JP2017512842A5 - - Google Patents

Info

Publication number

JP2017512842A5

JP2017512842A5 JP2017504259A JP2017504259A JP2017512842A5 JP 2017512842 A5 JP2017512842 A5 JP 2017512842A5 JP 2017504259 A JP2017504259 A JP 2017504259A JP 2017504259 A JP2017504259 A JP 2017504259A JP 2017512842 A5 JP2017512842 A5 JP 2017512842A5

Authority

JP

Japan

Prior art keywords

stem cells

ang1

cells

vegf

composition

Prior art date

2015-04-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000000130 stem cell Anatomy 0.000 claims 23
• 238000000034 method Methods 0.000 claims 18
• 239000000203 mixture Substances 0.000 claims 15
• 102100034594 Angiopoietin-1 Human genes 0.000 claims 14
• 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 claims 14
• 210000004027 cell Anatomy 0.000 claims 11
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 9
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 9
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 9
• 108091003079 Bovine Serum Albumin Proteins 0.000 claims 6
• 239000012894 fetal calf serum Substances 0.000 claims 6
• 210000002966 serum Anatomy 0.000 claims 6
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical group OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
• 150000000996 L-ascorbic acids Chemical class 0.000 claims 3
• 230000033115 angiogenesis Effects 0.000 claims 3
• 239000006143 cell culture medium Substances 0.000 claims 3
• 238000012258 culturing Methods 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
• LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 108010048154 Angiopoietin-1 Proteins 0.000 claims 1
• 102000009088 Angiopoietin-1 Human genes 0.000 claims 1
• 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
• 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
• 239000011612 calcitriol Substances 0.000 claims 1
• 244000309466 calf Species 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000001605 fetal effect Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical group [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1