JP2017527605A5 - - Google Patents

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Publication number
JP2017527605A5
JP2017527605A5 JP2017515198A JP2017515198A JP2017527605A5 JP 2017527605 A5 JP2017527605 A5 JP 2017527605A5 JP 2017515198 A JP2017515198 A JP 2017515198A JP 2017515198 A JP2017515198 A JP 2017515198A JP 2017527605 A5 JP2017527605 A5 JP 2017527605A5
Authority
JP
Japan
Prior art keywords
ring
alkyl
membered heterocyclic
membered heteroaryl
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017515198A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017527605A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/050458 external-priority patent/WO2016044441A1/en
Publication of JP2017527605A publication Critical patent/JP2017527605A/ja
Publication of JP2017527605A5 publication Critical patent/JP2017527605A5/ja
Pending legal-status Critical Current

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JP2017515198A 2014-09-17 2015-09-16 sGC刺激剤 Pending JP2017527605A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462051620P 2014-09-17 2014-09-17
US62/051,620 2014-09-17
US201562204672P 2015-08-13 2015-08-13
US62/204,672 2015-08-13
PCT/US2015/050458 WO2016044441A1 (en) 2014-09-17 2015-09-16 Sgc stimulators

Publications (2)

Publication Number Publication Date
JP2017527605A JP2017527605A (ja) 2017-09-21
JP2017527605A5 true JP2017527605A5 (https=) 2018-10-25

Family

ID=54293334

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017515198A Pending JP2017527605A (ja) 2014-09-17 2015-09-16 sGC刺激剤

Country Status (12)

Country Link
US (1) US10047095B2 (https=)
EP (1) EP3194395B1 (https=)
JP (1) JP2017527605A (https=)
KR (1) KR20170055531A (https=)
CN (1) CN107223125B (https=)
AU (1) AU2015317818A1 (https=)
BR (1) BR112017005248A2 (https=)
CA (1) CA2961531A1 (https=)
EA (1) EA201790627A1 (https=)
IL (1) IL251115A0 (https=)
MX (1) MX2017003517A (https=)
WO (1) WO2016044441A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3194386A2 (en) * 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
AU2016371762A1 (en) 2015-12-14 2018-06-21 Cyclerion Therapeutics, Inc. Use of sGC stimulators for the treatment of gastrointestinal sphincter dysfunction
CN109563077B (zh) 2016-07-07 2026-03-10 赛克里翁治疗有限公司 用于制备可溶性鸟苷酸环化酶刺激剂的新方法
CA3039735A1 (en) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Combination containing sgc activators and mineralocorticoid receptor antagonists
US10918639B2 (en) 2016-10-11 2021-02-16 Bayer Pharma Aktiengesellschaft Combination containing SGC stimulators and mineralocorticoid receptor antagonists
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
WO2018111795A2 (en) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
JP7204758B2 (ja) * 2017-11-08 2023-01-16 オムニペプ・エスタブリッシュメント 糖尿病性足の場合における組織酸素化を増強するための医療用製剤とその使用
MA71753A (fr) * 2018-01-10 2025-05-30 Cyclerion Therapeutics, Inc. Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble
CA3100096A1 (en) 2018-05-15 2019-11-21 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
KR20210031931A (ko) 2018-07-11 2021-03-23 사이클리온 테라퓨틱스, 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
US12478624B2 (en) 2019-10-02 2025-11-25 Tolremo Therapeutics Ag Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer
IL299344A (en) 2020-06-25 2023-02-01 Tolremo Therapeutics Ag Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer
CA3184062A1 (en) * 2020-06-25 2021-12-30 Stefanie Fluckiger-Mangual Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of fibrotic disease
BR112023020538A2 (pt) 2021-04-07 2024-01-23 Tolremo Therapeutics Ag Derivados heterocíclicos, composições farmacêuticas e seus usos no tratamento ou na melhoria de câncer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4544999B2 (ja) * 2002-11-25 2010-09-15 持田製薬株式会社 4−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤
CN101679371A (zh) * 2006-12-04 2010-03-24 艾美罗股份公司 作为腺苷受体拮抗剂的取代的嘧啶
AR088020A1 (es) * 2010-06-30 2014-05-07 Ironwood Pharmaceuticals Inc Compuestos heterociclicos como estimuladores de sgc
EP2637659B1 (en) * 2010-11-09 2016-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
DE102012200360A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
US9487508B2 (en) * 2012-09-19 2016-11-08 Ironwood Pharmaceuticals, Inc. SGC stimulators
SI2970243T1 (sl) * 2013-03-15 2020-04-30 Cyclerion Therapeutics, Inc. SGC stimulatorji
WO2015106268A1 (en) * 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS

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