JP2017522323A5 - - Google Patents
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- Publication number
- JP2017522323A5 JP2017522323A5 JP2017502695A JP2017502695A JP2017522323A5 JP 2017522323 A5 JP2017522323 A5 JP 2017522323A5 JP 2017502695 A JP2017502695 A JP 2017502695A JP 2017502695 A JP2017502695 A JP 2017502695A JP 2017522323 A5 JP2017522323 A5 JP 2017522323A5
- Authority
- JP
- Japan
- Prior art keywords
- rna
- cell
- repeat sequence
- moiety
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 20
- 231100000331 toxic Toxicity 0.000 claims 6
- 230000002588 toxic effect Effects 0.000 claims 6
- 150000001345 alkine derivatives Chemical class 0.000 claims 5
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 201000009340 myotonic dystrophy type 1 Diseases 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 238000006482 condensation reaction Methods 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000035699 permeability Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 208000035955 Proximal myotonic myopathy Diseases 0.000 claims 2
- 208000037140 Steinert myotonic dystrophy Diseases 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 201000008709 myotonic dystrophy type 2 Diseases 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 claims 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical class N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462026266P | 2014-07-18 | 2014-07-18 | |
| US62/026,266 | 2014-07-18 | ||
| PCT/US2015/040902 WO2016011348A1 (en) | 2014-07-18 | 2015-07-17 | Toxic rna inhibitors self-assembled in situ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018241478A Division JP2019068831A (ja) | 2014-07-18 | 2018-12-25 | インサイチュで自己組織化した、毒性のあるｒｎａ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522323A JP2017522323A (ja) | 2017-08-10 |
| JP2017522323A5 true JP2017522323A5 (cg-RX-API-DMAC7.html) | 2018-08-30 |
| JP6461306B2 JP6461306B2 (ja) | 2019-01-30 |
Family
ID=55079084
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502695A Active JP6461306B2 (ja) | 2014-07-18 | 2015-07-17 | インサイチュで自己組織化した、毒性のあるｒｎａ阻害剤 |
| JP2018241478A Pending JP2019068831A (ja) | 2014-07-18 | 2018-12-25 | インサイチュで自己組織化した、毒性のあるｒｎａ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018241478A Pending JP2019068831A (ja) | 2014-07-18 | 2018-12-25 | インサイチュで自己組織化した、毒性のあるｒｎａ阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10220031B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3169404A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6461306B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106714908A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015289524A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2955428A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL250113A0 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201700387QA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016011348A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10220031B2 (en) * | 2014-07-18 | 2019-03-05 | The Scripps Research Institute | Toxic RNA inhibitors self-assembled in situ |
| WO2018098297A1 (en) * | 2016-11-28 | 2018-05-31 | The Scripps Research Institute | Precise small molecule recognition of a toxic cug rna repeat expansion |
| US11807623B2 (en) | 2017-11-30 | 2023-11-07 | Arrakis Therapeutics, Inc. | Nucleic acid-binding photoprobes and uses thereof |
| AU2021336880A1 (en) * | 2020-09-02 | 2023-04-13 | Promega Corporation | Nucleic acid modifying reagents and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9150612B2 (en) * | 2007-02-23 | 2015-10-06 | The Research Foundation Of State University Of New York | RNA targeting compounds and methods for making and using same |
| WO2012050896A2 (en) * | 2010-09-29 | 2012-04-19 | Kansas State University Research Foundation | Protease selective supramolecular assemblies |
| US20140050778A1 (en) * | 2010-12-28 | 2014-02-20 | University Of Rochester | Nucleic acid binding compounds, methods of making, and use thereof |
| WO2013138662A1 (en) * | 2012-03-16 | 2013-09-19 | 4S3 Bioscience, Inc. | Antisense conjugates for decreasing expression of dmpk |
| US9550769B2 (en) * | 2012-08-30 | 2017-01-24 | The Scripps Research Institute | Small molecules targeting repeat r(CGG) sequences |
| US10220031B2 (en) * | 2014-07-18 | 2019-03-05 | The Scripps Research Institute | Toxic RNA inhibitors self-assembled in situ |
-
2015
- 2015-07-17 US US15/327,117 patent/US10220031B2/en active Active
- 2015-07-17 EP EP15822000.4A patent/EP3169404A4/en not_active Withdrawn
- 2015-07-17 CN CN201580050560.0A patent/CN106714908A/zh active Pending
- 2015-07-17 AU AU2015289524A patent/AU2015289524A1/en not_active Abandoned
- 2015-07-17 WO PCT/US2015/040902 patent/WO2016011348A1/en not_active Ceased
- 2015-07-17 JP JP2017502695A patent/JP6461306B2/ja active Active
- 2015-07-17 CA CA2955428A patent/CA2955428A1/en not_active Abandoned
- 2015-07-17 SG SG11201700387QA patent/SG11201700387QA/en unknown
-
2017
- 2017-01-15 IL IL250113A patent/IL250113A0/en unknown
-
2018
- 2018-12-25 JP JP2018241478A patent/JP2019068831A/ja active Pending
-
2019
- 2019-02-04 US US16/266,832 patent/US10471057B2/en active Active
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