JP2017538697A5 - - Google Patents

Info

Publication number

JP2017538697A5

JP2017538697A5 JP2017530168A JP2017530168A JP2017538697A5 JP 2017538697 A5 JP2017538697 A5 JP 2017538697A5 JP 2017530168 A JP2017530168 A JP 2017530168A JP 2017530168 A JP2017530168 A JP 2017530168A JP 2017538697 A5 JP2017538697 A5 JP 2017538697A5

Authority

JP

Japan

Prior art keywords

dihydro

cyano

carbamimidoyl

dichlorophenyl

ethyl

Prior art date

2015-12-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 14
• 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
• -1 N'-cyano-N- {2- [2- (pyrrolidin-1-yl) ethoxy] -5- (trifluoromethyl) phenyl} carbamimidoyl Chemical group 0.000 claims 8
• 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 6
• 239000012453 solvate Substances 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 5
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 4
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
• 229910052801 chlorine Inorganic materials 0.000 claims 4
• 125000001309 chloro group Chemical group Cl* 0.000 claims 4
• 229910052731 fluorine Inorganic materials 0.000 claims 4
• 239000011737 fluorine Substances 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
• 108010077895 Sarcosine Proteins 0.000 claims 3
• 230000000069 prophylactic effect Effects 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• DRABPHUFBFTADU-UHFFFAOYSA-N 4-amino-N-[2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethylbutanamide Chemical class NCCCC(=O)N(CC)C1C(=NN(C1)C(NC1=CC(=CC=C1)OC(F)F)=NC#N)C1=CC(=C(C=C1)Cl)Cl DRABPHUFBFTADU-UHFFFAOYSA-N 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• 206010059245 Angiopathy Diseases 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• GAPYHYWZUSFPBS-UHFFFAOYSA-N N-[2-[N'-[4-chloro-3-(difluoromethoxy)phenyl]-N-cyanocarbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamide Chemical compound ClC1=C(C=C(C=C1)NC(=NC#N)N1N=C(C(C1)N(C(CO)=O)CC)C1=CC(=C(C=C1)Cl)Cl)OC(F)F GAPYHYWZUSFPBS-UHFFFAOYSA-N 0.000 claims 1
• 229940098750 SMYD2 inhibitor Drugs 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 230000003143 atherosclerotic effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 206010020718 hyperplasia Diseases 0.000 claims 1
• 230000003463 hyperproliferative effect Effects 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
• 208000019553 vascular disease Diseases 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1