JP2017513842A5 - - Google Patents
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- JP2017513842A5 JP2017513842A5 JP2016561879A JP2016561879A JP2017513842A5 JP 2017513842 A5 JP2017513842 A5 JP 2017513842A5 JP 2016561879 A JP2016561879 A JP 2016561879A JP 2016561879 A JP2016561879 A JP 2016561879A JP 2017513842 A5 JP2017513842 A5 JP 2017513842A5
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- JP
- Japan
- Prior art keywords
- group
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- atom
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014082057 | 2014-04-11 | ||
| JP2014082057 | 2014-04-11 | ||
| PCT/JP2015/061651 WO2015156417A1 (en) | 2014-04-11 | 2015-04-09 | Cyclopropanamine compound and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513842A JP2017513842A (ja) | 2017-06-01 |
| JP2017513842A5 true JP2017513842A5 (https=) | 2018-05-24 |
| JP6470310B2 JP6470310B2 (ja) | 2019-02-13 |
Family
ID=53055078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016561879A Expired - Fee Related JP6470310B2 (ja) | 2014-04-11 | 2015-04-09 | シクロプロパンアミン化合物およびその用途 |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US10053456B2 (https=) |
| EP (1) | EP3129369A1 (https=) |
| JP (1) | JP6470310B2 (https=) |
| KR (1) | KR102359836B1 (https=) |
| CN (1) | CN106459024B (https=) |
| AR (1) | AR099994A1 (https=) |
| AU (1) | AU2015244698B2 (https=) |
| BR (1) | BR112016023382B1 (https=) |
| CA (1) | CA2945085C (https=) |
| CL (1) | CL2016002573A1 (https=) |
| CR (1) | CR20160485A (https=) |
| DO (1) | DOP2016000273A (https=) |
| EA (1) | EA034197B1 (https=) |
| EC (1) | ECSP16087256A (https=) |
| IL (1) | IL248181B (https=) |
| MA (1) | MA39732A (https=) |
| MX (1) | MX375990B (https=) |
| MY (1) | MY180575A (https=) |
| NZ (1) | NZ725262A (https=) |
| PE (1) | PE20161441A1 (https=) |
| PH (1) | PH12016502016B1 (https=) |
| SG (2) | SG11201608340UA (https=) |
| TN (1) | TN2016000418A1 (https=) |
| TW (1) | TWI669291B (https=) |
| UA (1) | UA122205C2 (https=) |
| UY (1) | UY36071A (https=) |
| WO (1) | WO2015156417A1 (https=) |
| ZA (1) | ZA201607773B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6602779B2 (ja) | 2014-02-13 | 2019-11-06 | インサイト・コーポレイション | Ｌｓｄ１阻害剤としてのシクロプロピルアミン類 |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| EP3105218B1 (en) | 2014-02-13 | 2019-09-25 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| EP3105219B9 (en) | 2014-02-13 | 2018-10-03 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| MY180575A (en) | 2014-04-11 | 2020-12-02 | Takeda Pharmaceuticals Co | Cyclopropanamine compound and use thereof |
| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| WO2016007731A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines and imidazopyrazines as lsd1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
| WO2016083458A1 (en) | 2014-11-26 | 2016-06-02 | Ieo - Istituto Europeo Di Oncologia S.R.L. | Reprogramming-based models of neurodevelopmental disorders and uses thereof |
| EP3277689B1 (en) | 2015-04-03 | 2019-09-04 | Incyte Corporation | Heterocyclic compounds as lsd1 inhibitors |
| AU2016275702A1 (en) | 2015-06-12 | 2017-12-21 | Oryzon Genomics, S.A. | Biomarkers associated with LSD1 inhibitors and uses thereof |
| WO2017013061A1 (en) | 2015-07-17 | 2017-01-26 | Oryzon Genomics, S.A. | Biomarkers associated with lsd1 inhibitors and uses thereof |
| MY189367A (en) | 2015-08-12 | 2022-02-08 | Incyte Corp | Salts of an lsd1 inhibitor |
| US10059668B2 (en) | 2015-11-05 | 2018-08-28 | Mirati Therapeutics, Inc. | LSD1 inhibitors |
| US9809541B2 (en) | 2015-12-29 | 2017-11-07 | Mirati Therapeutics, Inc. | LSD1 inhibitors |
| RU2018127657A (ru) | 2015-12-30 | 2020-01-31 | Новартис Аг | Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью |
| JPWO2017130933A1 (ja) * | 2016-01-25 | 2018-11-29 | 国立大学法人 熊本大学 | 神経変性疾患治療剤 |
| ES3057783T3 (en) | 2016-03-15 | 2026-03-04 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases |
| WO2017158136A1 (en) | 2016-03-16 | 2017-09-21 | Oryzon Genomics, S.A. | Methods to determine kdm1a target engagement and chemoprobes useful therefor |
| TWI833686B (zh) | 2016-04-22 | 2024-03-01 | 美商英塞特公司 | Lsd1 抑制劑之調配物 |
| WO2018083189A1 (en) | 2016-11-03 | 2018-05-11 | Oryzon Genomics, S.A. | Biomarkers for determining responsiveness to lsd1 inhibitors |
| EP3535414A1 (en) | 2016-11-03 | 2019-09-11 | Oryzon Genomics, S.A. | Pharmacodynamic biomarkers for personalized cancer care using epigenetic modifying agents |
| FI3661510T3 (fi) | 2017-08-03 | 2024-12-18 | Oryzon Genomics Sa | Menetelmiä käyttäytymismuutosten hoitamiseksi |
| US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
| CN109553591B (zh) * | 2019-01-15 | 2020-12-15 | 山东安信制药有限公司 | 一种富马酸喹硫平中间体的制备方法 |
| US20220151999A1 (en) | 2019-03-20 | 2022-05-19 | Oryzon Genomics, S.A. | Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat |
| LT3941466T (lt) | 2019-03-20 | 2026-02-25 | Oryzon Genomics, S.A. | Vafidemstatas ribinio asmenybės sutrikimo simptomų, nesusijusių su agresija, gydymui |
| CN114341366A (zh) | 2019-07-05 | 2022-04-12 | 奥莱松基因组股份有限公司 | 用于使用kdm1a抑制剂个体化治疗小细胞肺癌的生物标志物和方法 |
| WO2022224267A1 (en) * | 2021-04-21 | 2022-10-27 | Natco Pharma Limited | Improved process for the preparation of 7-(morpholinyl)-2-(n-piperazinyl)methylthieno[2, 3-c]pyridine derivatives |
| CN113512031B (zh) * | 2021-07-01 | 2024-01-30 | 都创(上海)医药开发有限公司 | 一种lsd1酶抑制剂tak-418中间体化合物制备方法 |
| CN117164465B (zh) * | 2023-09-04 | 2025-07-01 | 郑州大学 | 一种苯基环丙胺类化合物及其制备方法和应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1395257A1 (en) | 2001-06-12 | 2004-03-10 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| CN101445469B (zh) | 2003-09-24 | 2013-02-13 | 梅特希尔基因公司 | 组蛋白脱乙酰基酶抑制剂 |
| WO2005030705A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| RU2006125441A (ru) | 2003-12-15 | 2008-01-27 | Джапан Тобакко Инк. (Jp) | Производные циклопропана и их фармацевтическое применение |
| WO2010043721A1 (en) * | 2008-10-17 | 2010-04-22 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| US8993808B2 (en) * | 2009-01-21 | 2015-03-31 | Oryzon Genomics, S.A. | Phenylcyclopropylamine derivatives and their medical use |
| US8389580B2 (en) | 2009-06-02 | 2013-03-05 | Duke University | Arylcyclopropylamines and methods of use |
| JPWO2010143582A1 (ja) * | 2009-06-11 | 2012-11-22 | 公立大学法人名古屋市立大学 | フェニルシクロプロピルアミン誘導体及びｌｓｄ１阻害剤 |
| US8859555B2 (en) | 2009-09-25 | 2014-10-14 | Oryzon Genomics S.A. | Lysine Specific Demethylase-1 inhibitors and their use |
| EP2486002B1 (en) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| CA2796726C (en) | 2010-04-19 | 2021-02-16 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| BR112012027062B8 (pt) | 2010-04-20 | 2021-05-25 | Fond Ieo | composto, processo para a preparação de um composto e usos do mesmo |
| BR112013002164B1 (pt) | 2010-07-29 | 2021-11-09 | Oryzon Genomics S.A. | Inibidores de desmetilase à base de arilciclopropilamina de lsd1, seus usos, e composição farmacêutica |
| US9006449B2 (en) * | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| JP2012036124A (ja) | 2010-08-06 | 2012-02-23 | Nagoya City Univ | Ｈｉｖ複製阻害剤 |
| US8709048B2 (en) * | 2010-08-20 | 2014-04-29 | Tongji University | Rod system for gradual dynamic spinal fixation |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| PH12013501871A1 (en) * | 2011-03-25 | 2019-06-03 | Glaxosmithkline Ip No 2 Ltd | Cyclopropylamines as lsd1 inhibitors |
| US20140329833A1 (en) * | 2011-05-19 | 2014-11-06 | Oryzon Genomics, S.A | Lysine demethylase inhibitors for inflammatory diseases or conditions |
| US20140296255A1 (en) | 2011-05-19 | 2014-10-02 | Oryzong Genomics, S.A. | Lysine demethylase inhibitors for thrombosis and cardiovascular diseases |
| PE20141202A1 (es) | 2011-08-09 | 2014-10-03 | Takeda Pharmaceutical | Compuesto de ciclopropanoamina |
| JP6046154B2 (ja) | 2011-10-20 | 2016-12-14 | オリソン ヘノミクス エセ． アー． | Ｌｓｄ１阻害剤としての（ヘテロ）アリールシクロプロピルアミン化合物 |
| EP2768805B1 (en) | 2011-10-20 | 2020-03-25 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
| CA2887598A1 (en) * | 2012-10-12 | 2014-04-17 | Takeda Pharmaceutical Company Limited | Cyclopropanamine compound and use thereof |
| CN104042616B (zh) | 2014-02-20 | 2016-08-24 | 复旦大学附属眼耳鼻喉科医院 | 赖氨酸特异性去甲基化酶1抑制剂的应用 |
| MY180575A (en) * | 2014-04-11 | 2020-12-02 | Takeda Pharmaceuticals Co | Cyclopropanamine compound and use thereof |
| US10603295B2 (en) | 2014-04-28 | 2020-03-31 | Massachusetts Eye And Ear Infirmary | Sensorineural hair cell differentiation |
-
2015
- 2015-04-09 MY MYPI2016703700A patent/MY180575A/en unknown
- 2015-04-09 NZ NZ725262A patent/NZ725262A/en unknown
- 2015-04-09 MA MA039732A patent/MA39732A/fr unknown
- 2015-04-09 BR BR112016023382-4A patent/BR112016023382B1/pt active IP Right Grant
- 2015-04-09 AR ARP150101073A patent/AR099994A1/es active IP Right Grant
- 2015-04-09 SG SG11201608340UA patent/SG11201608340UA/en unknown
- 2015-04-09 UY UY0001036071A patent/UY36071A/es not_active Application Discontinuation
- 2015-04-09 EP EP15721046.9A patent/EP3129369A1/en not_active Withdrawn
- 2015-04-09 CN CN201580031044.3A patent/CN106459024B/zh active Active
- 2015-04-09 KR KR1020167029899A patent/KR102359836B1/ko active Active
- 2015-04-09 US US15/302,405 patent/US10053456B2/en active Active
- 2015-04-09 TN TN2016000418A patent/TN2016000418A1/en unknown
- 2015-04-09 MX MX2016013369A patent/MX375990B/es active IP Right Grant
- 2015-04-09 PH PH1/2016/502016A patent/PH12016502016B1/en unknown
- 2015-04-09 SG SG10201808780YA patent/SG10201808780YA/en unknown
- 2015-04-09 PE PE2016001947A patent/PE20161441A1/es unknown
- 2015-04-09 EA EA201692052A patent/EA034197B1/ru not_active IP Right Cessation
- 2015-04-09 US US14/682,695 patent/US9487511B2/en active Active
- 2015-04-09 UA UAA201611450A patent/UA122205C2/uk unknown
- 2015-04-09 TW TW104111396A patent/TWI669291B/zh active
- 2015-04-09 WO PCT/JP2015/061651 patent/WO2015156417A1/en not_active Ceased
- 2015-04-09 CA CA2945085A patent/CA2945085C/en active Active
- 2015-04-09 JP JP2016561879A patent/JP6470310B2/ja not_active Expired - Fee Related
- 2015-04-09 CR CR20160485A patent/CR20160485A/es unknown
- 2015-04-09 AU AU2015244698A patent/AU2015244698B2/en active Active
-
2016
- 2016-07-06 US US15/203,522 patent/US9718814B2/en not_active Expired - Fee Related
- 2016-07-06 US US15/203,551 patent/US9714241B2/en not_active Expired - Fee Related
- 2016-09-20 US US15/270,863 patent/US9920047B2/en active Active
- 2016-10-05 IL IL248181A patent/IL248181B/en active IP Right Grant
- 2016-10-07 DO DO2016000273A patent/DOP2016000273A/es unknown
- 2016-10-07 CL CL2016002573A patent/CL2016002573A1/es unknown
- 2016-11-10 ZA ZA2016/07773A patent/ZA201607773B/en unknown
- 2016-11-11 EC ECIEPI201687256A patent/ECSP16087256A/es unknown
-
2018
- 2018-01-29 US US15/882,386 patent/US10414761B2/en active Active
-
2019
- 2019-06-27 US US16/455,359 patent/US10968213B2/en active Active
-
2021
- 2021-02-16 US US17/176,861 patent/US20210179603A1/en not_active Abandoned
-
2023
- 2023-08-14 US US18/449,326 patent/US20240317733A1/en active Pending
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