JP2017527605A5 - - Google Patents

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Publication number
JP2017527605A5
JP2017527605A5 JP2017515198A JP2017515198A JP2017527605A5 JP 2017527605 A5 JP2017527605 A5 JP 2017527605A5 JP 2017515198 A JP2017515198 A JP 2017515198A JP 2017515198 A JP2017515198 A JP 2017515198A JP 2017527605 A5 JP2017527605 A5 JP 2017527605A5
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JP
Japan
Prior art keywords
ring
alkyl
membered heterocyclic
membered heteroaryl
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017515198A
Other languages
English (en)
Japanese (ja)
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JP2017527605A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/050458 external-priority patent/WO2016044441A1/en
Publication of JP2017527605A publication Critical patent/JP2017527605A/ja
Publication of JP2017527605A5 publication Critical patent/JP2017527605A5/ja
Pending legal-status Critical Current

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JP2017515198A 2014-09-17 2015-09-16 sGC刺激剤 Pending JP2017527605A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462051620P 2014-09-17 2014-09-17
US62/051,620 2014-09-17
US201562204672P 2015-08-13 2015-08-13
US62/204,672 2015-08-13
PCT/US2015/050458 WO2016044441A1 (en) 2014-09-17 2015-09-16 Sgc stimulators

Publications (2)

Publication Number Publication Date
JP2017527605A JP2017527605A (ja) 2017-09-21
JP2017527605A5 true JP2017527605A5 (https=) 2018-10-25

Family

ID=54293334

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017515198A Pending JP2017527605A (ja) 2014-09-17 2015-09-16 sGC刺激剤

Country Status (12)

Country Link
US (1) US10047095B2 (https=)
EP (1) EP3194395B1 (https=)
JP (1) JP2017527605A (https=)
KR (1) KR20170055531A (https=)
CN (1) CN107223125B (https=)
AU (1) AU2015317818A1 (https=)
BR (1) BR112017005248A2 (https=)
CA (1) CA2961531A1 (https=)
EA (1) EA201790627A1 (https=)
IL (1) IL251115A0 (https=)
MX (1) MX2017003517A (https=)
WO (1) WO2016044441A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3194386A2 (en) * 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US20180344735A1 (en) 2015-12-14 2018-12-06 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION
CN109563077B (zh) 2016-07-07 2026-03-10 赛克里翁治疗有限公司 用于制备可溶性鸟苷酸环化酶刺激剂的新方法
CN109890379A (zh) 2016-10-11 2019-06-14 拜耳制药股份公司 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品
EP3525779B1 (de) 2016-10-11 2024-06-05 Bayer Pharma Aktiengesellschaft Kombination enthaltend den sgc stimulator vericuguat und den mineralcorticoid-rezeptor-antagonist finerenone
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
EP3554488A2 (en) 2016-12-13 2019-10-23 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
EP3638281B1 (en) * 2017-11-08 2021-03-03 Omnipep Establishment L-glu-l-trp for enhancing tissue oxygenation in case of diabetic foot and use of it
US11274096B2 (en) * 2018-01-10 2022-03-15 Cyclerion Therapeutics, Inc. Processes and intermediates for the preparation of soluble guanylate cyclase stimulators
EP3793553A1 (en) 2018-05-15 2021-03-24 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
KR20250141845A (ko) 2018-07-11 2025-09-29 티센토 쎄라퓨틱스 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
EP4041399A1 (en) 2019-10-02 2022-08-17 Tolremo Therapeutics AG Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer
KR20230028798A (ko) 2020-06-25 2023-03-02 톨레모 테라퓨틱스 아게 암 치료를 위한 CBP/p300 브로모도메인 억제제 및 KRAS 억제제의 조합물
WO2021260110A1 (en) * 2020-06-25 2021-12-30 Tolremo Therapeutics Ag Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of fibrotic disease
IL307402A (en) 2021-04-07 2023-12-01 Tolremo Therapeutics Ag The tercyclic derivatives, pharmaceutical compounds and their use in the treatment or amelioration of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4544999B2 (ja) * 2002-11-25 2010-09-15 持田製薬株式会社 4−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤
JP2010511727A (ja) * 2006-12-04 2010-04-15 ニューロクライン バイオサイエンシーズ,インコーポレイテッド アデノシン受容体アンタゴニストとしての置換ピリミジン
EP2588465B1 (en) * 2010-06-30 2017-01-25 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CN107266433A (zh) * 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
DE102012200360A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
EP2897953B8 (en) * 2012-09-19 2019-06-26 Cyclerion Therapeutics, Inc. Sgc stimulators
EA033168B1 (ru) * 2013-03-15 2019-09-30 Сайклерион Терапьютикс, Инк. СТИМУЛЯТОРЫ sGC
EP3094327A1 (en) * 2014-01-13 2016-11-23 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS

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