JP2017527577A - 置換ピロリジン化合物 - Google Patents

置換ピロリジン化合物 Download PDF

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Publication number
JP2017527577A
JP2017527577A JP2017513208A JP2017513208A JP2017527577A JP 2017527577 A JP2017527577 A JP 2017527577A JP 2017513208 A JP2017513208 A JP 2017513208A JP 2017513208 A JP2017513208 A JP 2017513208A JP 2017527577 A JP2017527577 A JP 2017527577A
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JP
Japan
Prior art keywords
cancer
tumor
cell
alkyl
lymphoma
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JP2017513208A
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English (en)
Japanese (ja)
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JP2017527577A5 (enExample
Inventor
アリーン クルーナン フォーリー メーガン
アリーン クルーナン フォーリー メーガン
ウェイン クンツ ケヴィン
ウェイン クンツ ケヴィン
ヘレン ミッチェル ローナ
ヘレン ミッチェル ローナ
ジョン マンチホフ マイケル
ジョン マンチホフ マイケル
マーティン ハーヴィー ダレン
マーティン ハーヴィー ダレン
Original Assignee
エピザイム，インコーポレイティド
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Application filed by エピザイム，インコーポレイティド filed Critical エピザイム，インコーポレイティド
Publication of JP2017527577A publication Critical patent/JP2017527577A/ja
Publication of JP2017527577A5 publication Critical patent/JP2017527577A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017513208A 2014-09-10 2015-09-09 置換ピロリジン化合物 Pending JP2017527577A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462048757P 2014-09-10 2014-09-10
US62/048,757 2014-09-10
US201562146808P 2015-04-13 2015-04-13
US62/146,808 2015-04-13
PCT/US2015/049219 WO2016040504A1 (en) 2014-09-10 2015-09-09 Substituted pyrrolidine compounds

Publications (2)

Publication Number Publication Date
JP2017527577A true JP2017527577A (ja) 2017-09-21
JP2017527577A5 JP2017527577A5 (enExample) 2018-10-18

Family

ID=55459527

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017513208A Pending JP2017527577A (ja) 2014-09-10 2015-09-09 置換ピロリジン化合物

Country Status (6)

Country Link
US (2) US20170253601A1 (enExample)
EP (1) EP3193604B1 (enExample)
JP (1) JP2017527577A (enExample)
AU (1) AU2015315173A1 (enExample)
CA (1) CA2960273A1 (enExample)
WO (1) WO2016040504A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021511382A (ja) * 2018-01-26 2021-05-06 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ （３ｓ，４ｓ）−１−シクロプロピルメチル−４−｛［５−（２，４−ジフルオロ−フェニル）−イソオキサゾール−３−カルボニル］−アミノ｝−ピペリジン−３−カルボン酸 （１−ピリミジン−２−イル−シクロプロピル）−アミドの結晶形

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017526706A (ja) * 2014-09-10 2017-09-14 エピザイム，インコーポレイティド イソオキサゾールカルボキサミド化合物
AU2015315171A1 (en) 2014-09-10 2017-03-16 Epizyme, Inc. Substituted cyclohexylamine compounds
MX2017002986A (es) 2014-09-10 2017-10-24 Epizyme Inc Compuestos de piperidina sustituidos.
KR102496364B1 (ko) 2014-09-10 2023-02-06 에피자임, 인코포레이티드 Ｓｍｙｄ 억제제
JP2017528460A (ja) 2014-09-10 2017-09-28 エピザイム インコーポレイテッド 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド
WO2018151678A1 (en) * 2017-02-15 2018-08-23 Agency For Science, Technology And Research Compounds for treatment of cancer and epigenetics
EP3986886A2 (en) 2019-06-19 2022-04-27 Grünenthal GmbH Substituted pyrrolidine amides v
WO2025133989A1 (en) * 2023-12-20 2025-06-26 Alt-Bio Pte. Ltd. Smyd modulators and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534338A (ja) * 2006-04-21 2009-09-24 ノバルティス アクチエンゲゼルシャフト アデノシンａ２ａ受容体アゴニストとして使用するためのプリン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1287434A (en) * 1918-05-16 1918-12-10 Waterbury Mfg Co Combined shade-holder and socket-cover.
CA2657078A1 (en) * 2006-07-13 2008-01-17 High Point Pharmaceuticals, Llc 11beta-hydroxysteroid dehydrogenase type 1 active compounds
WO2014175370A1 (ja) * 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534338A (ja) * 2006-04-21 2009-09-24 ノバルティス アクチエンゲゼルシャフト アデノシンａ２ａ受容体アゴニストとして使用するためのプリン誘導体

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
FILE REGISTRY ON STN, RN 1249719-24-1, ENTERED STN:31 OCT 2010, JPN7019001732, ISSN: 0004044758 *
FILE REGISTRY ON STN, RN 1287434-68-7, ENTERED STN: 29 APR 2011, JPN7019001724, ISSN: 0004179019 *
FILE REGISTRY ON STN, RN 1287486-46-7, ENTERED STN: 29 APR 2011, JPN7019001723, ISSN: 0004179018 *
FILE REGISTRY ON STN, RN 1331042-99-9, ENTERED STN:11 SEP 2011, JPN7019001733, ISSN: 0004044759 *
FILE REGISTRY ON STN, RN 1332181-49-3, ENTERED STN:14 SEP 2011, JPN7019001726, ISSN: 0004044752 *
FILE REGISTRY ON STN, RN 1351589-14-4, ENTERED STN: 22 DEC 2011, JPN7019001721, ISSN: 0004179016 *
FILE REGISTRY ON STN, RN 1360215-57-1, ENTERED STN:07 MAR 2012, JPN7019001727, ISSN: 0004044753 *
FILE REGISTRY ON STN, RN 1385269-82-8, ENTERED STN: 02 AUG 2012, JPN7019001722, ISSN: 0004179017 *
FILE REGISTRY ON STN, RN 1434918-70-3, ENTERED STN:05 JUN 2013, JPN7019001734, ISSN: 0004044760 *
FILE REGISTRY ON STN, RN 1434972-84-5, ENTERED STN: 05 JUN 2013, JPN7019001725, ISSN: 0004179020 *
FILE REGISTRY ON STN, RN 1465364-27-5, ENTERED STN:29 OCT 2013, JPN7019001731, ISSN: 0004044757 *
FILE REGISTRY ON STN, RN 1552197-71-3, ENTERED STN:21 FEB 2014, JPN7019001730, ISSN: 0004044756 *
FILE REGISTRY ON STN, RN 1567237-57-3, ENTERED STN: 12 MAR 2014, JPN7019001720, ISSN: 0004179015 *
FILE REGISTRY ON STN, RN 1568022-81-0, ENTERED STN:13 MAR 2014, JPN7019001729, ISSN: 0004044755 *
FILE REGISTRY ON STN, RN 1568165-24-1, ENTERED STN:13 MAR 2014, JPN7019001728, ISSN: 0004044754 *
FILE REGISTRY ON STN, RN 1568259-94-8, ENTERED STN: 13 MAR 2014, JPN7019001719, ISSN: 0004179014 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021511382A (ja) * 2018-01-26 2021-05-06 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ （３ｓ，４ｓ）−１−シクロプロピルメチル−４−｛［５−（２，４−ジフルオロ−フェニル）−イソオキサゾール−３−カルボニル］−アミノ｝−ピペリジン−３−カルボン酸 （１−ピリミジン−２−イル−シクロプロピル）−アミドの結晶形
JP7076010B2 (ja) 2018-01-26 2022-05-26 イドーシア ファーマシューティカルズ リミテッド （３ｓ，４ｓ）－１－シクロプロピルメチル－４－｛［５－（２，４－ジフルオロ－フェニル）－イソオキサゾール－３－カルボニル］－アミノ｝－ピペリジン－３－カルボン酸 （１－ピリミジン－２－イル－シクロプロピル）－アミドの結晶形

Also Published As

Publication number Publication date
US20200102314A1 (en) 2020-04-02
EP3193604A4 (en) 2018-02-21
EP3193604B1 (en) 2021-06-16
WO2016040504A1 (en) 2016-03-17
CA2960273A1 (en) 2016-03-17
EP3193604A1 (en) 2017-07-26
US20170253601A1 (en) 2017-09-07
AU2015315173A1 (en) 2017-03-16

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