JP2017517498A5 - - Google Patents
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- JP2017517498A5 JP2017517498A5 JP2016564054A JP2016564054A JP2017517498A5 JP 2017517498 A5 JP2017517498 A5 JP 2017517498A5 JP 2016564054 A JP2016564054 A JP 2016564054A JP 2016564054 A JP2016564054 A JP 2016564054A JP 2017517498 A5 JP2017517498 A5 JP 2017517498A5
- Authority
- JP
- Japan
- Prior art keywords
- defensin
- composition
- spp
- candida
- list consisting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108010002069 Defensins Proteins 0.000 claims description 60
- 102000000541 Defensins Human genes 0.000 claims description 60
- 239000000203 mixture Substances 0.000 claims description 43
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 23
- 244000052769 pathogen Species 0.000 claims description 19
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 16
- 239000013043 chemical agent Substances 0.000 claims description 16
- 238000009472 formulation Methods 0.000 claims description 16
- 230000001717 pathogenic effect Effects 0.000 claims description 15
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims description 14
- 108010049047 Echinocandins Proteins 0.000 claims description 13
- 230000009545 invasion Effects 0.000 claims description 10
- -1 PhD1A Proteins 0.000 claims description 9
- 239000003112 inhibitor Substances 0.000 claims description 9
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 8
- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 claims description 8
- RYAUSSKQMZRMAI-ALOPSCKCSA-N (2S,6R)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine Chemical compound C=1C=C(C(C)(C)C)C=CC=1CC(C)CN1C[C@H](C)O[C@H](C)C1 RYAUSSKQMZRMAI-ALOPSCKCSA-N 0.000 claims description 8
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 8
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims description 8
- 229930183010 Amphotericin Natural products 0.000 claims description 8
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 claims description 8
- 101100116664 Arabidopsis thaliana ATTI1 gene Proteins 0.000 claims description 8
- 241000351920 Aspergillus nidulans Species 0.000 claims description 8
- 229920002498 Beta-glucan Polymers 0.000 claims description 8
- 101000984722 Bos taurus Pancreatic trypsin inhibitor Proteins 0.000 claims description 8
- KAWOEDMUUFFXAM-UHFFFAOYSA-N CC1(C)CCCC2(C)C(C)C(C=O)=CCC21 Polymers CC1(C)CCCC2(C)C(C)C(C=O)=CCC21 KAWOEDMUUFFXAM-UHFFFAOYSA-N 0.000 claims description 8
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims description 8
- 239000005778 Fenpropimorph Substances 0.000 claims description 8
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 8
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 claims description 8
- AZJUJOFIHHNCSV-KCQAQPDRSA-N Polygodial Polymers C[C@@]1([C@H](C(C=O)=CC2)C=O)[C@@H]2C(C)(C)CCC1 AZJUJOFIHHNCSV-KCQAQPDRSA-N 0.000 claims description 8
- 241001634942 Trichosporon inkin Species 0.000 claims description 8
- 229960003204 amorolfine Drugs 0.000 claims description 8
- 229940009444 amphotericin Drugs 0.000 claims description 8
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 8
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229960003749 ciclopirox Drugs 0.000 claims description 8
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical group ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 claims description 8
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims description 8
- 229960004884 fluconazole Drugs 0.000 claims description 8
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 claims description 8
- 229960002867 griseofulvin Drugs 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- VHVPQPYKVGDNFY-ZPGVKDDISA-N itraconazole Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-ZPGVKDDISA-N 0.000 claims description 8
- 229960004125 ketoconazole Drugs 0.000 claims description 8
- 150000004291 polyenes Chemical class 0.000 claims description 8
- FPGPDEPMWUWLOV-UHFFFAOYSA-N polygodial Natural products CC1(C)CCCC2(C)C(C=O)C(=CC(O)C12)C=O FPGPDEPMWUWLOV-UHFFFAOYSA-N 0.000 claims description 8
- 229960002722 terbinafine Drugs 0.000 claims description 8
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims description 8
- 229960002703 undecylenic acid Drugs 0.000 claims description 8
- CTETYYAZBPJBHE-UHFFFAOYSA-N Haloprogin Chemical compound ClC1=CC(Cl)=C(OCC#CI)C=C1Cl CTETYYAZBPJBHE-UHFFFAOYSA-N 0.000 claims description 7
- 101100100081 Oryza sativa subsp. japonica TPP3 gene Proteins 0.000 claims description 7
- 101000918971 Papio hamadryas Defensin-1 Proteins 0.000 claims description 7
- 101000918969 Petunia hybrida Floral defensin-like protein 1 Proteins 0.000 claims description 7
- 101000722180 Petunia hybrida Floral defensin-like protein 2 Proteins 0.000 claims description 7
- 229960001906 haloprogin Drugs 0.000 claims description 7
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 6
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 6
- 108010020326 Caspofungin Proteins 0.000 claims description 6
- 241000223218 Fusarium Species 0.000 claims description 6
- 230000001775 anti-pathogenic effect Effects 0.000 claims description 6
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 claims description 6
- 229960003034 caspofungin Drugs 0.000 claims description 6
- 229960004413 flucytosine Drugs 0.000 claims description 6
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims description 6
- 230000002538 fungal effect Effects 0.000 claims description 6
- 229940123277 Chitin synthase inhibitor Drugs 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 claims description 4
- 241000228212 Aspergillus Species 0.000 claims description 4
- 241001527609 Cryptococcus Species 0.000 claims description 4
- 101000883593 Nicotiana alata Flower-specific defensin Proteins 0.000 claims description 4
- 241001634922 Tausonia pullulans Species 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 244000053095 fungal pathogen Species 0.000 claims description 4
- 244000005700 microbiome Species 0.000 claims description 4
- 230000002195 synergetic effect Effects 0.000 claims description 4
- 102000005469 Chitin Synthase Human genes 0.000 claims description 3
- 108700040089 Chitin synthases Proteins 0.000 claims description 3
- 229940127488 Glucan Synthase Inhibitors Drugs 0.000 claims description 3
- 241000894007 species Species 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 241000223602 Alternaria alternata Species 0.000 claims description 2
- 241000002049 Amesia atrobrunnea Species 0.000 claims description 2
- 241001634943 Apiotrichum domesticum Species 0.000 claims description 2
- 241000293034 Apophysomyces elegans Species 0.000 claims description 2
- 241000228197 Aspergillus flavus Species 0.000 claims description 2
- 241001225321 Aspergillus fumigatus Species 0.000 claims description 2
- 241000228245 Aspergillus niger Species 0.000 claims description 2
- 241001480523 Basidiobolus ranarum Species 0.000 claims description 2
- 241001465178 Bipolaris Species 0.000 claims description 2
- 241000228405 Blastomyces dermatitidis Species 0.000 claims description 2
- 241000079253 Byssochlamys spectabilis Species 0.000 claims description 2
- 241000222122 Candida albicans Species 0.000 claims description 2
- 241000144583 Candida dubliniensis Species 0.000 claims description 2
- 241000222173 Candida parapsilosis Species 0.000 claims description 2
- 241000222178 Candida tropicalis Species 0.000 claims description 2
- 241000222157 Candida viswanathii Species 0.000 claims description 2
- 241001508813 Clavispora lusitaniae Species 0.000 claims description 2
- 241000223203 Coccidioides Species 0.000 claims description 2
- 241001522757 Coccidioides posadasii Species 0.000 claims description 2
- 241000293020 Cokeromyces recurvatus Species 0.000 claims description 2
- 241001480521 Conidiobolus coronatus Species 0.000 claims description 2
- 241000293017 Conidiobolus incongruus Species 0.000 claims description 2
- 201000007336 Cryptococcosis Diseases 0.000 claims description 2
- 241001522864 Cryptococcus gattii VGI Species 0.000 claims description 2
- 241000221204 Cryptococcus neoformans Species 0.000 claims description 2
- 241000293018 Cunninghamella bertholletiae Species 0.000 claims description 2
- 241000223233 Cutaneotrichosporon cutaneum Species 0.000 claims description 2
- 241001634927 Cutaneotrichosporon mucoides Species 0.000 claims description 2
- 102100028007 Cystatin-SA Human genes 0.000 claims description 2
- 101710144510 Cysteine proteinase inhibitor Proteins 0.000 claims description 2
- 241000215396 Dactylaria Species 0.000 claims description 2
- 241000235036 Debaryomyces hansenii Species 0.000 claims description 2
- 241000223221 Fusarium oxysporum Species 0.000 claims description 2
- 241000228402 Histoplasma Species 0.000 claims description 2
- 241000228404 Histoplasma capsulatum Species 0.000 claims description 2
- 244000285963 Kluyveromyces fragilis Species 0.000 claims description 2
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims description 2
- 241000144128 Lichtheimia corymbifera Species 0.000 claims description 2
- 241000132887 Lomentospora prolificans Species 0.000 claims description 2
- 241001480037 Microsporum Species 0.000 claims description 2
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- 241000908234 Mucor indicus Species 0.000 claims description 2
- 241000526686 Paracoccidioides brasiliensis Species 0.000 claims description 2
- 241000228143 Penicillium Species 0.000 claims description 2
- 102000035195 Peptidases Human genes 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 241000235645 Pichia kudriavzevii Species 0.000 claims description 2
- 241000235056 Pichia norvegensis Species 0.000 claims description 2
- 241001465752 Purpureocillium lilacinum Species 0.000 claims description 2
- 241001524162 Ramichloridium Species 0.000 claims description 2
- 241000235402 Rhizomucor Species 0.000 claims description 2
- 240000005384 Rhizopus oryzae Species 0.000 claims description 2
- 235000013752 Rhizopus oryzae Nutrition 0.000 claims description 2
- 241000293025 Saksenaea vasiformis Species 0.000 claims description 2
- 241000852049 Scedosporium apiospermum Species 0.000 claims description 2
- 241000223598 Scedosporium boydii Species 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 101710187074 Serine proteinase inhibitor Proteins 0.000 claims description 2
- 241001149963 Sporothrix schenckii Species 0.000 claims description 2
- 241001279361 Stachybotrys Species 0.000 claims description 2
- 241001523006 Talaromyces marneffei Species 0.000 claims description 2
- 241000223238 Trichophyton Species 0.000 claims description 2
- 241001045770 Trichophyton mentagrophytes Species 0.000 claims description 2
- 241000223230 Trichosporon Species 0.000 claims description 2
- 241001634961 Trichosporon asahii Species 0.000 claims description 2
- 241001673999 Trichosporon japonicum Species 0.000 claims description 2
- 241001634925 Trichosporon ovoides Species 0.000 claims description 2
- 241000222126 [Candida] glabrata Species 0.000 claims description 2
- 241000191353 [Candida] haemulonis Species 0.000 claims description 2
- 230000002223 anti-pathogen Effects 0.000 claims description 2
- 229940091771 aspergillus fumigatus Drugs 0.000 claims description 2
- 239000000022 bacteriostatic agent Substances 0.000 claims description 2
- 229940095731 candida albicans Drugs 0.000 claims description 2
- 208000032343 candida glabrata infection Diseases 0.000 claims description 2
- 229940055022 candida parapsilosis Drugs 0.000 claims description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002852 cysteine proteinase inhibitor Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000017066 negative regulation of growth Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 235000019833 protease Nutrition 0.000 claims description 2
- 239000003001 serine protease inhibitor Substances 0.000 claims description 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 claims description 2
- XOQABDOICLHPIS-UHFFFAOYSA-N 1-hydroxy-2,1-benzoxaborole Chemical compound C1=CC=C2B(O)OCC2=C1 XOQABDOICLHPIS-UHFFFAOYSA-N 0.000 claims 2
- 229960004880 tolnaftate Drugs 0.000 claims 2
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 claims 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 229960004418 trolamine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 23
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014901480A AU2014901480A0 (en) | 2014-04-24 | Agents and methods of treatment | |
| AU2014901480 | 2014-04-24 | ||
| PCT/AU2015/050195 WO2015161348A1 (en) | 2014-04-24 | 2015-04-24 | Agents and methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017517498A JP2017517498A (ja) | 2017-06-29 |
| JP2017517498A5 true JP2017517498A5 (enExample) | 2018-05-31 |
Family
ID=54331510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564054A Pending JP2017517498A (ja) | 2014-04-24 | 2015-04-24 | 薬剤および治療方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10568930B2 (enExample) |
| EP (1) | EP3134108A4 (enExample) |
| JP (1) | JP2017517498A (enExample) |
| CN (1) | CN106456708A (enExample) |
| AU (1) | AU2015251501B2 (enExample) |
| CA (1) | CA2946163A1 (enExample) |
| WO (1) | WO2015161348A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| EP3209319B1 (en) | 2014-10-21 | 2021-07-14 | Hexima Limited | A method of treatment of fungal infections |
| EP3303376A4 (en) * | 2015-05-29 | 2019-01-23 | Hexima Limited | IN VIVO METHOD |
| WO2017155879A1 (en) | 2016-03-07 | 2017-09-14 | Agrofresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| CN112625920B (zh) * | 2020-12-25 | 2023-04-28 | 广西壮族自治区农业科学院 | 一株抗病虫内生真菌的应用 |
| IT202100018530A1 (it) * | 2021-07-14 | 2023-01-14 | Clever Bioscience S R L | Composizioni antimicrobiche sinergiche contenenti peptidi selezionati e acidi grassi |
| CN120025912B (zh) * | 2025-04-18 | 2025-07-01 | 深圳市兰科植物保护研究中心 | 一株支孢瓶霉cnocc pp35及其在增强紫纹兜兰光合作用中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9918155D0 (en) * | 1999-08-02 | 1999-10-06 | Zeneca Ltd | Proteins and peptides |
| CN101029308B (zh) * | 2001-02-08 | 2012-07-25 | 赫希玛有限公司 | 植物来源分子、其编码遗传序列及其用途 |
| AU2002322388A1 (en) * | 2001-06-22 | 2003-01-08 | E.I. Du Pont De Nemours And Company | Defensin polynucleotides and methods of use |
| AR052947A1 (es) * | 2005-03-18 | 2007-04-11 | Novozymes As | Polipeptidos que tienen actividad antimicrobiana y polinucleotidos que codifican para los mismos |
| WO2008018488A1 (fr) * | 2006-08-09 | 2008-02-14 | Takara Bio Inc. | Agent antibactérien |
| JP5147866B2 (ja) * | 2007-03-15 | 2013-02-20 | メルク・シャープ・アンド・ドーム・コーポレーション | グルカン合成酵素阻害剤として有用であるピリダジノン誘導体 |
| EP2762498A1 (en) * | 2007-04-20 | 2014-08-06 | Hexima Limited | Modified plant defensin |
| AR075257A1 (es) | 2008-02-01 | 2011-03-23 | Hexima Ltd | Sistema de proteccion de plantas contra la infeccion por agentes patogenos |
| BRPI0916867A2 (pt) * | 2008-08-05 | 2017-05-23 | Hexima Ltd | métodos para proteger uma planta de uma doença associada com infecção por um patógeno, e para identificar uma defensiva, uso de uma defensina de planta e um inibidor de proteinase ou uma forma precursora, planta geneticamente modificada ou progênie desta, e, defensiva |
| JP2010070503A (ja) * | 2008-09-19 | 2010-04-02 | Daiichi Sankyo Co Ltd | 抗真菌作用２−アミノトリアゾロピリジン誘導体 |
| AR073917A1 (es) * | 2008-10-23 | 2010-12-09 | Novozymes Adenium Biotech As | Sinergismo antibiotico |
| CA2807785A1 (en) * | 2010-08-23 | 2012-03-01 | Pioneer Hi-Bred International, Inc. | Novel defensin variants and methods of use |
| KR101951057B1 (ko) * | 2011-02-07 | 2019-02-21 | 헥시마 리미티드 | 항병원성 물질로서 유용한 변경된 식물 데펜신 |
| JP6457945B2 (ja) * | 2012-11-23 | 2019-01-23 | ヘキシマ リミテッドＨｅｘｉｍａ Ｌｉｍｉｔｅｄ | 抗病原体方法 |
| EP3133919A4 (en) * | 2014-04-23 | 2018-02-21 | Hexima Limited | Agents and methods for treatment of pathogens |
| EP3209319B1 (en) * | 2014-10-21 | 2021-07-14 | Hexima Limited | A method of treatment of fungal infections |
-
2015
- 2015-04-24 AU AU2015251501A patent/AU2015251501B2/en not_active Ceased
- 2015-04-24 WO PCT/AU2015/050195 patent/WO2015161348A1/en not_active Ceased
- 2015-04-24 US US15/306,307 patent/US10568930B2/en not_active Expired - Fee Related
- 2015-04-24 JP JP2016564054A patent/JP2017517498A/ja active Pending
- 2015-04-24 CN CN201580016768.0A patent/CN106456708A/zh active Pending
- 2015-04-24 EP EP15782467.3A patent/EP3134108A4/en not_active Withdrawn
- 2015-04-24 CA CA2946163A patent/CA2946163A1/en not_active Abandoned
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