JP2017537106A5 - - Google Patents

Info

Publication number

JP2017537106A5

JP2017537106A5 JP2017528970A JP2017528970A JP2017537106A5 JP 2017537106 A5 JP2017537106 A5 JP 2017537106A5 JP 2017528970 A JP2017528970 A JP 2017528970A JP 2017528970 A JP2017528970 A JP 2017528970A JP 2017537106 A5 JP2017537106 A5 JP 2017537106A5

Authority

JP

Japan

Prior art keywords

vaccine

antigen

adjuvant composition

composition according

polymer

Prior art date

2015-11-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims description 40
• 229960005486 vaccine Drugs 0.000 claims description 29
• 239000002671 adjuvant Substances 0.000 claims description 26
• 239000000427 antigen Substances 0.000 claims description 23
• 102000036639 antigens Human genes 0.000 claims description 23
• 108091007433 antigens Proteins 0.000 claims description 23
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 20
• NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 13
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
• SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 11
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 11
• 229920000642 polymer Polymers 0.000 claims description 11
• 239000000126 substance Substances 0.000 claims description 11
• 235000012000 cholesterol Nutrition 0.000 claims description 10
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 7
• 229930182490 saponin Natural products 0.000 claims description 7
• 150000007949 saponins Chemical class 0.000 claims description 7
• 241001465754 Metazoa Species 0.000 claims description 4
• 229920002125 Sokalan® Polymers 0.000 claims description 4
• UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims description 3
• 229960001631 carbomer Drugs 0.000 claims description 3
• 238000007918 intramuscular administration Methods 0.000 claims description 3
• 238000007912 intraperitoneal administration Methods 0.000 claims description 3
• 238000001990 intravenous administration Methods 0.000 claims description 3
• 229940057917 medium chain triglycerides Drugs 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 3
• 238000007920 subcutaneous administration Methods 0.000 claims description 3
• 241000271566 Aves Species 0.000 claims description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 150000003626 triacylglycerols Chemical class 0.000 claims 2
• 241000283690 Bos taurus Species 0.000 claims 1
• 241000283707 Capra Species 0.000 claims 1
• 241000282693 Cercopithecidae Species 0.000 claims 1
• 241000282326 Felis catus Species 0.000 claims 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
• 230000000890 antigenic effect Effects 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 239000008206 lipophilic material Substances 0.000 claims 1
• -1 medium chain fatty acid triglycerides Chemical class 0.000 claims 1
• 150000007523 nucleic acids Chemical group 0.000 claims 1
• WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 238000002255 vaccination Methods 0.000 claims 1
• 239000002504 physiological saline solution Substances 0.000 description 2
• 210000003491 skin Anatomy 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 1
• 241000700605 Viruses Species 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 210000004207 dermis Anatomy 0.000 description 1
• 230000037317 transdermal delivery Effects 0.000 description 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1