JP2017522903A5 - - Google Patents

Info

Publication number

JP2017522903A5

JP2017522903A5 JP2017517406A JP2017517406A JP2017522903A5 JP 2017522903 A5 JP2017522903 A5 JP 2017522903A5 JP 2017517406 A JP2017517406 A JP 2017517406A JP 2017517406 A JP2017517406 A JP 2017517406A JP 2017522903 A5 JP2017522903 A5 JP 2017522903A5

Authority

JP

Japan

Prior art keywords

seq

sequence

antibody

antigen

macromolecule

Prior art date

2015-06-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000427 antigen Substances 0.000 claims 40
• 102000036639 antigens Human genes 0.000 claims 40
• 108091007433 antigens Proteins 0.000 claims 40
• 229920002521 macromolecule Polymers 0.000 claims 22
• 239000012634 fragment Substances 0.000 claims 21
• 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims 20
• 102000049284 human IL7R Human genes 0.000 claims 15
• 230000003278 mimic effect Effects 0.000 claims 15
• 150000001413 amino acids Chemical class 0.000 claims 11
• 210000004027 cell Anatomy 0.000 claims 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
• 238000002054 transplantation Methods 0.000 claims 9
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 150000007523 nucleic acids Chemical class 0.000 claims 8
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 6
• 208000023275 Autoimmune disease Diseases 0.000 claims 5
• 102100021592 Interleukin-7 Human genes 0.000 claims 5
• 108010002586 Interleukin-7 Proteins 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 239000004480 active ingredient Substances 0.000 claims 5
• 208000026935 allergic disease Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 5
• 208000027866 inflammatory disease Diseases 0.000 claims 5
• 208000023504 respiratory system disease Diseases 0.000 claims 5
• 238000011282 treatment Methods 0.000 claims 5
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
• 230000005764 inhibitory process Effects 0.000 claims 4
• 230000011664 signaling Effects 0.000 claims 4
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 3
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 3
• 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims 3
• 206010025323 Lymphomas Diseases 0.000 claims 3
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 3
• 102100031294 Thymic stromal lymphopoietin Human genes 0.000 claims 3
• 208000036142 Viral infection Diseases 0.000 claims 3
• 239000005557 antagonist Substances 0.000 claims 3
• 230000001363 autoimmune Effects 0.000 claims 3
• 230000005784 autoimmunity Effects 0.000 claims 3
• 230000001684 chronic effect Effects 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• 108040006861 interleukin-7 receptor activity proteins Proteins 0.000 claims 3
• 208000032839 leukemia Diseases 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• 230000009385 viral infection Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 238000011284 combination treatment Methods 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 201000002491 encephalomyelitis Diseases 0.000 claims 2
• 206010025135 lupus erythematosus Diseases 0.000 claims 2
• 230000035800 maturation Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 238000011084 recovery Methods 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• 238000011269 treatment regimen Methods 0.000 claims 2
• 241000271566 Aves Species 0.000 claims 1
• 102100023698 C-C motif chemokine 17 Human genes 0.000 claims 1
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 1
• 101000978362 Homo sapiens C-C motif chemokine 17 Proteins 0.000 claims 1
• 108010041012 Integrin alpha4 Proteins 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 102000001712 STAT5 Transcription Factor Human genes 0.000 claims 1
• 108010029477 STAT5 Transcription Factor Proteins 0.000 claims 1
• 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
• 206010042953 Systemic sclerosis Diseases 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 125000003636 chemical group Chemical group 0.000 claims 1
• 210000004443 dendritic cell Anatomy 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 230000033581 fucosylation Effects 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 108010021315 integrin beta7 Proteins 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 201000000050 myeloid neoplasm Diseases 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 230000026731 phosphorylation Effects 0.000 claims 1
• 238000006366 phosphorylation reaction Methods 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1