JP2017526700A - 抗ｐｄ１若しくは抗ｐｄｌ１モノクローナル抗体と組み合わせてシチジン類似体の経口製剤を使用する疾患または障害の治療方法 - Google Patents

抗ｐｄ１若しくは抗ｐｄｌ１モノクローナル抗体と組み合わせてシチジン類似体の経口製剤を使用する疾患または障害の治療方法 Download PDF

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JP2017526700A
JP2017526700A JP2017513044A JP2017513044A JP2017526700A JP 2017526700 A JP2017526700 A JP 2017526700A JP 2017513044 A JP2017513044 A JP 2017513044A JP 2017513044 A JP2017513044 A JP 2017513044A JP 2017526700 A JP2017526700 A JP 2017526700A
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azacytidine
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disease
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ファンディ アブデラヒム
ファンディ アブデラヒム
レイセル デビッド
レイセル デビッド
バートン デボラ
バートン デボラ
ベジク ダミル
ベジク ダミル
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Celgene Corp
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JP2017513044A 2014-09-08 2015-09-08 抗ｐｄ１若しくは抗ｐｄｌ１モノクローナル抗体と組み合わせてシチジン類似体の経口製剤を使用する疾患または障害の治療方法 Pending JP2017526700A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462047463P 2014-09-08 2014-09-08
US62/047,463 2014-09-08
PCT/US2015/048812 WO2016040238A1 (en) 2014-09-08 2015-09-08 Methods for treating a disease or disorder using oral formulations of cytidine analogs in combination with an anti-pd1 or anti-pdl1 monoclonal antibody

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JP2017526700A true JP2017526700A (ja) 2017-09-14
JP2017526700A5 JP2017526700A5 (enExample) 2018-03-08

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US (1) US20160067336A1 (enExample)
EP (1) EP3191104A1 (enExample)
JP (1) JP2017526700A (enExample)
KR (1) KR20170045237A (enExample)
CN (1) CN106604745A (enExample)
AU (1) AU2015315435A1 (enExample)
CA (1) CA2960490A1 (enExample)
EA (1) EA201790543A1 (enExample)
IL (1) IL250887A0 (enExample)
MX (1) MX2017002875A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022522843A (ja) * 2019-03-04 2022-04-20 ノース カロライナ ステート ユニバーシティ エピジェネティック調節と免疫チェックポイント遮断の組み合わせのための薬物送達

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20160319A (es) 2013-12-12 2016-11-08 Jiangsu Hengrui Medicine Co Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este
WO2016022955A1 (en) 2014-08-07 2016-02-11 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
MA42971A (fr) * 2015-03-13 2018-08-15 Cytomx Therapeutics Inc Anticorps anti-pdl1, anticorps anti-pld1 activables, et leurs procédés d'utilisation
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
WO2016196389A1 (en) 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Treatment of renal cell carcinoma
MX383464B (es) 2015-07-13 2025-03-14 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos.
US11287428B2 (en) 2016-03-16 2022-03-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. PD1 and PDL-1 expression during progression from myelodysplastic syndrome to acute myelogenous leukemia
CA3026563C (en) 2016-06-10 2023-11-28 Io Therapeutics, Inc. Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy
WO2018007554A1 (en) * 2016-07-06 2018-01-11 Pierre Fabre Medicament Vinflunine and pd1 and/or pdl1 inhibitor as pharmaceutical combination
BR112019006504A2 (pt) * 2016-10-06 2019-06-25 Pfizer Inc. regime de dosagem de avelumabe para o tratamento de câncer
US11124577B2 (en) 2016-11-02 2021-09-21 Engmab Sàrl Bispecific antibody against BCMA and CD3 and an immunological drug for combined use in treating multiple myeloma
WO2018160717A1 (en) * 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
CN110913906A (zh) * 2017-05-02 2020-03-24 默沙东公司 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂
US12168054B2 (en) 2017-05-19 2024-12-17 Syndax Pharmaceuticals, Inc. Method of treating cancer using a combination of entinostat and an anti-CSF-1R antibody
CN110914302A (zh) 2017-06-01 2020-03-24 赛托姆克斯治疗学股份有限公司 可活化抗pdl1抗体及其使用方法
CA3069672A1 (en) 2017-07-13 2019-01-17 Io Therapeutics, Inc. Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy
CA3073953A1 (en) 2017-08-31 2019-03-07 Io Therapeutics, Inc. Rar selective agonists in combination with immune modulators for cancer immunotherapy
EP3880191A4 (en) * 2018-11-13 2022-08-10 Yee, Amy COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPY
WO2020257671A1 (en) 2019-06-20 2020-12-24 Celgene Corporation Azacitidine in combination with venetoclax, gilteritinib, midostaurin or other compounds for treating leukemia or myelodysplastic syndrome
KR20210097882A (ko) * 2020-01-30 2021-08-10 삼성바이오에피스 주식회사 안정한 항-pd-1 항체 약제학적 제제
EP4132490A4 (en) * 2020-04-07 2024-04-24 Metanoi Therapeutics, Inc. ETHANOLAMINE FORMULATION FOR THE TREATMENT OF EPITHELIAL OVARIAN CARCINOMA
MX2024004801A (es) 2021-10-19 2024-06-28 Akirabio Inc Composiciones que comprenden análogos de 2'- desoxicitidina, y uso de las mismas para el tratamiento de anemia de células falciformes, talasemia y cánceres.
KR20260057078A (ko) 2023-08-18 2026-04-27 브리스톨-마이어스 스큅 컴퍼니 Bcma 및 cd3에 결합하는 항체를 포함하는 조성물 및 치료 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036993A1 (es) * 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
WO2010036959A2 (en) * 2008-09-26 2010-04-01 Dana-Farber Cancer Institute Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
EP2396007A1 (en) * 2009-02-10 2011-12-21 Celgene International Sarl Methods for treating non-small cell lung cancer using 5-azacytidine
WO2013043569A1 (en) * 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
US20140357567A1 (en) * 2011-11-01 2014-12-04 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs
EP2958571B1 (en) * 2013-02-21 2024-04-10 Michele Maio Dna hypomethylating agents for cancer therapy
WO2015035112A1 (en) * 2013-09-05 2015-03-12 The Johns Hopkins University Cancer therapy via a combination of epigenetic modulation and immune modulation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CANCER RES., 2012, VOL.72, NO.9, PP.2197-2205, JPN6018015446, ISSN: 0003960858 *
CLIN. CANCER RES., 2013, VOL.19, NO.5, PP.1009-1020, JPN6018015448, ISSN: 0003960859 *
ERIC LAILLE; TAO SHI; GUILLERMO GARCIA-MANERO; ET AL: "EXTENDED DOSING OF ORAL AZACITIDINE (CC-486) FOR 14 AND 21 DAYS PROVIDES MORE EFFECTIVE 以下備考", AMERICAN SOCIETY OF HEMATOLOGY,54TH ASH ANNUAL MEETING AND EXPOSITION, JPN5017007170, December 2012 (2012-12-01), ISSN: 0003960860 *
LEUKEMIA, 2014, VOL.28, NO.6, PP.1280-1288, JPN6018015444, ISSN: 0003960857 *
ONCOTARGET, 2013, VOL.4, NO.11, PP.2067-2079, JPN6018015441, ISSN: 0003960856 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022522843A (ja) * 2019-03-04 2022-04-20 ノース カロライナ ステート ユニバーシティ エピジェネティック調節と免疫チェックポイント遮断の組み合わせのための薬物送達

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SG11201701710SA (en) 2017-04-27
EA201790543A1 (ru) 2017-07-31
CN106604745A (zh) 2017-04-26
IL250887A0 (en) 2017-04-30
CA2960490A1 (en) 2016-03-17
WO2016040238A1 (en) 2016-03-17
AU2015315435A1 (en) 2017-03-23
KR20170045237A (ko) 2017-04-26
US20160067336A1 (en) 2016-03-10
EP3191104A1 (en) 2017-07-19
MX2017002875A (es) 2017-05-30

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