JP2017534665A - サーチュイン調節因子としての置換架橋尿素類似体 - Google Patents

サーチュイン調節因子としての置換架橋尿素類似体 Download PDF

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Publication number
JP2017534665A
JP2017534665A JP2017526965A JP2017526965A JP2017534665A JP 2017534665 A JP2017534665 A JP 2017534665A JP 2017526965 A JP2017526965 A JP 2017526965A JP 2017526965 A JP2017526965 A JP 2017526965A JP 2017534665 A JP2017534665 A JP 2017534665A
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JP
Japan
Prior art keywords
branched
linear
heteroaryl
heterocyclyl
haloalkyl
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JP2017526965A
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English (en)
Japanese (ja)
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JP2017534665A5 (enExample
Inventor
ジェームズ、ラモンド、エリス
カレン、アンダーソン、エバンス
ライアン、マイケル、フォックス
ウィリアム、ヘンリー、ミラー
マーク、アンドリュー、シーフェルド
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GlaxoSmithKline Intellectual Property No 2 Ltd
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GlaxoSmithKline Intellectual Property No 2 Ltd
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Publication of JP2017534665A publication Critical patent/JP2017534665A/ja
Publication of JP2017534665A5 publication Critical patent/JP2017534665A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017526965A 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体 Pending JP2017534665A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462081916P 2014-11-19 2014-11-19
US62/081,916 2014-11-19
PCT/IB2015/058981 WO2016079712A1 (en) 2014-11-19 2015-11-19 Substituted bridged urea analogs as sirtuin modulators

Publications (2)

Publication Number Publication Date
JP2017534665A true JP2017534665A (ja) 2017-11-24
JP2017534665A5 JP2017534665A5 (enExample) 2019-01-10

Family

ID=54705247

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017526965A Pending JP2017534665A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526875A Withdrawn JP2017534663A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526852A Expired - Fee Related JP6806679B2 (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526950A Pending JP2017534664A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2017526875A Withdrawn JP2017534663A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526852A Expired - Fee Related JP6806679B2 (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526950A Pending JP2017534664A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体

Country Status (21)

Country Link
US (4) US20190048016A1 (enExample)
EP (4) EP3221316A1 (enExample)
JP (4) JP2017534665A (enExample)
KR (4) KR20170087907A (enExample)
CN (4) CN107207520A (enExample)
AU (4) AU2015348944A1 (enExample)
BR (4) BR112017010599A2 (enExample)
CA (4) CA2968029A1 (enExample)
CL (1) CL2017001275A1 (enExample)
CO (1) CO2017004994A2 (enExample)
CR (1) CR20170209A (enExample)
DO (1) DOP2017000123A (enExample)
EA (1) EA201791074A1 (enExample)
ES (1) ES2823748T3 (enExample)
IL (1) IL252252A0 (enExample)
MX (1) MX2017006658A (enExample)
PE (1) PE20171257A1 (enExample)
PH (1) PH12017500913A1 (enExample)
RU (3) RU2017120857A (enExample)
SG (1) SG11201703824QA (enExample)
WO (4) WO2016079709A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10653782B2 (en) * 2014-11-25 2020-05-19 Nortwestern University Retroviral particles expressing Sirt1 embedded within PPCN
CN108329388A (zh) * 2018-01-18 2018-07-27 天津市湖滨盘古基因科学发展有限公司 一种人的沉默配型信息调节蛋白突变蛋白及其应用
CN108707150B (zh) * 2018-05-14 2021-04-16 江苏惠利生物科技有限公司 一种咪唑并吡嗪医药中间体的制备方法
CN108395436B (zh) * 2018-05-14 2021-01-12 鹤壁市人民医院 一种咪唑并吡嗪医药中间体的制备方法
CN110478339A (zh) * 2019-08-12 2019-11-22 昆明理工大学 紫铆因在制备靶向恢复突变p53构象药物中的应用
US12108665B2 (en) 2019-09-02 2024-10-01 Merck Kgaa Materials for organic electroluminescent devices
JP7764372B2 (ja) * 2019-11-19 2025-11-05 ルピン・リミテッド クロマン化合物を調製する方法
MX2022008805A (es) * 2020-01-17 2022-08-11 Lupin Ltd Metodos, procesos e intermedios para preparar compuestos cromanos.
CN114890955A (zh) * 2022-06-23 2022-08-12 江西瑞威尔生物科技有限公司 一种n取代吗啉类有机化合物的制备工艺
WO2025194094A1 (en) * 2024-03-15 2025-09-18 The Regents Of The University Of Michigan Small molecule modulators of sirt5 and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006094210A2 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Tetrahydroquinoxalinone sirtuin modulators
JP2013509442A (ja) * 2009-10-29 2013-03-14 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン調節因子としての二環式ピリジンおよび類似体
WO2013090369A1 (en) * 2011-12-12 2013-06-20 Smb Innovation Novel heterocyclic compounds useful in sirtuin binding and modulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
UA108596C2 (xx) 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
BR112015028613A2 (pt) * 2013-05-13 2017-07-25 Glaxosmithkline Llc análogos de uréia com ligações por pontes substituída como moduladores de sirtuína

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006094210A2 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Tetrahydroquinoxalinone sirtuin modulators
JP2013509442A (ja) * 2009-10-29 2013-03-14 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン調節因子としての二環式ピリジンおよび類似体
WO2013090369A1 (en) * 2011-12-12 2013-06-20 Smb Innovation Novel heterocyclic compounds useful in sirtuin binding and modulation

Also Published As

Publication number Publication date
EA201791074A1 (ru) 2017-10-31
RU2017120858A (ru) 2018-12-19
ES2823748T3 (es) 2021-05-10
BR112017010601A2 (pt) 2017-12-26
PE20171257A1 (es) 2017-08-28
KR20170087907A (ko) 2017-07-31
US20170355705A1 (en) 2017-12-14
EP3221322A1 (en) 2017-09-27
CN107207509B (zh) 2020-04-21
US20190048016A1 (en) 2019-02-14
CN107207521A (zh) 2017-09-26
BR112017010599A2 (pt) 2017-12-26
JP6806679B2 (ja) 2021-01-06
SG11201703824QA (en) 2017-06-29
AU2015348944A1 (en) 2017-06-01
CN107207520A (zh) 2017-09-26
KR20170083134A (ko) 2017-07-17
EP3221316A1 (en) 2017-09-27
WO2016079709A1 (en) 2016-05-26
WO2016079711A1 (en) 2016-05-26
MX2017006658A (es) 2018-01-15
CN107108627A (zh) 2017-08-29
CL2017001275A1 (es) 2017-12-15
BR112017010595A2 (pt) 2018-01-02
DOP2017000123A (es) 2017-08-15
JP2017534663A (ja) 2017-11-24
CO2017004994A2 (es) 2017-09-20
US10072011B2 (en) 2018-09-11
KR20170083133A (ko) 2017-07-17
JP2017534664A (ja) 2017-11-24
US20170362234A1 (en) 2017-12-21
WO2016079712A1 (en) 2016-05-26
AU2015348943A1 (en) 2017-06-01
CA2968029A1 (en) 2016-05-26
AU2015348942B2 (en) 2018-07-05
JP2017534662A (ja) 2017-11-24
BR112017010602A2 (pt) 2017-12-26
WO2016079710A1 (en) 2016-05-26
CA2968030A1 (en) 2016-05-26
PH12017500913A1 (en) 2017-12-04
AU2015348942A1 (en) 2017-06-01
RU2017120855A (ru) 2018-12-19
CA2968032A1 (en) 2016-05-26
RU2017120857A (ru) 2018-12-19
EP3220918A1 (en) 2017-09-27
EP3221317A1 (en) 2017-09-27
CN107207509A (zh) 2017-09-26
EP3221317B1 (en) 2020-07-22
CR20170209A (es) 2017-07-17
US20180319810A1 (en) 2018-11-08
KR20170083135A (ko) 2017-07-17
AU2015348941A1 (en) 2017-06-01
IL252252A0 (en) 2017-07-31
CA2968027A1 (en) 2016-05-26

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