JP2017537972A5 - - Google Patents
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- JP2017537972A5 JP2017537972A5 JP2017538182A JP2017538182A JP2017537972A5 JP 2017537972 A5 JP2017537972 A5 JP 2017537972A5 JP 2017538182 A JP2017538182 A JP 2017538182A JP 2017538182 A JP2017538182 A JP 2017538182A JP 2017537972 A5 JP2017537972 A5 JP 2017537972A5
- Authority
- JP
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- Prior art keywords
- cancer
- antibody
- seq
- pharmaceutical composition
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 201000011510 cancer Diseases 0.000 claims description 15
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 9
- 210000003162 effector t lymphocyte Anatomy 0.000 claims description 6
- 201000005962 mycosis fungoides Diseases 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 claims description 4
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 4
- 108700012439 CA9 Proteins 0.000 claims description 4
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 4
- 102000012220 Member 14 Tumor Necrosis Factor Receptors Human genes 0.000 claims description 4
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 4
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims description 4
- 201000006966 adult T-cell leukemia Diseases 0.000 claims description 4
- 230000003915 cell function Effects 0.000 claims description 4
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 4
- 210000003289 regulatory T cell Anatomy 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 230000006052 T cell proliferation Effects 0.000 claims description 3
- 201000005787 hematologic cancer Diseases 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims description 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 102000004498 CCR4 Receptors Human genes 0.000 claims description 2
- 108010017317 CCR4 Receptors Proteins 0.000 claims description 2
- 102100024263 CD160 antigen Human genes 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 102100031351 Galectin-9 Human genes 0.000 claims description 2
- 101100229077 Gallus gallus GAL9 gene Proteins 0.000 claims description 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 2
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims description 2
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims description 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 102100030704 Interleukin-21 Human genes 0.000 claims description 2
- 102000004527 Interleukin-21 Receptors Human genes 0.000 claims description 2
- 108010017411 Interleukin-21 Receptors Proteins 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 102000017578 LAG3 Human genes 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 2
- 208000009359 Sezary Syndrome Diseases 0.000 claims description 2
- 208000021388 Sezary disease Diseases 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 208000024386 fungal infectious disease Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 108010074108 interleukin-21 Proteins 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 claims description 2
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- 230000005012 migration Effects 0.000 claims description 2
- 238000013508 migration Methods 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 208000000814 primary cutaneous anaplastic large cell lymphoma Diseases 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 230000001629 suppression Effects 0.000 claims description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 230000035755 proliferation Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060381P | 2014-10-06 | 2014-10-06 | |
| US62/060,381 | 2014-10-06 | ||
| PCT/US2015/054202 WO2016057488A1 (en) | 2014-10-06 | 2015-10-06 | Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020138331A Division JP7129449B2 (ja) | 2014-10-06 | 2020-08-19 | ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537972A JP2017537972A (ja) | 2017-12-21 |
| JP2017537972A5 true JP2017537972A5 (cg-RX-API-DMAC7.html) | 2018-11-15 |
| JP6795505B2 JP6795505B2 (ja) | 2020-12-02 |
Family
ID=54337425
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538182A Active JP6795505B2 (ja) | 2014-10-06 | 2015-10-06 | ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 |
| JP2020138331A Active JP7129449B2 (ja) | 2014-10-06 | 2020-08-19 | ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 |
| JP2022131610A Active JP7589204B2 (ja) | 2014-10-06 | 2022-08-22 | ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020138331A Active JP7129449B2 (ja) | 2014-10-06 | 2020-08-19 | ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 |
| JP2022131610A Active JP7589204B2 (ja) | 2014-10-06 | 2022-08-22 | ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10675349B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3699196A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6795505B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN114634571A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015328273B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2962949C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016057488A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016057488A1 (en) * | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof |
| IL252295B2 (en) | 2014-12-19 | 2023-10-01 | Dana Farber Cancer Inst Inc | Chimeric antigen receptors and methods of using them |
| WO2016178779A1 (en) | 2015-05-01 | 2016-11-10 | Dana-Farber Cancer Institute, Inc. | Methods of mediating cytokine expression with anti ccr4 antibodies |
| CN116903741A (zh) | 2016-06-20 | 2023-10-20 | 科马布有限公司 | 特异性结合于pd-l1的抗体或其抗原结合片段及其用途 |
| MX2019001815A (es) * | 2016-09-01 | 2019-05-16 | Bebeachibuli Romeo | Formulacion basada en factores alimentarios, productos producidos usando la referida formulacion y metodos para producir la misma. |
| WO2018071913A2 (en) | 2016-10-14 | 2018-04-19 | Dana-Farber Cancer Institute, Inc. | Modular tetrameric bispecific antibody platform |
| CA3081750A1 (en) | 2017-11-06 | 2019-05-09 | Rapt Therapeutics, Inc. | Anticancer agents |
| CN108250290B (zh) * | 2018-02-23 | 2024-03-12 | 上海捌加壹医药科技有限公司 | Ccr4的n端重组蛋白及其用途 |
| EP3765070A4 (en) | 2018-03-14 | 2021-12-15 | Dana-Farber Cancer Institute, Inc. | SPECIFICALLY MODIFIED CELLS, T-LYMPHOCYTE IMMUNE MODULATION ANTIBODIES AND THEIR USE PROCEDURES |
| JP7277255B2 (ja) * | 2018-05-31 | 2023-05-18 | 佳寛 大矢 | インビトロでの制御性ｔ細胞の特異性評価方法 |
| US12421316B2 (en) | 2019-02-19 | 2025-09-23 | The Regents Of The University Of Colorado, A Body Corporate | Bispecific immunotoxins targeting human CD25+CCR4+ tumors and regulatory T-cells |
| AU2020250846B2 (en) * | 2019-03-29 | 2025-07-24 | Universität Zürich | Fc-modified biologicals for local delivery to compartment, in particular to the CNS |
| US20220249560A1 (en) * | 2019-05-24 | 2022-08-11 | City Of Hope | Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies |
| CA3141926A1 (en) | 2019-06-14 | 2020-12-17 | Dana-Farber Cancer Institute, Inc. | Antibodies against muc1 and methods of use thereof |
| CN111704668B (zh) * | 2020-06-27 | 2021-03-30 | 天津金域医学检验实验室有限公司 | 抗ccr4抗体及其在治疗癌症中的应用 |
| US20240018248A1 (en) | 2020-12-02 | 2024-01-18 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| GB8426467D0 (en) | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| EP0279862B1 (en) | 1986-08-28 | 1993-11-03 | Teijin Limited | Cytocidal antibody complex and process for its preparation |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| AU641673B2 (en) | 1989-06-29 | 1993-09-30 | Medarex, Inc. | Bispecific reagents for aids therapy |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| AU8295491A (en) | 1990-06-29 | 1992-01-23 | Biosource Technologies Incorporated | Melanin production by transformed microorganisms |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| WO1992003918A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| CA2102511A1 (en) | 1991-05-14 | 1992-11-15 | Paul J. Higgins | Heteroconjugate antibodies for treatment of hiv infection |
| WO1993004701A1 (en) | 1991-09-05 | 1993-03-18 | University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
| US5233409A (en) | 1992-02-25 | 1993-08-03 | Schwab Karl W | Color analysis of organic constituents in sedimentary rocks for thermal maturity |
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| WO2001064754A1 (en) * | 2000-03-03 | 2001-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Gene recombinant antibody and its fragment |
| JP2003208610A (ja) | 2002-01-16 | 2003-07-25 | Noritsu Koki Co Ltd | 画像処理装置、画像処理方法、画像処理プログラム、および画像処理プログラムを記録した記録媒体 |
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| US8962806B2 (en) | 2007-12-28 | 2015-02-24 | Dana-Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
| GB0909906D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Antibodies |
| GB201020738D0 (en) * | 2010-12-07 | 2011-01-19 | Affitech Res As | Antibodies |
| HK1207655A1 (en) | 2012-05-04 | 2016-02-05 | Dana-Farber Cancer Institute, Inc. | Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use |
| US9111624B2 (en) | 2013-03-22 | 2015-08-18 | Katsuyuki Fujita | Semiconductor memory device |
| WO2016057488A1 (en) * | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof |
-
2015
- 2015-10-06 WO PCT/US2015/054202 patent/WO2016057488A1/en not_active Ceased
- 2015-10-06 US US15/517,108 patent/US10675349B2/en active Active
- 2015-10-06 CN CN202210046788.4A patent/CN114634571A/zh active Pending
- 2015-10-06 CA CA2962949A patent/CA2962949C/en active Active
- 2015-10-06 CN CN201580066273.9A patent/CN107250160B/zh active Active
- 2015-10-06 EP EP20153701.6A patent/EP3699196A1/en active Pending
- 2015-10-06 AU AU2015328273A patent/AU2015328273B2/en active Active
- 2015-10-06 EP EP15782195.0A patent/EP3204418B1/en active Active
- 2015-10-06 JP JP2017538182A patent/JP6795505B2/ja active Active
-
2020
- 2020-06-02 US US16/890,429 patent/US11723973B2/en active Active
- 2020-08-19 JP JP2020138331A patent/JP7129449B2/ja active Active
- 2020-12-10 AU AU2020286302A patent/AU2020286302B2/en active Active
-
2022
- 2022-08-22 JP JP2022131610A patent/JP7589204B2/ja active Active
-
2023
- 2023-06-22 US US18/213,132 patent/US12337034B2/en active Active
-
2025
- 2025-05-20 US US19/213,611 patent/US20250339521A1/en active Pending
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