiently kneaded to prepare a dough.
(4) A dough was put into an extruding granulator and pressed to prepare a granulated product having a grain length of about 5 mm.
(5) The granulated product was dried with a fluidized bed dryer to a moisture value of 7% or less and a water activity (AW) of 0.7 or less.
(6) The fine powder was passed through a sieve having an opening of 355 μm to obtain a granular composition.
The beverage composition was produced by the following method.

  Turmeric pigments and bisaclone (form of turmeric extract) were obtained by the method described in “III. Effect on hangover symptoms” above. The amount of bisaclone in the turmeric extract was measured by the above method.

  The pH value of each beverage composition was adjusted using citric acid and / or trisodium citrate. The pH value in the table refers to a value measured at a product temperature of 20 ° C.

  Each beverage composition is mixed with ingredients other than water (powder raw material), then added and dissolved in water, charged with liquid raw material to make a 100 mL aqueous solution, hot-sterilized at 93 ° C and hot-packed into a metal can Made.

  After storing the granular composition and each beverage composition produced as described above under the condition of 40 ° C., the amount of bisaclone in each composition was subjected to the experiment of “III. Effect on hangover symptoms”. It measured similarly. The bisaclone content of each sample was calculated as a percentage when the bisaclone content of the sample immediately before storage at 40 ° C. was taken as 100%.

  The results are shown in FIG. In the beverage composition, it was confirmed that the bisaclone content attenuated over time. In particular, it was confirmed that the lower the pH value, the faster the decay rate (graph slope). On the other hand, in the granular composition, the bisaclone content was only slightly decreased.

  These results show that, in order to stably maintain a certain amount (or effective amount) of bisaclone over a long period of time, the low-moisture-based composition of the bisaclone-containing composition is less than the form of a beverage composition. It shows that it is more advantageous to use the form. In particular, when adding a sour agent to impart sourness to the composition, it is better to include it in a low-moisture composition than to include bisaclone in the beverage composition whose pH value is lowered by the addition of the sour agent. Therefore, it can be said that it is advantageous for the storage stability of bisaclone.

Claims (11)

A composition containing 0.3 mg or more of bisaclone per oral intake, wherein the water content is 7% by weight or less and / or the water activity (Aw) is 0.7 or less object.   The composition of claim 1, wherein the bisaclone is derived from a turmeric extract.   The composition according to claim 1, further comprising curcumin.   The composition according to any one of claims 1 to 3, wherein the composition has the form of a granular, chewable tablet, or powdered beverage.   The composition of any one of Claims 1-4 which is a foodstuff or a pharmaceutical.   The inhibitor of the symptom of a hangover containing the composition of any one of Claims 1-4.   The suppressant according to claim 6, wherein the hangover symptom is head sensation, nausea, malaise, feeling of remaining alcohol, and / or stomach discomfort.   A method for producing a bisaclone-containing composition, comprising mixing bisaclone and an edible raw material to obtain a composition having a water content of 7% by weight or less and / or a water activity (Aw) of 0.7 or less.   9. The method of claim 8, wherein the bisaclone is derived from a turmeric extract.   The method according to claim 8 or 9, wherein bisaclone is mixed with an edible raw material in an amount of 0.15 mg or more per oral intake.   A method for improving the stability of bisaclone in a composition, comprising mixing bisaclone and an edible raw material so that the water content is 7% by weight or less and / or the water activity (Aw) is 0.7 or less. .

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