JP2017514831A - アルツハイマー病（ａｄ）の処置および予防 - Google Patents

アルツハイマー病（ａｄ）の処置および予防 Download PDF

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Publication number
JP2017514831A
JP2017514831A JP2016565238A JP2016565238A JP2017514831A JP 2017514831 A JP2017514831 A JP 2017514831A JP 2016565238 A JP2016565238 A JP 2016565238A JP 2016565238 A JP2016565238 A JP 2016565238A JP 2017514831 A JP2017514831 A JP 2017514831A
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Japan
Prior art keywords
aluminum
administered
aluminum salt
patient
oxyhydroxide
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JP2016565238A
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Japanese (ja)
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JP2017514831A5 (enExample
Inventor
マルクス・マントラー
アヒム・シュネーベルガー
フランク・マットナー
ヴァルター・シュミット
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Affiris AG
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Affiris AG
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Publication of JP2017514831A5 publication Critical patent/JP2017514831A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2016565238A 2014-04-29 2015-04-29 アルツハイマー病（ａｄ）の処置および予防 Pending JP2017514831A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461985710P 2014-04-29 2014-04-29
EP14166355.9 2014-04-29
US61/985,710 2014-04-29
EP14166355 2014-04-29
PCT/EP2015/059337 WO2015165964A1 (en) 2014-04-29 2015-04-29 Treatment and prevention of alzheimer's disease (ad)

Publications (2)

Publication Number Publication Date
JP2017514831A true JP2017514831A (ja) 2017-06-08
JP2017514831A5 JP2017514831A5 (enExample) 2018-05-31

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JP2016565238A Pending JP2017514831A (ja) 2014-04-29 2015-04-29 アルツハイマー病（ａｄ）の処置および予防

Country Status (10)

Country Link
US (3) US10646565B2 (enExample)
EP (1) EP3137097B1 (enExample)
JP (1) JP2017514831A (enExample)
KR (1) KR102460465B1 (enExample)
CN (1) CN106535924A (enExample)
AU (3) AU2015254661A1 (enExample)
CA (1) CA2946929A1 (enExample)
ES (1) ES2953381T3 (enExample)
PL (1) PL3137097T3 (enExample)
WO (2) WO2015165964A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017515812A (ja) * 2014-04-29 2017-06-15 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防
JP2017518275A (ja) * 2014-04-29 2017-07-06 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防
US10646565B2 (en) 2014-04-29 2020-05-12 Affiris Ag Treatment of alzheimer'S disease (AD) with an aluminum salt

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3643319A1 (en) * 2018-10-25 2020-04-29 Grifols Worldwide Operations Limited Use of low volume plasma exchange for the treatment of alzheimer's disease in early and middle stages

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994016327A1 (en) * 1993-01-14 1994-07-21 Pollard Harvey B Methods and compositions for blocking amyloid protein ion channels
JP2002502802A (ja) * 1997-12-02 2002-01-29 ニューララブ リミテッド アミロイド形成疾患の予防および処置
JP2008506666A (ja) * 2004-07-13 2008-03-06 アフィリス・フォルシュングス−ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アルツハイマー病の予防および治療方法
JP2011522840A (ja) * 2008-06-12 2011-08-04 アフィリス・アクチェンゲゼルシャフト アミロイドーシス治療のための化合物
JP2011522841A (ja) * 2008-06-12 2011-08-04 アフィリス・アクチェンゲゼルシャフト 疾患を治療するための化合物
JP2013523682A (ja) * 2010-03-29 2013-06-17 ノバルティス アーゲー ウイルス様粒子に結合しているアミロイドベータ１−６ペプチドおよびアジュバントを含む組成物
JP2017515812A (ja) * 2014-04-29 2017-06-15 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防
JP2017518275A (ja) * 2014-04-29 2017-07-06 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US6905686B1 (en) * 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US10383887B2 (en) * 2008-02-20 2019-08-20 New York University Preventing and treating amyloid-beta deposition by stimulation of innate immunity
EP2659908A1 (en) * 2012-05-01 2013-11-06 Affiris AG Compositions
CN106535924A (zh) 2014-04-29 2017-03-22 阿费里斯股份公司 阿尔茨海默病(ad)的治疗和预防

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994016327A1 (en) * 1993-01-14 1994-07-21 Pollard Harvey B Methods and compositions for blocking amyloid protein ion channels
JP2002502802A (ja) * 1997-12-02 2002-01-29 ニューララブ リミテッド アミロイド形成疾患の予防および処置
JP2008506666A (ja) * 2004-07-13 2008-03-06 アフィリス・フォルシュングス−ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アルツハイマー病の予防および治療方法
JP2011522840A (ja) * 2008-06-12 2011-08-04 アフィリス・アクチェンゲゼルシャフト アミロイドーシス治療のための化合物
JP2011522841A (ja) * 2008-06-12 2011-08-04 アフィリス・アクチェンゲゼルシャフト 疾患を治療するための化合物
JP2013523682A (ja) * 2010-03-29 2013-06-17 ノバルティス アーゲー ウイルス様粒子に結合しているアミロイドベータ１−６ペプチドおよびアジュバントを含む組成物
JP2017515812A (ja) * 2014-04-29 2017-06-15 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防
JP2017518275A (ja) * 2014-04-29 2017-07-06 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ADV.DRUG DELIV.REV.,1998,32(3),P.155-172, JPN6019038134, ISSN: 0004386119 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017515812A (ja) * 2014-04-29 2017-06-15 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防
JP2017518275A (ja) * 2014-04-29 2017-07-06 アフィリス・アクチェンゲゼルシャフトＡｆｆｉｒｉｓ Ａｇ アルツハイマー病（ａｄ）の処置および予防
US10646565B2 (en) 2014-04-29 2020-05-12 Affiris Ag Treatment of alzheimer'S disease (AD) with an aluminum salt
US11065273B2 (en) 2014-04-29 2021-07-20 Affiris Ag Treatment and prevention of alzheimer's disease (AD)
US11147873B2 (en) 2014-04-29 2021-10-19 Advantage Therapeutics, Inc. Treatment of Alzheimer's Disease (AD) with an aluminum salt
US11857568B2 (en) 2014-04-29 2024-01-02 Advantage Therapeutics, Inc. Treatment and prevention of Alzheimer's disease (AD)

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CN106535924A (zh) 2017-03-22
CA2946929A1 (en) 2015-11-05
KR102460465B1 (ko) 2022-10-27
AU2015254661A1 (en) 2016-11-10
EP3137097A1 (en) 2017-03-08
AU2024201099A1 (en) 2024-03-14
WO2015165964A8 (en) 2017-02-09
WO2015165964A1 (en) 2015-11-05
EP3137097C0 (en) 2023-06-21
US10646565B2 (en) 2020-05-12
EP3137097B1 (en) 2023-06-21
AU2021200093B2 (en) 2024-03-07
US20220062412A1 (en) 2022-03-03
WO2015165974A1 (en) 2015-11-05
AU2015254661A9 (en) 2019-08-01
US11147873B2 (en) 2021-10-19
ES2953381T3 (es) 2023-11-13
US20200338192A1 (en) 2020-10-29
AU2021200093A1 (en) 2021-03-18
PL3137097T3 (pl) 2023-09-11
KR20160145820A (ko) 2016-12-20
US20170056495A1 (en) 2017-03-02

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