JP2017530943A5 - - Google Patents
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- Publication number
- JP2017530943A5 JP2017530943A5 JP2017506931A JP2017506931A JP2017530943A5 JP 2017530943 A5 JP2017530943 A5 JP 2017530943A5 JP 2017506931 A JP2017506931 A JP 2017506931A JP 2017506931 A JP2017506931 A JP 2017506931A JP 2017530943 A5 JP2017530943 A5 JP 2017530943A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- hydrocarbyl
- hydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000004678 hydrides Chemical class 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 3
- 150000001540 azides Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000852 azido group Chemical class *N=[N+]=[N-] 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- NQMWSLIHWDKBNB-UHXSJXRISA-N CC(/C=C\C(\CCOc1cc(C(NCc(cc2)ccc2Cl)=O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=C/C)O Chemical compound CC(/C=C\C(\CCOc1cc(C(NCc(cc2)ccc2Cl)=O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=C/C)O NQMWSLIHWDKBNB-UHXSJXRISA-N 0.000 description 1
- UDONUCIRFUXGIS-UHFFFAOYSA-N CC(C)(CC(NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O)[IH]C)Cc(cc1)ccc1F Chemical compound CC(C)(CC(NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O)[IH]C)Cc(cc1)ccc1F UDONUCIRFUXGIS-UHFFFAOYSA-N 0.000 description 1
- 0 CC(C*(C)Cc1ccccc1)NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O Chemical compound CC(C*(C)Cc1ccccc1)NC(c(cc1OCCc(cc2)ccc2O)ccc1NC(c1cc(cccc2)c2[o]1)=O)=O 0.000 description 1
- AMMBMVABWQUVRF-UHFFFAOYSA-N Oc1ccc(CCOc2cc(C(NCCc3cc(Cl)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 Chemical compound Oc1ccc(CCOc2cc(C(NCCc3cc(Cl)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 AMMBMVABWQUVRF-UHFFFAOYSA-N 0.000 description 1
- MIRCOJZCTWWZPT-UHFFFAOYSA-N Oc1ccc(CCOc2cc(C(NCc3cc(F)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 Chemical compound Oc1ccc(CCOc2cc(C(NCc3cc(F)ccc3)=O)ccc2NC(c2cc(cccc3)c3[o]2)=O)cc1 MIRCOJZCTWWZPT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033918P | 2014-08-06 | 2014-08-06 | |
| US62/033,918 | 2014-08-06 | ||
| PCT/US2015/043830 WO2016022700A2 (en) | 2014-08-06 | 2015-08-05 | Tlr-independent small molecule adjuvants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530943A JP2017530943A (ja) | 2017-10-19 |
| JP2017530943A5 true JP2017530943A5 (https=) | 2017-12-14 |
| JP6353159B2 JP6353159B2 (ja) | 2018-07-04 |
Family
ID=55264758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506931A Active JP6353159B2 (ja) | 2014-08-06 | 2015-08-05 | Ｔｌｒ非依存性低分子アジュバント |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9918959B2 (https=) |
| EP (1) | EP3177601B1 (https=) |
| JP (1) | JP6353159B2 (https=) |
| AU (1) | AU2015301100B2 (https=) |
| CA (1) | CA2957372C (https=) |
| ES (1) | ES2944541T3 (https=) |
| WO (1) | WO2016022700A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102522730B1 (ko) * | 2016-06-29 | 2023-04-19 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 디프로보심: 새로운 강력한 부류의 tlr 작용제 |
| CN113164445A (zh) * | 2018-08-02 | 2021-07-23 | 得克萨斯系统大学评议会 | Tlr1/2激动剂地普罗考姆的佐剂作用协同增效检查点抑制性抗体以消除疾病 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2577514T3 (es) * | 2005-08-22 | 2016-07-15 | The Regents Of The University Of California | Antagonistas de TLR |
| ES2552471T3 (es) | 2007-02-07 | 2015-11-30 | The Regents Of The University Of California | Conjugados de agonistas de TLR sintéticos y usos de los mismos |
| WO2008112939A2 (en) * | 2007-03-13 | 2008-09-18 | Board Of Regents, The University Of Texas System | Composition and method for making oligo-benzamide compounds |
| PT2268618E (pt) * | 2008-03-03 | 2015-10-12 | Novartis Ag | Compostos e composições moduladores da actividade tlr |
-
2015
- 2015-08-05 US US15/502,117 patent/US9918959B2/en active Active
- 2015-08-05 EP EP15830729.8A patent/EP3177601B1/en active Active
- 2015-08-05 ES ES15830729T patent/ES2944541T3/es active Active
- 2015-08-05 CA CA2957372A patent/CA2957372C/en active Active
- 2015-08-05 WO PCT/US2015/043830 patent/WO2016022700A2/en not_active Ceased
- 2015-08-05 JP JP2017506931A patent/JP6353159B2/ja active Active
- 2015-08-05 AU AU2015301100A patent/AU2015301100B2/en active Active