JP2017531659A - Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方 - Google Patents

Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方 Download PDF

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Publication number
JP2017531659A
JP2017531659A JP2017518466A JP2017518466A JP2017531659A JP 2017531659 A JP2017531659 A JP 2017531659A JP 2017518466 A JP2017518466 A JP 2017518466A JP 2017518466 A JP2017518466 A JP 2017518466A JP 2017531659 A JP2017531659 A JP 2017531659A
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Prior art keywords
pharmaceutical composition
factor
composition according
blood
colloidal particles
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Japanese (ja)
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JP2017531659A5 (cg-RX-API-DMAC10.html
Inventor
ヘンリー，ウィリアム
Original Assignee
カンタブ バイオファーマシューティカルズ パテンツ リミテッド
カンタブ バイオファーマシューティカルズ パテンツ リミテッド
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Publication of JP2017531659A publication Critical patent/JP2017531659A/ja
Publication of JP2017531659A5 publication Critical patent/JP2017531659A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2017518466A 2014-10-06 2015-10-06 Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方 Pending JP2017531659A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1417589.7 2014-10-06
GBGB1417589.7A GB201417589D0 (en) 2014-10-06 2014-10-06 Pharmaceutical Formulations
PCT/EP2015/073003 WO2016055447A1 (en) 2014-10-06 2015-10-06 Pharmaceutical formulations of pegylated liposomes and blood coagulation factors

Related Child Applications (1)

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JP2020129101A Division JP2020183446A (ja) 2014-10-06 2020-07-30 Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方

Publications (2)

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JP2017531659A true JP2017531659A (ja) 2017-10-26
JP2017531659A5 JP2017531659A5 (cg-RX-API-DMAC10.html) 2018-11-15

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JP2017518466A Pending JP2017531659A (ja) 2014-10-06 2015-10-06 Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方
JP2020129101A Pending JP2020183446A (ja) 2014-10-06 2020-07-30 Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方
JP2022168146A Active JP7573582B2 (ja) 2014-10-06 2022-10-20 Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方

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JP2022168146A Active JP7573582B2 (ja) 2014-10-06 2022-10-20 Ｐｅｇ化リポソームおよび血液凝固因子の製剤処方

Country Status (17)

Country Link
US (2) US20170304203A1 (cg-RX-API-DMAC10.html)
EP (1) EP3204034B9 (cg-RX-API-DMAC10.html)
JP (3) JP2017531659A (cg-RX-API-DMAC10.html)
AU (1) AU2015330102B2 (cg-RX-API-DMAC10.html)
BR (1) BR112017007031A2 (cg-RX-API-DMAC10.html)
CA (1) CA2994891C (cg-RX-API-DMAC10.html)
CY (1) CY1126253T1 (cg-RX-API-DMAC10.html)
ES (1) ES2954134T3 (cg-RX-API-DMAC10.html)
GB (1) GB201417589D0 (cg-RX-API-DMAC10.html)
HR (1) HRP20230985T1 (cg-RX-API-DMAC10.html)
HU (1) HUE063656T2 (cg-RX-API-DMAC10.html)
MX (1) MX384517B (cg-RX-API-DMAC10.html)
PL (1) PL3204034T3 (cg-RX-API-DMAC10.html)
RS (1) RS64461B1 (cg-RX-API-DMAC10.html)
RU (1) RU2737291C2 (cg-RX-API-DMAC10.html)
SM (1) SMT202300271T1 (cg-RX-API-DMAC10.html)
WO (1) WO2016055447A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024532163A (ja) * 2021-08-17 2024-09-05 カンタブ バイオファーマシューティカルズ パテンツ リミテッド 血友病ａの治療における使用のための修飾コロイド粒子

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201417589D0 (en) * 2014-10-06 2014-11-19 Cantab Biopharmaceuticals Patents Ltd Pharmaceutical Formulations
WO2017204896A1 (en) * 2016-05-26 2017-11-30 Becton, Dickinson And Company Methods and devices for liposome preparation by centrifugation

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JP2002512947A (ja) * 1998-04-27 2002-05-08 オッパーバス・ホールディング・ビー・ブイ 第ｖｉｉｉ因子及び中性リポソームを含有する薬学的組成物
JP2003531862A (ja) * 2000-05-03 2003-10-28 ノボ ノルディスク アクティーゼルスカブ 凝固因子ｖｉｉの皮下投与
JP2006523683A (ja) * 2003-04-15 2006-10-19 オッパーバス・ホールディング・ビー・ブイ タンパク質及び／またはポリペプチド及びコロイド粒子を含む医薬組成物
JP2008544990A (ja) * 2005-06-29 2008-12-11 ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク 低免疫原性蛋白質−脂質複合体に関する組成物および方法
JP2010514819A (ja) * 2007-01-03 2010-05-06 ノボ ノルディスク ヘルス ケア アーゲー 凝固第ｖｉｉ因子関連ポリペプチドの皮下投与
JP2013525415A (ja) * 2010-04-30 2013-06-20 カンタブ バイオファーマシューティカルズ パテンツ リミテッド 共役血液凝固第ＶＩＩａ因子
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JP2013525415A (ja) * 2010-04-30 2013-06-20 カンタブ バイオファーマシューティカルズ パテンツ リミテッド 共役血液凝固第ＶＩＩａ因子
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024532163A (ja) * 2021-08-17 2024-09-05 カンタブ バイオファーマシューティカルズ パテンツ リミテッド 血友病ａの治療における使用のための修飾コロイド粒子

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Publication number Publication date
GB201417589D0 (en) 2014-11-19
MX2017004378A (es) 2018-02-09
US20190060235A1 (en) 2019-02-28
RU2737291C2 (ru) 2020-11-26
HUE063656T2 (hu) 2024-01-28
JP7573582B2 (ja) 2024-10-25
CY1126253T1 (el) 2026-02-25
PL3204034T3 (pl) 2023-11-06
CA2994891A1 (en) 2016-04-14
BR112017007031A2 (pt) 2018-01-30
JP2023002687A (ja) 2023-01-10
CA2994891C (en) 2023-04-04
EP3204034A1 (en) 2017-08-16
RU2017115831A3 (cg-RX-API-DMAC10.html) 2019-05-06
RU2017115831A (ru) 2018-11-14
EP3204034C0 (en) 2023-06-07
RS64461B1 (sr) 2023-09-29
US20170304203A1 (en) 2017-10-26
AU2015330102A1 (en) 2017-05-25
US11484499B2 (en) 2022-11-01
MX384517B (es) 2025-03-14
ES2954134T3 (es) 2023-11-20
AU2015330102B2 (en) 2021-01-28
EP3204034B1 (en) 2023-06-07
SMT202300271T1 (it) 2023-09-06
EP3204034B9 (en) 2023-10-04
JP2020183446A (ja) 2020-11-12
WO2016055447A1 (en) 2016-04-14
HRP20230985T1 (hr) 2023-12-08

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