|
US9260753B2
(en)
|
2011-03-24 |
2016-02-16 |
President And Fellows Of Harvard College |
Single cell nucleic acid detection and analysis
|
|
US9892230B2
(en)
|
2012-03-08 |
2018-02-13 |
The Chinese University Of Hong Kong |
Size-based analysis of fetal or tumor DNA fraction in plasma
|
|
US11261494B2
(en)
|
2012-06-21 |
2022-03-01 |
The Chinese University Of Hong Kong |
Method of measuring a fractional concentration of tumor DNA
|
|
US11913065B2
(en)
|
2012-09-04 |
2024-02-27 |
Guardent Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US20160040229A1
(en)
|
2013-08-16 |
2016-02-11 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
US10876152B2
(en)
|
2012-09-04 |
2020-12-29 |
Guardant Health, Inc. |
Systems and methods to detect rare mutations and copy number variation
|
|
GB2533006B
(en)
|
2012-09-04 |
2017-06-07 |
Guardant Health Inc |
Systems and methods to detect copy number variation
|
|
ES2660989T3
(es)
|
2013-12-28 |
2018-03-27 |
Guardant Health, Inc. |
Métodos y sistemas para detectar variantes genéticas
|
|
ES2741400T3
(es)
|
2014-07-18 |
2020-02-10 |
Univ Hong Kong Chinese |
Análisis de patrones de metilación de tejidos en mezcla de ADN
|
|
CN107002122B
(zh)
|
2014-07-25 |
2023-09-19 |
华盛顿大学 |
确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
|
|
US10364467B2
(en)
|
2015-01-13 |
2019-07-30 |
The Chinese University Of Hong Kong |
Using size and number aberrations in plasma DNA for detecting cancer
|
|
WO2016123698A1
(en)
*
|
2015-02-06 |
2016-08-11 |
Uti Limited Partnership |
Diagnostic assay for post-transplant assessment of potential rejection of donor organs
|
|
EP3256605B1
(en)
|
2015-02-10 |
2022-02-09 |
The Chinese University Of Hong Kong |
Detecting mutations for cancer screening and fetal analysis
|
|
IL305462A
(en)
|
2015-07-23 |
2023-10-01 |
Univ Hong Kong Chinese |
DNA fragmentation pattern analysis suitable clean
|
|
US20180327825A1
(en)
*
|
2015-11-09 |
2018-11-15 |
Progenity, Inc. |
Methods for determining the origin of dna molecules
|
|
WO2017106768A1
(en)
|
2015-12-17 |
2017-06-22 |
Guardant Health, Inc. |
Methods to determine tumor gene copy number by analysis of cell-free dna
|
|
US11514289B1
(en)
|
2016-03-09 |
2022-11-29 |
Freenome Holdings, Inc. |
Generating machine learning models using genetic data
|
|
KR102610098B1
(ko)
*
|
2016-07-06 |
2023-12-04 |
가던트 헬쓰, 인크. |
무세포 핵산의 프래그멘톰 프로파일링을 위한 방법
|
|
US11299780B2
(en)
|
2016-07-15 |
2022-04-12 |
The Regents Of The University Of California |
Methods of producing nucleic acid libraries
|
|
US11788135B2
(en)
|
2016-08-05 |
2023-10-17 |
The Broad Institute, Inc. |
Methods for genome characterization
|
|
JP6560465B1
(ja)
|
2016-09-30 |
2019-08-21 |
ガーダント ヘルス， インコーポレイテッド |
無細胞核酸の多重解像度分析のための方法
|
|
US9850523B1
(en)
|
2016-09-30 |
2017-12-26 |
Guardant Health, Inc. |
Methods for multi-resolution analysis of cell-free nucleic acids
|
|
US20200048711A1
(en)
*
|
2016-10-12 |
2020-02-13 |
Bellwether Bio, Inc |
Determining cell type origin of circulating cell-free dna with molecular counting
|
|
EP4209598A1
(en)
|
2016-10-19 |
2023-07-12 |
The Chinese University of Hong Kong |
Gestational age assessment by methylation and size profiling of maternal plasma dna
|
|
TWI797095B
(zh)
|
2016-10-24 |
2023-04-01 |
美商格瑞爾有限責任公司 |
腫瘤檢測之方法及系統
|
|
WO2018099418A1
(en)
|
2016-11-30 |
2018-06-07 |
The Chinese University Of Hong Kong |
Analysis of cell-free dna in urine and other samples
|
|
EP4450648A3
(en)
*
|
2016-12-13 |
2025-01-15 |
Bellwether Bio, Inc. |
Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
|
|
CA3046007A1
(en)
|
2016-12-22 |
2018-06-28 |
Guardant Health, Inc. |
Methods and systems for analyzing nucleic acid molecules
|
|
MX2019008227A
(es)
|
2017-01-10 |
2020-08-17 |
Juno Therapeutics Inc |
Analisis epigenetico de terapia celular y metodos relacionados.
|
|
EP4421489B1
(en)
|
2017-01-25 |
2026-03-11 |
The Chinese University of Hong Kong |
Diagnostic applications using nucleic acid fragments
|
|
CA3063627A1
(en)
|
2017-05-15 |
2018-11-22 |
Katholieke Universiteit Leuven |
Method for analysing cell-free nucleic acids
|
|
EP3635134A4
(en)
*
|
2017-06-09 |
2021-03-03 |
Bellwether Bio, Inc. |
DIAGNOSTIC CANCER OR OTHER PHYSIOLOGICAL CONDITIONS USING CIRCULATING NUCLEIC ACID FRAGMENT SENTINEL END POINTS
|
|
WO2018227202A1
(en)
|
2017-06-09 |
2018-12-13 |
Bellwether Bio, Inc. |
Determination of cancer type in a subject by probabilistic modeling of circulating nucleic acid fragment endpoints
|
|
US10636512B2
(en)
|
2017-07-14 |
2020-04-28 |
Cofactor Genomics, Inc. |
Immuno-oncology applications using next generation sequencing
|
|
IL316163A
(en)
|
2017-07-26 |
2024-12-01 |
Univ Hong Kong Chinese |
Enhancement of cancer screening using cell-free viral nucleic acids
|
|
WO2019075251A2
(en)
*
|
2017-10-12 |
2019-04-18 |
Nantomics, Llc |
CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS
|
|
CN107545153B
(zh)
*
|
2017-10-25 |
2021-06-11 |
桂林电子科技大学 |
一种基于卷积神经网络的核小体分类预测方法
|
|
US12104203B2
(en)
|
2017-11-27 |
2024-10-01 |
Bgi Shenzhen |
Method for constructing library of cell-free DNAs in body fluids and application thereof
|
|
CN108061794B
(zh)
*
|
2017-12-25 |
2020-03-27 |
苏州大学 |
一种无染色、无探针、无损检测细胞或类细胞结构微生物的类型及其周期的方法
|
|
US12590326B2
(en)
|
2018-01-10 |
2026-03-31 |
Guardant Health, Inc. |
Methods for fragmentome profiling of cell-free nucleic acids
|
|
US11584929B2
(en)
|
2018-01-12 |
2023-02-21 |
Claret Bioscience, Llc |
Methods and compositions for analyzing nucleic acid
|
|
CN112119166B
(zh)
*
|
2018-03-13 |
2025-08-22 |
耶路撒冷希伯来大学伊萨姆研发有限公司 |
无细胞dna染色质免疫沉淀的诊断应用
|
|
CN119753091A
(zh)
|
2018-04-02 |
2025-04-04 |
格里尔公司 |
用于扩增与癌症相关联的cfDNA分子的化验板
|
|
WO2019209884A1
(en)
|
2018-04-23 |
2019-10-31 |
Grail, Inc. |
Methods and systems for screening for conditions
|
|
WO2019222657A1
(en)
|
2018-05-18 |
2019-11-21 |
The Johns Hopkins University |
Cell-free dna for assessing and/or treating cancer
|
|
WO2019236478A1
(en)
*
|
2018-06-04 |
2019-12-12 |
Guardant Health, Inc. |
Methods and systems for determining the cellular origin of cell-free nucleic acids
|
|
JP7537748B2
(ja)
|
2018-06-06 |
2024-08-21 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
核酸ライブラリを生成する方法ならびにそれを実施するための組成物およびキット
|
|
CN108796056A
(zh)
*
|
2018-06-28 |
2018-11-13 |
元码基因科技（北京）股份有限公司 |
基于游离dna的目标基因捕获技术进行组织溯源的方法
|
|
WO2020006369A1
(en)
*
|
2018-06-29 |
2020-01-02 |
Guardant Health, Inc. |
Methods and systems for analysis of ctcf binding regions in cell-free dna
|
|
CN108913682A
(zh)
*
|
2018-07-05 |
2018-11-30 |
上海奥测医疗科技有限公司 |
一种制备cfDNA参考品的方法
|
|
CN112703254A
(zh)
*
|
2018-07-23 |
2021-04-23 |
香港中文大学 |
游离dna损伤分析及其临床应用
|
|
CN109448783B
(zh)
*
|
2018-08-07 |
2022-05-13 |
清华大学 |
一种染色质拓扑结构域边界的分析方法
|
|
IL281741B2
(en)
|
2018-09-27 |
2026-04-01 |
Grail Inc |
Methylation markers and a targeted methylation detection panel
|
|
JP7654538B2
(ja)
*
|
2018-10-08 |
2025-04-01 |
フリーノム ホールディングス，インク． |
転写因子プロファイリング
|
|
CN111172263A
(zh)
*
|
2018-11-12 |
2020-05-19 |
北京医院 |
一种应用于无创产前检测的参考物质及其制备方法
|
|
CA3118742A1
(en)
*
|
2018-11-21 |
2020-05-28 |
Karius, Inc. |
Detection and prediction of infectious disease
|
|
US20200199685A1
(en)
|
2018-12-17 |
2020-06-25 |
Guardant Health, Inc. |
Determination of a physiological condition with nucleic acid fragment endpoints
|
|
KR20210113237A
(ko)
*
|
2018-12-19 |
2021-09-15 |
더 차이니즈 유니버시티 오브 홍콩 |
무 세포 dna 말단 특성
|
|
US11657897B2
(en)
*
|
2018-12-31 |
2023-05-23 |
Nvidia Corporation |
Denoising ATAC-seq data with deep learning
|
|
MX2020014095A
(es)
*
|
2019-01-24 |
2021-03-09 |
Illumina Inc |
Metodos y sistemas para monitorear la salud y enfermedad de organos.
|
|
EP4567131A3
(en)
|
2019-01-31 |
2025-09-03 |
Guardant Health, Inc. |
Compositions and methods for isolating cell-free dna
|
|
CN109841265B
(zh)
*
|
2019-02-22 |
2021-09-21 |
清华大学 |
使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
|
|
WO2020198942A1
(zh)
*
|
2019-03-29 |
2020-10-08 |
中国科学技术大学 |
基于峰聚类的单细胞染色质可及性测序数据分析方法和系统
|
|
WO2020243722A1
(en)
|
2019-05-31 |
2020-12-03 |
Guardant Health, Inc. |
Methods and systems for improving patient monitoring after surgery
|
|
CN110272985B
(zh)
*
|
2019-06-26 |
2021-08-17 |
广州市雄基生物信息技术有限公司 |
基于外周血血浆游离dna高通量测序技术的肿瘤筛查试剂盒及其系统与方法
|
|
US11891653B2
(en)
|
2019-09-30 |
2024-02-06 |
Guardant Health, Inc. |
Compositions and methods for analyzing cell-free DNA in methylation partitioning assays
|
|
EP4041888A4
(en)
|
2019-10-11 |
2023-11-01 |
Guardant Health, Inc. |
USE OF CELLULAR BACTERIAL NUCLEIC ACIDS FOR CANCER DETECTION
|
|
CN110739027B
(zh)
*
|
2019-10-23 |
2023-04-18 |
深圳吉因加医学检验实验室 |
一种基于染色质区域覆盖深度的癌症组织定位方法及系统
|
|
CA3157560A1
(en)
|
2019-11-26 |
2021-06-03 |
Dustin Howard HITE |
Methods, compositions and systems for improving the binding of methylated polynucleotides
|
|
WO2021121368A1
(en)
*
|
2019-12-18 |
2021-06-24 |
The Chinese University Of Hong Kong |
Cell-free dna fragmentation and nucleases
|
|
CN115066500A
(zh)
*
|
2019-12-19 |
2022-09-16 |
新加坡科技研究局 |
估计循环肿瘤dna负荷的方法以及相关的试剂盒和方法
|
|
CN115151657A
(zh)
*
|
2019-12-20 |
2022-10-04 |
安可济控股有限公司 |
用于疾病检测的方法和系统
|
|
WO2021130356A1
(en)
|
2019-12-24 |
2021-07-01 |
Vib Vzw |
Disease detection in liquid biopsies
|
|
US20210238668A1
(en)
*
|
2020-01-08 |
2021-08-05 |
The Chinese University Of Hong Kong |
Biterminal dna fragment types in cell-free samples and uses thereof
|
|
WO2021141220A1
(ko)
*
|
2020-01-09 |
2021-07-15 |
서울대학교 산학협력단 |
ATAC-seq 데이터 정규화 및 이의 활용 방법
|
|
CN111254194B
(zh)
*
|
2020-01-13 |
2021-09-07 |
东南大学 |
基于cfDNA的测序及数据分析的癌症相关生物标记及其在cfDNA样品分类中的应用
|
|
CN115428088A
(zh)
*
|
2020-02-13 |
2022-12-02 |
10X基因组学有限公司 |
用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法
|
|
US11211147B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
|
|
US11475981B2
(en)
|
2020-02-18 |
2022-10-18 |
Tempus Labs, Inc. |
Methods and systems for dynamic variant thresholding in a liquid biopsy assay
|
|
US11211144B2
(en)
|
2020-02-18 |
2021-12-28 |
Tempus Labs, Inc. |
Methods and systems for refining copy number variation in a liquid biopsy assay
|
|
CN113362897A
(zh)
*
|
2020-03-06 |
2021-09-07 |
福建和瑞基因科技有限公司 |
基于核小体分布特征的肿瘤标志物筛选方法及应用
|
|
JP7843243B2
(ja)
|
2020-04-30 |
2026-04-09 |
ガーダント ヘルス， インコーポレイテッド |
分配された核酸を使用した配列決定のための方法
|
|
CN116018646A
(zh)
*
|
2020-05-22 |
2023-04-25 |
阿克图尔公司 |
用于表征无细胞核酸片段的方法
|
|
CN111724860B
(zh)
*
|
2020-06-18 |
2021-03-16 |
深圳吉因加医学检验实验室 |
一种基于测序数据识别染色质开放区域的方法及装置
|
|
EP4407042A3
(en)
|
2020-07-10 |
2024-09-18 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
WO2023282916A1
(en)
|
2021-07-09 |
2023-01-12 |
Guardant Health, Inc. |
Methods of detecting genomic rearrangements using cell free nucleic acids
|
|
CN111881418B
(zh)
*
|
2020-07-27 |
2023-05-16 |
中国农业科学院农业信息研究所 |
一种基于二分法的大豆气象产量预测方法及系统
|
|
ES3018032T3
(en)
|
2020-07-30 |
2025-05-14 |
Guardant Health Inc |
Methods for isolating cell-free dna
|
|
CN112085067B
(zh)
*
|
2020-08-17 |
2022-07-12 |
浙江大学 |
一种高通量筛选dna损伤反应抑制剂的方法
|
|
JP2023540221A
(ja)
|
2020-08-25 |
2023-09-22 |
ガーダント ヘルス， インコーポレイテッド |
バリアントの起源を予測するための方法およびシステム
|
|
WO2022061080A1
(en)
*
|
2020-09-17 |
2022-03-24 |
The Regents Of The University Of Colorado, A Body Corporate |
Signatures in cell-free dna to detect disease, track treatment response, and inform treatment decisions
|
|
US20220154285A1
(en)
|
2020-09-30 |
2022-05-19 |
Guardant Health, Inc. |
Analysis of methylated dna comprising methylation-sensitive or methylation-dependent restrictions
|
|
US12234518B2
(en)
|
2020-10-23 |
2025-02-25 |
Guardant Health, Inc. |
Compositions and methods for analyzing DNA using partitioning and base conversion
|
|
EP4251765A1
(en)
|
2020-11-30 |
2023-10-04 |
Guardant Health, Inc. |
Compositions and methods for enriching methylated polynucleotides
|
|
EP4267757A1
(en)
|
2020-12-23 |
2023-11-01 |
Guardant Health, Inc. |
Methods and systems for analyzing methylated polynucleotides
|
|
TW202242145A
(zh)
*
|
2020-12-29 |
2022-11-01 |
比利時商比利時意志有限公司 |
核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
|
|
US20230175064A1
(en)
*
|
2021-02-09 |
2023-06-08 |
Illumina, Inc. |
Methods and systems for monitoring organ health and disease
|
|
WO2022174109A1
(en)
|
2021-02-12 |
2022-08-18 |
Guardant Health, Inc. |
Methods and compositions for detecting nucleic acid variants
|
|
EP4314329A1
(en)
|
2021-03-25 |
2024-02-07 |
Guardant Health, Inc. |
Methods and compositions for quantifying immune cell dna
|
|
JP2024515565A
(ja)
*
|
2021-04-08 |
2024-04-10 |
フレッド ハッチンソン キャンサー センター |
ヌクレオソーム保護およびクロマチンアクセシビリティを調査するためのセルフリーｄｎａ配列データ解析法
|
|
JP2024515558A
(ja)
*
|
2021-04-08 |
2024-04-10 |
デルフィ ダイアグノスティックス インコーポレイテッド |
ゲノム全体のｃｆＤＮＡ断片化プロファイルを使用するがんを検出する方法
|
|
JP2024523401A
(ja)
|
2021-06-21 |
2024-06-28 |
ガーダント ヘルス， インコーポレイテッド |
コピー数情報に基づく組織起源分析のための方法および組成物
|
|
EP4409024A1
(en)
|
2021-09-30 |
2024-08-07 |
Guardant Health, Inc. |
Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
|
|
CA3246524A1
(en)
|
2022-04-07 |
2023-10-12 |
Guardant Health, Inc. |
TUMOR PRESENCE DETECTION BASED ON THE METHYLATION STATE OF ACELLULAR NUCLEIC ACID MOLECULES
|
|
GB202205710D0
(en)
|
2022-04-19 |
2022-06-01 |
Univ Of Essex Enterprises Limited |
Cell-free DNA-based methods
|
|
JP2025522763A
(ja)
|
2022-06-30 |
2025-07-17 |
ガーダント ヘルス， インコーポレイテッド |
異常にメチル化されたｄｎａの富化
|
|
WO2024056720A1
(en)
|
2022-09-13 |
2024-03-21 |
Medizinische Universität Graz |
Determining of health status and treatment monitoring with cell-free dna
|
|
WO2024073508A2
(en)
|
2022-09-27 |
2024-04-04 |
Guardant Health, Inc. |
Methods and compositions for quantifying immune cell dna
|
|
JP2025542261A
(ja)
|
2022-12-22 |
2025-12-25 |
ガーダント ヘルス， インコーポレイテッド |
統合された対象および全ゲノム体細胞およびｄｎａメチル化シーケンシングワークフロー
|
|
EP4638781A2
(en)
|
2022-12-22 |
2025-10-29 |
Guardant Health, Inc. |
Methods involving methylation preserving amplification with error correction
|
|
EP4705522A1
(en)
|
2023-05-05 |
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|
|
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|
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|
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|
|
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|
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|
|
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|
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|
|
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|
|
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|
|
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|