JP2017537151A - キレート化金属酸化物のゲル組成物 - Google Patents
キレート化金属酸化物のゲル組成物 Download PDFInfo
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- JP2017537151A JP2017537151A JP2017544845A JP2017544845A JP2017537151A JP 2017537151 A JP2017537151 A JP 2017537151A JP 2017544845 A JP2017544845 A JP 2017544845A JP 2017544845 A JP2017544845 A JP 2017544845A JP 2017537151 A JP2017537151 A JP 2017537151A
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- gel composition
- chelated
- metal oxide
- homogeneous
- homogeneous gel
- Prior art date
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- 235000021419 vinegar Nutrition 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Abstract
Description
第1の態様において、本発明は、沈殿物を呈さない安定で均質なキレート化金属酸化物錯体ゲルを形成する、主に水溶液および/またはポリオールベース溶液中の抗菌性、抗細菌性、場合によっては抗ウイルス性の金属酸化物錯体を提供する。
第1の態様において、本発明は、本発明に係る組成物を作製する方法に関する。概括的に言えば、方法は、ポリオール中に懸濁した最初に調製されたオリゴダイナミック剤のキレートを形成し、同時にまたは引き続いて、圧力および/熱を使用してまたは使用せずに、混合すること/ブレンドすること/配合することを介して、すでに形成が完了したゲル組成物に添加することを含む。通常は、キレート化金属酸化物の懸濁液が最初に形成され、次いでゲル組成物に添加され、またはゲル化時にその場で形成することができる。
<250ppmの均質なキレート化酸化銀ゲルを作製する手順>
以下に、ポリオールベースの液体錯体懸濁液用のキレート化酸化銀を形成する方法を説明する。
1. 別の容器に、蒸留水(イオンを含有しないDI水または他の好適な濾過水)を用意し、キトサンを1〜5重量%(好ましくは2%)の濃度で添加する。次に、アルファ−ヒドロキシ酸を添加する。この場合、キトサンを十分に分散させ、可溶化する働きをするグリコール酸を添加する。このスラリ溶液を別にしておく。
2. 別の容器に、5.65重量%(28.25グラム)のクエン酸を取り、その酸を5.65%(28.25グラム)の蒸留水に導入し、82℃に加熱し、高速撹拌下で3〜4分間混合し、スラリ中、継続して高速(やはり1000rpm以上)で3〜4分間混合することによって、酸溶液を調製する。この溶液のpHは1.83で一様になるはずである。この溶液も別にしておく。
3. 0.47重量%(2.35グラム)の酸化銀粉末(公称粒径分布は4〜40ミクロンである)を取る。この場合、Elkton, MDのColonial Metals社製の酸化銀(I)を取り、高速(少なくとも1000rpm)で31.54重量%(157.7グラム)の蒸留水(この場合、水を使用したが、グリセリンおよび/プロパンジオールおよび/またはPEGもこの場合使用することができる)に180°F(82℃)で最大3分間ブレンドすることによって、第3のAgO水溶液を調製する。このスラリのpHは、(おそらくAgOHの生成のため)少なくとも8.0、好ましくは8.3から8.4の間に上昇するはずである。3分を超えると、酸化が進みすぎる。この暗色スラリ溶液を別にしておく。
4. 上記の(1)と(2)の溶液を1つの容器に合わせる。次いで、酸化銀溶液(3)をビュレット(滴定の様な方法)で、1つの容器内でゆっくり撹拌している(1)と(2)の溶液に迅速に添加する。(1)と(2)の合わせた重量の比は最終溶液の56.18重量%であり、43.82重量%は、最初にすべて一緒に82℃で混合されたAgO溶液の重量比である。この方法によって、キレート化プロセス時においてクエン酸銀が形成されず、本方法にとって重大な意味をもつことが確実になる。キレート化反応は、かなり急速である(AgO溶液(3)を(1)と(2)の合わせた溶液に完全に添加した後3分未満以内)。
5. 温度は82℃で行われ、反応は数分以内に完了する(銀粉末の形跡は溶液に残っていない)と思われ、溶液は清澄になる。この段階で、好ましくは炭酸ナトリウムおよび/もしくはアルギニンまたは微量のNaOHを使用して、pHを7以上に中和して、確実に沈殿が起こらないようにすることが可能である。アルギニンおよび他のアミノ酸は、溶液状態のキレート化酸化物錯体溶液と結合するようである。
1. 室温で736.8グラムの蒸留水(83.98%)を取り、44グラムのポリクオタニウム(Celquat H−100)(4.415%)を穏やかな撹拌下でゆっくりと導入する。5分間混合する。
2. 115.5グラムのUSPグリセリン(99%)を室温で取り、H2O/ポリクオタニウム混合物(1.155%)に添加する。穏やかに撹拌しながら継続する。
3. 24.5グラムのポリクオタニウム/ヒアルロン酸混合物(BHA−10)(2.45%)を直ちに添加し、穏やかな撹拌を継続する。
4. 17.5グラムの25%アルギニン水溶液(1.75%)を直ちに添加する。
5. キトサンを含む4,000ppmのキレート化酸化銀液体懸濁液61.5グラム(6.25%)を直ちに添加する。
1. 第1の容器に、44.211kgの蒸留水、および2.649kgの陽イオン性であるポリクオタニウム(Chicago, Ill.に本拠地を置くAkzo Nobel社、U.S.部門によって製造されたCelquat H−100(登録商標)など)、ならびに6.930kgのコーシャ認定を受けたUSPグレードの有機グリセリンを充填し、それらをすべて、容器中、室温で(気泡形成を回避するために)ゆっくりと混合することによって分散させた。これにより、ゲル化が即座に始まる。次に、同じ容器に、1.470kgのヒアルロン酸とポリクオタニウムポリマー(Ontario, CanadaのKoda Corporation社によって製造されたBHA−10(登録商標)など)との組合せを添加した。2〜4分間撹拌した後にこの可溶化させたゲル化溶液のpHは7.0未満である。
2. 容器中の溶液のpHを上昇させるために、別の容器で75重量%の蒸留水と25重量%のアルギニンの溶液を一緒に混合する。次いで、1.040kgのこの溶液を、上記ステップ(1)の第1の容器に添加する。これによって、第1の容器中の溶液のpHが少なくとも7.4以上に上昇するはずである。
3. 次いで、第3のステップは、この場合、ステップ(2)が完了して10分以内に、4,000ppmのキレート化酸化銀錯体懸濁液溶液3.69kgを添加し、遊星型(または他の好適な)混合器を用いて混合を開始して、均質性を確実することである。
100ppmの酸化銀錯体と共に500ml量のポリオールベースの錯体懸濁液を以下のように調製した。
0.265gのクエン酸を、2%キトサン溶液を含む299.735gの蒸留水に添加し、5〜10分間混合する。
0.11gの酸化銀を99.89gの蒸留水に添加し、5〜10分間分散させる。
Claims (30)
- 抗菌性、抗細菌性、および/または抗ウイルス性の均質なゲル組成物であって、
沈殿物を含まない安定で均質な水溶液ベースのキレート化金属酸化物液体錯体の懸濁液と、水、ポリクオタニウム、グリセリンおよびヒアルロン酸を含み、キレート化金属酸化物を含まないゲル組成物との組合せを含み、
前記均質なゲル組成物が、前記均質なゲル組成物中に均質に懸濁しているキレート化金属酸化物粒子を、前記均質なゲル組成物内に含有されている前記キレート化金属酸化物粒子の濃度が少なくとも0.001重量%の濃度となるように含有している、均質なゲル組成物。 - 前記均質なゲル組成物が沈殿物を形成しない、請求項1に記載の均質なゲル組成物。
- 前記キレート化金属酸化物粒子は、初期状態では、水と共にアルカリ性の酸化銀水性分散体を構成する酸化銀粒子であり、脱イオン水および/または蒸留水への初期状態の酸化銀粒子の添加によって前記水性分散体のpHを5.5と7.0との間から7.7と8.5との間に上昇させる、請求項1に記載の均質なゲル組成物。
- 前記初期状態では、水性の分散体が、キトサンとカルボン酸との組合せと錯体を形成し、それによって前記キレート化金属酸化物が得られ、前記キレート化金属酸化物粒子の前記金属酸化物がキレート化酸化銀粒子であり、前記酸化銀粒子の粒径分布が4ミクロンから40ミクロンの間である、請求項3に記載の均質なゲル組成物。
- 前記金属酸化物粒子の前記金属が、銀、銅、亜鉛、チタン、金、ニッケル、およびスズ酸化物からなる群の少なくとも1種である、請求項1に記載の均質なゲル組成物。
- 前記組成物がL−アルギニン、および二糖のポリマーを含み、前記二糖がヒアルロン酸とのポリマーを含む、請求項1に記載の均質なゲル組成物。
- 前記キレート化酸化銀粒子が、前記ゲル組成物中に10ppmから4000ppmの間の濃度、好ましくは前記ゲル組成物中に100ppmから250ppmの間の濃度、最も好ましくは前記ゲル組成物中に250ppmの濃度で存在する、請求項1に記載の均質なゲル組成物。
- 前記均質なゲル組成物がゲル化ホストに混ぜ込まれ、前記ゲル化ホストがポリマーホストであってもよく、前記ポリマーがバイオポリマーを含む、請求項1に記載の均質なゲル組成物。
- 前記ゲル組成物が、コンディショナ、毛髪ムース、毛髪スプレー、毛髪染料、コンタクトレンズ溶液、消臭剤、パーソナルおよび工業用潤滑剤、食品グレードの食用物質、氷の形態の水、スキンローション、局所剤、練り歯磨き、口腔ゲル、および食品グリースの代替物と混合され、かつ/またはそれらに注入され、またはそうでなければ、直接使用される、請求項1に記載の均質なゲル組成物。
- 前記ゲル組成物の前記ゲルが陽イオン系で形成され、前記陽イオン系は陽イオンポリマー系とすることができ、前記陽イオンポリマー系は、アルギネート、キトサン、デキストラン、カラギーナン、ペクチン、およびキサンタンガムからなる群から選択される、請求項1に記載の均質なゲル組成物。
- 抗菌性、抗細菌性、および/または抗ウイルス性の均質なゲル組成物であって、
安定で均質なポリオール溶液ベースのキレート化金属酸化物液体錯体の懸濁液と、水、ポリクオタニウム、グリセリンおよびヒアルロン酸を含み、キレート化金属酸化物を含まないゲル組成物との組合せを含み、
前記均質なゲル組成物が、前記均質なゲル組成物中に均質に懸濁しているキレート化金属酸化物粒子を、前記均質なゲル組成物内に含有されている前記キレート化金属酸化物粒子の濃度が少なくとも0.001重量%の濃度となるように含有している、均質なゲル組成物。 - 前記ポリオールが、グリセリン、プロパンジオール、およびポリエチレングリコールから選択された群の1種または複数である、請求項11に記載の均質なゲル組成物。
- 前記均質なゲル組成物が沈殿物を形成しない、請求項11に記載の均質なゲル組成物。
- 前記キレート化金属酸化物粒子は、初期状態では、水と共にアルカリ性の酸化銀水性分散体を構成する酸化銀粒子であり、脱イオン水および/または蒸留水への初期状態の酸化銀粒子の添加によって前記水性分散体のpHを5.5と7.0との間から7.7と8.5との間に上昇させた、請求項11に記載の均質なゲル組成物。
- 前記初期状態では、水性の分散体が、キトサンとカルボン酸との組合せと錯体を形成し、それによって前記キレート化金属酸化物粒子が得られ、前記酸化銀粒子の粒径分布が4ミクロンから40ミクロンの間である、請求項14に記載の均質なゲル組成物。
- 前記金属酸化物粒子の前記金属が、銅、亜鉛、チタン、金、ニッケル、およびスズ酸化物の1種または複数からなる群である、請求項11に記載の均質なゲル組成物。
- 前記組成物が、L−アルギニン、および二糖のポリマーを含み、前記二糖がヒアルロン酸とのポリマーを含む、請求項11に記載の均質なゲル組成物。
- 前記キレート化酸化銀粒子が、前記ゲル組成物中に10ppmから4000ppmの間の濃度、より好ましくは前記ゲル組成物中に100ppmから250ppmの間の濃度、最も好ましくは前記ゲル組成物中に250ppmの濃度で存在する、請求項11に記載の均質なゲル組成物。
- 前記ゲル組成物がゲル化ホストに混ぜ込まれ、前記ゲル化ホストがポリマーホストであってもよく、前記ポリマーがバイオポリマーを含む、請求項11に記載の均質なゲル組成物。
- 前記ゲル組成物が、コンディショナ、毛髪ムース、毛髪スプレー、毛髪染料、コンタクトレンズ溶液、消臭剤、パーソナルおよび工業用潤滑剤、食品グレードの食用物質、氷の形態の水、スキンローション、局所剤、練り歯磨き、口腔ゲル、および食品グリースの代替物と混合され、かつ/またはそれらに注入されるもののいずれかで、またはそうでなければ直接使用されるものである、請求項16に記載の均質なゲル組成物。
- 前記ゲル組成物の前記ゲルが陽イオン系で形成され、前記陽イオン系は陽イオンポリマー系とすることができ、前記陽イオンポリマー系は、アルギネート、キトサン、デキストラン、カラギーナン、ペクチン、およびキサンタンガムからなる群から選択される、請求項11に記載の均質なゲル組成物。
- 前記ゲルが、塗料、ならびにシャンプー、毛髪ゲル、リップクリーム、および手用清浄薬などのパーソナルケア製品、ならびにプールおよびスパ用製品、グラウトおよびシーラント、ならびに接着剤にブレンドされるまたは注入されるものである、請求項11に記載の均質なゲル組成物。
- 前記ゲルが、ヒトにとって摂取可能なものであり、乳製品、肉製品、およびパンまたはパン製品などの食品調理および食品配膳用品目、ならびに香料および香味剤を含めて、いずれか適切な飲料または食品品目に注入される、請求項11に記載の均質なゲル組成物。
- 前記ゲルが水に注入され、前記水が液相、固相、または気相である、請求項11に記載の均質なゲル組成物。
- 前記ゲルを熱可塑性加工装置に直接注入して、前記キレート化金属酸化物の特性を任意選択的な製品に直接注入する、請求項11に記載の均質なゲル組成物。
- 前記ゲルが任意選択的な海産食品に注入され、または氷と組合せて使用されて、海産食品の貯蔵における細菌増殖の低減または排除を確実にする、請求項11に記載の均質なゲル組成物。
- 酸化銀ならびに水および/またはポリオールキレート化酸化銀の混合物を含み、前記混合物が共錯化性バイオフィルム形成剤も含有する均質なゲル組成物を作製する方法であって、
前記ゲル組成物が、負に帯電した表面に静電気的に結合しており、前記ゲル組成物が、前記混合物中に懸濁しているキレート化酸化銀粒子と、水、ポリクオタニウム、グリセリンおよびヒアルロン酸を含むゲルとを含み、
前記キレート化酸化銀粒子が前記ゲルに均質に分散され、注入され、前記均質なゲル組成物を生成し、
前記キレート化酸化銀粒子が、前記キレート化酸化銀粒子の濃度が少なくとも0.001重量%となるように、前記均質なゲル組成物内に安定な錯体懸濁液として存在し、前記均質なゲル組成物中に懸濁したままとする、方法。 - 前記ゲル組成物が沈殿物を形成しない、請求項27に記載の均質なゲル組成物。
- 前記共錯化性バイオフィルム形成剤が選択された量のカルボン酸およびキトサンである、請求項27に記載の均質なゲル組成物。
- 前記ゲル組成物が250ppmの前記キレート化酸化銀を含む、請求項27に記載の均質なゲル組成物。
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TWI800164B (zh) * | 2021-12-16 | 2023-04-21 | 國立陽明交通大學 | 具有柱狀通孔之幾丁聚醣/銀三維支架及其製法 |
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CA3005145A1 (en) | 2016-05-19 |
US20150351406A1 (en) | 2015-12-10 |
BR112017009984A2 (pt) | 2018-01-02 |
US11547116B2 (en) | 2023-01-10 |
US20150079141A1 (en) | 2015-03-19 |
CN107205402A (zh) | 2017-09-26 |
EP3217797A4 (en) | 2018-08-01 |
MX2017006335A (es) | 2018-02-16 |
WO2014092747A1 (en) | 2014-06-19 |
US10687535B2 (en) | 2020-06-23 |
EP3217797A1 (en) | 2017-09-20 |
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