JP2017522277A5 - - Google Patents
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- Publication number
- JP2017522277A5 JP2017522277A5 JP2016570862A JP2016570862A JP2017522277A5 JP 2017522277 A5 JP2017522277 A5 JP 2017522277A5 JP 2016570862 A JP2016570862 A JP 2016570862A JP 2016570862 A JP2016570862 A JP 2016570862A JP 2017522277 A5 JP2017522277 A5 JP 2017522277A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 16
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009910P | 2014-06-10 | 2014-06-10 | |
| US62/009,910 | 2014-06-10 | ||
| PCT/US2015/034964 WO2015191630A1 (en) | 2014-06-10 | 2015-06-09 | Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522277A JP2017522277A (ja) | 2017-08-10 |
| JP2017522277A5 true JP2017522277A5 (OSRAM) | 2018-07-19 |
| JP6552061B2 JP6552061B2 (ja) | 2019-07-31 |
Family
ID=54834213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570862A Active JP6552061B2 (ja) | 2014-06-10 | 2015-06-09 | 代謝型グルタミン酸受容体の負のアロステリックモジュレーター（ｎａｍｓ）とその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9969726B2 (OSRAM) |
| EP (1) | EP3154954B1 (OSRAM) |
| JP (1) | JP6552061B2 (OSRAM) |
| AU (1) | AU2015274781C1 (OSRAM) |
| CA (1) | CA2950952C (OSRAM) |
| WO (1) | WO2015191630A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015157187A1 (en) * | 2014-04-06 | 2015-10-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor positive allosteric modulators (pams) and uses thereof |
| CA2950952C (en) * | 2014-06-10 | 2023-01-10 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof |
| EA034912B1 (ru) | 2015-06-03 | 2020-04-06 | Бристол-Маерс Сквибб Компани | 4-гидрокси-3-(гетероарил)пиридин-2-оновые агонисты apj для применения в лечении сердечно-сосудистых заболеваний |
| CN108299303B (zh) * | 2018-02-09 | 2022-10-11 | 中山大学 | 一种四芳基吡唑类化合物的合成新方法 |
| CN108997325B (zh) * | 2018-07-06 | 2020-08-04 | 浙江工业大学 | 一种芳基联噻唑类化合物和应用 |
| AU2019310122A1 (en) * | 2018-07-27 | 2021-03-18 | With Great Power, Llc | Clinical methods and pharmaceutical compositions employing ampa receptor antagonists to treat glioblastoma and other cancers |
| EP3924348A4 (en) * | 2019-03-21 | 2023-03-22 | University of Virginia Patent Foundation | SULFUR HETEROCYCLENE EXCHANGE CHEMISTRY AND ITS USES |
| CN110183382A (zh) * | 2019-06-06 | 2019-08-30 | 东北师范大学 | 新型三氟甲基吡唑类化合物合成方法 |
| JP2022541829A (ja) * | 2019-07-22 | 2022-09-27 | アンジオン バイオメディカ コーポレーション | Ｒｈｏ関連コイルドコイルキナーゼ（ＲＯＣＫ）阻害剤としてのエチニルヘテロ環 |
| EP4074700A4 (en) | 2019-12-10 | 2024-02-07 | Shionogi & Co., Ltd | HISTONE DEACETYLASE INHIBITOR COMPRISING AROMATIC HETEROCYCLIC GROUP CONTAINING NITROGEN |
| JP2023541153A (ja) * | 2020-09-14 | 2023-09-28 | ジェンザイム・コーポレーション | 鎌状赤血球症を処置するための、ビスホスホグリセリン酸ムターゼのモジュレーターとしてのカルボン酸含有化合物 |
| CN112480073B (zh) * | 2020-12-02 | 2022-03-22 | 武汉药明康德新药开发有限公司 | 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法 |
| US20220265601A1 (en) * | 2021-02-10 | 2022-08-25 | David Alan Heldreth, JR. | Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses. |
| CN116041277B (zh) * | 2023-01-18 | 2024-11-01 | 中国药科大学 | 苯基和联苯基取代的五元杂环类化合物及其制备方法、药物组合物和应用 |
| US11970460B1 (en) | 2023-10-24 | 2024-04-30 | King Faisal University | 4-(4,5-bis(4-bromophenyl)-2-phenyl-1H-imidazol-1-yl)benzoic acid as an antimicrobial compound |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20020259A2 (en) | 1999-10-15 | 2004-04-30 | Hoffmann La Roche | Benzodiazepine derivatives |
| PL357433A1 (en) | 1999-10-15 | 2004-07-26 | F.Hoffmann-La Roche Ag | Benzodiazepine derivatives as metabotropic glutamate receptor antagonists |
| PL369598A1 (en) * | 2001-02-21 | 2005-05-02 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| IL157873A0 (en) * | 2001-04-12 | 2004-03-28 | Hoffmann La Roche | DIHYDRO-BENZO [b] [1,4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II |
| YU79103A (sh) * | 2001-04-12 | 2006-05-25 | F. Hoffmann-La Roche Ag. | Derivati dihidro-benzo/b/ /1,4/diazepin-2-ona kao antagonisti mglur2 i receptora |
| JP4523271B2 (ja) * | 2001-06-01 | 2010-08-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチアゾール化合物 |
| US6949542B2 (en) | 2002-02-06 | 2005-09-27 | Hoffman-La Roche Inc. | Dihydro-benzo[b][1,4]diazepin-2-one derivatives |
| WO2003077918A1 (en) * | 2002-03-12 | 2003-09-25 | Merck & Co., Inc. | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 |
| AU2003301226A1 (en) * | 2002-12-20 | 2004-07-22 | Pharmacia Corp | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
| JP2006522128A (ja) * | 2003-04-03 | 2006-09-28 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体−５のモジュレーターとしての４環イミダゾール誘導体 |
| JP2006528617A (ja) * | 2003-07-24 | 2006-12-21 | ファーマジーン ラボラトリーズ リミテッド | ５−ｈｔ２ｂ受容体アンタゴニスト |
| US20060074102A1 (en) * | 2004-05-14 | 2006-04-06 | Kevin Cusack | Kinase inhibitors as therapeutic agents |
| MX2008000141A (es) * | 2005-06-27 | 2008-04-07 | Exelixis Inc | Moduladores de lxr basados en imidazol. |
| JP5249919B2 (ja) * | 2006-03-29 | 2013-07-31 | エフ．ホフマン−ラ ロシュ アーゲー | ｍＧｌｕＲ２アンタゴニストとしてのピリジン及びピリミジン誘導体 |
| US8012986B2 (en) * | 2007-04-02 | 2011-09-06 | Hoffmann-La Roche Inc. | Pyridine and pyrimidine derivatives as MGLUR2 antagonists |
| EP2145873A1 (fr) * | 2008-06-17 | 2010-01-20 | Commissariat A L'energie Atomique | Nouveaux composés ayant une activité protectrice vis-à-vis de l'action de toxines et de virus au mode d'action intracellulaire |
| CN102712641B (zh) | 2009-12-14 | 2015-12-09 | 默沙东有限责任公司 | Mk2抑制剂 |
| WO2011116356A2 (en) * | 2010-03-19 | 2011-09-22 | Sanford-Burnham Medical Research Institute | Positive allosteric modulators of group ii mglurs |
| US9193710B2 (en) | 2011-08-29 | 2015-11-24 | Sanford-Burnham Medical Research Institute | Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof |
| GB201321743D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| CA2950952C (en) | 2014-06-10 | 2023-01-10 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof |
-
2015
- 2015-06-09 CA CA2950952A patent/CA2950952C/en active Active
- 2015-06-09 US US15/315,363 patent/US9969726B2/en active Active
- 2015-06-09 AU AU2015274781A patent/AU2015274781C1/en active Active
- 2015-06-09 JP JP2016570862A patent/JP6552061B2/ja active Active
- 2015-06-09 EP EP15806027.7A patent/EP3154954B1/en active Active
- 2015-06-09 WO PCT/US2015/034964 patent/WO2015191630A1/en not_active Ceased
-
2018
- 2018-04-11 US US15/950,683 patent/US10597367B2/en active Active
-
2020
- 2020-03-12 US US16/817,209 patent/US11447453B2/en active Active
-
2022
- 2022-08-08 US US17/883,255 patent/US20230113588A1/en active Pending