JP2017533920A5 - - Google Patents
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- Publication number
- JP2017533920A5 JP2017533920A5 JP2017524349A JP2017524349A JP2017533920A5 JP 2017533920 A5 JP2017533920 A5 JP 2017533920A5 JP 2017524349 A JP2017524349 A JP 2017524349A JP 2017524349 A JP2017524349 A JP 2017524349A JP 2017533920 A5 JP2017533920 A5 JP 2017533920A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- situ vaccine
- mosaic virus
- cowpea mosaic
- empty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000011065 in-situ storage Methods 0.000 claims 10
- 229960005486 vaccines Drugs 0.000 claims 10
- 241000723655 Cowpea mosaic virus Species 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000002105 nanoparticle Substances 0.000 claims 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000038129 antigens Human genes 0.000 claims 1
- 108091007172 antigens Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 200000000023 metastatic cancer Diseases 0.000 claims 1
- 201000003708 skin melanoma Diseases 0.000 claims 1
Claims (9)
- 対象において癌に直接投与されるエンプティ・ササゲモザイクウイルスナノ粒子の治療有効量を含む、癌の処置における使用のためのインサイチュ・ワクチンであって、前記エンプティ・ササゲモザイクウイルスナノ粒子が、薬物または抗原の送達のためのビヒクルとして使用されない、インサイチュ・ワクチン。
- 前記エンプティ・ササゲモザイクウイルスナノ粒子の治療有効量が、前記対象において免疫応答を刺激するのに有効な量である、請求項１のインサイチュ・ワクチン。
- 前記癌が転移癌である、請求項１のインサイチュ・ワクチン。
- 前記癌が、黒色腫、乳癌、結腸癌、肺癌、および卵巣癌からなる群から選択される、請求項１のインサイチュ・ワクチン。
- 前記癌が肺癌であり、前記エンプティ・ササゲモザイクウイルスナノ粒子が吸入によって投与される、請求項１のインサイチュ・ワクチン。
- 前記癌が皮膚黒色腫であり、前記エンプティ・ササゲモザイクウイルスナノ粒子が腫瘍内投与される、請求項１のインサイチュ・ワクチン。
- 抗癌剤と組み合わせて投与される、請求項１のインサイチュ・ワクチン。
- 前記抗癌剤がドキソルビシンを含む、請求項９のインサイチュ・ワクチン。
- 前記エンプティ・ササゲモザイクウイルスナノ粒子が、カーゴ分子を負荷されるか、またはカーゴ分子に結合される、請求項１のインサイチュ・ワクチン。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076543P | 2014-11-07 | 2014-11-07 | |
| US62/076,543 | 2014-11-07 | ||
| US201562107617P | 2015-01-26 | 2015-01-26 | |
| US62/107,617 | 2015-01-26 | ||
| US201562159389P | 2015-05-11 | 2015-05-11 | |
| US62/159,389 | 2015-05-11 | ||
| PCT/US2015/059675 WO2016073972A1 (en) | 2014-11-07 | 2015-11-09 | Cancer immunotherapy using virus particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533920A JP2017533920A (ja) | 2017-11-16 |
| JP2017533920A5 true JP2017533920A5 (ja) | 2018-11-22 |
| JP6731405B2 JP6731405B2 (ja) | 2020-07-29 |
Family
ID=55909946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017524349A Active JP6731405B2 (ja) | 2014-11-07 | 2015-11-09 | ウイルス粒子を用いた癌免疫療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10639363B2 (ja) |
| EP (2) | EP3957644A1 (ja) |
| JP (1) | JP6731405B2 (ja) |
| CN (1) | CN107001428B (ja) |
| AU (1) | AU2015342790B2 (ja) |
| CA (1) | CA2967336C (ja) |
| WO (2) | WO2016073972A1 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2906260B1 (en) | 2012-10-09 | 2019-06-26 | Case Western Reserve University | Rod-shaped plant virus nanoparticles as imaging agent platforms |
| US9925281B2 (en) | 2014-08-05 | 2018-03-27 | Case Western Reserve University | Coated plant virus imaging agents |
| US11617787B2 (en) | 2014-11-07 | 2023-04-04 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| AU2015342790B2 (en) | 2014-11-07 | 2019-10-03 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| WO2017004123A1 (en) | 2015-06-29 | 2017-01-05 | Case Western Reserve University | Anticancer drug-containing plant virus particles |
| WO2017011826A1 (en) | 2015-07-16 | 2017-01-19 | Case Western Reserve University | Plant virus particles for delivery of antimitotic agents |
| US11433123B2 (en) | 2016-07-21 | 2022-09-06 | Case Western Reserve University | Sustained release cowpea mosaic virus or virus-like particle therapeutic constructs for the treatment of cancer |
| EP3535283A4 (en) | 2016-11-03 | 2020-08-12 | Case Western Reserve University | CONSTRUCTIONS OF FUSION TREATED VIRAL NANOPARTICLES |
| US11590183B2 (en) | 2017-03-10 | 2023-02-28 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| WO2018213587A1 (en) | 2017-05-17 | 2018-11-22 | Case Western Reserve University | Anticancer trail-targeted plant virus particles |
| WO2019084555A1 (en) | 2017-10-27 | 2019-05-02 | Case Western Reserve University | TYMOVIRUS VIRUSES AND VIRAL TYPE PARTICLES USEFUL AS NANOVECTORS FOR IMAGING AND THERAPEUTIC AGENTS |
| US20210030829A1 (en) * | 2018-03-06 | 2021-02-04 | University Of Louisville Research Foundation, Inc. | Methods for treatment of cancer and enhancement of nanoparticle accumulation in tissues |
| US20220145316A1 (en) * | 2019-03-01 | 2022-05-12 | The Regents Of The University Of California | Cancer immunotherapy |
| US11390853B2 (en) | 2019-04-26 | 2022-07-19 | Case Western Reserve University | Freeze dried viral nanoparticle constructs |
| US11896676B2 (en) | 2019-08-07 | 2024-02-13 | Case Western Reserve University | Targeting cancer cells and tissue using filamentous plant virus particles |
| CN110859861A (zh) * | 2019-12-04 | 2020-03-06 | 武汉工程大学 | 植物病原微生物杀灭癌细胞或艾滋病病毒的用途 |
| US20240066108A1 (en) * | 2021-01-08 | 2024-02-29 | The Regents Of The University Of California | Ovarian cancer vaccine |
| WO2023139103A1 (en) * | 2022-01-19 | 2023-07-27 | Universität Bern | Compositions of virus-like particles and microcrystalline tyrosine |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004606A (en) | 1986-09-24 | 1991-04-02 | Hybritech Incorporated | Non-covalent antibody-anthracycline immunocomplexes |
| GB9921337D0 (en) * | 1999-09-09 | 1999-11-10 | Axis Genetics Plc | Modified plant viruses |
| GB9924351D0 (en) * | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| PL224150B1 (pl) | 2002-05-02 | 2016-11-30 | Wyeth Corp | Kompozycja zawierająca koniugat leku obejmujący pochodne kalicheamycyny i przeciwciało, oraz kompozycja farmaceutyczna ją zawierająca |
| CA2435632A1 (en) * | 2003-07-21 | 2005-01-21 | Warren Hugh Finlay | Formulation of powder containing nanoparticles for aerosol delivery to the lung |
| US20070248617A1 (en) | 2004-06-02 | 2007-10-25 | Bachmann Martin F | Medical Uses of Carrier Conjugates of Non-Human Tnf -Peptides |
| US20070258889A1 (en) | 2005-11-09 | 2007-11-08 | Montana State University | Novel nanoparticles and use thereof |
| BRPI0619089A2 (pt) | 2005-12-02 | 2011-09-13 | Dow Global Tecnologies Inc | partìculas virais de plantas e métodos para a inativação da mesma |
| US7771339B2 (en) * | 2006-05-31 | 2010-08-10 | Ab Mimator | Method and system for radiotherapy treatment |
| US20100183504A1 (en) | 2007-06-14 | 2010-07-22 | Fanqing Frank Chen | Multimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics |
| WO2016149264A1 (en) | 2015-03-18 | 2016-09-22 | The Johns Hopkins University | Compositions and methods for sensitizing cells to trail-induced apoptosis |
| US20130236491A1 (en) | 2010-12-09 | 2013-09-12 | Iosif Grigorievich Atabekov | Spherical nano and microparticles derived from plant viruses for the display of foreign proteins or epitopes |
| JP5799294B2 (ja) | 2011-07-29 | 2015-10-21 | 株式会社ユーテック | 強誘電体膜 |
| WO2013158620A1 (en) | 2012-04-16 | 2013-10-24 | North Carolina State University | Nanotechnology system for agricultural applications |
| ES2932952T3 (es) | 2012-04-24 | 2023-01-30 | Ohio State Innovation Foundation | Composiciones y métodos para tratar y prevenir el síndrome reproductivo y respiratorio porcino |
| US10232057B2 (en) | 2012-05-31 | 2019-03-19 | Case Western Reserve University | Targeting cancer cells and tissue using filamentous plant virus particles |
| EP2906260B1 (en) | 2012-10-09 | 2019-06-26 | Case Western Reserve University | Rod-shaped plant virus nanoparticles as imaging agent platforms |
| EP3046565A4 (en) * | 2013-09-19 | 2017-06-28 | Folia Biotech Inc. | Papaya mosaic virus and virus-like particles in cancer therapy |
| WO2015188110A1 (en) | 2014-06-05 | 2015-12-10 | The Johns Hopkins University | Reversible pegylation for screeing of therapeutic proteins in vivo |
| EP3174976B1 (en) | 2014-08-01 | 2020-10-28 | GPB Scientific, Inc. | Methods and systems for processing particles |
| US9925281B2 (en) | 2014-08-05 | 2018-03-27 | Case Western Reserve University | Coated plant virus imaging agents |
| AU2015342790B2 (en) * | 2014-11-07 | 2019-10-03 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| WO2017004123A1 (en) * | 2015-06-29 | 2017-01-05 | Case Western Reserve University | Anticancer drug-containing plant virus particles |
| WO2017011826A1 (en) | 2015-07-16 | 2017-01-19 | Case Western Reserve University | Plant virus particles for delivery of antimitotic agents |
| WO2018213587A1 (en) | 2017-05-17 | 2018-11-22 | Case Western Reserve University | Anticancer trail-targeted plant virus particles |
-
2015
- 2015-11-09 AU AU2015342790A patent/AU2015342790B2/en active Active
- 2015-11-09 EP EP21201960.8A patent/EP3957644A1/en active Pending
- 2015-11-09 JP JP2017524349A patent/JP6731405B2/ja active Active
- 2015-11-09 WO PCT/US2015/059675 patent/WO2016073972A1/en active Application Filing
- 2015-11-09 CA CA2967336A patent/CA2967336C/en active Active
- 2015-11-09 CN CN201580063662.6A patent/CN107001428B/zh active Active
- 2015-11-09 EP EP15857504.3A patent/EP3215520B1/en active Active
-
2017
- 2017-05-08 US US15/589,677 patent/US10639363B2/en active Active
-
2018
- 2018-05-08 WO PCT/US2018/031661 patent/WO2018208828A1/en active Application Filing
-
2020
- 2020-04-17 US US16/851,778 patent/US11260121B2/en active Active
-
2022
- 2022-02-25 US US17/680,813 patent/US11730803B2/en active Active
-
2023
- 2023-08-22 US US18/236,676 patent/US20240024452A1/en active Pending
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