JP2017523149A5 - - Google Patents
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- Publication number
- JP2017523149A5 JP2017523149A5 JP2016574064A JP2016574064A JP2017523149A5 JP 2017523149 A5 JP2017523149 A5 JP 2017523149A5 JP 2016574064 A JP2016574064 A JP 2016574064A JP 2016574064 A JP2016574064 A JP 2016574064A JP 2017523149 A5 JP2017523149 A5 JP 2017523149A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- dosage form
- composition according
- edoxaban
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 6
- 239000002552 dosage form Substances 0.000 claims 5
- 229920003086 cellulose ether Polymers 0.000 claims 4
- PSMMNJNZVZZNOI-SJILXJHISA-N edoxaban tosylate hydrate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1.N([C@H]1CC[C@@H](C[C@H]1NC(=O)C=1SC=2CN(C)CCC=2N=1)C(=O)N(C)C)C(=O)C(=O)NC1=CC=C(Cl)C=N1 PSMMNJNZVZZNOI-SJILXJHISA-N 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 229920001531 copovidone Polymers 0.000 claims 3
- 229960000622 edoxaban Drugs 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 229940069328 povidone Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000005846 sugar alcohols Chemical class 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 208000005189 Embolism Diseases 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14180078.9 | 2014-08-06 | ||
| EP14180078 | 2014-08-06 | ||
| PCT/EP2015/060656 WO2016020080A1 (en) | 2014-08-06 | 2015-05-13 | Pharmaceutical compositions of edoxaban |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017523149A JP2017523149A (ja) | 2017-08-17 |
| JP2017523149A5 true JP2017523149A5 (enExample) | 2018-06-21 |
Family
ID=53177487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574064A Pending JP2017523149A (ja) | 2014-08-06 | 2015-05-13 | エドキサバンの医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170231969A1 (enExample) |
| EP (1) | EP3177290B1 (enExample) |
| JP (1) | JP2017523149A (enExample) |
| WO (1) | WO2016020080A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI826474B (zh) * | 2018-06-27 | 2023-12-21 | 日商第一三共股份有限公司 | 包含二胺衍生物之顆粒劑、以及其用途及製造方法 |
| EP3744320A1 (en) | 2019-05-29 | 2020-12-02 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising edoxaban |
| EP3838267A1 (en) * | 2019-12-19 | 2021-06-23 | Biohorm, S.L. | Edoxaban tablets |
| WO2022129535A1 (en) | 2020-12-18 | 2022-06-23 | Krka, D.D., Novo Mesto | Edoxaban formulation containing no sugar alcohols |
| AU2023390819A1 (en) | 2022-12-09 | 2025-07-03 | Synthon B.V. | Formulation comprising edoxaban and preparation thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY155256A (en) * | 2009-06-18 | 2015-09-30 | Daiichi Sankyo Co Ltd | Pharmaceutical composition having improved solubility |
| CN102791271B (zh) * | 2010-03-19 | 2014-05-14 | 第一三共株式会社 | 抗凝剂的溶出改善方法 |
| WO2013026553A1 (en) * | 2011-08-22 | 2013-02-28 | Ratiopharm Gmbh | Composition comprising edoxaban |
| US20130158069A1 (en) * | 2011-12-14 | 2013-06-20 | Daiichi Sankyo Company, Limited | Preventive and/or therapeutic agent for thromboembolism in thromboembolism patient with severe renal impairment |
| CN103919746A (zh) * | 2014-04-17 | 2014-07-16 | 山东省医药工业研究所 | 依度沙班缓释片及其制备方法 |
-
2015
- 2015-05-13 EP EP15722530.1A patent/EP3177290B1/en not_active Not-in-force
- 2015-05-13 US US15/501,518 patent/US20170231969A1/en not_active Abandoned
- 2015-05-13 JP JP2016574064A patent/JP2017523149A/ja active Pending
- 2015-05-13 WO PCT/EP2015/060656 patent/WO2016020080A1/en not_active Ceased
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