JP2017520582A5 - - Google Patents
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- JP2017520582A5 JP2017520582A5 JP2016575898A JP2016575898A JP2017520582A5 JP 2017520582 A5 JP2017520582 A5 JP 2017520582A5 JP 2016575898 A JP2016575898 A JP 2016575898A JP 2016575898 A JP2016575898 A JP 2016575898A JP 2017520582 A5 JP2017520582 A5 JP 2017520582A5
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- 239000000203 mixture Substances 0.000 claims description 38
- 210000002536 stromal cell Anatomy 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 8
- -1 CD49A Proteins 0.000 claims description 6
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 4
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 4
- 210000000577 adipose tissue Anatomy 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 102100024484 Codanin-1 Human genes 0.000 claims description 3
- 101000980888 Homo sapiens Codanin-1 Proteins 0.000 claims description 3
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- 102000007469 Actins Human genes 0.000 claims description 2
- 108010085238 Actins Proteins 0.000 claims description 2
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 2
- 102100032912 CD44 antigen Human genes 0.000 claims description 2
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 2
- 102100037904 CD9 antigen Human genes 0.000 claims description 2
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 2
- 108010036949 Cyclosporine Proteins 0.000 claims description 2
- 102100036912 Desmin Human genes 0.000 claims description 2
- 108010044052 Desmin Proteins 0.000 claims description 2
- 102100037241 Endoglin Human genes 0.000 claims description 2
- 102000001690 Factor VIII Human genes 0.000 claims description 2
- 108010054218 Factor VIII Proteins 0.000 claims description 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 2
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims description 2
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims description 2
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims description 2
- 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 claims description 2
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 2
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims description 2
- 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 claims description 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 2
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 2
- 102100022338 Integrin alpha-M Human genes 0.000 claims description 2
- 102100022337 Integrin alpha-V Human genes 0.000 claims description 2
- 102100022297 Integrin alpha-X Human genes 0.000 claims description 2
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 2
- 102000011782 Keratins Human genes 0.000 claims description 2
- 108010076876 Keratins Proteins 0.000 claims description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 2
- 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 claims description 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 2
- 102000003729 Neprilysin Human genes 0.000 claims description 2
- 108090000028 Neprilysin Proteins 0.000 claims description 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims description 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 230000000735 allogeneic effect Effects 0.000 claims description 2
- 229960001265 ciclosporin Drugs 0.000 claims description 2
- 229930182912 cyclosporin Natural products 0.000 claims description 2
- 210000005045 desmin Anatomy 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229960000301 factor viii Drugs 0.000 claims description 2
- 238000007917 intracranial administration Methods 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007919 intrasynovial administration Methods 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 229960000485 methotrexate Drugs 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 19
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 11
- 210000000130 stem cell Anatomy 0.000 description 2
- GNENVASJJIUNER-UHFFFAOYSA-N 2,4,6-tricyclohexyloxy-1,3,5,2,4,6-trioxatriborinane Chemical compound C1CCCCC1OB1OB(OC2CCCCC2)OB(OC2CCCCC2)O1 GNENVASJJIUNER-UHFFFAOYSA-N 0.000 description 1
- 208000022120 Jeavons syndrome Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14175096 | 2014-06-30 | ||
| EP14175096.8 | 2014-06-30 | ||
| PCT/IB2015/054922 WO2016001845A1 (en) | 2014-06-30 | 2015-06-30 | Mesenchymal stromal cells for treating rheumatoid arthritis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520582A JP2017520582A (ja) | 2017-07-27 |
| JP2017520582A5 true JP2017520582A5 (OSRAM) | 2018-08-09 |
| JP6722598B2 JP6722598B2 (ja) | 2020-07-15 |
Family
ID=51033024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575898A Active JP6722598B2 (ja) | 2014-06-30 | 2015-06-30 | 関節リウマチ治療のための間葉系間質細胞 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170136065A1 (OSRAM) |
| EP (1) | EP3160480B1 (OSRAM) |
| JP (1) | JP6722598B2 (OSRAM) |
| WO (1) | WO2016001845A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10851347B2 (en) | 2016-06-06 | 2020-12-01 | Pluristem Ltd. | Altered adherent stromal cells and methods of producing and using same |
| KR101969229B1 (ko) * | 2016-09-27 | 2019-04-15 | 가톨릭대학교 산학협력단 | 통증이 경감되는 골관절염 치료용 키트 |
| RU2659204C1 (ru) * | 2017-02-03 | 2018-06-28 | Федеральное государственное автономное образовательное учреждение высшего образования "Балтийский федеральный университет имени Иммануила Канта" (БФУ им. И. Канта) | Биотрансплантат для лечения дисплазии суставов и способ его получения |
| US20230346842A1 (en) * | 2020-05-07 | 2023-11-02 | Primegen Biotech, Llc | Methods and Compositions For Reducing Joint Inflammation Using Mesenchymal Stem Cells |
| EP4623302A1 (en) | 2022-11-23 | 2025-10-01 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Biomarkers predictive of immunomodulatory mesenchymal stromal cells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5627175A (en) | 1992-12-02 | 1997-05-06 | Shellinternationale Research Maatschappij B.V. | Azoxycyanobenzene compounds |
| WO1995002698A1 (en) | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| CA2222328C (en) | 1995-06-07 | 2012-01-10 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| US5705308A (en) | 1996-09-30 | 1998-01-06 | Eastman Kodak Company | Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element |
| US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| WO2007039150A2 (en) | 2005-09-23 | 2007-04-12 | Cellerix, S.L. | Cell populations having immunoregulatory activity, method for isolation and uses |
| US20120201791A1 (en) * | 2009-10-15 | 2012-08-09 | Tai June Yoo | Methods of treating diseases or conditions using mesenchymal stem cells |
| ES2479565T1 (es) * | 2011-03-11 | 2014-08-20 | Tigenix, S.A.U. | Poblaciones celulares que tienen actividad immunoreguladora, método para el aislamiento y usos |
| US20160120910A1 (en) * | 2013-06-25 | 2016-05-05 | Tigenix S.A.U. | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
-
2015
- 2015-06-30 US US15/323,371 patent/US20170136065A1/en not_active Abandoned
- 2015-06-30 WO PCT/IB2015/054922 patent/WO2016001845A1/en not_active Ceased
- 2015-06-30 EP EP15742101.7A patent/EP3160480B1/en active Active
- 2015-06-30 JP JP2016575898A patent/JP6722598B2/ja active Active
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