|
US4603203A
(en)
|
1983-12-14 |
1986-07-29 |
Takeda Chemical Industries, Ltd. |
3-aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof
|
|
CA1251448A
(en)
|
1985-03-27 |
1989-03-21 |
William J. Coates |
Pyridazinone derivatives
|
|
US4666908A
(en)
|
1985-04-05 |
1987-05-19 |
Warner-Lambert Company |
5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
|
|
ATE126207T1
(de)
|
1989-01-26 |
1995-08-15 |
Bayer Ag |
Optisch aktive (meth)acrylsäure-derivate, ihre herstellung, ihre polymerisation zu optisch aktiven polymeren und deren verwendung.
|
|
NZ238609A
(en)
|
1990-06-21 |
1993-12-23 |
Schering Corp |
Polycyclic guanine derivatives; preparation, pharmaceutical compositions,
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
CA2156918A1
(en)
|
1993-02-26 |
1994-09-01 |
Deen Tulshian |
2-benzyl-polycyclic guanine derivatives and process for preparing them
|
|
DE19541264A1
(de)
|
1995-11-06 |
1997-05-07 |
Bayer Ag |
Purin-6-on-derivate
|
|
US5824683A
(en)
|
1995-11-28 |
1998-10-20 |
Schering Corporation |
2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
|
|
DE19702785A1
(de)
|
1997-01-27 |
1998-07-30 |
Bayer Ag |
Neue cyclische Harnstoffderivate
|
|
SE9701398D0
(sv)
|
1997-04-15 |
1997-04-15 |
Astra Pharma Prod |
Novel compounds
|
|
IT1291372B1
(it)
|
1997-05-21 |
1999-01-07 |
Schering Plough S P A |
Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
|
|
US6013621A
(en)
|
1997-10-17 |
2000-01-11 |
The Rockfeller University |
Method of treating psychosis and/or hyperactivity
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
DE19931206A1
(de)
|
1999-07-07 |
2001-01-11 |
Stief Christian |
Arzneimittel zur Erhöhung des cAMP-Spiegels und deren Verwendung
|
|
JP2003511452A
(ja)
|
1999-10-11 |
2003-03-25 |
ファイザー・インク |
ホスホジエステラーゼ阻害剤としての5−(2−置換−5−ヘテロシクリルスルホニルピリド−3−イル)−ジヒドロピラゾロ[4,3−d]ピリミジン−7−オン
|
|
IL139073A0
(en)
|
1999-10-21 |
2001-11-25 |
Pfizer |
Treatment of neuropathy
|
|
AU2001255849B8
(en)
|
2000-04-19 |
2006-04-27 |
Lilly Icos, Llc. |
PDE-V inhibitors for treatment of Parkinson's Disease
|
|
AU2001289751A1
(en)
|
2000-08-01 |
2002-02-13 |
Bayer Aktiengesellschaft |
Selective pde 2 inhibitors, used as medicaments for improving cognition
|
|
DE10064105A1
(de)
|
2000-12-21 |
2002-06-27 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
DE10108752A1
(de)
|
2001-02-23 |
2002-09-05 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
SE0102315D0
(sv)
|
2001-06-28 |
2001-06-28 |
Astrazeneca Ab |
Compounds
|
|
CN1315835C
(zh)
|
2001-08-28 |
2007-05-16 |
先灵公司 |
多环鸟嘌呤磷酸二酯酶v抑制剂
|
|
CA2459161A1
(en)
|
2001-08-31 |
2003-03-13 |
The Rockefeller University |
Phosphodiesterase activity and regulation of phosphodiesterase 1b-mediated signaling in brain
|
|
US6943171B2
(en)
|
2001-11-09 |
2005-09-13 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase V inhibitors
|
|
US20050153372A1
(en)
|
2002-02-21 |
2005-07-14 |
Paul Greengard |
Compositions and method for regulation of calcium-dependent signaling in brain
|
|
DE60324449D1
(de)
|
2002-10-30 |
2008-12-11 |
Via Pharmaceuticals Inc |
Inhibitoren der phosphodiesterase der zyklischen n, und deren verwendung in therapie
|
|
ES2372600T3
(es)
|
2002-11-06 |
2012-01-24 |
Aska Pharmaceutical Co., Ltd. |
Derivado de pirazolonaftiridina.
|
|
AU2004228360A1
(en)
|
2003-03-04 |
2004-10-21 |
Altana Pharma Ag |
Purin-6-one-derivatives
|
|
EP1613747A1
(en)
|
2003-03-31 |
2006-01-11 |
Pfizer Products Inc. |
Crystal structure of 3 ,5 -cyclic nucleotide phosphodiesterase 1b (pde1b) and uses thereof
|
|
BRPI0409229A
(pt)
|
2003-04-01 |
2006-03-28 |
Applied Research Systems |
inibidores das fosfodiesterases na infertilidade
|
|
US7268133B2
(en)
*
|
2003-04-23 |
2007-09-11 |
Pfizer, Inc. Patent Department |
Cannabinoid receptor ligands and uses thereof
|
|
WO2005041957A1
(en)
|
2003-10-29 |
2005-05-12 |
Pfizer Products Inc. |
Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
|
|
BRPI0417663A
(pt)
|
2003-12-16 |
2007-04-03 |
Pfizer Prod Inc |
pirido[2,3-d]pirimidina-2,4diaminas como inibidores de pde 2
|
|
EP1548011A1
(en)
|
2003-12-23 |
2005-06-29 |
Neuro3D |
Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof
|
|
WO2005083069A1
(en)
*
|
2004-01-30 |
2005-09-09 |
Pfizer Products Inc. |
Pde2 crystal structures for structure based drug design
|
|
JP5140427B2
(ja)
|
2004-09-02 |
2013-02-06 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
トリアゾロフタラジン
|
|
WO2006072612A2
(en)
|
2005-01-05 |
2006-07-13 |
Nycomed Gmbh |
Triazolophthalazines as pde2- inhibitors
|
|
NZ555661A
(en)
|
2005-01-05 |
2010-11-26 |
Nycomed Gmbh |
Triazolophthalazines as PDE2-inhibitors
|
|
DOP2006000009A
(es)
*
|
2005-01-13 |
2006-08-15 |
Arena Pharm Inc |
Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
|
|
CN101248050B
(zh)
|
2005-06-06 |
2013-07-17 |
武田药品工业株式会社 |
有机化合物
|
|
EP1749824A1
(en)
|
2005-08-03 |
2007-02-07 |
Neuro3D |
Benzodiazepine derivatives, their preparation and the therapeutic use thereof
|
|
EP1919287A4
(en)
|
2005-08-23 |
2010-04-28 |
Intra Cellular Therapies Inc |
ORGANIC COMPOUNDS FOR TREATING A REDUCED DOPAMINE RECEPTOR SIGNALING ACTIVITY
|
|
CA2622605A1
(en)
|
2005-09-15 |
2007-03-22 |
Aska Pharmaceutical Co., Ltd. |
Heterocycle compound, and production process and application thereof
|
|
JP2009512711A
(ja)
|
2005-10-21 |
2009-03-26 |
ブレインセルス,インコーポレイティド |
Pde阻害による神経新生の調節
|
|
KR20090042227A
(ko)
|
2006-06-06 |
2009-04-29 |
인트라-셀룰라 써래피스, 인코퍼레이티드. |
유기 화합물
|
|
WO2008063505A1
(en)
|
2006-11-13 |
2008-05-29 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
US9006258B2
(en)
|
2006-12-05 |
2015-04-14 |
Intra-Cellular Therapies, Inc. |
Method of treating female sexual dysfunction with a PDE1 inhibitor
|
|
DK2152712T3
(da)
|
2007-05-11 |
2012-03-26 |
Pfizer |
Aminoheterocykliske fobindelser
|
|
US7807629B1
(en)
|
2007-06-05 |
2010-10-05 |
Alcon Research, Ltd. |
Use of bradykinin and related B2R agonists to treat ocular hypertension and glaucoma
|
|
WO2009075784A1
(en)
|
2007-12-06 |
2009-06-18 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
AU2008331833A1
(en)
|
2007-12-06 |
2009-06-11 |
Intra-Cellular Therapies, Inc |
Organic compounds
|
|
WO2010062366A1
(en)
|
2008-10-31 |
2010-06-03 |
Arginetix, Inc. |
Compositions and methods of treating endothelial disorders
|
|
US20100120762A1
(en)
|
2008-11-07 |
2010-05-13 |
Wyeth |
Triazine derivatives as inhibitors of phosphodiesterases
|
|
US20100120763A1
(en)
|
2008-11-07 |
2010-05-13 |
Wyeth |
Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
|
|
KR20110098731A
(ko)
|
2008-12-06 |
2011-09-01 |
인트라-셀룰라 써래피스, 인코퍼레이티드. |
유기 화합물
|
|
EP2367429B1
(en)
|
2008-12-06 |
2017-06-07 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
CN102223799A
(zh)
|
2008-12-06 |
2011-10-19 |
细胞内治疗公司 |
有机化合物
|
|
EP2358204B1
(en)
|
2008-12-06 |
2015-08-05 |
Intra-Cellular Therapies, Inc. |
4,5,7,8-tetrahydro-4-oxo-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors.
|
|
CN102232077A
(zh)
|
2008-12-06 |
2011-11-02 |
细胞内治疗公司 |
有机化合物
|
|
WO2010065147A1
(en)
|
2008-12-06 |
2010-06-10 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EP2400970A4
(en)
|
2009-02-25 |
2012-07-18 |
Intra Cellular Therapies Inc |
PDE-1-HEMMER FOR EYE DRESSING
|
|
US9468637B2
(en)
|
2009-05-13 |
2016-10-18 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
WO2011011312A1
(en)
|
2009-07-22 |
2011-01-27 |
Merck Sharp & Dohme Corp. |
Quinolinone pde2 inhibitors
|
|
JP2013507360A
(ja)
|
2009-10-08 |
2013-03-04 |
イントラ−セルラー・セラピーズ・インコーポレイテッド |
ホスホジエステラーゼ1−標的トレーサーおよび方法
|
|
WO2011049722A1
(en)
|
2009-10-19 |
2011-04-28 |
Merck Sharp & Dohme Corp. |
PYRAZOLO [3,4-b] PYRIDIN-4-ONE KINASE INHIBITORS
|
|
WO2011153135A1
(en)
|
2010-05-31 |
2011-12-08 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
JP5911854B2
(ja)
|
2010-05-31 |
2016-04-27 |
イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. |
有機化合物
|
|
JP5879336B2
(ja)
|
2010-05-31 |
2016-03-08 |
イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. |
有機化合物
|
|
TW201206937A
(en)
|
2010-05-31 |
2012-02-16 |
Intra Cellular Therapies Inc |
Organic compounds
|
|
US9540379B2
(en)
|
2011-01-31 |
2017-01-10 |
Boehringer Ingelheim International Gmbh |
(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
|
|
AP2013007070A0
(en)
*
|
2011-02-23 |
2013-08-31 |
Pfizer |
Imidazo[5,1-f][1,2,4] triazines for the treatment of neurological disorders
|
|
KR101626681B1
(ko)
*
|
2011-06-07 |
2016-06-01 |
화이자 인코포레이티드 |
피라졸로[3,4-d]피리미딘 화합물 및 pde2 억제제 및/또는 cyp3a4 억제제로서의 이의 용도
|
|
US10561656B2
(en)
|
2011-06-10 |
2020-02-18 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
MX344600B
(es)
|
2011-06-27 |
2016-12-20 |
Janssen Pharmaceutica Nv |
Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina.
|
|
WO2013034755A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders
|
|
JP2014526453A
(ja)
|
2011-09-09 |
2014-10-06 |
ハー・ルンドベック・アクチエゼルスカベット |
ピリジン化合物およびそれらの使用
|
|
WO2013034758A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Substituted triazolopyrazines and uses thereof
|
|
AR091507A1
(es)
|
2012-06-21 |
2015-02-11 |
Intra Cellular Therapies Inc |
SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA
|
|
ES2836129T3
(es)
|
2013-03-15 |
2021-06-24 |
Intra Cellular Therapies Inc |
Compuestos orgánicos
|
|
MX2015013740A
(es)
|
2013-03-25 |
2016-02-29 |
Sanofi Sa |
Derivados de pirazolnaftridinona, preparacion y uso terapautico de los mismos.
|
|
US9546175B2
(en)
|
2014-08-07 |
2017-01-17 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|