JP2017536904A - 改善された生理学的監視のためのシステムおよび方法 - Google Patents
改善された生理学的監視のためのシステムおよび方法 Download PDFInfo
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Abstract
Description
▽×H=J (7)
ここで、B[T]は磁場密度に対応し、Hは磁場強度に対応し、J[A/m2]は電流密度に対応する。
μ=μ0μr (9)
M=χH (10)
μr=χ+1 (11)
ここで、μは血液の透磁率に対応し、μ0は真空の透磁率に対応し、μrは血液の比透磁率に対応し、χは血液の磁化率に対応する。
T=μ0M×H (13)
ここで、μ0は自由空間の透磁率に相当し、Mは磁化に相当し、Hは磁場強度に相当する。
102 検出装置
104 血管
106 外部磁場、変動磁場
108 磁気源
110 磁気センサアレイ
112 基板
114 磁場変調器
116 磁気センサ、GMRセンサ
118 磁気センサ、SMRセンサ
120 磁気センサ、AMRセンサ
122 相互接続
124 相互接続
126 電源
128 処理サブシステム
130 増幅器
132 デジタイザ
133 有線および/または無線結合手段
134 ストレージリポジトリ
136 I/Oデバイス
138 ユーザインターフェイス
140 リモート表示装置
142 警報サブシステム
202 磁石
203 磁石
204 磁石
206 磁石
208 磁気源
210 磁気源
212 SMRセンサ
302 磁気センサ、GMRセンサ
304 磁気センサ、GMRセンサ
306 磁気センサ、AMRセンサ
308 磁気センサ、SMRセンサ
400 検出装置
402 磁気センサアレイ
404 磁気源
406 磁気センサ
500 検出装置
502 磁気センサアレイ
600 結合モデル
700 結合モデル
902 ステップ
904 ステップ
906 ステップ
908 ステップ
910 ステップ
912 ステップ
914 ステップ
Claims (23)
- 被験者を監視するためのシステム(100)であって、
磁場(106)を生成するための少なくとも1つの磁気源(108、208、404)と、
前記磁場(106)内に配置され、1つ以上の磁性粒子を含む流体を含む管(104)に沿った複数の位置において前記磁場(106)に対応する複数の測定値を得る磁気センサのアレイ(110、402、502)と、
検出装置(102、400、500)に通信可能に結合した処理サブシステム(128)であって、
磁化−緩和、前記磁場(106)の割り出された勾配に向かう前記流体内の前記磁性粒子のバルク運動、静磁気学、および運動量の保存の原理にもとづいて前記変動磁場(106)における前記流体の挙動を定義する結合モデルにもとづいて、前記管(104)を通って流れる前記流体内の前記磁性粒子の磁化−緩和によって引き起こされる前記複数の測定値の変化を割り出し、
前記割り出された変化にもとづいて1つ以上の所望のパラメータの値を推定する、
処理サブシステム(128)と
を含む検出装置(102、400、500)
を備えたシステム(100)。 - 前記磁気センサのアレイ(110、402、502)は、1つ以上の半導体磁気抵抗センサを含む、請求項1に記載のシステム(100)。
- 前記少なくとも1つの磁気源(108、208、404)は、交互のN極およびS極を有する複数の磁気源(210)に相当し、前記半導体磁気抵抗センサは、複数の磁気源(210)の上に配置されるか、前記複数の磁気源(210)から所定の距離に配置されるか、あるいはそれらの組み合わせである、請求項2に記載のシステム(100)。
- 前記磁気センサのアレイ(110、402、502)は、磁気抵抗センサ、ホール効果センサ、異方性磁気抵抗センサ、巨大磁気抵抗センサ、コイルセンサ、またはそれらの組み合わせを含む、請求項1に記載のシステム(100)。
- 前記磁気源(108、208、404)と前記磁気センサのアレイ(110、402、502)とが配置された基板(112)をさらに備え、前記基板(112)は、可撓な基板、堅固な基板、またはそれらの組み合わせを含む、請求項1に記載のシステム(100)。
- 前記磁気源(108、208、404)および前記磁気センサのアレイ(110、402、502)は、1つ以上の選択された向きで前記基板(112)上に配置されるか、1つ以上の選択されたサイズを有するか、あるいはそれらの組み合わせである、請求項5に記載のシステム(100)。
- 前記磁気センサのアレイ(110、402、502)内の1つ以上の磁気センサ(116、118、120、302、304、306、406)は、前記磁気源(108、208、404)からの1つ以上の選択された距離において前記基板(112)上に配置される、請求項5に記載のシステム(100)。
- 前記検出装置(102、400、500)に動作可能に結合させられ、時間ドメイン、空間ドメイン、またはそれらの組み合わせにおいて前記磁場(106)を変化させる変調器(114)、
をさらに備える、請求項1に記載のシステム(100)。 - 前記検出装置は、有線結合手段、無線結合手段、またはそれらの組み合わせ(133)によって前記処理サブシステム(128)に通信可能に結合させられる、請求項1に記載のシステム(100)。
- 1つ以上の所望のパラメータの値が所定のしきい値の外にある場合に、聴覚による警報、視覚による警報、またはそれらの組み合わせを生成する警報サブシステム(142)、
をさらに備える、請求項1に記載のシステム(100)。 - 前記流体は、血液を含み、前記1つ以上の所望のパラメータは、血液量、血圧、血中酸素、心拍数、心拍出量、またはそれらの組み合わせを含む、請求項1に記載のシステム(100)。
- 前記処理サブシステム(128)は、別の生理学的監視装置に動作可能に結合させられる、請求項11に記載のシステム(100)。
- 前記生理学的監視装置は、血中酸素モニタ、ドップラ超音波システム、光学式の心拍モニタ、またはそれらの組み合わせを含む、請求項12に記載のシステム(100)。
- 前記処理サブシステム(128)は、前記1つ以上の所望のパラメータの値および前記生理学的監視装置を使用して割り出された情報にもとづいて、前記被験者の病理学的状態を判断する、請求項12に記載のシステム(100)。
- 前記流体は、非生物学的流体を含み、前記非生物学的流体は、オイル、ガソリン、水、ガス、またはそれらの組み合わせを含む、請求項1に記載のシステム(100)。
- 被験者を監視するための方法であって、
少なくとも1つの磁気源を使用して、時間ドメイン、空間ドメイン、またはそれらの組み合わせにおいて変化する変動磁場をもたらすステップ(906)と、
前記変動磁場内に配置された1つ以上の磁気センサを使用して、1つ以上の磁性粒子を含む流体を含む管に沿った複数の位置において前記変動磁場に対応する複数の測定値を取得するステップ(908)と、
結合モデルにもとづいて前記管を通って流れる前記流体の磁化−緩和によって引き起こされる前記複数の測定値の変化を割り出すステップ(910)と、
前記割り出された変化にもとづいて1つ以上の所望のパラメータの値を推定するステップ(912)と
を含む方法。 - 磁化−緩和、前記磁場の割り出された勾配に向かう前記流体内の前記磁性粒子のバルク運動、静磁気学、および運動量の保存の原理にもとづいて前記変動磁場における前記流体内の前記磁性粒子の挙動を定義するように前記結合モデルを生成するステップ、
をさらに含む、請求項16に記載の方法。 - 前記複数の測定値を取得するステップ(908)は、前記管に沿った前記複数の位置において前記変動磁場を同時に測定することを含む、請求項16に記載の方法。
- 前記1つ以上の所望のパラメータの値を継続的に監視するステップ、をさらに含む、請求項16に記載の方法。
- 前記所望のパラメータの1つ以上の値が所定のしきい値の外にある場合に、聴覚による警報、視覚による警報、またはそれらの組み合わせを生成するステップ(914)、
をさらに含む、請求項19に記載のシステム。 - 1つ以上の所望のパラメータの前記値にもとづいて、前記被験者の病理学的状態を判断するステップ、
をさらに含む、請求項19に記載の方法。 - 1つ以上の所望のパラメータの前記値を、有線結合手段、無線結合手段、またはそれらの組み合わせを介して前記磁気センサのアレイへと遠隔接続されたシステムに通信するステップ、
をさらに含む、請求項16に記載の方法。 - 被験者を監視するための方法を実行するために1つ以上のプロセッサによって実行することができる命令を格納する非一時的なコンピュータ可読媒体であって、
少なくとも1つの磁気源を使用して、時間ドメイン、空間ドメイン、またはそれらの組み合わせにおいて変化する変動磁場をもたらすステップ(906)と、
前記変動磁場内に配置された1つ以上の磁気センサを使用して、1つ以上の磁性粒子を含む流体を含む管に沿った複数の位置において前記変動磁場に対応する複数の測定値を取得するステップ(908)と、
磁化−緩和、前記磁場の割り出された勾配に向かう前記流体のバルク運動、静磁気学、および運動量の保存の原理にもとづいて前記変動磁場における前記流体の挙動を定義する結合モデルにもとづいて、前記管を通って流れる前記流体の磁化−緩和によって引き起こされる前記複数の測定値の変化を割り出すステップ(910)と、
前記割り出された変化にもとづいて1つ以上の所望のパラメータの値を推定するステップ(912)と
を含む非一時的なコンピュータ可読媒体。
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