CN113599522B - Kdm6作为靶标在制备用于提高早期神经外胚层分化效率的药物中的应用 - Google Patents
Kdm6作为靶标在制备用于提高早期神经外胚层分化效率的药物中的应用 Download PDFInfo
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- CN113599522B CN113599522B CN202110886224.7A CN202110886224A CN113599522B CN 113599522 B CN113599522 B CN 113599522B CN 202110886224 A CN202110886224 A CN 202110886224A CN 113599522 B CN113599522 B CN 113599522B
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Abstract
Description
细胞系名称 | KDM6A缺失碱基 | KDM6B缺失碱基 |
DKO1 | (del 10bp) | (del 753bp敲掉起始密码子) |
DKO2 | (del 53bp) | (del 728bp) |
Claims (2)
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CN202110886224.7A CN113599522B (zh) | 2021-08-03 | 2021-08-03 | Kdm6作为靶标在制备用于提高早期神经外胚层分化效率的药物中的应用 |
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CN202110886224.7A CN113599522B (zh) | 2021-08-03 | 2021-08-03 | Kdm6作为靶标在制备用于提高早期神经外胚层分化效率的药物中的应用 |
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CN113599522A CN113599522A (zh) | 2021-11-05 |
CN113599522B true CN113599522B (zh) | 2022-09-20 |
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WO2023097422A1 (zh) * | 2021-11-30 | 2023-06-08 | 首都医科大学附属北京口腔医院 | Kdm6b的多肽序列及对间充质干细胞功能的调控应用 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101361984A (zh) * | 2008-09-12 | 2009-02-11 | 清华大学 | Dpys12基因在制备抑制或促进早期神经发生的药物中的应用 |
CN104195102A (zh) * | 2014-09-09 | 2014-12-10 | 安徽医科大学 | 诱导人胚胎干细胞向神经外胚层分化的方法 |
CN105228640A (zh) * | 2013-02-26 | 2016-01-06 | 王荣福 | Phf20和jmjd3组合物及其在肿瘤免疫治疗中的使用方法 |
US20160272579A1 (en) * | 2013-11-05 | 2016-09-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of histone deacetylase |
CN109550051A (zh) * | 2019-01-31 | 2019-04-02 | 上海交通大学医学院附属第九人民医院 | 组蛋白去甲基化酶kdm6a抑制剂在制备肥胖症治疗药物的用途 |
US20190100769A1 (en) * | 2014-10-31 | 2019-04-04 | Massachusetts Institute Of Technology | Massively parallel combinatorial genetics for crispr |
CN109749986A (zh) * | 2019-03-13 | 2019-05-14 | 武汉大学 | 一种由人多能干细胞分化获得胰腺前体细胞及胰岛β细胞的方法 |
CN112641790A (zh) * | 2019-10-09 | 2021-04-13 | 复旦大学 | Jmjd3抑制剂gsk-j1 hcl在制备治疗心肌纤维化药物中的用途 |
-
2021
- 2021-08-03 CN CN202110886224.7A patent/CN113599522B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101361984A (zh) * | 2008-09-12 | 2009-02-11 | 清华大学 | Dpys12基因在制备抑制或促进早期神经发生的药物中的应用 |
CN105228640A (zh) * | 2013-02-26 | 2016-01-06 | 王荣福 | Phf20和jmjd3组合物及其在肿瘤免疫治疗中的使用方法 |
US20160272579A1 (en) * | 2013-11-05 | 2016-09-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of histone deacetylase |
CN104195102A (zh) * | 2014-09-09 | 2014-12-10 | 安徽医科大学 | 诱导人胚胎干细胞向神经外胚层分化的方法 |
US20190100769A1 (en) * | 2014-10-31 | 2019-04-04 | Massachusetts Institute Of Technology | Massively parallel combinatorial genetics for crispr |
CN109550051A (zh) * | 2019-01-31 | 2019-04-02 | 上海交通大学医学院附属第九人民医院 | 组蛋白去甲基化酶kdm6a抑制剂在制备肥胖症治疗药物的用途 |
CN109749986A (zh) * | 2019-03-13 | 2019-05-14 | 武汉大学 | 一种由人多能干细胞分化获得胰腺前体细胞及胰岛β细胞的方法 |
CN112641790A (zh) * | 2019-10-09 | 2021-04-13 | 复旦大学 | Jmjd3抑制剂gsk-j1 hcl在制备治疗心肌纤维化药物中的用途 |
Non-Patent Citations (5)
Title |
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H3K27me3去甲基化酶Jmjd3调节胎鼠肺上皮细胞增殖和分化;冯欢等;《基础医学与临床》;20150930;第35卷(第9期);第1176-1181页 * |
Inhibition of KDM6 activity during murine ESC differentiation induces DNA damage;Christine Hofstetter et al;《Journal of Cell Science》;20161231;第129卷;第788-803页 * |
Utx Is Required for Proper Induction of Ectoderm and Mesoderm during Differentiation of Embryonic Stem Cells;Cristina Morales Torres et al;《PLOS ONE》;20130430;第8卷(第4期);第1-15页 * |
组蛋白去甲基化酶JMJD3 对乳腺癌干细胞的影响;胡楠等;《华西药学杂志》;20181231;第33卷(第5期);第485-489页 * |
组蛋白去甲基化酶JMJD3 研究进展;胡姗等;《生物技术通报》;20171231;第33卷(第9期);第64-72页 * |
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Application publication date: 20211105 Assignee: Harbin Beike Health Technology Co.,Ltd. Assignor: SHENZHEN BEIKE BIO-TECHNOLOGY Co.,Ltd. Contract record no.: X2023440020002 Denomination of invention: Application of KDM6 as a target in the preparation of drugs for improving the efficiency of early neuroectodermal differentiation Granted publication date: 20220920 License type: Common License Record date: 20230116 |
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Effective date of registration: 20230804 Address after: 518063 North Science Building 1502, No. 59 Gaoxin South 9th Road, Gaoxin Community, Yuehai Street, Nanshan District, Shenzhen, Guangdong Province Patentee after: Shenzhen Beikeyuan Cell Technology Co.,Ltd. Address before: 518057 16th floor, Beike building, No. 59, Gaoxin South ninth Road, Yuehai street, Nanshan District, Shenzhen, Guangdong Patentee before: SHENZHEN BEIKE BIO-TECHNOLOGY Co.,Ltd. |