JP2017537067A5 - - Google Patents
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- Publication number
- JP2017537067A5 JP2017537067A5 JP2017521530A JP2017521530A JP2017537067A5 JP 2017537067 A5 JP2017537067 A5 JP 2017537067A5 JP 2017521530 A JP2017521530 A JP 2017521530A JP 2017521530 A JP2017521530 A JP 2017521530A JP 2017537067 A5 JP2017537067 A5 JP 2017537067A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- egf
- administered
- subject
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 43
- 101000871708 Homo sapiens Proheparin-binding EGF-like growth factor Proteins 0.000 claims description 30
- 102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 claims description 30
- 208000002847 Surgical Wound Diseases 0.000 claims description 24
- 238000007483 tonsillectomy Methods 0.000 claims description 12
- 206010052428 Wound Diseases 0.000 claims description 11
- 208000027418 Wounds and injury Diseases 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 230000008556 epithelial cell proliferation Effects 0.000 claims description 8
- 230000004936 stimulating effect Effects 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 5
- 210000005081 epithelial layer Anatomy 0.000 claims description 4
- 230000035876 healing Effects 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 238000013268 sustained release Methods 0.000 claims description 4
- 239000012730 sustained-release form Substances 0.000 claims description 4
- 241000021559 Dicerandra Species 0.000 claims description 2
- 101500025336 Homo sapiens Heparin-binding EGF-like growth factor Proteins 0.000 claims description 2
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 2
- 206010029113 Neovascularisation Diseases 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 210000000981 epithelium Anatomy 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000000865 liniment Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims 3
- 229940035676 analgesics Drugs 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 241000321096 Adenoides Species 0.000 description 9
- 210000002534 adenoid Anatomy 0.000 description 9
- 238000002271 resection Methods 0.000 description 9
- 230000001613 neoplastic effect Effects 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 210000001184 pharyngeal muscle Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066564P | 2014-10-21 | 2014-10-21 | |
| US62/066,564 | 2014-10-21 | ||
| PCT/US2015/056651 WO2016064998A1 (en) | 2014-10-21 | 2015-10-21 | Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537067A JP2017537067A (ja) | 2017-12-14 |
| JP2017537067A5 true JP2017537067A5 (enExample) | 2018-11-29 |
Family
ID=55761476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521530A Pending JP2017537067A (ja) | 2014-10-21 | 2015-10-21 | ヘパリン結合性上皮成長因子様成長因子を用いた、扁桃摘出後の上皮再生促進の方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20170232065A1 (enExample) |
| EP (1) | EP3209322A4 (enExample) |
| JP (1) | JP2017537067A (enExample) |
| AU (2) | AU2015336008B2 (enExample) |
| CA (1) | CA2964378A1 (enExample) |
| WO (1) | WO2016064998A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019231860A1 (en) * | 2018-05-27 | 2019-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Method for treating or preventing radiotherapy- and chemotherapy-associated oral mucositis using locally administered heparin binding epidermal growth factor like growth factor (hb-egf) |
| US20210138036A1 (en) * | 2014-10-21 | 2021-05-13 | The Board Of Trustees Of The Leland Stanford Junior University | Method for Treating or Preventing Radiotherapy-and Chemotherapy-Associated Oral Mucositis Using Locally Administered Heparin Binding Epidermal Growth Factor Like Growth Factor (HB-EGF) |
| WO2020014524A1 (en) * | 2018-07-12 | 2020-01-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for reversing hiv latency using baf complex modulating compounds |
| WO2020243607A1 (en) * | 2019-05-31 | 2020-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Mucoadhesive microgel compositions and methods for using the same |
| US20240050593A1 (en) * | 2020-12-18 | 2024-02-15 | Duke University | Compositions For and Methods of Enhancing Spinal Cord Tissue Regeneration |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112620A (en) * | 1990-09-20 | 1992-05-12 | Mikkur, Inc. | Polyethylene glycol ointment for apthous ulcers |
| AU663298B2 (en) * | 1990-10-16 | 1995-10-05 | California Biotechnology, Inc. | Heparin binding mitogen with homology to epidermal growth factor (EGF) |
| US6682501B1 (en) * | 1996-02-23 | 2004-01-27 | Gyrus Ent, L.L.C. | Submucosal tonsillectomy apparatus and method |
| US8912165B2 (en) * | 1999-03-12 | 2014-12-16 | Biotec Pharmacon Asa | Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents |
| WO2007014167A2 (en) * | 2005-07-22 | 2007-02-01 | Five Prime Therapeutics, Inc. | Compositions for and methods of treating epithelial diseases with growth factors |
| WO2007061411A2 (en) * | 2005-11-21 | 2007-05-31 | Kevin Todd Kotecki | A method for developing and marketing a post operative home recovery kit for use by a patient after discharge from a hospital and for recuperation at home |
| JP2009543778A (ja) * | 2006-07-10 | 2009-12-10 | シネクサス， インコーポレイテッド | 洞口鼻道複合体へ活性薬剤を放出するための移植可能な持続性薬物送達装置 |
| US8093213B2 (en) * | 2007-04-30 | 2012-01-10 | Nationwide Children's Hospital, Inc. | Heparin binding epidermal growth factor (HB-EGF) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation |
| EP2424448A4 (en) * | 2009-04-27 | 2015-03-04 | Intersect Ent Inc | DEVICES AND METHODS FOR TREATING A PAIN ASSOCIATED WITH AMYGDALECTOMIES |
| US10058631B2 (en) * | 2014-07-09 | 2018-08-28 | Cook Medical Technologies Llc | Tonsillectomy sponge |
| US20200008825A1 (en) * | 2017-01-27 | 2020-01-09 | Southern Research Institute | Sustained intratonsillar drug delivery with needle array |
-
2015
- 2015-10-21 CA CA2964378A patent/CA2964378A1/en not_active Abandoned
- 2015-10-21 EP EP15853304.2A patent/EP3209322A4/en not_active Withdrawn
- 2015-10-21 JP JP2017521530A patent/JP2017537067A/ja active Pending
- 2015-10-21 WO PCT/US2015/056651 patent/WO2016064998A1/en not_active Ceased
- 2015-10-21 AU AU2015336008A patent/AU2015336008B2/en not_active Ceased
-
2017
- 2017-04-20 US US15/492,773 patent/US20170232065A1/en not_active Abandoned
-
2019
- 2019-11-29 AU AU2019272030A patent/AU2019272030A1/en not_active Abandoned
-
2020
- 2020-08-19 US US16/997,607 patent/US20210038690A1/en not_active Abandoned
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