JP2017538697A5 - - Google Patents
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- Publication number
- JP2017538697A5 JP2017538697A5 JP2017530168A JP2017530168A JP2017538697A5 JP 2017538697 A5 JP2017538697 A5 JP 2017538697A5 JP 2017530168 A JP2017530168 A JP 2017530168A JP 2017530168 A JP2017530168 A JP 2017530168A JP 2017538697 A5 JP2017538697 A5 JP 2017538697A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- cyano
- carbamimidoyl
- dichlorophenyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- -1 N'-cyano-N- {2- [2- (pyrrolidin-1-yl) ethoxy] -5- (trifluoromethyl) phenyl} carbamimidoyl Chemical group 0.000 claims 8
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
- 108010077895 Sarcosine Proteins 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- DRABPHUFBFTADU-UHFFFAOYSA-N 4-amino-N-[2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethylbutanamide Chemical class NCCCC(=O)N(CC)C1C(=NN(C1)C(NC1=CC(=CC=C1)OC(F)F)=NC#N)C1=CC(=C(C=C1)Cl)Cl DRABPHUFBFTADU-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 206010059245 Angiopathy Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- GAPYHYWZUSFPBS-UHFFFAOYSA-N N-[2-[N'-[4-chloro-3-(difluoromethoxy)phenyl]-N-cyanocarbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamide Chemical compound ClC1=C(C=C(C=C1)NC(=NC#N)N1N=C(C(C1)N(C(CO)=O)CC)C1=CC(=C(C=C1)Cl)Cl)OC(F)F GAPYHYWZUSFPBS-UHFFFAOYSA-N 0.000 claims 1
- 229940098750 SMYD2 inhibitor Drugs 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196766.1 | 2014-12-08 | ||
| EP14196766 | 2014-12-08 | ||
| EP15163993.7 | 2015-04-17 | ||
| EP15163993 | 2015-04-17 | ||
| PCT/EP2015/078912 WO2016091845A1 (en) | 2014-12-08 | 2015-12-08 | Novel aryl-cyanoguanidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538697A JP2017538697A (ja) | 2017-12-28 |
| JP2017538697A5 true JP2017538697A5 (OSRAM) | 2019-01-24 |
Family
ID=54838348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017530168A Pending JP2017538697A (ja) | 2014-12-08 | 2015-12-08 | 新規なアリール−シアノグアニジン化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10023539B2 (OSRAM) |
| EP (1) | EP3230274B1 (OSRAM) |
| JP (1) | JP2017538697A (OSRAM) |
| CN (1) | CN107207442A (OSRAM) |
| CA (1) | CA2969771A1 (OSRAM) |
| ES (1) | ES2722431T3 (OSRAM) |
| WO (1) | WO2016091845A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11339157B1 (en) | 2017-10-24 | 2022-05-24 | Bayer Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CN111172770B (zh) * | 2019-02-18 | 2022-10-18 | 玛伊娅服饰(上海)有限公司 | 一种抗菌面料及其制备方法 |
| BR112021019998B1 (pt) | 2019-04-24 | 2024-01-16 | The Broad Institute, Inc. | 4h-pirrolo[3,2-c]piridin-4-ona, seus usos, composição farmacêutica, e kit de partes |
| WO2020216773A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| WO2020216774A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CA3177214A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| CN115998869B (zh) * | 2022-09-23 | 2025-08-05 | 华中科技大学同济医学院附属同济医院 | 组蛋白甲基转移酶smyd2在制备防治血管损伤后内膜新生导致再狭窄的药物中的应用 |
| CN116327748B (zh) * | 2023-04-21 | 2024-09-17 | 武汉科技大学 | 联合用药物在制备抗肿瘤药物中的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0513046B1 (en) | 1990-01-31 | 1997-07-09 | E.I. Du Pont De Nemours And Company | Arthropodicidal pyrazolines, pyrazolidines and hydrazines |
| BRPI0412554A (pt) | 2003-07-15 | 2006-09-19 | Bayer Healthcare Ag | pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular |
| DE102004061748A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Azetidin-substituierte Pyrazoline |
| DE102004061747A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Thiophen-substituierte Pyrazoline |
| DE102004061751A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Cyanoguanidin-substituierte Pyrazoline |
| CA2810049A1 (en) * | 2010-09-03 | 2012-03-08 | Forma Tm, Llc | Guanidine compounds and compositions for the inhibition of nampt |
-
2015
- 2015-12-08 US US15/534,404 patent/US10023539B2/en active Active
- 2015-12-08 ES ES15807653T patent/ES2722431T3/es active Active
- 2015-12-08 EP EP15807653.9A patent/EP3230274B1/en not_active Not-in-force
- 2015-12-08 CA CA2969771A patent/CA2969771A1/en not_active Abandoned
- 2015-12-08 JP JP2017530168A patent/JP2017538697A/ja active Pending
- 2015-12-08 WO PCT/EP2015/078912 patent/WO2016091845A1/en not_active Ceased
- 2015-12-08 CN CN201580075621.9A patent/CN107207442A/zh active Pending
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