JP2018126315A - Multilayer container and multilayer body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a multilayer container having excellent gas barrier properties and necessary transparency even after heating, a multilayer body and a method for producing a multilayer container.SOLUTION: A multilayer container has a layer (X) containing at least one of polyolefin resins as the main component, an adhesive layer, and a layer (Y) containing a polyamide resin (A) as the main component, in this order, where the polyamide resin (A) has a diamine-derived constitutional unit and a dicarboxylate-derived constitutional unit, where 70 mol% or more of the diamine-derived constitutional unit is derived from m-xylylenediamine, and 30-60 mol% of the dicarboxylate-derived constitutional unit is derived from C4-20 α,ω-linear aliphatic dicarboxylate and 70-40 mol% of it is derived from isophthalic acid.SELECTED DRAWING: None

Description

  The present invention relates to a multilayer container and a multilayer body. Specifically, the present invention relates to a multilayer container and a multilayer body that are preferably used for medical packaging.

Conventionally, glass containers have been used as containers for filling and storing chemicals in a sealed state. However, these glass containers have a problem that a fine glass substance called flakes is generated during use, and is easily broken by an impact such as dropping. Further, since glass has a relatively large specific gravity, there is also a problem that the container itself is heavy.
On the other hand, plastics are lighter than glass and, depending on the material, are excellent in impact resistance, heat resistance, transparency, etc., plastic containers are being considered as substitutes for glass containers. For example, Patent Document 1 discloses a medical container made of a polyester resin. In addition, cycloolefin polymers (hereinafter sometimes abbreviated as “COP”) are excellent in impact resistance, heat resistance, and transparency, and are generally used as glass substitute materials in containers.

  However, since a plastic container is generally inferior to a glass container in comparison with a glass container, improvement of the gas barrier property is required. Therefore, in order to improve the gas barrier property of the plastic container, a multilayer container having a gas barrier layer as an intermediate layer has been studied. For example, Patent Document 2 discloses a prefilled syringe in which the innermost layer and the outermost layer are made of a polyolefin resin, and the intermediate layer is a resin layer having excellent barrier properties.

JP 08-127641 A JP 2004-229750 A

  As described above, multilayer containers made of a resin are known. Further, in order to improve the adhesion between the inner and outer layers and the gas barrier layer, an adhesive layer is often provided between these layers. A multilayer container provided with such an adhesive layer is also often heat sterilized when it is used for medical packaging. The present invention is intended to solve such a problem, and is a multilayer container having an adhesive layer, the multilayer container having excellent gas barrier properties while ensuring necessary transparency after heat treatment, and the multilayer container. It is providing the manufacturing method of the multilayer body used as a raw material, and a multilayer container.

  As a result of intensive research on multilayer containers having excellent gas barrier properties while ensuring the necessary transparency after heat treatment, the present inventors have solved the above problems by using a specific polyamide resin for the gas barrier layer. As a result, the present invention has been completed.

As a result of investigations based on the above problems, the present inventors have found that the above problems can be solved by the following means. Specifically, the above problem has been solved by the following means <1>, preferably <2> to <13>.
<1> A layer (X) having at least one polyolefin resin as a main component, an adhesive layer, and a layer (Y) having a polyamide resin (A) as a main component in the order, wherein the polyamide resin (A) 30 to 60 of the structural unit derived from diamine and the structural unit derived from dicarboxylic acid, 70 mol% or more of the structural unit derived from diamine is derived from metaxylylenediamine, A multilayer container in which mol% is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms and 70 to 40 mol% is derived from isophthalic acid.
<2> The multilayer container according to <1>, wherein the polyamide resin (A) contains a calcium atom.
<3> The multilayer container according to <2>, wherein the calcium atom contained in the polyamide resin (A) is derived from calcium hypophosphite.
<4> The multilayer container according to any one of <1> to <3>, wherein the polyamide resin (A) contains phosphorus atoms in a proportion of 3 to 300 ppm by mass.
<5> The polyamide resin (A) contains phosphorus atoms in a proportion of 20 to 200 ppm by mass, and contains calcium atoms in a proportion of a molar ratio of phosphorus atoms to calcium atoms of 1: 0.3 to 0.7. , <1> or <3>.
<6> The multilayer container according to any one of <1> to <5>, wherein the layer (X) includes at least one polypropylene-based polymer as a main component.
<7> The multilayer container according to any one of <1> to <6>, wherein 30 to 60 mol% of the structural unit derived from the dicarboxylic acid is a structural unit derived from adipic acid.
<8> The multilayer container includes at least five layers, the inner layer and the outer layer are the layer (X), and at least one of the intermediate layers is the layer (Y). <1> to <7> The multilayer container as described in any one.
<9> The multilayer container according to any one of <1> to <8>, which is for medical packaging.
<10> The multilayer container according to any one of <1> to <8>, which is a container for infusion.
<11> A layer (X) containing at least one polyolefin resin as a main component, an adhesive layer, and a layer (Y) containing a polyamide resin (A) as a main component in this order, wherein the polyamide resin (A) 30 to 60 of the structural unit derived from diamine and the structural unit derived from dicarboxylic acid, 70 mol% or more of the structural unit derived from diamine is derived from metaxylylenediamine, A multilayer body in which mol% is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms and 70 to 40 mol% is derived from isophthalic acid.
<12> The polyamide resin contains phosphorus atoms in a proportion of 20 to 200 ppm by mass, and contains calcium atoms in a proportion of a molar ratio of phosphorus atoms to calcium atoms of 1: 0.3 to 0.7. The multilayer body described in>.
<13> A material constituting the layer (X) mainly comprising at least one polyolefin resin, a material constituting the adhesive layer, and a material constituting the layer (Y) mainly comprising the polyamide resin (A). It is a manufacturing method of a multilayer container including using direct blow molding, Comprising: The said polyamide resin (A) is comprised from the structural unit derived from a diamine, and the structural unit derived from a dicarboxylic acid, The structural unit derived from the said diamine 70 mol% or more of the above is derived from metaxylylenediamine, 30 to 60 mol% of the structural unit derived from the dicarboxylic acid is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms, and 70 A method for producing a multilayer container, wherein -40 mol% is derived from isophthalic acid.

  The multilayer container of the present invention has excellent gas barrier properties and necessary transparency even after heat treatment. Therefore, the multilayer container of the present invention can be suitably used as a medical packaging container that requires heat sterilization treatment.

  Hereinafter, the contents of the present invention will be described in detail. In the present specification, “to” is used to mean that the numerical values described before and after it are included as a lower limit and an upper limit.

The multilayer container of the present invention has a layer (X) containing at least one polyolefin resin as a main component, an adhesive layer, and a layer (Y) containing a polyamide resin (A) as a main component in the above order. (A) is composed of a structural unit derived from a diamine and a structural unit derived from a dicarboxylic acid, 70 mol% or more of the structural unit derived from the diamine is derived from metaxylylenediamine, and the structural unit derived from the dicarboxylic acid. 30 to 60 mol% is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms, and 70 to 40 mol% is derived from isophthalic acid.
The polyamide resin (A) is usually an amorphous polyamide resin, but by using such a polyamide resin, a multilayer container having excellent gas barrier properties and transparency can be obtained even after heat sterilization treatment. it can.
Here, the amorphous polyamide resin is a resin having no clear melting point. Specifically, it means that the crystal melting enthalpy ΔHm is less than 5 J / g, preferably 3 J / g or less, preferably 1 J / g. g or less is more preferable.

<Layer structure>
The layer configuration in the multilayer container of the present invention is not particularly limited as long as the layer (X), the adhesive layer, and the layer (Y) are arranged in the order described above, and the number and type of the layers (X) and layers (Y) are There is no particular limitation. In the present invention, if the layer (X), the adhesive layer, and the layer (Y) are arranged in the above order, other layers are provided between the layer (X) and the adhesive layer, and between the adhesive layer and the layer (Y). You may have. However, in the present invention, the layer (X) is preferably in contact with the adhesive layer. Moreover, it is preferable that the layer (Y) and the adhesive layer are in contact.
The number of layers constituting the multilayer container is preferably at least 3 layers, more preferably 3 to 10 layers, and even more preferably 3 to 5 layers.
The number of layers (X) in the multilayer container is preferably 1 to 5 layers, and more preferably 2 to 4 layers. The number of layers (Y) in the multilayer container is preferably 1 to 3 layers, more preferably 1 layer or 2 layers.
For example, an X / adhesive layer / Y configuration (layer (X) is an inner layer) consisting of one layer (X), one adhesive layer, and one layer (Y), or Y / Adhesive layer / X configuration (layer (Y) is an inner layer), X / adhesive layer / consisting of two layers (X), two adhesive layers, and one layer (Y) A five-layer configuration of Y / adhesive layer / X may be used.
In the multilayer container of the present invention, the inner layer and the outer layer are the layer (X), and at least one of the intermediate layers is the layer (Y) (X / adhesive layer / Y / adhesive layer / X configuration). Is preferred. In the present embodiment, as (X / adhesive layer / Y / X / Y / X), the layer (X), the adhesive layer, and the layer (Y) are arranged in the order described above, and are arranged in the order mentioned above. It may include both of the areas that are not. Moreover, in this invention, it is possible to further have various thermoplastic resin layers according to the purpose, not limited to these.
Here, the inner layer refers to a layer located on the inner side of the (Y) layer that is one intermediate layer among the layers constituting the multilayer container, and the outer layer refers to 1 of the layers constituting the multilayer container. A layer located outside the (Y) layer, which is one intermediate layer. The inner layer and the outer layer may be the innermost layer and the outermost layer, respectively, or may have an innermost layer and an outermost layer separately.

  The total thickness of the multilayer container of the present invention can be appropriately determined according to the application. In an example of the embodiment, the lower limit value is preferably 0.3 mm or more, more preferably 0.5 mm or more, and further preferably 0.7 mm or more. The upper limit of the total thickness is preferably 2.0 mm or less, more preferably 1.5 mm or less, and further preferably 1.2 mm or less.

<Layer (X)>
The layer (X) constituting the multilayer container of the present invention is a layer containing at least one polyolefin resin as a main component, and usually functions as a water vapor barrier layer. Here, “main component” means that the layer (X) contains a polyolefin resin (water vapor barrier polymer) in the layer (X) of 70% by mass or more, preferably 80% by mass or more, more preferably 90%. It means that -100 mass% is contained. Layer (X) may contain only 1 type of polyolefin resin, or may contain 2 or more types. When 2 or more types are included, the total amount of the polyolefin resin falls within the above range.
In addition to the polyolefin resin, the layer (X) includes an antioxidant, a matting agent, a weather resistance stabilizer, an ultraviolet absorber, a crystallization nucleating agent, and the like within a range that does not impair the effects of the present invention, depending on the desired performance and the like. Additives such as plasticizers, flame retardants and antistatic agents may be included.
The multilayer container of the present invention may have a plurality of layers (X), and the configurations of the plurality of layers (X) may be the same as or different from each other. Although the thickness of layer (X) is not specifically limited, From a viewpoint of intensity | strength and cost, 20-2000 micrometers is preferable and 50-1500 micrometers is more preferable. In particular, when the multilayer container is molded by direct blow molding, the thickness of the layer (X) is preferably 20 to 800 μm, and more preferably 50 to 700 μm. In the present invention, since the adhesive layer is provided, even if the thickness of each layer is reduced and the capacity of the multilayer container is increased, layer peeling can be effectively suppressed.

<< Polyolefin resin >>
The polyolefin resin used in the present invention is not particularly defined, and a known polyolefin resin can be used. Specific examples thereof include polyolefin resins described in paragraphs 0101 to 0103 of JP-A-2014-068767, and the contents thereof are incorporated in the present specification.
The polyolefin resin is preferably at least one selected from the group consisting of a cycloolefin polymer and a polypropylene polymer (PP). The cycloolefin polymer may be a cycloolefin polymer (COP) or a cycloolefin copolymer (COC).

  COP is, for example, a polymer obtained by ring-opening polymerization of norbornene and hydrogenation. COP is described in, for example, Japanese Patent Application Laid-Open No. 5-317411, and ZEONEX (registered trademark) or ZEONOR (registered trademark) manufactured by Nippon Zeon Co., Ltd. or Daikyo Resin CZ manufactured by Daikyo Seiko Co., Ltd. It is marketed as (registered trademark).

  COC is, for example, a copolymer made from olefins such as norbornene and ethylene, and a copolymer made from olefins such as tetracyclododecene and ethylene. COC is commercially available, for example, as Apel (registered trademark) manufactured by Mitsui Chemicals.

  As PP, well-known polymers, such as a propylene homopolymer, a propylene-ethylene block copolymer, a propylene-ethylene random copolymer, can be used. As a commercial item, Boredalis company make, Bormed RB845MO etc. are mentioned.

<Layer (Y)>
The layer (Y) constituting the multilayer container of the present invention is a layer mainly composed of at least one kind of the predetermined polyamide resin (A), and usually functions as a gas barrier layer.
The layer (Y) usually has a role of blocking oxygen entering from the outside of the container and preventing oxidative deterioration of the contents in the container. From the viewpoint of good gas barrier properties, the oxygen permeability coefficient of the layer (Y) in an environment of 23 ° C. and a relative humidity of 60% is preferably 1.0 mL · mm / (m ² · day · atm) or less. It is more preferable that it is 0.05-0.8mL * mm / (m < ² > * day * atm). The oxygen permeability coefficient can be measured according to ASTM D3985, and can be measured using, for example, “OX-TRAN (registered trademark) 2/61” (manufactured by MOCON).

In addition, the above “main component” means that the polyamide resin (A) (gas barrier polymer) in the layer (Y) is 70 to 100% by mass, preferably 80 to 100% by mass, more preferably 90 to 100%. It means that it is contained by mass%, more preferably 95-100 mass%, and still more preferably 98-100 mass%. The layer (Y) may contain only 1 type of polyamide resin (A), or may contain 2 or more types. When 2 or more types are included, the total amount of the polyamide resin (A) falls within the above range.
The multilayer container of the present invention may have a plurality of layers (Y), and the configurations of the plurality of layers (Y) may be the same as or different from each other. Although the thickness of a layer (Y) is not specifically limited, 1-800 micrometers is preferable from a viewpoint of gas barrier property, transparency, and cost, and 100-700 micrometers is more preferable. In particular, when the multilayer container is formed by direct blow molding, the thickness of the layer (Y) is preferably 1 to 500 μm, more preferably 20 to 300 μm, and even more preferably 50 to 200 μm. . In addition, the thickness of the layer (Y) in the multilayer container of the present invention is preferably in the range of 2 to 40% with respect to the total thickness of the multilayer container, more preferably from the viewpoint of gas barrier properties, transparency and cost. It is 5-38%, More preferably, it is 10-35%. The thickness of the layer (Y) in the multilayer container can be measured by cutting the container and peeling it from the layer (X). In addition, when there are two or more layers (Y), the total is calculated as the thickness of the layer (Y).
In addition to the polyamide resin (A), the layer (Y) may contain additives in a range that does not impair the effects of the present invention, depending on the desired performance and the like. Specifically, pigments (such as inorganic pigments), lubricants (such as sodium stearate and calcium stearate), matting agents, heat stabilizers (such as antioxidants, more preferably phosphorous antioxidants), weathering stabilizers, Examples thereof include ultraviolet absorbers, crystallization nucleating agents, plasticizers, flame retardants, antistatic agents, anti-coloring agents, and anti-gelling agents. One type of additive may be used, or a combination of two or more types may be used. The content of the additive in the layer (Y) is preferably 10% by mass or less, more preferably 5% by mass or less, although it depends on the type of additive. Details of the additive can be referred to the descriptions in paragraphs 0071 to 0099 of JP-A-2014-068767, the contents of which are incorporated herein.
The following are illustrated as preferable embodiment of the layer (Y) in this invention.
(1) A layer consisting essentially of only one or two or more polyamide resins (A) (2) Substantially other than one or two or more polyamide resins (A) and a polyamide resin (A) Layer consisting only of polyamide resin (3) Layer consisting essentially of one or more polyamide resins (A) and antioxidants (4) One or more polyamide resins (A) and polyamide A layer consisting only of a polyamide resin other than the resin (A) and an antioxidant (5) One or two or more types of polyamide resins (A) and a layer consisting only of a lubricant (6) One or more types of polyamide resins ( A layer consisting only of a polyamide resin and a lubricant other than A) and the polyamide resin (A) (7) A layer consisting of only one or more polyamide resins (A), an antioxidant and a lubricant (8) One or two More than species polya A layer consisting only of a polyamide resin (A) and a polyamide resin (A), an antioxidant and a lubricant. (9) In the above, a layer wherein the polyamide resin other than the polyamide resin (A) is an amorphous polyamide resin.

<Polyamide resin (A)>
The polyamide resin (A) used in the present invention is composed of a structural unit derived from diamine and a structural unit derived from dicarboxylic acid, and 70 mol% or more of the structural unit derived from diamine is derived from metaxylylenediamine, Of the structural unit derived from acid, 30 to 60 mol% is derived from α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms, and 70 to 40 mol% is derived from isophthalic acid. The polyamide resin (A) used in the present invention is an amorphous resin. Transparency can be improved by using an amorphous resin. Furthermore, the polyamide resin (A) used in the present invention is also excellent in barrier properties after the heat sterilization treatment.
The polyamide resin (A) used in the present invention preferably contains calcium atoms. By including calcium atoms, the transparency after the heat treatment can be further improved.
The polyamide resin (A) used in the present invention contains phosphorus atoms in a proportion of 20 to 200 ppm by mass, and contains calcium atoms in a proportion such that the molar ratio of phosphorus atoms: calcium atoms is 1: 0.3 to 0.7. It is more preferable. By setting it as such a structure, the multilayer container with higher transparency after heat processing and lower YI value (yellowness) after heat processing is obtained. The calcium atom is preferably derived from calcium hypophosphite.

  When a polyamide resin synthesized from metaxylylenediamine, an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms, and isophthalic acid is used, the yellowness may increase. Therefore, it is conceivable to add a phosphorus-containing compound that is a coloring inhibitor during polycondensation. However, when the proportion of isophthalic acid in all dicarboxylic acids constituting the structural unit derived from dicarboxylic acid increases to 40 mol% or more, sodium hypophosphite, which is generally used as a phosphorus-containing compound, was used. In this case, it was found that although the yellowness is improved, the transparency may be inferior. Furthermore, when sodium hypophosphite was used, even if the obtained polyamide resin was transparent, it was found that transparency may deteriorate when subjected to water immersion treatment or the like. As a result of further investigation, by adding calcium hypophosphite instead of sodium hypophosphite as the phosphorus-containing compound, the transparency (haze) is further improved and the transparency is further improved after the water immersion treatment. It was found that it can be improved. However, calcium salts such as calcium hypophosphite have low solubility in α, ω-linear aliphatic dicarboxylic acids and isophthalic acids having 4 to 20 carbon atoms, and white foreign matter is generated when the amount of calcium salt added increases. It turns out that it may end up. Based on the above knowledge, the present invention succeeded in providing a polyamide resin with higher transparency by setting the ratio of phosphorus atoms and calcium atoms of the polyamide resin as described above, and improving the transparency of the multilayer container. It has succeeded in improving it.

In the present invention, 70 mol% or more of the structural unit derived from diamine is derived from metaxylylenediamine. The structural unit derived from diamine is preferably 80 mol% or more, more preferably 90 mol% or more, still more preferably 95 mol% or more, still more preferably 98 mol% or more, and even more preferably 99 mol% or more. Derived from range amine.
Examples of diamines other than metaxylylenediamine include aromatic diamines such as paraphenylenediamine and paraxylylenediamine, 1,3-bis (aminomethyl) cyclohexane, 1,4-bis (aminomethyl) cyclohexane, and tetramethylenediamine. And aliphatic diamines such as pentamethylenediamine, hexamethylenediamine, octamethylenediamine, and nonamethylenediamine. These other diamines may be used alone or in combination of two or more.

In the present invention, 30 to 60 mol% of the structural unit derived from dicarboxylic acid is derived from α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms, and 70 to 40 mol% is derived from isophthalic acid.
Of all dicarboxylic acids constituting the structural unit derived from dicarboxylic acid, the lower limit of the proportion of isophthalic acid is preferably 41 mol% or more, more preferably 43 mol% or more, and even more preferably 45 mol% or more. The upper limit of the proportion of isophthalic acid is preferably 68 mol% or less, and more preferably 66 mol% or less. By setting it as such a range, it exists in the tendency for the haze after the heat processing of a multilayer container to fall more, and is preferable.

Of all dicarboxylic acids constituting the structural unit derived from dicarboxylic acid, the lower limit of the proportion of α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms is preferably 32 mol% or more, and 34 mol% or more. More preferred. 59 mol% or less is preferable, as for the upper limit of the ratio of a C4-C20 linear aliphatic dicarboxylic acid, 57 mol% or less is more preferable, and 55 mol% or less is more preferable. By setting it as such a range, it exists in the tendency for the oxygen barrier property of a multilayer container, especially the oxygen barrier property after heat processing to improve more.
Examples of the α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms include fats such as succinic acid, glutaric acid, pimelic acid, suberic acid, azelaic acid, adipic acid, sebacic acid, undecanedioic acid, and dodecanedioic acid. Adipic acid and sebacic acid are preferable, and adipic acid is more preferable. The α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms may be one type or two or more types.

  Of all dicarboxylic acids constituting the structural unit derived from dicarboxylic acid, the total proportion of isophthalic acid and α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms is preferably 90 mol% or more, More preferably, it is 95 mol% or more, More preferably, it is 98 mol% or more, and 100 mol% may be sufficient. By setting it as such a ratio, it exists in the tendency for the transparency of a multilayer container to improve more and for yellowness to fall more.

  Examples of dicarboxylic acids other than isophthalic acid and α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms include terephthalic acid, 2,6-naphthalenedicarboxylic acid, and alicyclic dicarboxylic acids having 6 to 12 carbon atoms. Illustrated. Specific examples thereof include 1,4-cyclohexanedicarboxylic acid and 1,3-cyclohexanedicarboxylic acid.

  In addition, although the polyamide resin (A) used by this invention is comprised from the structural unit derived from dicarboxylic acid and the structural unit derived from diamine, structural units other than the structural unit derived from dicarboxylic acid and the structural unit derived from diamine, and the terminal Other sites such as groups may be included. Examples of other structural units include structural units derived from lactams such as ε-caprolactam, valerolactam, laurolactam, and undecanalactam, and aminocarboxylic acids such as 11-aminoundecanoic acid and 12-aminododecanoic acid. It is not limited to these. Furthermore, the polyamide resin (A) used in the present invention contains trace components such as additives used in the synthesis. The polyamide resin (A) used in the present invention is usually 95% by mass or more, preferably 98% by mass or more of a structural unit derived from a dicarboxylic acid or a structural unit derived from a diamine.

As described above, the polyamide resin (A) used in the present invention preferably contains phosphorus atoms at a rate of 3 to 300 ppm by mass, more preferably 4 to 250 ppm by mass, and more preferably 20 to 200 ppm by mass. More preferably, it is contained at a ratio of Moreover, it is preferable to contain a calcium atom in the ratio from which the molar ratio of a phosphorus atom: calcium atom will be 1: 0.3-0.7.
The lower limit of the phosphorus atom concentration in the polyamide resin (A) used in the present invention is preferably 3 mass ppm or more, more preferably 4 mass ppm or more, further preferably 20 mass ppm or more, and 22 mass. More preferably, it is more than ppm, 50 mass ppm or more may be sufficient, 100 mass ppm or more may be sufficient, and especially 150 mass ppm or more may be sufficient. By increasing the phosphorus atom concentration in the polyamide resin (A), the yellowness (YI value) can be more effectively lowered. The upper limit of the phosphorus atom concentration is preferably 300 mass ppm or less, more preferably 230 mass ppm or less, further preferably 200 mass ppm or less, still more preferably 190 mass ppm or less, and even more preferably 180 mass ppm or less. By setting the phosphorus atom concentration in the polyamide resin to the lower limit value or more, the yellowness of the multilayer container can be lowered, and the color tone is further improved. Moreover, it exists in the tendency which the transparency of the multilayer container obtained improves more by making the phosphorus atom concentration in a polyamide resin below into an upper limit.
The molar ratio of phosphorus atom: calcium atom in the polyamide resin (A) used in the present invention is preferably a ratio of 1: 0.3 to 0.7, and a ratio of 1: 0.4 to 0.6 is preferred. More preferably, the ratio is 1: 0.45 to 0.55, and particularly preferably the ratio is 1: 0.48 to 0.52. The phosphorus atom and calcium atom contained in the polyamide resin (A) used in the present invention are preferably derived from calcium hypophosphite, respectively. By setting the molar ratio of phosphorus atoms: calcium atoms in the polyamide resin to the lower limit value or more, the haze of the resulting multilayer container tends to be lower. Moreover, it exists in the tendency for the haze of the multilayer container obtained to become lower by making the molar ratio of the phosphorus atom: calcium atom in a polyamide resin below an upper limit.
The measurement method of a phosphorus atom concentration and a calcium atom concentration follows the method as described in the Example mentioned later, respectively. However, when the device used in the embodiment is an abandoned number or the like, other devices having the same performance can be used. Hereinafter, the same applies to other measurement methods.

<< Physical properties of polyamide resin (A) >>
Relative viscosity is generally used as an index of the degree of polymerization of polyamide resin. The relative viscosity of the polyamide resin (A) used in the present invention is preferably 1.5 to 3.0 from the viewpoint of the melt viscosity of the layer (X) and the co-injection moldability. The lower limit of the relative viscosity is more preferably 1.6 or more, further preferably 1.8 or more, and particularly preferably 1.9 or more. The upper limit value of the relative viscosity is more preferably 2.8 or less, further preferably 2.5 or less, still more preferably 2.3 or less, and even more preferably 2.0 or less. By setting it as such a range, co-injection moldability improves and the effect that the multilayer container with high interlayer adhesiveness is obtained is exhibited.
The relative viscosity referred to here means that 0.2 g of polyamide resin is precisely weighed, dissolved in 20 mL of 96 mass% sulfuric acid aqueous solution at 25 ° C. with stirring, completely dissolved, and immediately, 5 mL of the solution is immediately added to the viscometer. Take the sample for 10 minutes in a constant temperature bath at 25 ° C., and then measure the drop time (t). Further, the dropping time (t0) of the 96% by mass sulfuric acid aqueous solution itself is measured in the same manner. The relative viscosity is calculated from t and t0 according to the following equation. More specifically, the method described in the examples is followed.
Relative viscosity = t / t0

<Method for producing polyamide resin (A)>
Next, an example of the manufacturing method of the polyamide resin (A) used by this invention is described. The polyamide resin (A) used in the present invention is preferably a polyamide resin produced by the method described below, but it goes without saying that the present invention is not limited to this.

In the method for producing the polyamide resin (A) used in the present invention, a diamine and a dicarboxylic acid are used in the presence of hypophosphite (for example, sodium hypophosphite and / or calcium hypophosphite, preferably calcium hypophosphite). Including 70% by mole of the diamine is metaxylylenediamine, and 30 to 60% by mole of the dicarboxylic acid is an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms. 70 to 40 mol% is isophthalic acid.
In particular, by synthesizing in the presence of calcium hypophosphite, the phosphorus atom concentration in the obtained polyamide resin can be set to a predetermined value, the yellowness can be further reduced, and the calcium atom concentration is set to a predetermined range. And transparency can be further improved. In addition, a part or all of hypophosphite is phosphite (for example, calcium phosphite), phosphate (for example, calcium phosphate), polyphosphate (due to oxidation during polycondensation or secondary processing) For example, it changes to calcium polyphosphate). The ratio varies depending on the polycondensation conditions, the oxygen concentration during the polycondensation, and the like. Therefore, for example, even if the polyamide resin (A) used in the present invention contains a calcium atom or a phosphorus atom, calcium hypophosphite may not exist at all.
The polycondensation is usually a melt polycondensation method, in which a raw material diamine is added dropwise to a molten raw material dicarboxylic acid, the temperature is increased under pressure, and polymerization is performed while removing condensed water, or the raw material diamine and the raw material dicarboxylic acid. A method is preferred in which a salt composed of is heated in the presence of water under pressure and polymerized in a molten state while removing added water and condensed water.
In the present invention, hypophosphorous acid salt (for example, sodium hypophosphite and / or calcium hypophosphite, preferably calcium hypophosphite), and the concentration of phosphorus atoms contained in the polyamide resin (A) is 3 to 300 masses. It is preferable to add at a ratio of ppm. A more preferable range is a range in which the ratio is the same as the preferable range of the ratio of phosphorus atoms contained in the polyamide resin (A).

Further, at the time of polycondensation, another alkali metal compound may be added in combination with hypophosphite (for example, sodium hypophosphite and / or calcium hypophosphite, preferably calcium hypophosphite). By adding an alkali metal compound, it becomes possible to adjust the amidation reaction rate. An example of the alkali metal compound is sodium acetate. When blending an alkali metal compound, the molar ratio of alkali metal compound / hypophosphite (for example, sodium hypophosphite and / or calcium hypophosphite, preferably calcium hypophosphite) is 0.5 to 2.0. It is preferable that
Regarding other polymerization conditions, descriptions in JP-A-2015-098669 and International Publication WO2012 / 140785 can be referred to, and the contents thereof are incorporated in the present specification.
The details of diamine, dicarboxylic acid and the like are the same as those described in the above-mentioned polyamide resin, and the preferred ranges are also the same.

The layer (Y) in the present invention may contain a polyamide resin other than the polyamide resin (A). The polyamide resin other than the polyamide resin (A) may be an amorphous resin or crystalline. A resin may be used, but an amorphous resin is preferred.
Moreover, the layer (Y) in this invention can also be set as the structure which does not contain polyamide resins other than the said polyamide resin (A) substantially. “Substantially free” means, for example, that the amount of the polyamide resin other than the polyamide resin (A) in the layer (Y) is 1% by mass or less of the polyamide resin (A).

<Adhesive layer>
In the multilayer container of the present invention, an adhesive layer is provided. The adhesive layer preferably contains a thermoplastic resin having adhesiveness. Examples of the thermoplastic resin having adhesiveness include polyolefin resins such as polyethylene or polypropylene with acids such as unsaturated carboxylic acids (such as acrylic acid, methacrylic acid, maleic acid, maleic anhydride, fumaric acid, and itaconic acid). Examples include modified acid-modified polyolefin resins and polyester-based thermoplastic elastomers mainly composed of polyester-based block copolymers, and acid-modified polyolefin resins are preferred. More specifically, when a polypropylene polymer is used as the polyolefin resin, an embodiment in which the resin contained in the adhesive layer is an acid-modified polypropylene polymer can be mentioned.
The adhesive layer may contain only one type of adhesive thermoplastic resin or two or more types. In the adhesive layer, the total amount of the thermoplastic resin having adhesiveness preferably occupies 80% by mass or more, and more preferably 90% by mass or more. Components other than the thermoplastic resin having adhesiveness contained in the adhesive layer include antioxidants, matting agents, weathering stabilizers, UV absorbers, crystallization nucleating agents, plasticizers, flame retardants, antistatic agents, etc. Additives are exemplified.
The lower limit of the thickness of the adhesive layer is preferably 2 μm or more, more preferably 5 μm or more, and even more preferably 10 μm or more from the viewpoint of ensuring molding processability while exhibiting practical adhesive strength. The upper limit of the thickness is preferably 100 μm or less, more preferably 90 μm or less, still more preferably 80 μm or less, still more preferably 50 μm or less, still more preferably 30 μm or less, and even more preferably. Is 20 μm or less.

<Arbitrary layer>
In addition to the layer (X), the adhesive layer and the layer (Y), the multilayer container of the present invention may contain an arbitrary layer depending on the desired performance.

<Physical properties of multilayer container>
The multilayer container of the present invention preferably has the following ranges for the physical properties of YI, oxygen transmission rate (OTR), and water vapor transmission rate (WVTR), and particularly preferably has both of these physical properties.

<< YI >>
In the multilayer container of the present invention, the YI value after heat treatment at 121 ° C. for 30 minutes is preferably 8 or less, more preferably 7 or less, and even more preferably 6 or less. The lower limit value of the YI value is preferably 0, but is 2 or more, further 3 or more, and particularly 4 or more is sufficiently practical. The measurement method of the YI value after the heat treatment at 121 ° C. for 30 minutes is measured according to the method described in Examples described later.

<< Oxygen transmission rate (OTR) >>
The oxygen transmission rate (OTR) of the multilayer container of the present invention at 23 ° C., relative humidity 100% inside the multilayer container and 50% relative humidity outside the multilayer container is 0.00031 mL / (0.21 atm · day · package) The following is preferable. The lower limit value of the oxygen permeability is preferably 0 mL / (0.21 atm · day · package), but it is sufficiently practical even at 0.00025 mL / (0.21 atm · day · package) or more. The measuring method of the said oxygen permeability is measured according to the method as described in the Example mentioned later.
The multilayer container of the present invention has an oxygen permeability (mL / (0.21 atm · day · package)) after heat treatment at 121 ° C. for 30 minutes of 0.00032 mL / (0.21 atm · day · package) or less. Preferably, it is 0.00029 mL / (0.21 atm · day · package) or less. The lower limit value of the oxygen permeability is preferably 0 mL / (0.21 atm · day · package), but it is sufficiently practical even at 0.00025 mL / (0.21 atm · day · package) or more. The method for measuring the oxygen transmission rate after the heat treatment is measured according to the method described in Examples described later.
In addition, the oxygen transmission rate of the multilayer container of the present invention at 23 ° C., relative humidity of 100% inside the multilayer container and 50% relative humidity outside the multilayer container, and heating of the multilayer container of the present invention at 121 ° C. for 30 minutes. The difference in oxygen permeability after treatment is preferably 0.00005 mL / (0.21 atm · day · package) or less, more preferably 0.00004 mL / (0.21 atm · day · package) or less, 0 More preferably, it is 0.0003 mL / (0.21 atm · day · package) or less. In particular, in the present invention, the polyamide resin (A) contains a phosphorus atom in a proportion of 20 to 200 ppm by mass, and a calcium atom is a proportion in which the molar ratio of phosphorus atom to calcium atom is 1: 0.3 to 0.7. By including, it becomes possible to improve the oxygen permeability after heat processing.

<< Water vapor transmission rate (WVTR) >>
The multilayer container of the present invention preferably has a water vapor transmission rate (WVTR) of 0.0009 g / (day · package) or less, more preferably 0.0008 g / (day · package) or less. The lower limit value of the water vapor transmission rate is preferably 0 g / (day · package), but 0.0005 g / (day · package) or more is sufficiently practical. The water vapor transmission rate is measured according to the method described in Examples described later.

<Manufacturing method of multilayer container>
The multilayer container of the present invention is preferably produced by injection molding, injection blow molding, or direct blow molding, and is preferably produced by direct blow molding. It is more preferable. By performing direct blow molding, the total thickness of the multilayer container, in particular, the thickness of the layer (X) can be reduced.
That is, the present invention constitutes a material constituting the layer (X) mainly comprising at least one polyolefin resin, a material constituting the adhesive layer, and a layer (Y) mainly comprising the polyamide resin (A). A method for producing a multi-layer container including direct blow molding using a material to be used, wherein the polyamide resin (A) is composed of a structural unit derived from a diamine and a structural unit derived from a dicarboxylic acid, and is derived from the diamine 70 mol% or more of the structural unit of is derived from metaxylylenediamine, and 30 to 60 mol% of the structural unit derived from the dicarboxylic acid is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms. And the manufacturing method of a multilayer container which 70-40 mol% originates in isophthalic acid is disclosed. Details of the material constituting the layer (X) mainly comprising at least one polyolefin resin, the material constituting the adhesive layer, and the material constituting the layer (Y) mainly comprising the polyamide resin (A), Each is composed of the materials described in the description of the layer (X), the layer (Y), and the adhesive layer, and the blending amount of each component is the same.

  As an example of the direct blow molding, a material that constitutes the layer (X), a material that constitutes the layer (Y), and a material that constitutes the adhesive layer are included using a multilayer direct blow apparatus including a plurality of extruders and dies. Examples of the method include forming a multi-layer parison, extruding the parison into a tube shape, sandwiching the parison with a mold, and blowing from the lower portion of the parison to inflate the parison. The multi-layer parison is preferably an embodiment consisting of only the material constituting the layer (X), the material constituting the layer (Y), and the material constituting the adhesive layer. Moreover, although a die is determined according to the shape of the multilayer container to shape | mold, a cylindrical die is illustrated, for example. Further, in the present invention, the multilayer parison is extruded into a tube shape, the multilayer parison is sandwiched between molds adjusted to a temperature of 10 ° C. to 80 ° C., the lower portion of the parison is pinched off and fused, and high pressure air or the like before being cooled. It is preferable that the multi-layer parison is inflated and formed into a container shape suitable for a use form such as a bottle shape.

The direct blow device is not particularly limited, and may be a device composed of a single cylindrical die and a single mold, a device having a plurality of cylindrical dies and a plurality of molds, or a rotary direct blow device. Good.
Alternatively, an in-mold label method may be used in which an in-mold label is inserted into a mold in advance and the label is attached to the surface of the container. Regardless of the in-mold labeling method, when applying a label, it is preferable to perform a frame treatment or a corona treatment before applying the label. Furthermore, it is possible to give a frosted appearance by sandblasting the mold.
For details of the direct blow molding, the descriptions in Japanese Patent Application Laid-Open No. 2015-217971 and Japanese Patent No. 5895935 can be referred to, and the contents thereof are incorporated in the present specification.

The multilayer container of the present invention may be coated with an inorganic or inorganic oxide vapor deposition film or an amorphous carbon film.
Examples of the inorganic substance or inorganic oxide include aluminum, alumina, silicon oxide, and the like. The vapor deposition film of an inorganic substance or an inorganic oxide can shield eluents such as acetaldehyde and formaldehyde from the multilayer container of the present invention. The formation method of a vapor deposition film is not specifically limited, For example, physical vapor deposition methods, such as a vacuum evaporation method, sputtering method, and an ion plating method, Chemical vapor deposition methods, such as PECVD, etc. are mentioned. The thickness of the deposited film is preferably 5 to 500 nm, more preferably 5 to 200 nm, from the viewpoints of gas barrier properties, light shielding properties, bending resistance, and the like.
The amorphous carbon film is a diamond-like carbon film, which is a hard carbon film also called i-carbon film or hydrogenated amorphous carbon film. Examples of the method for forming the film include a method in which the inside of the hollow molded body is evacuated by evacuation, a carbon source gas is supplied thereto, and plasma generating energy is supplied by supplying plasma generating energy, Thereby, an amorphous carbon film can be formed on the inner surface of the multilayer container. The amorphous carbon film not only can remarkably reduce the permeability of low-molecular inorganic gases such as oxygen and carbon dioxide, but can also suppress the sorption of various low-molecular organic compounds having an odor. The thickness of the amorphous carbon film is preferably 50 to 5000 nm from the viewpoint of the effect of suppressing the sorption of the low-molecular organic compound, the effect of improving the gas barrier property, the adhesion to plastic, the durability and the transparency.

The multilayer container of the present invention is preferably used for medical packaging. Medical packaging means a container used for packaging pharmaceutical products, quasi drugs and medical products.
The multilayer container in the present invention is particularly suitable as an ampoule, a vial, a prefilled syringe, a vacuum blood collection tube and an infusion container (sometimes referred to as an infusion bag or the like), and more suitable as an infusion container.
When the multi-layer container for medical packaging of the present invention is used for an infusion container, the volume thereof can be, for example, 10 to 1000 mL, further 50 to 700 mL, and particularly 80 to 700 mL. can do.
Examples of the shape of the multilayer container of the present invention include a bottle having a bottom part and a body part such as a columnar or prismatic shape.
In particular, the multi-layer container used in the present invention preferably has self-supporting property. Self-supporting is not deformed when left standing in an atmosphere of 25 ° C. and 35% relative humidity for one week, and It means not to fall down. Specifically, the bottle is exemplified.
Various drugs can be stored in the multilayer container of the present invention. Details of these can be referred to the description in paragraph 0100 of JP2014-148076A, the contents of which are incorporated herein.

  The multilayer container of the present invention is assumed to be heat sterilized. Examples of the heat sterilization method include a steam type, a hot water storage type, a shower type, and the like. The sterilization temperature is preferably in the range of 80 ° C to 140 ° C, and the sterilization time is preferably 10 to 120 minutes.

<Multilayer body>
The multilayer body of the present invention has a layer (X) containing at least one polyolefin resin as a main component, an adhesive layer, and a layer (Y) containing a polyamide resin (A) as a main component in the above order. (A) is composed of a structural unit derived from a diamine and a structural unit derived from a dicarboxylic acid, 70 mol% or more of the structural unit derived from the diamine is derived from metaxylylenediamine, and the structural unit derived from the dicarboxylic acid. 30 to 60 mol% is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms, and 70 to 40 mol% is derived from isophthalic acid. An example of such a multilayer body is the multilayer preform described above. The multilayer body of the present invention can be preferably used as a packaging sheet.
Layer (X) and layer (Y) are synonymous with layer (X) and layer (Y), respectively, in the multilayer container, and the preferred ranges are also the same.
In particular, the polyamide resin (A) in the multilayer body of the present invention preferably contains a calcium atom, contains a phosphorus atom in a proportion of 20 to 200 ppm by mass, and the calcium atom has a molar ratio of phosphorus atom: calcium atom of 1: More preferably, it is contained at a ratio of 0.3 to 0.7.

  The present invention will be described more specifically with reference to the following examples. The materials, amounts used, ratios, processing details, processing procedures, and the like shown in the following examples can be changed as appropriate without departing from the spirit of the present invention. Therefore, the scope of the present invention is not limited to the specific examples shown below.

(1) Relative viscosity 0.2 g of polyamide resin was precisely weighed and dissolved in 20 mL of 96 mass% sulfuric acid aqueous solution at 25 ° C with stirring. After the polyamide resin was completely dissolved, 5 mL of the solution was quickly taken into a Cannon Fenceke viscometer, and allowed to stand in a constant temperature bath at 25 ° C. for 10 minutes, and then the drop time (t) was measured. The drop time (t0) of the 96 mass% sulfuric acid aqueous solution itself was also measured in the same manner. The relative viscosity was calculated from t and t0 according to the following formula.
Relative viscosity = t / t0

(2) Oxygen transmission rate (OTR) of multilayer container
The oxygen permeability (OTR) of the multilayer container at 23 ° C., the relative humidity inside the multilayer container of 100%, and the relative humidity of 50% outside the multilayer container was measured according to ASTM D3985 (manufactured by MOCON, Product name: “OX-TRAN (registered trademark) 2/61”). It shows that oxygen barrier property is so favorable that a measured value is low.

(3) Water vapor transmission rate of multilayer container (WVTR)
The water vapor transmission rate (WVTR) on the 10th day from the start of measurement was measured in an atmosphere of 40 ° C. and a relative humidity of 0% outside the multilayer container. For the measurement, a water vapor transmission rate measuring device (manufactured by MOCON, product name: “PERMATRAN-W (registered trademark) 3 / 33G”) was used. It shows that water vapor | steam barrier property is so favorable that a measured value is low.

(4) Heat treatment The multilayer container was heat-treated (retort) at 121 ° C. for 30 minutes using an autoclave (product name: “SR-240” manufactured by Tommy Seiko Co., Ltd.). The heat treatment time does not include the temperature raising time and the cooling time.

(5) Transparency of multi-layer container (haze)
The side part of the multilayer container after heat processing was cut out, and haze (HAZE) was measured. The haze was measured according to JIS K7136. A color / turbidity measuring device (manufactured by Nippon Denshoku Industries Co., Ltd., product name: “COH-300A”) was used as a measuring device. The thickness of the side surface portion of the multilayer container at the measurement location was measured and shown as a value converted to a thickness of 300 μm.

(6) Color tone of the multilayer container after the heat treatment The side portion of the multilayer container after the heat treatment was cut out and the yellowness (YI value) was measured. A color / turbidity measuring device (manufactured by Nippon Denshoku Industries Co., Ltd., product name: “COH-300A”) was used as a measuring device.

(7) Measuring method of phosphorus atom concentration and calcium atom concentration Put 0.2 g of polyamide resin and 8 mL of 35 mass% nitric acid aqueous solution in a TFM-modified PTFE (manufactured by 3M) container and use ETHOS One by Milestone General Microwave decomposition was performed at a temperature of 230 ° C. for 30 minutes. The decomposition solution was made up to volume with ultrapure water to obtain an ICP measurement solution. The phosphorus atom concentration and calcium atom concentration were measured using ICPE-9000 manufactured by Shimadzu Corporation.

(8) Self-sustainability With the bottom of the multilayer container (bottle) down, the multi-layer container (bottle) was allowed to stand for 1 week in an atmosphere of 25 ° C. and relative humidity of 35%. Evaluation was performed as follows.
A: The multilayer bottle was not deformed and did not fall down.
B: The multilayer bottle was in a state other than A.

<Example 1>
A polyamide resin shown in Table 1 was synthesized according to the following method.
In a reaction vessel equipped with a stirrer, a partial condenser, a full condenser, a thermometer, a dropping funnel and a nitrogen introduction tube, and a strand die, 6,000 g (41.06 mol) of adipic acid and 6,821 g of isophthalic acid were precisely weighed ( 41.06 mol), 10.04 g of calcium hypophosphite (Ca (H ₂ PO ₂ ) ₂ ) (175 mass ppm as the phosphorus atom concentration in the polyamide resin), 7.26 g of sodium acetate, and after sufficient nitrogen substitution, Nitrogen was charged to an internal pressure of 0.4 MPa, and the system was heated to 190 ° C. with stirring in a small amount of nitrogen. The molar ratio of sodium acetate / calcium hypophosphite was 1.50.
To this, 11,185 g (82.12 mol) of metaxylylenediamine was added dropwise with stirring, and the inside of the system was continuously heated while removing the condensed water to be produced. After completion of the dropwise addition of metaxylylenediamine, the internal temperature was raised, and when the temperature reached 265 ° C., the pressure in the reaction vessel was reduced, and the internal temperature was further raised to continue the melt polycondensation reaction at 270 ° C. for 10 minutes. Thereafter, the inside of the system was pressurized with nitrogen, and the obtained polymer was taken out from the strand die and pelletized to obtain about 21 kg of polyamide resin (A1) pellets. The relative viscosity of the polyamide resin (A1) was 1.95.

  Next, using a multilayer direct blow apparatus equipped with first to third extruders, cylindrical dies, and molds, a polypropylene polymer (manufactured by Nippon Polypro Co., Ltd., product name: “NOVATEC PP FY6”) from the first extruder , Hereinafter also abbreviated as “PP”) at 260 ° C., the polyamide resin (A1) from the second extruder at 260 ° C., and the third extruder from adhesive polypropylene (Mitsubishi Chemical Co., Ltd., product name). : “Modic P604V” (hereinafter also abbreviated as “adhesive PP”) at 230 ° C., respectively, and blow-molded with a mold to produce a 100 mL multi-layer container (multi-layer bottle) with 3 types and 5 layers. did. The layer structure of the multilayer container is, from the inner layer, PP layer (400 μm) / adhesive PP layer (15 μm) / polyamide resin (A1) layer (100 μm) / adhesive PP layer (15 μm) / PP layer (400 μm). It was.

<Example 2>
In Example 1, it adjusted so that the molar ratio of adipic acid and isophthalic acid might be set to 40:60, and others performed similarly and obtained the polyamide resin pellet (A2). The relative viscosity of the polyamide resin (A2) was 1.94.

  A multilayer container was produced in the same manner as in Example 1 except that the polyamide resin (A2) was used instead of the polyamide resin (A1).

<Example 3>
In Example 1, it adjusted so that the molar ratio of adipic acid and isophthalic acid might be set to 60:40, and others performed similarly and obtained the polyamide resin pellet (A3). The relative viscosity of the polyamide resin (A3) was 1.94.

  A multilayer container was produced in the same manner as in Example 1 except that the polyamide resin (A3) was used instead of the polyamide resin (A1).

<Example 4>
In Example 1, sodium hypophosphite was used as the hypophosphite, and others were performed in the same manner to obtain polyamide resin (A4) pellets. The relative viscosity of the polyamide resin (A4) was 1.95.

  A multilayer container was produced in the same manner as in Example 1 except that the polyamide resin (A4) was used instead of the polyamide resin (A1).

<Example 5>
In Example 1, the amount of calcium hypophosphite added was changed as shown in Table 1, and the others were performed in the same manner to obtain polyamide resin (A5) pellets. The relative viscosity of the polyamide resin (A5) was 1.93.

  A multilayer container was produced in the same manner as in Example 1 except that the polyamide resin (A5) was used instead of the polyamide resin (A1).

<Example 6>
In Example 1, the amount of calcium hypophosphite added was changed as shown in Table 1, and the others were carried out in the same manner to obtain polyamide resin (A6) pellets. The relative viscosity of the polyamide resin (A6) was 1.93.

  A multilayer container was produced in the same manner as in Example 1 except that the polyamide resin (A6) was used instead of the polyamide resin (A1).

<Example 7>
In Example 1, the amount of calcium hypophosphite added was changed as shown in Table 1, and the others were carried out in the same manner to obtain polyamide resin (A7) pellets. The relative viscosity of the polyamide resin (A7) was 1.93.

  A multilayer container was produced in the same manner as in Example 1 except that the polyamide resin (A7) was used instead of the polyamide resin (A1).

<Comparative Example 1>
In Example 1, it adjusted so that the molar ratio of adipic acid and isophthalic acid might be set to 94: 6, and others were performed similarly and the polyamide resin pellet (A8) of the comparative example 1 was obtained. The relative viscosity of the polyamide resin (A8) was 2.65.

  A multilayer container was produced in the same manner as in Example 1 except that the polyamide resin (A8) was used instead of the polyamide resin (A1).

<Comparative example 2>
Instead of polyamide resin (A1), N-MXD6 (Mitsubishi Gas Chemical Co., Ltd., product name: “MX nylon S6007”, relative viscosity = 2.65) consisting of a metaxylylenediamine unit and an adipic acid unit is used. A multilayer container was produced in the same manner as in Example 1 except that it was.

<Comparative Example 3>
Polyhexamethylene isophthalamide / polyhexamethylene terephthalamide copolymer (manufactured by DSM Japan Engineering Plastics Co., Ltd., product name: “Novamid (registered trademark) X21”) instead of polyamide resin (A1) A multilayer container was produced in the same manner as in Example 1 except that was used.

  About the multilayer container obtained in Examples 1-7 and Comparative Examples 1-3, oxygen transmission rate (OTR) and water vapor transmission rate (WVTR) were measured by the said method. In addition, the independence was evaluated. Furthermore, the obtained multilayer container was heat-treated under the above-described conditions, and the haze, YI value, and oxygen permeability (OTR) after the heat treatment were measured. The results are shown in Table 1 or Table 2.

In Table 1 and Table 2, abbreviations and the like are as follows.
* 1: Amount in diamine unit (mol%)
* 2: Amount in dicarboxylic units (mol%)
PP: Polypropylene polymer N-6I / 6T: Polyhexamethylene isophthalamide / polyhexamethylene terephthalamide copolymer

  The multilayer containers of Comparative Examples 1 and 2 had high haze after the heat treatment, resulting in poor transparency after the heat treatment. In Comparative Example 3 using a polyhexamethylene isophthalamide / polyhexamethylene terephthalamide copolymer, the oxygen barrier property was insufficient before and after the heat treatment.

On the other hand, it turned out that the multilayer container of Examples 1-7 is excellent in oxygen barrier property after heat processing, ensuring required transparency, and excellent in water vapor | steam barrier property. In particular, when the polyamide resin contains phosphorus atoms in a proportion of 20 to 200 ppm by mass and contains calcium atoms in a proportion of a molar ratio of phosphorus atoms to calcium atoms of 1: 0.3 to 0.7, transparency An excellent low multilayer container was obtained. When using for the multilayer container for medical packaging, it is important to have the visibility of the content after heat processing, and the multilayer container of this invention is highly effective.
In addition, the polyamide resins (A1) to (A7) used in Examples 1 to 7 were found to be amorphous with a crystal melting enthalpy ΔHm of approximately 0 J / g during the temperature rising process.

  The multilayer container of the present invention has oxygen barrier properties and contents visibility suitable for medical packaging that requires heat sterilization treatment. Furthermore, it is excellent in water vapor barrier properties. Therefore, the contents can be stored for a long period of time, and the contents can be visually recognized even after the heat sterilization treatment, and the convenience of the customer can be improved as an alternative to the glass container.

Claims (13)

A layer (X) containing at least one polyolefin resin as a main component, an adhesive layer, and a layer (Y) containing a polyamide resin (A) as a main component in that order;
The polyamide resin (A) is composed of a structural unit derived from a diamine and a structural unit derived from a dicarboxylic acid, 70 mol% or more of the structural unit derived from the diamine is derived from metaxylylenediamine, and derived from the dicarboxylic acid. A multilayer container in which 30 to 60 mol% of the structural unit is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms and 70 to 40 mol% is derived from isophthalic acid. The multilayer container according to claim 1, wherein the polyamide resin (A) contains calcium atoms. The multilayer container according to claim 2, wherein the calcium atom contained in the polyamide resin (A) is derived from calcium hypophosphite. The multilayer container of any one of Claims 1-3 in which the said polyamide resin (A) contains a phosphorus atom in the ratio of 3-300 mass ppm. The said polyamide resin (A) contains a phosphorus atom in the ratio of 20-200 mass ppm, and contains a calcium atom in the ratio from which the molar ratio of a phosphorus atom: calcium atom will be 1: 0.3-0.7. The multilayer container according to 1 or 3. The multilayer container according to any one of claims 1 to 5, wherein the layer (X) contains at least one polypropylene-based polymer as a main component. The multilayer container according to any one of claims 1 to 6, wherein 30 to 60 mol% of the structural unit derived from the dicarboxylic acid is a structural unit derived from adipic acid. The multilayer container is composed of at least five layers, the inner layer and the outer layer are the layer (X), and at least one of the intermediate layers is the layer (Y). The multilayer container as described. The multilayer container according to any one of claims 1 to 8, which is for medical packaging. The multilayer container according to any one of claims 1 to 8, which is an infusion container. A layer (X) containing at least one polyolefin resin as a main component, an adhesive layer, and a layer (Y) containing a polyamide resin (A) as a main component in that order;
The polyamide resin (A) is composed of a structural unit derived from a diamine and a structural unit derived from a dicarboxylic acid, 70 mol% or more of the structural unit derived from the diamine is derived from metaxylylenediamine, and derived from the dicarboxylic acid. A multilayer body in which 30 to 60 mol% of the structural unit is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms and 70 to 40 mol% is derived from isophthalic acid. The said polyamide resin contains a phosphorus atom in the ratio of 20-200 mass ppm, and contains the calcium atom in the ratio from which the molar ratio of a phosphorus atom: calcium atom will be 1: 0.3-0.7. Multilayered body. Directly using a material constituting the layer (X) mainly composed of at least one polyolefin resin, a material constituting the adhesive layer, and a material constituting the layer (Y) mainly composed of the polyamide resin (A) A method for producing a multilayer container, comprising blow molding,
The polyamide resin (A) is composed of a structural unit derived from a diamine and a structural unit derived from a dicarboxylic acid, 70 mol% or more of the structural unit derived from the diamine is derived from metaxylylenediamine, and derived from the dicarboxylic acid. A method for producing a multi-layer container, wherein 30 to 60 mol% of the structural unit is derived from an α, ω-linear aliphatic dicarboxylic acid having 4 to 20 carbon atoms and 70 to 40 mol% is derived from isophthalic acid.