JP2017525489A - 炎症性メディエーター並びに顆粒球及び単球を血液から除去するためのシステム - Google Patents
炎症性メディエーター並びに顆粒球及び単球を血液から除去するためのシステム Download PDFInfo
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- JP2017525489A JP2017525489A JP2017510850A JP2017510850A JP2017525489A JP 2017525489 A JP2017525489 A JP 2017525489A JP 2017510850 A JP2017510850 A JP 2017510850A JP 2017510850 A JP2017510850 A JP 2017510850A JP 2017525489 A JP2017525489 A JP 2017525489A
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Classifications
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- A61M2202/00—Special media to be introduced, removed or treated
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- A61M2202/0439—White blood cells; Leucocytes
- A61M2202/0443—Macrophages, e.g. monocytes
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- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0445—Proteins
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D2325/00—Details relating to properties of membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D39/00—Filtering material for liquid or gaseous fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14182261.9 | 2014-08-26 | ||
| EP14182261 | 2014-08-26 | ||
| PCT/EP2015/069415 WO2016030357A1 (de) | 2014-08-26 | 2015-08-25 | System zur entfernung von proinflammatorischen mediatoren sowie von granulozyten und monozyten aus blut |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017525489A true JP2017525489A (ja) | 2017-09-07 |
| JP2017525489A5 JP2017525489A5 (cg-RX-API-DMAC7.html) | 2018-10-04 |
Family
ID=51392162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510850A Withdrawn JP2017525489A (ja) | 2014-08-26 | 2015-08-25 | 炎症性メディエーター並びに顆粒球及び単球を血液から除去するためのシステム |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170266362A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3185926B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017525489A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106659834B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016030357A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3473327A1 (en) | 2017-10-19 | 2019-04-24 | 3M Innovative Properties Company | Integrated fluid treatment device, and process using such device |
| WO2021022115A1 (en) * | 2019-08-01 | 2021-02-04 | Seastar Medical, Inc. | Device and method for preparing a donor organ for transplantation |
| CN112511569B (zh) * | 2021-02-07 | 2021-05-11 | 杭州筋斗腾云科技有限公司 | 网络资源访问请求的处理方法、系统及计算机设备 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2077137B (en) | 1980-03-12 | 1983-09-07 | Asahi Chemical Ind | Granulocyte-separating material and granulocyte separator |
| DE3578502D1 (de) | 1984-03-15 | 1990-08-09 | Asahi Medical Co | Filtereinheit zum abtrennen von leukozyten. |
| JP2673567B2 (ja) | 1987-12-10 | 1997-11-05 | 株式会社日本抗体研究所 | 血液中の顆粒球除去方法及びこれに用いる顆粒球除去装置 |
| EP0478914B1 (en) | 1990-07-27 | 1996-05-22 | Pall Corporation | Leucocyte depleting filter device and method of use |
| ATE197547T1 (de) | 1991-08-22 | 2000-12-15 | Asahi Medical Co | Filtermedium zur selektiven entfernung von leukozyten und entsprechende vorrichtung |
| EP0606646B1 (en) | 1992-12-28 | 1997-09-24 | Asahi Medical Co., Ltd. | Filtermaterial, apparatus and method for removing leukocytes |
| US5571418A (en) | 1993-08-20 | 1996-11-05 | Lee; Patrice A. | Hemofiltration of toxic mediator-related disease |
| DE69634141T2 (de) | 1996-02-06 | 2005-12-22 | Bellco S.P.A. | Adsorptive extrakoporale Entfernung von Zytokinen bei akutem Organversagen |
| KR100343092B1 (ko) | 1997-08-28 | 2002-07-05 | 추후보충 | 백혈구-제거용 여과재 |
| US6287516B1 (en) | 1998-07-10 | 2001-09-11 | Immunocept, L.L.C. | Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease |
| PT1126859E (pt) | 1999-03-17 | 2006-09-29 | Jimro Co Ltd | Aferese dos leucocitos sanguineos para o tratamento do vih ep1126859 |
| DE19913707A1 (de) | 1999-03-26 | 2000-10-05 | Privates Inst Bioserv Gmbh | Immunadsorber zur Sepsistherapie |
| WO2003009885A2 (en) | 2001-07-25 | 2003-02-06 | Immunocept, L.L.C. | Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease |
| WO2003033053A1 (en) | 2001-10-16 | 2003-04-24 | Asahi Medical Co., Ltd. | Method of selectively eliminating virus and leukocytes, eliminating material and eliminating apparatus |
| CA2489471C (en) | 2002-06-17 | 2011-01-18 | Asahi Medical Co., Ltd. | Biocompatible polymer and filter for selective removing leukocytes using the same |
| ITTO20020736A1 (it) | 2002-08-21 | 2004-02-22 | Fresenius Hemocare Italia Srl | Filtro per leucociti e suo impiego per l'impoverimento di prodotti del sangue da leucociti. |
| CA2502405A1 (en) | 2002-10-25 | 2004-05-13 | Pall Corporation | Biological fluid filter |
| WO2004050146A1 (ja) | 2002-12-02 | 2004-06-17 | Asahi Medical Co., Ltd. | 白血球除去方法、白血球除去フィルター及びその使用 |
| SE0203855L (sv) * | 2002-12-20 | 2004-06-21 | Gambro Lundia Ab | Permselektivt membran |
| ITTO20030039A1 (it) | 2003-01-24 | 2004-07-25 | Fresenius Hemocare Italia Srl | Filtro per separare leucociti da sangue intero e/o da preparati derivati dal sangue, procedimento per la fabbricazione del filtro, dispositivo e utilizzazione. |
| ES2280656T3 (es) | 2003-07-03 | 2007-09-16 | Fresenius Hemocare Italia S.R.L. | Filtro para la eliminacion de sustancias de productos sanguineos. |
| JP4863714B2 (ja) | 2003-08-07 | 2012-01-25 | 旭化成クラレメディカル株式会社 | 複合多孔膜とその製造方法 |
| US8900462B2 (en) | 2004-06-09 | 2014-12-02 | Asahi Kasei Medical Co., Ltd | Method for removing leukocyte and filter for use therein |
| CA2578539A1 (en) * | 2004-07-30 | 2006-02-09 | Hans-Werner Heinrich | Appliances and methods for cell, bio-particle and molecule sorting |
| WO2006061862A1 (en) | 2004-12-10 | 2006-06-15 | Fresenius Hemocare Italia S.R.L. | A porous web, particularly for filtration of biological fluids |
| EP1882738A4 (en) | 2005-05-20 | 2009-02-25 | Arkray Inc | METHOD FOR OBTAINING MICROORGANISMS AND NUCLEIC ACIDS USING FINE PARTICLES AND FOR THE METHOD OF USING THE KIT |
| EP1931445B1 (en) | 2005-08-31 | 2018-08-01 | Gambro Lundia AB | Cyclic olefin copolymer as a leukoreduction material |
| ATE518555T1 (de) | 2005-09-09 | 2011-08-15 | Membrana Gmbh | Verfahren zur entfernung von leukozyten aus blut |
| EP1897571A1 (en) | 2006-09-06 | 2008-03-12 | Fresenius Hemocare Italia S.r.l. | A filter for the removal of substances from blood products |
| EP1944046B1 (en) | 2007-01-12 | 2010-08-11 | Bellco S.r.l. | Kit for treating a systematic inflammation related diseases |
| US7985337B2 (en) * | 2007-01-13 | 2011-07-26 | Membrana Gmbh | Device for removing leukocytes from blood |
| MX2010002351A (es) * | 2007-08-31 | 2010-05-27 | Univ Michigan | Dispositivos de citoforesis selectivos y metodos relacionados con los mismos. |
| US8932470B2 (en) | 2008-04-14 | 2015-01-13 | Asahi Kasei Medical Co., Ltd. | Filter material for removing aggregates and method of filtering blood product |
| EP2380610B1 (en) | 2010-04-20 | 2014-05-07 | Gambro Lundia AB | High cut-off hemodialysis membrane for use in liver dialysis |
| US10064406B2 (en) | 2011-01-06 | 2018-09-04 | Cytosorbents Corporation | Polymeric sorbent for removal of impurities from whole blood and blood products |
| CA2844688C (en) | 2011-08-12 | 2021-10-19 | Cytosorbents Corporation | Polymeric sorbent for removal of impurities from whole blood and blood products |
| EP2606921A1 (fr) * | 2011-12-21 | 2013-06-26 | Infomed SA | Dispositif d'épuration du sang par circulation extracorporelle |
| EP2735359B1 (en) * | 2012-11-26 | 2017-02-08 | Gambro Lundia AB | Integrated device for liver support systems |
-
2015
- 2015-08-25 EP EP15763840.4A patent/EP3185926B1/de not_active Not-in-force
- 2015-08-25 US US15/505,724 patent/US20170266362A1/en not_active Abandoned
- 2015-08-25 CN CN201580045367.8A patent/CN106659834B/zh not_active Expired - Fee Related
- 2015-08-25 WO PCT/EP2015/069415 patent/WO2016030357A1/de not_active Ceased
- 2015-08-25 JP JP2017510850A patent/JP2017525489A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016030357A1 (de) | 2016-03-03 |
| CN106659834A (zh) | 2017-05-10 |
| CN106659834B (zh) | 2019-06-18 |
| EP3185926B1 (de) | 2018-11-28 |
| US20170266362A1 (en) | 2017-09-21 |
| EP3185926A1 (de) | 2017-07-05 |
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