|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
LT3105328T
(lt)
|
2014-02-11 |
2020-07-10 |
The Regents Of The University Of Colorado, A Body Corporate |
Daugiakomponentis genomo konstravimas, sudarantis sąlygas crispr
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
CA2969619A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
CN107787367B
(zh)
|
2015-04-06 |
2021-10-26 |
里兰斯坦福初级大学理事会 |
用于crispr/cas介导的基因调控的化学修饰的引导rna
|
|
WO2017070632A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
WO2017123559A2
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
|
JP7012645B2
(ja)
|
2016-01-11 |
2022-01-28 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
キメラタンパク質および免疫治療の方法
|
|
EP3448996A1
(en)
*
|
2016-04-26 |
2019-03-06 |
Massachusetts Institute of Technology |
Extensible recombinase cascades
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CN109688820B
(zh)
*
|
2016-06-24 |
2023-01-10 |
科罗拉多州立大学董事会(法人团体) |
用于生成条形码化组合文库的方法
|
|
WO2018005691A1
(en)
*
|
2016-06-29 |
2018-01-04 |
The Regents Of The University Of California |
Efficient genetic screening method
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
AU2017308889B2
(en)
|
2016-08-09 |
2023-11-09 |
President And Fellows Of Harvard College |
Programmable Cas9-recombinase fusion proteins and uses thereof
|
|
MX2019002004A
(es)
|
2016-08-19 |
2019-10-09 |
Whitehead Inst Biomedical Res |
Metodos para editar la metilacion del adn.
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
WO2018049075A1
(en)
|
2016-09-07 |
2018-03-15 |
Flagship Pioneering, Inc. |
Methods and compositions for modulating gene expression
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018111944A1
(en)
|
2016-12-12 |
2018-06-21 |
Whitehead Institute For Biomedical Research |
Regulation of transcription through ctcf loop anchors
|
|
US10815525B2
(en)
*
|
2016-12-22 |
2020-10-27 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CA3048939A1
(en)
*
|
2016-12-29 |
2018-07-05 |
Johann Wolfgang Goethe-Universitat Frankfurt Am Main |
Method for generating higher order genome editing libraries
|
|
US11873496B2
(en)
|
2017-01-09 |
2024-01-16 |
Whitehead Institute For Biomedical Research |
Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops
|
|
WO2018145041A1
(en)
*
|
2017-02-06 |
2018-08-09 |
10X Genomics, Inc. |
Systems and methods for nucleic acid preparation
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
KR20190123328A
(ko)
|
2017-03-09 |
2019-10-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
암 백신
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
IL306092A
(en)
|
2017-03-23 |
2023-11-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
CN111182790A
(zh)
|
2017-07-31 |
2020-05-19 |
瑞泽恩制药公司 |
Crispr报告体非人类动物及其用途
|
|
KR102712142B1
(ko)
|
2017-07-31 |
2024-10-07 |
리제너론 파마슈티칼스 인코포레이티드 |
Cas-형질전환 마우스 배아 줄기 세포 및 마우스 및 이것의 용도
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
US11547614B2
(en)
|
2017-10-31 |
2023-01-10 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
WO2020033585A1
(en)
*
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Methods for combinatorial screening and use of therapeutic targets thereof
|
|
EP3853363A4
(en)
|
2018-09-19 |
2022-12-14 |
The University of Hong Kong |
IMPROVED HIGH-THROUGHPUT COMBINATORY GENETIC MODIFICATION SYSTEM AND OPTIMIZED CAS9 ENZYME VARIANTS
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
KR20210106527A
(ko)
*
|
2018-12-20 |
2021-08-30 |
페킹 유니버시티 |
바코드화 가이드 rna 구축물을 사용한 고효율의 유전자 스크리닝을 위한 조성물 및 방법
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020191241A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN114729376A
(zh)
|
2019-09-23 |
2022-07-08 |
欧米茄治疗公司 |
用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN110652589A
(zh)
*
|
2019-10-12 |
2020-01-07 |
中国人民解放军陆军军医大学 |
Gasc1抑制剂在制备治疗肝癌的药物中的应用
|
|
US20230002756A1
(en)
*
|
2019-12-12 |
2023-01-05 |
The Trustees Of The University Of Pennsylvania |
High Performance Platform for Combinatorial Genetic Screening
|
|
US20230227814A1
(en)
|
2020-04-16 |
2023-07-20 |
The University Of Hong Kong |
System for three-way combinatorial crispr screens for analysing target interactions and methods thereof
|
|
CA3177481A1
(en)
|
2020-05-08 |
2021-11-11 |
David R. Liu |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
WO2022159402A1
(en)
*
|
2021-01-19 |
2022-07-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Composition and method for high-multiplexed genome engineering using synthetic crispr arrays
|
|
WO2022195582A1
(en)
*
|
2021-03-15 |
2022-09-22 |
G.T.A.I Innovation Ltd. |
A method and apparatus for lab tests
|
|
CN113599522B
(zh)
*
|
2021-08-03 |
2022-09-20 |
深圳市北科生物科技有限公司 |
Kdm6作为靶标在制备用于提高早期神经外胚层分化效率的药物中的应用
|
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
|
CN116019811B
(zh)
*
|
2023-02-07 |
2024-04-12 |
华中科技大学协和深圳医院 |
Gsk-j4用于制备抗革兰氏阳性菌感染药物中的应用
|
|
CN118425525B
(zh)
*
|
2024-03-13 |
2025-08-22 |
郑州大学第一附属医院 |
Kdm5b在肾纤维化治疗中的应用
|