JP2017528431A - 器官再生のための内因性回腸ブレーキホルモン経路の活性化、並びに関連する組成物、治療方法、診断、及び制御システム - Google Patents

器官再生のための内因性回腸ブレーキホルモン経路の活性化、並びに関連する組成物、治療方法、診断、及び制御システム Download PDF

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JP2017528431A
JP2017528431A JP2017502821A JP2017502821A JP2017528431A JP 2017528431 A JP2017528431 A JP 2017528431A JP 2017502821 A JP2017502821 A JP 2017502821A JP 2017502821 A JP2017502821 A JP 2017502821A JP 2017528431 A JP2017528431 A JP 2017528431A
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metabolic syndrome
glucose
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inhibitor
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JP2017528431A5 (OSRAM
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ジェローム シェンターク，
ジェローム シェンターク，
ジョセフ， エム． フェイヤッド，
ジョセフ， エム． フェイヤッド，
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JP2017502821A 2014-07-17 2015-07-17 器官再生のための内因性回腸ブレーキホルモン経路の活性化、並びに関連する組成物、治療方法、診断、及び制御システム Pending JP2017528431A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462025714P 2014-07-17 2014-07-17
US62/025,714 2014-07-17
PCT/US2015/040879 WO2016011335A1 (en) 2014-07-17 2015-07-17 Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems

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JP2017528431A true JP2017528431A (ja) 2017-09-28
JP2017528431A5 JP2017528431A5 (OSRAM) 2018-08-16

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JP2017502821A Pending JP2017528431A (ja) 2014-07-17 2015-07-17 器官再生のための内因性回腸ブレーキホルモン経路の活性化、並びに関連する組成物、治療方法、診断、及び制御システム

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US (1) US20170173060A1 (OSRAM)
EP (1) EP3169331A4 (OSRAM)
JP (1) JP2017528431A (OSRAM)
KR (1) KR20170026635A (OSRAM)
CN (1) CN106687119A (OSRAM)
AU (1) AU2015289511A1 (OSRAM)
CA (1) CA2955425A1 (OSRAM)
IL (1) IL250170A0 (OSRAM)
WO (1) WO2016011335A1 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112074197A (zh) * 2018-03-07 2020-12-11 安纳生物科技有限公司 用于ii型糖尿病及用于提供随着时间的持续的能量释放的组合物
JP2022545037A (ja) * 2019-08-23 2022-10-24 ブリッジ バイオセラピューティクス インコーポレイテッド パルミトイル－ｌ－プロリル－ｌ－プロリル－グリシル－ｌ－チロシンナトリウムを含む薬学的製剤及びこの製造方法
JP2023078291A (ja) * 2018-01-12 2023-06-06 メティメディ ファーマシューティカルズ カンパニー リミテッド 慢性炎症性疾患を処置する方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8999721B2 (en) 2009-10-23 2015-04-07 Therabrake, Inc. Method and system to provide personalized pharmaceutical compositions and dosages
US20180099001A1 (en) 2011-04-29 2018-04-12 Volant Holdings Gmbh Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of complications thereof
WO2016183535A1 (en) 2015-05-14 2016-11-17 University Of Puerto Rico Methods for restoring microbiota of newborns
EP3393496B1 (en) 2015-12-23 2023-10-11 The Johns Hopkins University Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions
US11564667B2 (en) 2015-12-28 2023-01-31 New York University Device and method of restoring microbiota of newborns
US10398389B1 (en) 2016-04-11 2019-09-03 Pricewaterhousecoopers Llp System and method for physiological health simulation
WO2017203367A2 (en) * 2016-05-22 2017-11-30 Volant Holdings Gmbh Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of complications thereof
AU2018219367A1 (en) * 2017-02-10 2019-09-19 Innovate Biopharmaceuticals, Inc. Compositions and methods for treating disease associated with permeability of intestinal epithelium
WO2018204918A1 (en) * 2017-05-05 2018-11-08 Ardelyx, Inc. Treatment of hepatic disorders
US20200199645A1 (en) * 2017-09-08 2020-06-25 Control Of Innate Immunity Technology Research Association Device and method for diagnosis of alzheimer's symptoms
KR102282490B1 (ko) 2018-01-12 2021-07-28 주식회사 엠디헬스케어 패칼리박테리움 프라우스니찌 유래 나노소포 및 이의 용도
AU2019228119A1 (en) * 2018-03-02 2020-09-10 Novaliq Gmbh Pharmaceutical compositions comprising nebivolol
WO2020081369A1 (en) * 2018-10-15 2020-04-23 James Glenn Norman Applied artificial intelligence technology for hormone therapy treatment
US10803981B2 (en) 2018-10-15 2020-10-13 James Glenn Norman Applied artificial intelligence technology for hormone therapy treatment
WO2021069504A1 (en) * 2019-10-11 2021-04-15 F. Hoffmann-La Roche Ag Drug dosage determination devices and methods
US20230241064A1 (en) * 2020-01-08 2023-08-03 Resverlogix Corp. Methods of treatment and/or prevention of major adverse cardiovascular events (mace) with a combination of a bet bromodomain inhibitor and a dipeptidyl peptidase 4 inhibitor
CN117056370A (zh) * 2020-03-19 2023-11-14 上海太美星云数字科技有限公司 医学数据处理方法、装置、设备和存储介质
WO2022243459A1 (en) * 2021-05-19 2022-11-24 Charité - Universitätsmedizin Berlin Computer assisted method for the evaluation of cardiac metabolism
CN113362925B (zh) * 2021-06-29 2022-04-08 山东第一医科大学附属省立医院(山东省立医院) 一种自动良肢位控制方法及设备
CN114705871A (zh) * 2022-04-12 2022-07-05 复旦大学附属中山医院 8异前列腺素F2α在重度哮喘诊断中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504806A (ja) * 1994-09-02 1997-05-13 アストラ・アクチエボラーグ Ａｃｅ阻害剤ラミプリルとジヒドロピリジン化合物を含有する新規医薬組成物
JP2007517766A (ja) * 2003-09-24 2007-07-05 コンビナトアールエックス インコーポレーティッド 薬物の組み合わせを投与するための治療法
JP2009502950A (ja) * 2005-07-28 2009-01-29 レリアント ファーマスーティカルズ インコーポレイテッド ジヒドロピリジンカルシウムチャネルブロッカー及びω３脂肪酸を用いた治療法、並びにそれらの混合生成物
JP2014506928A (ja) * 2011-03-02 2014-03-20 ジェローム シェンターク， 肝臓脂肪症単独又はｃ型肝炎ウイルス感染を伴った肝臓脂肪症の治療のための組成物、治療法及び診断法
WO2014110090A1 (en) * 2013-01-08 2014-07-17 Jerome Schentag Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009002166A (es) * 2006-08-31 2009-03-12 Eurand Inc Sistema de distribucion de farmacos, que comprenden soluciones solidas de farmacos debilmente basicos.
US8999721B2 (en) * 2009-10-23 2015-04-07 Therabrake, Inc. Method and system to provide personalized pharmaceutical compositions and dosages
US20130273154A1 (en) * 2011-03-02 2013-10-17 Joseph M. Fayad Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504806A (ja) * 1994-09-02 1997-05-13 アストラ・アクチエボラーグ Ａｃｅ阻害剤ラミプリルとジヒドロピリジン化合物を含有する新規医薬組成物
JP2007517766A (ja) * 2003-09-24 2007-07-05 コンビナトアールエックス インコーポレーティッド 薬物の組み合わせを投与するための治療法
JP2009502950A (ja) * 2005-07-28 2009-01-29 レリアント ファーマスーティカルズ インコーポレイテッド ジヒドロピリジンカルシウムチャネルブロッカー及びω３脂肪酸を用いた治療法、並びにそれらの混合生成物
JP2014506928A (ja) * 2011-03-02 2014-03-20 ジェローム シェンターク， 肝臓脂肪症単独又はｃ型肝炎ウイルス感染を伴った肝臓脂肪症の治療のための組成物、治療法及び診断法
WO2014110090A1 (en) * 2013-01-08 2014-07-17 Jerome Schentag Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023078291A (ja) * 2018-01-12 2023-06-06 メティメディ ファーマシューティカルズ カンパニー リミテッド 慢性炎症性疾患を処置する方法
JP7665220B2 (ja) 2018-01-12 2025-04-21 メティメディ ファーマシューティカルズ カンパニー リミテッド 慢性炎症性疾患を処置する方法
CN112074197A (zh) * 2018-03-07 2020-12-11 安纳生物科技有限公司 用于ii型糖尿病及用于提供随着时间的持续的能量释放的组合物
JP2022545037A (ja) * 2019-08-23 2022-10-24 ブリッジ バイオセラピューティクス インコーポレイテッド パルミトイル－ｌ－プロリル－ｌ－プロリル－グリシル－ｌ－チロシンナトリウムを含む薬学的製剤及びこの製造方法

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