JP2017524652A5 - - Google Patents
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- JP2017524652A5 JP2017524652A5 JP2016568591A JP2016568591A JP2017524652A5 JP 2017524652 A5 JP2017524652 A5 JP 2017524652A5 JP 2016568591 A JP2016568591 A JP 2016568591A JP 2016568591 A JP2016568591 A JP 2016568591A JP 2017524652 A5 JP2017524652 A5 JP 2017524652A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dose
- item
- multiple myeloma
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 49
- 201000011510 cancer Diseases 0.000 claims description 28
- 150000001875 compounds Chemical class 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 20
- 208000034578 Multiple myelomas Diseases 0.000 claims description 16
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 16
- 238000011275 oncology therapy Methods 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 229940079156 Proteasome inhibitor Drugs 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 10
- 239000002955 immunomodulating agent Substances 0.000 claims description 10
- 229940121354 immunomodulator Drugs 0.000 claims description 10
- 230000002584 immunomodulator Effects 0.000 claims description 10
- 238000009115 maintenance therapy Methods 0.000 claims description 10
- 239000003207 proteasome inhibitor Substances 0.000 claims description 10
- 238000011476 stem cell transplantation Methods 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 5
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 4
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims description 4
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims description 4
- 229960001467 bortezomib Drugs 0.000 claims description 4
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 4
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 claims description 4
- 229960004942 lenalidomide Drugs 0.000 claims description 4
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims description 4
- 239000007909 solid dosage form Substances 0.000 claims description 4
- MXAYKZJJDUDWDS-LBPRGKRZSA-N ixazomib Chemical compound CC(C)C[C@@H](B(O)O)NC(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl MXAYKZJJDUDWDS-LBPRGKRZSA-N 0.000 claims description 3
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims description 2
- 229930014124 (-)-epigallocatechin gallate Natural products 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 108010064641 ONX 0912 Proteins 0.000 claims description 2
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims description 2
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims description 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 2
- 206010002022 amyloidosis Diseases 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229960002438 carfilzomib Drugs 0.000 claims description 2
- 108010021331 carfilzomib Proteins 0.000 claims description 2
- BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- SJFBTAPEPRWNKH-CCKFTAQKSA-N delanzomib Chemical compound CC(C)C[C@@H](B(O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)C1=CC=CC(C=2C=CC=CC=2)=N1 SJFBTAPEPRWNKH-CCKFTAQKSA-N 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 229960002563 disulfiram Drugs 0.000 claims description 2
- 230000003325 follicular Effects 0.000 claims description 2
- 230000002489 hematologic effect Effects 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 229960003648 ixazomib Drugs 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 229950002736 marizomib Drugs 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims description 2
- 229960001924 melphalan Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- SWZXEVABPLUDIO-WSZYKNRRSA-N n-[(2s)-3-methoxy-1-[[(2s)-3-methoxy-1-[[(2s)-1-[(2r)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide Chemical compound N([C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)[C@]1(C)OC1)C(=O)C1=CN=C(C)S1 SWZXEVABPLUDIO-WSZYKNRRSA-N 0.000 claims description 2
- 229950005750 oprozomib Drugs 0.000 claims description 2
- 229960000688 pomalidomide Drugs 0.000 claims description 2
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- NGWSFRIPKNWYAO-UHFFFAOYSA-N salinosporamide A Natural products N1C(=O)C(CCCl)C2(C)OC(=O)C21C(O)C1CCCC=C1 NGWSFRIPKNWYAO-UHFFFAOYSA-N 0.000 claims description 2
- NGWSFRIPKNWYAO-SHTIJGAHSA-N salinosporamide A Chemical compound C([C@@H]1[C@H](O)[C@]23C(=O)O[C@]2([C@H](C(=O)N3)CCCl)C)CCC=C1 NGWSFRIPKNWYAO-SHTIJGAHSA-N 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 238000011269 treatment regimen Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 108700002672 epoxomicin Proteins 0.000 claims 1
- DOGIDQKFVLKMLQ-JTHVHQAWSA-N epoxomicin Chemical compound CC[C@H](C)[C@H](N(C)C(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 DOGIDQKFVLKMLQ-JTHVHQAWSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019104381A JP6906564B2 (ja) | 2014-05-20 | 2019-06-04 | 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462000991P | 2014-05-20 | 2014-05-20 | |
| US62/000,991 | 2014-05-20 | ||
| US201462019600P | 2014-07-01 | 2014-07-01 | |
| US62/019,600 | 2014-07-01 | ||
| US201462088154P | 2014-12-05 | 2014-12-05 | |
| US62/088,154 | 2014-12-05 | ||
| PCT/US2015/031633 WO2015179443A1 (en) | 2014-05-20 | 2015-05-19 | Boron-containing proteasome inhibitors for use after primary cancer therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104381A Division JP6906564B2 (ja) | 2014-05-20 | 2019-06-04 | 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017524652A JP2017524652A (ja) | 2017-08-31 |
| JP2017524652A5 true JP2017524652A5 (cg-RX-API-DMAC7.html) | 2018-06-28 |
Family
ID=54554652
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568591A Pending JP2017524652A (ja) | 2014-05-20 | 2015-05-19 | 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤 |
| JP2019104381A Active JP6906564B2 (ja) | 2014-05-20 | 2019-06-04 | 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104381A Active JP6906564B2 (ja) | 2014-05-20 | 2019-06-04 | 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤 |
Country Status (21)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017079572A1 (en) * | 2015-11-04 | 2017-05-11 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having multiple myeloma |
| EP3493793A4 (en) * | 2016-08-04 | 2020-04-01 | Millennium Pharmaceuticals, Inc. | COMBINATION OF PROTEASOME INHIBITORS AND ANTI-CD30 ANTIBODIES |
| WO2018123925A1 (ja) * | 2016-12-28 | 2018-07-05 | 第一三共株式会社 | アルポート症候群治療薬 |
| WO2019020099A1 (zh) | 2017-07-28 | 2019-01-31 | 成都地奥九泓制药厂 | 一种硼酸酯化合物、其合成方法及其用途 |
| US20250059214A1 (en) * | 2021-12-06 | 2025-02-20 | Pretzel Therapeutics, Inc. | Amide-containing lonp1 inhibitor compounds, uses and methods |
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-
2015
- 2015-05-19 CR CR20160577A patent/CR20160577A/es unknown
- 2015-05-19 BR BR112016026774A patent/BR112016026774A8/pt not_active Application Discontinuation
- 2015-05-19 CN CN201580029362.6A patent/CN106659761A/zh active Pending
- 2015-05-19 EP EP15726483.9A patent/EP3145526A1/en not_active Withdrawn
- 2015-05-19 SG SG10202003693RA patent/SG10202003693RA/en unknown
- 2015-05-19 TN TN2016000492A patent/TN2016000492A1/en unknown
- 2015-05-19 AU AU2015264272A patent/AU2015264272A1/en not_active Abandoned
- 2015-05-19 WO PCT/US2015/031633 patent/WO2015179443A1/en not_active Ceased
- 2015-05-19 UA UAA201612860A patent/UA121389C2/uk unknown
- 2015-05-19 UY UY0001036132A patent/UY36132A/es not_active Application Discontinuation
- 2015-05-19 US US14/716,761 patent/US20150335668A1/en not_active Abandoned
- 2015-05-19 SG SG11201609259VA patent/SG11201609259VA/en unknown
- 2015-05-19 MX MX2016015267A patent/MX2016015267A/es unknown
- 2015-05-19 CA CA2949517A patent/CA2949517A1/en not_active Abandoned
- 2015-05-19 TW TW104115971A patent/TWI746422B/zh active
- 2015-05-19 MA MA039964A patent/MA39964A/fr unknown
- 2015-05-19 EA EA201692332A patent/EA201692332A1/ru unknown
- 2015-05-19 KR KR1020167033753A patent/KR102481856B1/ko active Active
- 2015-05-19 KR KR1020227022220A patent/KR102509950B1/ko active Active
- 2015-05-19 JP JP2016568591A patent/JP2017524652A/ja active Pending
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2016
- 2016-11-17 IL IL249025A patent/IL249025B/en active IP Right Grant
- 2016-11-17 PH PH12016502301A patent/PH12016502301A1/en unknown
- 2016-11-18 MX MX2021009044A patent/MX2021009044A/es unknown
- 2016-11-18 CL CL2016002948A patent/CL2016002948A1/es unknown
-
2018
- 2018-12-21 US US16/229,524 patent/US20190125773A1/en not_active Abandoned
-
2019
- 2019-06-04 JP JP2019104381A patent/JP6906564B2/ja active Active
- 2019-07-22 US US16/517,963 patent/US20190343851A1/en not_active Abandoned
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2020
- 2020-02-04 US US16/781,432 patent/US20200171061A1/en not_active Abandoned
- 2020-04-19 IL IL274042A patent/IL274042A/en unknown
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2021
- 2021-01-20 AU AU2021200370A patent/AU2021200370B2/en not_active Ceased
- 2021-03-01 US US17/188,492 patent/US11241448B2/en active Active