JP2018102534A - Pollen rupture inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a pollen rupture inhibitor that inhibits the rupture of attached or floating pollen, and effectively inhibits the emission of allergen material.SOLUTION: A pollen rupture inhibitor contains boric acid and/or a salt thereof, is substantially free of alkali metal chloride, and contains at least one component selected from (A) component, (B) component, (C) component, (D) component, and (E) component: (A) polyoxyethylene sorbitan fatty acid ester, (B) terpenoid, (C) glycyrrhizinic acid and/or a salt thereof, (D) chlorpheniramine and/or a salt thereof, (E) ε-amino caproic acid and/or a salt thereof.SELECTED DRAWING: None

Description

  The present invention relates to a pollen burst inhibitor that is applied to textiles, indoor spaces, and the like, suppresses pollen bursting, and suppresses release of allergen substances.

  Hay fever is a type of rhinitis that develops due to allergic reactions caused by foreign substances such as pollen. Hay fever continuously causes unpleasant symptoms such as itchy eyes, sneezing, runny nose, and stuffy nose for a long period of time, impairing daily life. The prevalence of hay fever is increasing every year and has become a social problem in recent years.

  The pathogenesis of hay fever has been elucidated by vigorous studies so far. Specifically, the pathogenesis of hay fever is as follows. First, when pollen of cedar or the like adheres to the mucous membrane of the eye or nose, the outer shell of the pollen ruptures, releasing an antigen protein (allergen substance) and entering the mucous membrane. When the antigenic protein enters the mucosa, specific IgE antibodies are produced and sensitization occurs by binding of the antibodies to receptors on mucosal mast cells. In this state, when the antigen protein is exposed again, the antibody-antigen reaction releases chemical mediators such as histamine from mast cells, and these substances bind to the receptor, causing allergic symptoms such as pruritus. .

  Conventionally, various methods for preventing hay fever have been reported. For example, Patent Document 1 reports that a hay fever prevention solution containing an amino acid metal salt can destroy pollen and render it harmless. However, although the technique of Patent Document 1 intends to detoxify the pollen by deliberately destroying it, it cannot prevent contact with the allergen substance released by the rupture of pollen and prevent hay fever. The effect is not enough.

  On the other hand, to prevent hay fever, it is effective to avoid contact with pollen, but it is difficult to completely avoid contact with pollen in daily life. For this reason, it is important to prevent the outer shell of the pollen from being ruptured even if it comes into contact with the pollen.

JP 2013-75879 A

  An object of the present invention is to provide a pollen rupture inhibitor that can suppress the rupture of adhering or floating pollen and can effectively suppress the release of allergen substances.

  The present inventor conducted intensive research to solve the above problems, and found that a composition containing boric acid and / or a salt thereof and substantially free of alkali metal chloride was brought into contact with pollen. It was found that pollen rupture is extremely effectively suppressed. Furthermore, by blending the composition with at least one component selected from the group consisting of polyoxyethylene sorbitan fatty acid ester, terpenoid, glycyrrhizic acid, chlorpheniramine, ε-aminocaproic acid, and salts thereof, It was found that pollen bursting can be more effectively suppressed. The present invention has been completed by further studies based on these findings.

That is, this invention provides the invention of the aspect hung up below.
Item 1. A pollen burst inhibitor containing boric acid and / or a salt thereof and substantially free of alkali metal chloride.
Item 2. The pollen according to Item 1, further comprising at least one component selected from the group consisting of the following component (A), component (B), component (C), component (D), and component (E): Burst inhibitor.
(A) Polyoxyethylene sorbitan fatty acid ester
(B) Terpenoid
(C) Glycyrrhizic acid and / or its salt
(D) Chlorpheniramine and / or its salt
(E) ε-aminocaproic acid and / or salt thereof Item 3. The pollen burst inhibitor according to Item 1 or 2, which is substantially free of triethanolamine.
Item 4. Item 4. The pollen burst inhibitor according to any one of Items 1 to 3, which is applied to a textile product or an indoor space.
Item 5. Item 5. The pollen rupture inhibitor according to any one of Items 1 to 4, which is a liquid agent.

  The pollen rupture inhibitor of the present invention can extremely effectively prevent the outer shell of pollen from rupturing. Therefore, it is possible to suppress the release of the allergen substance from the pollen, and thus suppress the onset of hay fever.

  The pollen burst inhibitor of the present invention is characterized by containing boric acid and / or a salt thereof and substantially not containing an alkali metal chloride. Hereinafter, the pollen burst inhibitor component of the present invention will be described in detail.

[Boric acid and / or its salt]
The pollen rupture inhibitor of the present invention contains boric acid and / or a salt thereof as an active ingredient that exhibits a pollen rupture inhibitory action.

  The type of borate used in the present invention is not particularly limited, and may be any of orthoborate, diborate, metaborate, tetraborate and the like. Moreover, although it does not restrict | limit especially also about the base which comprises borate, For example, alkali metal salts, such as sodium and potassium, are mentioned. The boric acid salt used in the present invention is preferably borax.

  In the pollen burst inhibitor of the present invention, boric acid and boric acid salts may be used singly or in combination. Of the boric acid and boric acid salts, boric acid alone or a combination of boric acid and boric acid is preferably used from the viewpoint of more effectively exerting a pollen burst inhibiting effect.

  The content of boric acid and / or a salt thereof in the pollen rupture inhibitor of the present invention is not particularly limited and may be appropriately set according to the application target of the pollen rupture inhibitor. For example, boric acid and The total amount of the salt thereof is 0.01 to 10% by weight, preferably 0.1 to 5% by weight, more preferably 1.2 to 2% by weight.

[Alkali metal chloride]
Alkali metal chlorides have the effect of hindering pollen burst suppression. Therefore, the pollen burst inhibitor of the present invention does not substantially contain alkali metal chloride.

  Specific examples of the alkali metal salt include sodium chloride, potassium chloride, lithium chloride, rubidium chloride, cesium chloride, and francium chloride.

  Further, in the pollen rupture inhibitor of the present invention, “substantially free of alkali metal chloride” means that the alkali metal chloride is not contained in a content that prevents the pollen rupture inhibitory effect. Point to. That is, the pollen rupture inhibitor of the present invention is allowed to contain an alkali metal chloride as long as the pollen rupture inhibitory effect is not hindered. Specifically, the alkali metal chloride content permitted in the pollen burst inhibitor of the present invention is usually 0.01% by weight or less, preferably 0.005% by weight or less, and more preferably 0.001% by weight. % Or less, more preferably 0.0005% by weight or less, particularly preferably 0.0001% by weight or less, and most preferably 0% by weight.

[Ingredients to enhance pollen burst suppression effect]
The pollen rupture inhibitor of the present invention further includes polyoxyethylene sorbitan fatty acid ester (sometimes referred to as (A) component), terpenoid (also sometimes referred to as (B) component), glycyrrhizic acid and / or Its salt (sometimes referred to as (C) component), chlorpheniramine and / or its salt (also sometimes referred to as (D) component), and ε-aminocaproic acid and / or its salt ((E) (It may be expressed as a component), and may contain at least one component.

  In the pollen burst inhibitor of the present invention, among the components (A) to (E), one, two or more, three or more, four or more, or five (that is, all of the components (A) to (E)) From the viewpoint of more effectively improving the pollen burst inhibiting effect, preferably one or five of the components (A) to (E), more preferably (A) to (E) It is desirable to include all of the components (ie, five types).

  Hereinafter, the components (A) to (E) will be specifically described.

Component (A): Polyoxyethylene sorbitan fatty acid ester Polyoxyethylene sorbitan fatty acid ester is an ester of polyoxyethylene sorbitan and a fatty acid, and is a compound known as a nonionic surfactant.

  In the polyoxyethylene sorbitan fatty acid ester used in the present invention, the number of added moles of ethylenoxide is not particularly limited, and examples thereof include 6 to 160, preferably 6 to 60, and more preferably 6 to 30.

  The fatty acid constituting the polyoxyethylene sorbitan fatty acid ester may be either a saturated fatty acid or an unsaturated fatty acid. Moreover, although it does not restrict | limit especially about the carbon number of the fatty acid which comprises polyoxyethylene sorbitan fatty acid ester, For example, 8-30, Preferably it is 10-22, More preferably, 12-18 is mentioned. Specific examples of fatty acids constituting the polyoxyethylene sorbitan fatty acid ester include single fatty acids such as oleic acid, lauric acid, myristic acid, palmitic acid and stearic acid; mixtures derived from animal and vegetable oils such as coconut oil fatty acid and beef tallow fatty acid. Examples include fatty acids.

  Specific examples of the polyoxyethylene sorbitan fatty acid ester used in the present invention include POE (20) sorbitan monolaurate (polysorbate 20), POE (20) sorbitan monopalmitate (polysorbate 40), and POE (20) sorbitan. Examples include monostearate (polysorbate 60), POE (20) sorbitan tristearate (polysorbate 65), POE (20) sorbitan monooleate (polysorbate 80), and the like. These polyoxyethylene sorbitan fatty acid esters may be used alone or in combination of two or more. In the description of the polyoxyethylene sorbitan fatty acid ester, “POE” refers to polyoxyethylene, and the numerical value in parentheses after POE refers to the number of moles of ethylenoxide added.

  Among these polyoxyethylene sorbitan fatty acid esters, Polysorbate 80 is preferably used from the viewpoint of further improving the pollen burst inhibiting effect.

  When the pollen rupture inhibitor of the present invention contains the component (A), the content is not particularly limited. For example, the total amount of the component (A) is 0.0001 to 3% by weight, preferably 0.0001. -1% by weight, more preferably 0.001-0.1% by weight.

Component (B): Terpenoid Terpenoids are also called isoprenoids or terpenes, and are usually compounds in which a plurality of isoprene units (5 carbon atoms) are bonded. Terpenoids are monoterpenes (2 isoprene units), sesquiterpenes (3 isoprene units), diterpenes (4 isoprene units), triterpenes (6 isoprene units) depending on the number of isoprene units contained. And so on. Any of these terpenoids may be used in the pollen burst inhibitor of the present invention.

  Specific examples of monoterpenes include alcohol-based monoterpenes such as menthol, thymol, geraniol, linalool, borneol, cineol, and terpineol; aldehyde-based monoterpenes such as citral, citronellal, perylaldehyde, and safranal; camphor, menthone, and carbo Mentones such as menthone and ketones such as monoterpenes. As sesquiterpenes, specifically, camazulene, santalen, patchulene, cedrol, cedrenol, farnesol, eugenol, α-bisabolol, β-caryophyllene alcohol, sclareol, geranyl linalool, isophitol, nerolidol, globrol, guaioles, α-Santalol, Catolol, Farnesal, Germacron, Ciperon, Zerumbon, Betivon and the like can be mentioned. Specific examples of diterpenes include retinal and the like. These terpenoids may be any of d-form, l-form and dl-form when optical isomers are present.

  These terpenoids may be used individually by 1 type, and may be used in combination of 2 or more type.

  Among these terpenoids, monoterpenes are preferable, alcohol monoterpenes are more preferable, and menthol and borneol are particularly preferable.

  These terpenoids may be used in the state of an essential oil containing terpenoids. The essential oil containing terpene can be appropriately selected from known ones, and examples of the essential oil containing menthol include peppermint oil, peppermint oil, spearmint oil, and the like.

  When the pollen rupture inhibitor of the present invention contains the component (B), the content thereof is not particularly limited. For example, the total amount of the component (B) is 0.0001 to 1% by weight, preferably 0.0001. -0.5 weight%, More preferably, 0.001-0.05 weight% is mentioned.

Component (C): Glycyrrhizic acid and / or its salt glycyrrhizic acid is 20β-carboxy-11-oxo-30-noroleana-12-en-3β-yl-2-O-β-D-glucopyranuronosyl- It is a known compound also called α-D-glucopyranoside uronic acid.

  The salt of glycyrrhizic acid is not particularly limited. For example, alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; ammonium salt; arginine, lysine, histidine, ornithine and the like Basic amino acid salts; amine salts such as monoethanolamine salts and diethanolamine salts. Among these, an alkali metal salt is preferable. These salts may be used individually by 1 type, and may be used in combination of 2 or more type.

  Further, glycyrrhizic acid and a salt of glycyrrhizic acid may be used alone or in combination of glycyrrhizic acid and glycyrrhizic acid, respectively. Among glycyrrhizic acid and its salts, preferably a salt of glycyrrhizic acid, more preferably an alkali metal salt of glycyrrhizic acid, particularly preferably dipotassium glycyrrhizinate.

  The glycyrrhizic acid and / or salt thereof used in the present invention may be chemically synthesized or extracted or purified from a natural product-derived material. Moreover, you may use the commercially available glycyrrhizic acid or its salt.

  A method for producing glycyrrhizic acid or a salt thereof by extraction or purification from a natural product-derived material is not particularly limited, and examples thereof include a method for extraction and purification from a natural product-derived material by a known method. . Examples of the natural product-derived material for extracting glycyrrhizic acid include licorice root.

  When the component (C) is used in the pollen burst inhibitor of the present invention, the content thereof is not particularly limited, but for example, 0.001 to 0.3% by weight, preferably 0 in terms of the total amount of the component (C) 0.001 to 0.1% by weight, more preferably 0.005 to 0.05% by weight.

Component (D): Chlorpheniramine and / or its salt chlorpheniramine is also known as 3- (4-chlorophenyl) -N, N-dimethyl-3- (2-pyridinyl) propan-1-amine A compound.

  Although it does not restrict | limit especially as a salt of chlorpheniramine, For example, various salt, such as organic acid salts, such as maleate, hydrochloride, and fumarate; Inorganic acid salt; Metal salt. Among these salts, organic acid salts are preferable, and maleates are more preferable. These chlorpheniramine salts may be used alone or in any combination of two or more.

  Further, chlorpheniramine and a salt thereof may be in the form of a hydrate, and may be any of d-form, l-form, and dl-form.

  Further, each of chlorpheniramine and a salt of chlorpheniramine may be used alone or in combination with a salt of chlorpheniramine and chlorpheniramine. Among chlorpheniramine and its salts, a salt of chlorpheniramine is preferable, an organic acid salt of chlorpheniramine is more preferable, and a chlorpheniramine maleate is particularly preferable.

  The chlorpheniramine and / or salt thereof used in the present invention may be chemically synthesized, or may be extracted or purified from a natural product-derived material. Moreover, you may use the chlorpheniramine marketed as a reagent, or its salt.

  When the component (D) is used in the pollen rupture inhibitor of the present invention, the content thereof is not particularly limited. For example, the total amount of the component (D) is 0.0001 to 0.1% by weight, preferably 0. 0.0001 to 0.05% by weight, more preferably 0.0003 to 0.03% by weight.

Component (E): ε-aminocaproic acid and / or its salt ε-aminocaproic acid is a known compound in which the terminal hydrogen atom of a saturated fatty acid having 6 carbon atoms is substituted with an amino group.

  Although it does not restrict | limit especially as a salt of (epsilon) -aminocaproic acid, For example, alkali metal salts, such as sodium salt and potassium salt; Alkaline earth metal salts, such as calcium salt and magnesium salt; Inorganic acid salts, such as hydrochloride and sulfate Etc. These salts of ε-aminocaproic acid may be used alone or in combination of two or more.

  Further, ε-aminocaproic acid and a salt of ε-aminocaproic acid may be used alone or in combination of a salt of ε-aminocaproic acid and ε-aminocaproic acid. Among ε-aminocaproic acid and salts thereof, ε-aminocaproic acid is preferable.

  The ε-aminocaproic acid and / or salt thereof used in the present invention may be chemically synthesized or commercially available as a reagent.

  When the component (E) is used in the pollen burst inhibitor of the present invention, the content thereof is not particularly limited, but for example, 0.001 to 1% by weight, preferably 0.01, based on the total amount of the component (E) -1% by weight, more preferably 0.01-0.5% by weight.

[Chondroitin sulfate and / or salt thereof]
The pollen rupture inhibitor of the present invention may contain chondroitin sulfate and / or a salt thereof (also referred to as (F) component).

  Chondroitin sulfate is a compound known as acidic mucopolysaccharide in which sulfuric acid is bound to a sugar chain having a disaccharide of N-acetyl-D-galactosamine and D-glucuronic acid as repeating structural units.

  The salt of chondroitin sulfate is not particularly limited, but examples thereof include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; ammonium salt; arginine, lysine, histidine, ornithine and the like. Basic amino acid salts; amine salts such as monoethanolamine salts and diethanolamine salts. Among these, Preferably an alkali metal salt is mentioned. These salts may be used individually by 1 type, and may be used in combination of 2 or more type.

  Further, chondroitin sulfate and chondroitin sulfate salts may be used alone or in combination of chondroitin sulfate and chondroitin sulfate salts. Among chondroitin sulfates and salts thereof, a salt of chondroitin sulfate is preferable, an alkali metal salt of chondroitin sulfate is more preferable, and sodium chondroitin sulfate is particularly preferable.

  The chondroitin sulfate and / or salt thereof used in the present invention may be chemically synthesized, or may be extracted or purified from a natural product-derived material. Commercially available chondroitin sulfate and / or a salt thereof may be used.

  A method for producing chondroitin sulfate and / or a salt thereof by extraction or purification from a natural product-derived material is not particularly limited. For example, a method for extraction or purification from a natural product-derived material by a known method may be used. Can be mentioned. Examples of the material derived from a natural product for extracting chondroitin sulfate include mammals, fish cartilage such as salmon, ray, and shark. Among these, those derived from fish cartilage are preferred.

  In the case of using the component (F) in the pollen burst inhibitor of the present invention, the content is not particularly limited. For example, the total amount of the component (F) is 0.005 to 5% by weight, preferably 0.005. -3 wt%, more preferably 0.01-3 wt%.

[Chelating agent]
The pollen rupture inhibitor of the present invention may further contain a chelating agent (sometimes referred to as (G) component).

  The type of chelating agent used in the present invention is not particularly limited. For example, ethylenediaminetetraacetic acid (edetic acid), nitrilotriacetic acid, hydroxyethyliminodiacetic acid, dihydroxyethylglycine, hydroxyethylenediaminetriacetic acid, diethylenetriaminepentaacetic acid. , Triethylenetetramine hexaacetic acid, tartaric acid, metasilicic acid, citric acid, orthosilicic acid, glucuronic acid, and salts thereof. Specific examples of salts of these compounds include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts.

  These chelating agents may be used individually by 1 type, and may be used in combination of 2 or more type.

  Among these chelating agents, edetic acid and salts thereof are preferable, alkali metal salts of edetic acid are more preferable, and sodium edetate is more preferable.

  When the pollen rupture inhibitor of the present invention contains the component (G), the content is not particularly limited. For example, the total amount of the component (G) is 0.0001 to 1% by weight, preferably 0.001. -1% by weight, more preferably 0.001-0.3% by weight.

[Surfactants other than component (A)]
The pollen rupture inhibitor of the present invention may contain a surfactant other than the component (A) (sometimes referred to as the component (H)) as necessary.

  The type of surfactant (other than component (A)) used in the present invention is not particularly limited, and any of nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. However, nonionic surfactants are preferable.

  Specific examples of the surfactant include POE (10-50 mol) phytosterol ether, POE (10-50 mol) dihydrocholesterol ether, POE (10-50 mol) 2-octyldodecyl ether, POE (10-50 mol). Mol) decyltetradecyl ether, POE (10-50 mol) oleyl ether, POE (2-50 mol) cetyl ether, POE (5-50 mol) behenyl ether, POE (5-30 mol) polyoxypropylene (5-5 mol) 30 mol) Polyoxyethylene alkyl ethers such as 2-decyltetradecyl ether, POE (10 to 50 mol) polyoxypropylene (2 to 30 mol) cetyl ether, phosphoric acid / phosphate thereof (POE cetyl ether phosphoric acid) Sodium), POE (10-80 mol) Ryl monoisostearate, POE (10-30 mol) glyceryl monostearate, POE (20-100 mol) polyoxypropylene modified silicone, POE alkyl modified silicone, polyethylene glycol monolaurate, polyethylene glycol monopalmitate, mono Polyethylene glycol stearate, polyethylene glycol dilaurate, polyethylene glycol dipalmitate, polyethylene glycol distearate, polyethylene glycol dioleate, polyethylene glycol diricinoleate, polyoxyethylene hydrogenated castor oil (5 to 100), glycerin fatty acid ester (monostearin Acid glycerin, etc.), hydrogenated soybean phospholipid, hydrogenated lanolin alcohol, fatty acid polyglyceryl (stearial) Polyglyceryl etc.), an amide bond of an amino acid and a fatty acid (sodium stearoyl glutamate, etc.).

  These surfactants may be used individually by 1 type, and may be used in combination of 2 or more type. Among these surfactants, nonionic surfactants are preferable.

  When the pollen rupture inhibitor of the present invention contains the component (H), the content is not particularly limited. For example, the total amount of the component (H) is 0.0001 to 3% by weight, preferably 0.0001. -1% by weight, more preferably 0.001-0.1% by weight.

[Triethanolamine / Organic amine with alcoholic hydroxyl group]
When the pollen rupture inhibitor of the present invention contains triethanolamine, the pollen rupture inhibitory effect may be attenuated. Therefore, it is preferable that the pollen burst inhibitor of the present invention does not substantially contain triethanolamine. Here, “substantially free of triethanolamine” means that triethanolamine is not contained in an amount that is more than the content that attenuates the pollen burst inhibiting effect. That is, the pollen rupture inhibitor of the present invention is allowed to contain triethanolamine as long as the pollen rupture inhibitory effect is within a range that does not diminish. Specifically, the content of triethanolamine allowed in the pollen burst inhibitor of the present invention is usually 0.001 nmol / g or less, preferably 0.0005 nmol / g or less, more preferably 0 mol / g. .

  In addition, the organic amine having an alcoholic hydroxyl group other than triethanolamine may attenuate the pollen rupture inhibiting effect of the pollen rupture inhibitor of the present invention. Therefore, a preferred embodiment of the pollen rupture inhibitor of the present invention includes substantially no organic amine having an alcoholic hydroxyl group.

  Specific examples of the organic amine having an alcoholic hydroxyl group include triethanolamine, monoethanolamine, diethanolamine, N-methyldiethanolamine, N-ethyldiethanolamine, trometamol, diisopropanolamine, triisopropanolamine, and N-methylglucamine. , Meglumine and the like.

  Here, “substantially does not contain an organic amine having an alcoholic hydroxyl group” means that the organic amine is not contained in a content that reduces the pollen burst inhibiting effect. That is, the pollen rupture inhibitor of the present invention is allowed to contain an organic amine having an alcoholic hydroxyl group as long as the pollen rupture inhibitory effect is within a range that does not diminish. Specifically, the content of the organic amine having an alcoholic hydroxyl group allowed in the pollen burst inhibitor of the present invention is usually 0.001 nmol / g or less, preferably 0.0005 nmol / g or less, more preferably 0 mol / g.

[Other ingredients]
In addition to boric acid and / or a salt thereof, and (A) to (H) components, the pollen rupture inhibitor of the present invention contains other components as necessary within a range that does not affect the effects of the present invention. You may contain. Other components are not particularly limited, and may be appropriately selected according to the dosage form and product form of the pollen burst inhibitor of the present invention. For example, buffers, thickeners, stabilizers, preservatives, Antibacterial agents, bactericides, antioxidants, fillers, deodorants, buffers, ultraviolet absorbers, fragrances, dyes, enzymes, salts, sugars, sugar alcohols, amino acids and the like can be mentioned. These components may be used individually by 1 type, and may be used in combination of 2 or more type.

  The pollen burst inhibitor of the present invention may contain a solvent for application to an object on which pollen is floating or adhering in a state where the aforementioned components are dissolved. The solvent is not particularly limited as long as it can dissolve the compounding components, and can be appropriately selected from conventionally known ones. For example, water; methanol, ethanol, propanol, isopropanol, butanol, isobutanol, sec -Alcohols such as butanol, t-butanol, pentanol, hexanol, cyclohexanol, benzyl alcohol; ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, butylene glycol, hexanediol, Polyhydric alcohols such as pentanediol, glycerin, hexanetriol, thiodiglycol; ethylene glycol monomethyl ether, ethylene Glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, propylene glycol monomethyl ether, propylene glycol monobutyl ether, dipropylene glycol monomethyl ether, triethylene glycol monomethyl ether, ethylene glycol diacetate, ethylene glycol monomethyl ether acetate Glycol derivatives such as triethylene glycol monoethyl ether and ethylene glycol monophenyl ether; amines such as morpholine, N-ethylmorpholine, ethylenediamine, diethylenetriamine, triethylenetetramine, polyethyleneimine, and tetramethylpropylenediamine.

  These solvents may be used individually by 1 type, and may be used in combination of 2 or more type.

  Among these solvents, water and a mixed solution of water and an organic solvent are preferable, and water is more preferable.

pH
The pH of the pollen rupture inhibitor of the present invention is not particularly limited as long as it can exert a pollen rupture inhibitory effect. For example, it is 5.0 to 9.0, preferably 6.0 to 8.0, and more preferably. Is 6.5 to 7.5. The method for adjusting the pH of the pollen burst inhibitor is not particularly limited, and can be adjusted by including a known pH adjuster.

  In particular, among the components described above, the (A) component, the (C) component, and the (D) component have the property of exhibiting acidity. Therefore, the pollen burst inhibitor of the present invention contains at least one of these components. When contained, it is desirable to adjust the pH to the above-described range using a pH adjuster (alkali). Moreover, when adjusting pH to the range mentioned above using a pH adjuster (alkali), hydroxide of alkali metals, such as sodium hydroxide and potassium hydroxide, is used as a pH adjuster (alkali). It is preferable. Depending on the type of pH adjuster (alkali) used, the pollen rupture inhibiting effect may be attenuated, but the use of an alkali metal hydroxide can inhibit the pollen rupture inhibiting effect from being attenuated. . Moreover, from the viewpoint of more effectively suppressing the effect of suppressing pollen rupture, when using an alkali metal hydroxide as a pH adjuster (alkali), as a pH adjuster (acid) It is preferable not to use hydrochloric acid in combination.

Production Method The pollen burst inhibitor of the present invention can be prepared by adding boric acid and / or a salt thereof, and if necessary, components (A) to (H) and other components to a solvent and mixing them.

Form The form of the pollen rupture inhibitor of the present invention is not particularly limited, and examples thereof include known product forms such as a liquid agent, an aerosol agent, a solid agent, and a gel agent. In addition, depending on the product form, the pollen rupture inhibitor may appropriately contain components generally contained in the product form. Especially, as a form of a pollen rupture inhibitor, a liquid agent is preferable in terms of easy handling.

  The pollen rupture inhibitor of the present invention can be used, for example, as a spray agent, an air spray agent, etc. by accommodating the pollen rupture inhibitor of the present invention in an aerosol dispenser container. In addition, for example, a fiber product for preventing hay fever can be obtained by applying or impregnating the pollen burst inhibitor of the present invention to a fiber product. Specific examples of the fiber product for preventing hay fever include, for example, a sheet material for wiping the body such as the face and body, windows, floors, walls, etc. to which pollen can adhere. In addition, the pollen rupture inhibitor of the present invention can be used as a detergent that can clean an object while suppressing rupture of pollen attached to the object, for example, by using it together with a cleaning component such as a surfactant. it can.

Method of Use The pollen rupture inhibitor of the present invention is applied to an object for which suppression of pollen rupture is required. The object is not particularly limited as long as it is a space where pollen may float or may float, or pollen may or may adhere, for example, indoor or vehicle space; window; screen door ; Walls; floors; textile products such as curtains, carpets, futons, clothes, masks; bodies (mucous membranes, skin); accessories such as watches, necklaces, bracelets, rings; furniture; books and the like.

  The method for using the pollen rupture inhibitor of the present invention is not particularly limited, and a known method may be appropriately selected according to the form of the pollen rupture inhibitor, the type of an appropriate target, and the like. For example, the method of apply | coating the spray pollutant suppression agent of this invention to an application object, spraying, or washing away an application object etc. are mentioned.

  The amount of the pollen rupture inhibitor used in the present invention is not particularly limited as long as the pollen rupture inhibitory effect is exhibited, and may be applied in an appropriate amount to the subject.

  EXAMPLES Next, although an Example demonstrates this invention further in detail, this invention is not limited at all by these examples.

Test example 1
Each component was weighed and dissolved in purified water so as to have the composition described in Tables 1 to 3, and a liquid preparation was prepared. The pollen rupture rate of the obtained pollen rupture inhibitor and the amount of pollen antigen protein eluted were evaluated by the following methods.

(Pollen burst rate)
Sugi pollen (manufactured by Wako Pure Chemical Industries, Ltd.) was turbid in the liquid obtained as described above so that the pollen concentration was 10 mg / ml, and incubated at 37 ° C. After 5 minutes, 10 μl of the turbid solution was dropped on a slide glass and covered with a cover glass, and 200 pollens were counted under an optical microscope (magnification 100 times). The number of pollen ruptured out of 200 pollen was counted, and the pollen rupture rate was calculated by the following formula.

(Quantification of the amount of antigen protein released)
For the liquid preparations of Examples 9 and 14 and Comparative Example 1, the released amounts of antigen proteins (Cry j 1 and Cry j 2) were quantified according to the following method. Sugi pollen (manufactured by Wako Pure Chemical Industries, Ltd.) was turbid in each solution so as to be 10 mg / ml and incubated at 37 ° C. After 5 minutes, it was quickly cooled with ice water and centrifuged at 11,000 g for 3 minutes at 4 ° C. The supernatant was collected and centrifuged again. Thereafter, the supernatant (recovered solution) was collected, and Cry j 1 was quantified by the sandwich method using ELISA kit (manufactured by Special Immunity Research Institute). Cry j 2 was quantified under the same conditions as Cry j 1 except that cedar pollen (manufactured by Wako Pure Chemical Industries, Ltd.) was turbid in each solution so as to be 200 mg / ml.

  The obtained results are shown in Tables 1-3. From this result, it was confirmed that the liquid agents (Examples 1 to 15) containing boric acid and / or borax and not containing alkali metal chloride (sodium chloride, potassium chloride) have a pollen burst inhibiting action. It was. Further, in a solution containing boric acid and / or borax and not containing an alkali metal chloride (sodium chloride, potassium chloride), polysorbate 80, terpenoid (1-menthol, d-borneol), dipotassium glycyrrhizinate, It was also clarified that when any one of chlorpheniramine maleate and ε-aminocaproic acid is contained (Examples 2 to 6), the pollen burst inhibiting effect is further enhanced. In particular, in a solution containing boric acid and / or borax and not containing an alkali metal chloride (sodium chloride, potassium chloride), polysorbate 80, terpenoid (1-menthol, d-borneol), dipotassium glycyrrhizinate, chloro It was also confirmed that the pollen rupture inhibitory action was markedly improved when all of phenylamine maleate and ε-aminocaproic acid were included and hydrochloric acid was not included as a pH adjuster (Examples 14 and 15). It was.

  On the other hand, even if it contains boric acid and / or borax, the solution containing the alkali metal chloride (sodium chloride, potassium chloride) (Comparative Examples 1 to 6) has not been able to exert a sufficient pollen burst inhibiting effect. It was. Further, in the liquid preparation containing boric acid and / or borax and not containing alkali metal chloride (sodium chloride, potassium chloride), when triethanolamine is contained (Reference Example 1), it is compared with Comparative Example 1. Although the pollen rupture inhibitory action was high, compared with Example 1, the pollen rupture inhibitory action was attenuated.

Claims (5)

  A pollen burst inhibitor containing boric acid and / or a salt thereof and substantially free of alkali metal chloride. Furthermore, it contains at least one component selected from the group consisting of the following component (A), component (B), component (C), component (D), and component (E). Pollen rupture inhibitor.
(A) Polyoxyethylene sorbitan fatty acid ester
(B) Terpenoid
(C) Glycyrrhizic acid and / or its salt
(D) Chlorpheniramine and / or its salt
(E) ε-aminocaproic acid and / or salt thereof   The pollen burst inhibitor of Claim 1 or 2 which does not contain a triethanolamine substantially.   The pollen burst inhibitor according to any one of claims 1 to 3, which is applied to a textile product or an indoor space.   The pollen burst inhibitor according to any one of claims 1 to 4, which is a liquid agent.