JP2017529365A - 大環状ｌｒｒｋ２キナーゼ阻害剤 - Google Patents

大環状ｌｒｒｋ２キナーゼ阻害剤 Download PDF

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Publication number
JP2017529365A
JP2017529365A JP2017515823A JP2017515823A JP2017529365A JP 2017529365 A JP2017529365 A JP 2017529365A JP 2017515823 A JP2017515823 A JP 2017515823A JP 2017515823 A JP2017515823 A JP 2017515823A JP 2017529365 A JP2017529365 A JP 2017529365A
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JP2017529365A5 (cg-RX-API-DMAC7.html
Inventor
ホフラック，ジャン
ブロム，ペトラ
ラヴェルニュ，オリヴィエ
ゴメス，シルヴィー
Original Assignee
オンコデザイン エス．ア．
オンコデザイン エス．ア．
イプセン ファーマ エス．ア．エス
イプセン ファーマ エス．ア．エス
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Publication of JP2017529365A publication Critical patent/JP2017529365A/ja
Publication of JP2017529365A5 publication Critical patent/JP2017529365A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2017515823A 2014-09-17 2015-09-17 大環状ｌｒｒｋ２キナーゼ阻害剤 Pending JP2017529365A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14290279.0 2014-09-17
EP14290279 2014-09-17
PCT/EP2015/071349 WO2016042089A1 (en) 2014-09-17 2015-09-17 Macrocyclic lrrk2 kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2017529365A true JP2017529365A (ja) 2017-10-05
JP2017529365A5 JP2017529365A5 (cg-RX-API-DMAC7.html) 2018-09-13

Family

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Family Applications (1)

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JP2017515823A Pending JP2017529365A (ja) 2014-09-17 2015-09-17 大環状ｌｒｒｋ２キナーゼ阻害剤

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Country Link
US (1) US10377772B2 (cg-RX-API-DMAC7.html)
EP (1) EP3194405B1 (cg-RX-API-DMAC7.html)
JP (1) JP2017529365A (cg-RX-API-DMAC7.html)
KR (1) KR20170048599A (cg-RX-API-DMAC7.html)
CN (1) CN107108641A (cg-RX-API-DMAC7.html)
AU (1) AU2015316801B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017005299A2 (cg-RX-API-DMAC7.html)
CA (1) CA2960777A1 (cg-RX-API-DMAC7.html)
DK (1) DK3194405T3 (cg-RX-API-DMAC7.html)
EA (1) EA032838B1 (cg-RX-API-DMAC7.html)
ES (1) ES2717510T3 (cg-RX-API-DMAC7.html)
HU (1) HUE043972T2 (cg-RX-API-DMAC7.html)
IL (1) IL251054B (cg-RX-API-DMAC7.html)
MX (1) MX2017003470A (cg-RX-API-DMAC7.html)
PL (1) PL3194405T3 (cg-RX-API-DMAC7.html)
SG (1) SG11201701936WA (cg-RX-API-DMAC7.html)
TR (1) TR201904514T4 (cg-RX-API-DMAC7.html)
TW (1) TW201625639A (cg-RX-API-DMAC7.html)
WO (1) WO2016042089A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201701841B (cg-RX-API-DMAC7.html)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2023516551A (ja) * 2020-01-31 2023-04-20 オンコデザイン エス．ア． 大環状ｒｉｐ２－キナーゼ阻害剤

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111221514B (zh) * 2020-01-13 2023-03-03 陕西心像信息科技有限公司 基于OsgEarth的三维可视化组件实现方法及系统
CN115996932B (zh) 2020-05-06 2025-08-01 法国施维雅药厂 新的大环lrrk2激酶抑制剂
IL305877A (en) 2021-03-18 2023-11-01 Servier Lab Macrocyclic LRRK2 kinase inhibitors
WO2023064768A1 (en) * 2021-10-11 2023-04-20 Baylor College Of Medicine G-protein-coupled receptor regulators and methods of use thereof
EP4422750A1 (en) 2021-10-27 2024-09-04 H. Lundbeck A/S Lrrk2 inhibitors
WO2023222005A1 (zh) * 2022-05-18 2023-11-23 上海翊石医药科技有限公司 一种芳杂环类化合物及其中间体、药物组合物和用途
WO2024056775A1 (en) * 2022-09-15 2024-03-21 H. Lundbeck A/S Macrocyclic leucine-rich repeat kinase 2 (lrrk2) inhibitors
WO2024218296A1 (en) * 2023-04-20 2024-10-24 H. Lundbeck A/S Combination treatments comprising administration of leucine-rich repeat kinase 2 (lrrk2) inhibitors
AR132488A1 (es) * 2023-04-20 2025-07-02 H Lundbeck As Inhibidores de la cinasa con repeticiones ricas en leucina 2 (lrrk2)
TW202442235A (zh) * 2023-04-20 2024-11-01 丹麥商Ｈ 朗德貝克公司 富白胺酸重複激酶2（lrrk2）抑制劑
AR132486A1 (es) * 2023-04-20 2025-07-02 H Lundbeck As Inhibidores de la cinasa con repeticiones ricas en leucina 2 (lrrk2)

Citations (3)

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WO2013001310A1 (en) * 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
WO2013046029A1 (en) * 2011-09-30 2013-04-04 Ipsen Pharma S.A.S. Macrocyclic lrrk2 kinase inhibitors
WO2013045653A1 (en) * 2011-09-30 2013-04-04 Oncodesign S.A. Macrocyclic flt3 kinase inhibitors

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IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
CZ289214B6 (cs) 1993-10-01 2001-12-12 Astra Aktiebolag Způsob zpracování jemně děleného práąkového léčiva, zařízení k provádění tohoto způsobu a aglomeráty vyrobené tímto způsobem
EP0729758A3 (en) 1995-03-02 1997-10-29 Pfizer Pyrazolopyrimidines and pyrrolopyrimidines for the treatment of neuronal and other diseases
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
DK0915880T3 (da) 1996-07-24 2008-02-11 Bristol Myers Squibb Pharma Co Azolotriaziner og pyrimidiner
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6194410B1 (en) 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
KR100843281B1 (ko) 2000-12-28 2008-07-09 오노 야꾸힝 고교 가부시키가이샤 삼환식 복소환 유도체 화합물 및 그 화합물을 유효성분으로 하는 의약
WO2002100399A1 (en) * 2001-06-12 2002-12-19 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
EP2316927B1 (en) 2004-10-21 2014-11-05 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Kaspp (lrrk2) gene, its production and use for the detection and treatment of neurodegenerative disorders
NO323175B1 (no) 2004-12-23 2007-01-15 Jan O Aasly Framgangsmate for a pavise en mutasjon som forarsaker arvelig parkinsonisme
FI123725B (fi) 2005-08-01 2013-10-15 Reijo Viljanen Menetelmä sahalaitteen terän jännittämiseksi ja ohjaamiseksi sekä ohjaus- ja jännityslaitteet
US8143255B2 (en) 2005-11-16 2012-03-27 S*Bio Pte Ltd. Heteroalkyl linked pyrimidine derivatives
WO2009127642A2 (en) 2008-04-15 2009-10-22 Cellzome Limited Use of lrrk2 inhibitors for neurodegenerative diseases
BR112012006859A2 (pt) 2009-09-29 2019-09-24 Glaxo Group Ltd compostos
PT3205654T (pt) * 2010-05-20 2019-04-22 Array Biopharma Inc Compostos macrocíclicos como inibidores de cinases trk

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Publication number Priority date Publication date Assignee Title
WO2013001310A1 (en) * 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
WO2013046029A1 (en) * 2011-09-30 2013-04-04 Ipsen Pharma S.A.S. Macrocyclic lrrk2 kinase inhibitors
WO2013045653A1 (en) * 2011-09-30 2013-04-04 Oncodesign S.A. Macrocyclic flt3 kinase inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023516551A (ja) * 2020-01-31 2023-04-20 オンコデザイン エス．ア． 大環状ｒｉｐ２－キナーゼ阻害剤
JP7713461B2 (ja) 2020-01-31 2025-07-25 オンコデザイン プリシジャン メディシン（オーピーエム） 大環状ｒｉｐ２－キナーゼ阻害剤

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Publication number Publication date
US20170240565A1 (en) 2017-08-24
IL251054B (en) 2019-03-31
KR20170048599A (ko) 2017-05-08
AU2015316801A1 (en) 2017-04-27
CA2960777A1 (en) 2016-03-24
EP3194405B1 (en) 2018-12-26
TW201625639A (zh) 2016-07-16
IL251054A0 (en) 2017-04-30
PL3194405T4 (pl) 2019-07-31
EA032838B1 (ru) 2019-07-31
US10377772B2 (en) 2019-08-13
DK3194405T3 (en) 2019-04-15
MX2017003470A (es) 2017-08-07
ES2717510T3 (es) 2019-06-21
ZA201701841B (en) 2019-08-28
EA201790626A1 (ru) 2017-07-31
SG11201701936WA (en) 2017-04-27
WO2016042089A1 (en) 2016-03-24
CN107108641A (zh) 2017-08-29
BR112017005299A2 (pt) 2017-12-12
PL3194405T3 (pl) 2019-07-31
TR201904514T4 (tr) 2019-04-22
AU2015316801B2 (en) 2019-03-07
EP3194405A1 (en) 2017-07-26
HUE043972T2 (hu) 2019-09-30

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