JP2015506352A5 - - Google Patents
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- Publication number
- JP2015506352A5 JP2015506352A5 JP2014549212A JP2014549212A JP2015506352A5 JP 2015506352 A5 JP2015506352 A5 JP 2015506352A5 JP 2014549212 A JP2014549212 A JP 2014549212A JP 2014549212 A JP2014549212 A JP 2014549212A JP 2015506352 A5 JP2015506352 A5 JP 2015506352A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- formulation according
- treatment
- antagonist
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 230000003042 antagnostic Effects 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- 230000033115 angiogenesis Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000009956 Adenocarcinoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 108010017642 Integrin alpha2beta1 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 230000017066 negative regulation of growth Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Claims (15)
- 単独で投与されたときの治療上の有効量のα５β１アンタゴニストより少ない量のα５β１アンタゴニスト、単独で投与されたときの治療上の有効量のα５β１アンタゴニストより少ない量のα２β１アンタゴニストおよび薬学的に許容可能な担体を含む医薬製剤。
- ＶＬＯ４およびＶＰ１２（ＥＣＬ１２）を含む、請求項１に記載の医薬製剤。
- α５β１アンタゴニストがＶＬＯ４であり、α２β１アンタゴニストがα２β１インテグリン活性を遮断する抗体である、請求項１に記載の医薬製剤。
- 対象における血管新生の阻害における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 腫瘍浸潤の阻害における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 固形腫瘍の成長の阻害における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 対象における血管新生を逆行させることにおける使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 肺がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 腺がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 卵巣がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 前立腺がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 膀胱がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 乳がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 膵臓がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
- 結腸がんの処置における使用のための、請求項１〜３のいずれか一項に記載の医薬製剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/374,369 | 2011-12-22 | ||
| US13/374,369 US8946159B2 (en) | 2011-12-22 | 2011-12-22 | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
| PCT/US2012/070399 WO2013096335A1 (en) | 2011-12-22 | 2012-12-18 | Administration of an antagonist of alpha 5 beta 1 for anti-antiogenesis and cancer treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506352A JP2015506352A (ja) | 2015-03-02 |
| JP2015506352A5 true JP2015506352A5 (ja) | 2016-05-19 |
| JP6224615B2 JP6224615B2 (ja) | 2017-11-01 |
Family
ID=48655153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549212A Active JP6224615B2 (ja) | 2011-12-22 | 2012-12-18 | 抗血管新生およびがん処置のためのα５β１のアンタゴニストの投与 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8946159B2 (ja) |
| EP (2) | EP3777877A1 (ja) |
| JP (1) | JP6224615B2 (ja) |
| CN (1) | CN104159596B (ja) |
| HK (1) | HK1203391A1 (ja) |
| WO (1) | WO2013096335A1 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110319335A1 (en) | 2010-06-23 | 2011-12-29 | Xiaodong Feng | Combined administration of integrin receptor antagonists for anti-angiogenic therapy |
| US8946159B2 (en) * | 2011-12-22 | 2015-02-03 | California Northstate College Of Pharmacy, Llc | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
| CA2958906C (en) * | 2014-08-22 | 2021-05-04 | National Cheng Kung University | Disintegrin variants and pharmaceutical uses thereof |
| CA3092345A1 (en) | 2018-03-13 | 2019-09-19 | The Regents Of The University Of California | Inhibitors of integrin alpha 2 beta 1 and methods of use |
| CN115916176A (zh) | 2020-05-01 | 2023-04-04 | 加利福尼亚大学董事会 | α2β1整联蛋白的抑制剂和其使用方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993019088A1 (en) | 1992-03-17 | 1993-09-30 | Board Of Regents, The University Of Texas System | Neurotrophic peptides |
| PT1075277E (pt) * | 1998-05-08 | 2009-05-08 | Univ California | Métodos para detectar e inibir a angiogénese |
| US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
| NZ521437A (en) * | 2000-02-25 | 2004-04-30 | Immunex Corp | Integrin antagonists suitable as inhibitors of angiogenesis |
| US20040121031A1 (en) | 2002-12-09 | 2004-06-24 | Muhammed Majeed | Novel topical skin care and nutraceutical applications of Glabridin or extracts containing a defined amount (4-90%) of Glabridin |
| US7101707B2 (en) | 2002-12-23 | 2006-09-05 | Cedars-Sinai Medical Center | Secondary sprouting for isolation and expansion of endothelial sprout cells and endothelial precursor cells from a mixed population and for screening substances |
| EP1755659B1 (en) | 2004-03-24 | 2011-11-02 | Abbott Biotherapeutics Corp. | Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation |
| UA88294C2 (ru) * | 2004-03-24 | 2009-10-12 | Фейсит Биотек Корпорейшен | ПРИМЕНЕНИЕ АНТИ-α5β1 АНТИТЕЛ ДЛЯ УГНЕТЕНИЯ ПРОЛИФЕРАЦИИ РАКОВЫХ КЛЕТОК |
| JP2008542445A (ja) * | 2005-06-07 | 2008-11-27 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | α２β１／ＧＰＩａ−ＩＩａインテグリン阻害剤 |
| EP2243488B1 (en) | 2006-01-19 | 2013-08-14 | Eyegene Inc. | Pharmaceutical composition for treating vascular-related diseases comprising peptide |
| JP2009530382A (ja) | 2006-03-23 | 2009-08-27 | シェーリング コーポレイション | Ｈｃｖプロテアーゼインヒビターとｃｙｐ３ａ４インヒビターとの組み合わせ、および関連する処置方法 |
| US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
| US20080267978A1 (en) | 2006-08-28 | 2008-10-30 | Mary Zutter | Anti-angiogenic targets for cancer therapy |
| CN104225613A (zh) | 2008-03-14 | 2014-12-24 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
| US20100105644A1 (en) | 2008-10-27 | 2010-04-29 | The Regents Of The University Of Michigan | Botanical composition for enhanced skin repair and uses thereof |
| EP2358378A4 (en) | 2008-12-01 | 2012-08-08 | Laila Pharmaceuticals Pvt Ltd | TOPICAL FORMULATION FOR THE TREATMENT OF INFLAMMATORY DISEASE, SKIN AND SLAUGHTER DISEASES AND SIMILAR DISEASES |
| WO2011146842A1 (en) | 2010-05-20 | 2011-11-24 | Temple University - Of The Commonwealth System Of Higher Education | Process for synthesis of silane dipeptide analogs |
| US20110311335A1 (en) * | 2010-06-21 | 2011-12-22 | Douglas Wike | Removable fastener |
| US20110319335A1 (en) * | 2010-06-23 | 2011-12-29 | Xiaodong Feng | Combined administration of integrin receptor antagonists for anti-angiogenic therapy |
| IL210587A0 (en) | 2011-01-12 | 2011-03-31 | Adel Jamil Hidmi | Natural preparation for treatment of skin sores and lesions |
| US8946159B2 (en) * | 2011-12-22 | 2015-02-03 | California Northstate College Of Pharmacy, Llc | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
-
2011
- 2011-12-22 US US13/374,369 patent/US8946159B2/en active Active
-
2012
- 2012-11-07 US US13/671,462 patent/US8815805B2/en active Active
- 2012-12-18 EP EP20194742.1A patent/EP3777877A1/en active Pending
- 2012-12-18 CN CN201280070464.9A patent/CN104159596B/zh active Active
- 2012-12-18 JP JP2014549212A patent/JP6224615B2/ja active Active
- 2012-12-18 WO PCT/US2012/070399 patent/WO2013096335A1/en active Application Filing
- 2012-12-18 EP EP12859266.4A patent/EP2793924B1/en active Active
-
2014
- 2014-12-18 US US14/575,266 patent/US10722555B2/en active Active
-
2015
- 2015-04-27 HK HK15104052.0A patent/HK1203391A1/xx unknown
-
2020
- 2020-06-12 US US16/899,859 patent/US11318184B2/en active Active
-
2022
- 2022-03-25 US US17/704,522 patent/US20220226431A1/en active Pending
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