AU2015315173A1 - Substituted pyrrolidine compounds - Google Patents
Substituted pyrrolidine compounds Download PDFInfo
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- AU2015315173A1 AU2015315173A1 AU2015315173A AU2015315173A AU2015315173A1 AU 2015315173 A1 AU2015315173 A1 AU 2015315173A1 AU 2015315173 A AU2015315173 A AU 2015315173A AU 2015315173 A AU2015315173 A AU 2015315173A AU 2015315173 A1 AU2015315173 A1 AU 2015315173A1
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- Prior art keywords
- cancer
- cell
- tumor
- alkyl
- carcinoma
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- 150000003839 salts Chemical class 0.000 claims abstract description 74
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- 150000001875 compounds Chemical class 0.000 claims description 191
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 55
- 125000003118 aryl group Chemical group 0.000 claims description 54
- 125000001072 heteroaryl group Chemical group 0.000 claims description 54
- 125000003282 alkyl amino group Chemical group 0.000 claims description 52
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 50
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 48
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- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 34
- 125000003545 alkoxy group Chemical group 0.000 claims description 31
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 30
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 29
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048757P | 2014-09-10 | 2014-09-10 | |
| US62/048,757 | 2014-09-10 | ||
| US201562146808P | 2015-04-13 | 2015-04-13 | |
| US62/146,808 | 2015-04-13 | ||
| PCT/US2015/049219 WO2016040504A1 (en) | 2014-09-10 | 2015-09-09 | Substituted pyrrolidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2015315173A1 true AU2015315173A1 (en) | 2017-03-16 |
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|---|---|---|---|
| AU2015315173A Abandoned AU2015315173A1 (en) | 2014-09-10 | 2015-09-09 | Substituted pyrrolidine compounds |
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| US (2) | US20170253601A1 (enExample) |
| EP (1) | EP3193604B1 (enExample) |
| JP (1) | JP2017527577A (enExample) |
| AU (1) | AU2015315173A1 (enExample) |
| CA (1) | CA2960273A1 (enExample) |
| WO (1) | WO2016040504A1 (enExample) |
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| MX2017002985A (es) | 2014-09-10 | 2017-11-17 | Epizyme Inc | Inhibidores de smyd. |
| CA2960274A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| WO2016040502A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| JP2017528464A (ja) | 2014-09-10 | 2017-09-28 | エピザイム，インコーポレイティド | 置換ピペリジン化合物 |
| WO2016040511A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| WO2018151678A1 (en) * | 2017-02-15 | 2018-08-23 | Agency For Science, Technology And Research | Compounds for treatment of cancer and epigenetics |
| TWI822724B (zh) * | 2018-01-26 | 2023-11-21 | 瑞士商愛杜西亞製藥有限公司 | 唑-3-羰基]-胺基}-哌啶-3-羧酸(1-嘧啶-2-基-環丙基)-醯胺之結晶型 |
| WO2020254552A2 (en) * | 2019-06-19 | 2020-12-24 | Grünenthal GmbH | Substituted pyrrolidine amides v |
| WO2025133989A1 (en) * | 2023-12-20 | 2025-06-26 | Alt-Bio Pte. Ltd. | Smyd modulators and uses thereof |
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| US1287434A (en) * | 1918-05-16 | 1918-12-10 | Waterbury Mfg Co | Combined shade-holder and socket-cover. |
| PE20080361A1 (es) * | 2006-04-21 | 2008-06-03 | Novartis Ag | Compuestos derivados de purina como activadores del receptor de adenosina a2a |
| WO2008006702A1 (en) * | 2006-07-13 | 2008-01-17 | High Point Pharmaceuticals, Llc. | 11beta-hydroxysteroid dehydrogenase type 1 active compounds |
| WO2014175370A1 (ja) * | 2013-04-25 | 2014-10-30 | 塩野義製薬株式会社 | ピロリジン誘導体およびそれらを含有する医薬組成物 |
-
2015
- 2015-09-09 US US15/510,602 patent/US20170253601A1/en not_active Abandoned
- 2015-09-09 JP JP2017513208A patent/JP2017527577A/ja active Pending
- 2015-09-09 EP EP15840234.7A patent/EP3193604B1/en active Active
- 2015-09-09 AU AU2015315173A patent/AU2015315173A1/en not_active Abandoned
- 2015-09-09 WO PCT/US2015/049219 patent/WO2016040504A1/en not_active Ceased
- 2015-09-09 CA CA2960273A patent/CA2960273A1/en not_active Abandoned
-
2019
- 2019-08-05 US US16/531,798 patent/US20200102314A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2960273A1 (en) | 2016-03-17 |
| WO2016040504A1 (en) | 2016-03-17 |
| US20200102314A1 (en) | 2020-04-02 |
| EP3193604A4 (en) | 2018-02-21 |
| EP3193604A1 (en) | 2017-07-26 |
| JP2017527577A (ja) | 2017-09-21 |
| EP3193604B1 (en) | 2021-06-16 |
| US20170253601A1 (en) | 2017-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |