AU2015243575B2 - Improved stem cell composition - Google Patents

Improved stem cell composition Download PDF

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Publication number
AU2015243575B2
AU2015243575B2 AU2015243575A AU2015243575A AU2015243575B2 AU 2015243575 B2 AU2015243575 B2 AU 2015243575B2 AU 2015243575 A AU2015243575 A AU 2015243575A AU 2015243575 A AU2015243575 A AU 2015243575A AU 2015243575 B2 AU2015243575 B2 AU 2015243575B2
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Prior art keywords
stem cells
cells
angl
composition
vegf
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AU2015243575A
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AU2015243575A1 (en
Inventor
Silviu Itescu
Paul Simmons
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Mesoblast International SARL
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Mesoblast International SARL
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Priority claimed from AU2014901247A external-priority patent/AU2014901247A0/en
Application filed by Mesoblast International SARL filed Critical Mesoblast International SARL
Publication of AU2015243575A1 publication Critical patent/AU2015243575A1/en
Application granted granted Critical
Publication of AU2015243575B2 publication Critical patent/AU2015243575B2/en
Priority to AU2018200619A priority Critical patent/AU2018200619B9/en
Priority to AU2020202214A priority patent/AU2020202214B2/en
Priority to AU2022200640A priority patent/AU2022200640B2/en
Priority to AU2024203197A priority patent/AU2024203197B2/en
Active legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2301—Interleukin-1 (IL-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2015243575A 2014-04-07 2015-04-07 Improved stem cell composition Active AU2015243575B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2018200619A AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition
AU2020202214A AU2020202214B2 (en) 2014-04-07 2020-03-27 Improved stem cell composition
AU2022200640A AU2022200640B2 (en) 2014-04-07 2022-02-01 Improved stem cell composition
AU2024203197A AU2024203197B2 (en) 2014-04-07 2024-05-14 Improved stem cell composition

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2014901247A AU2014901247A0 (en) 2014-04-07 Improved stem cell composition
AU2014901247 2014-04-07
PCT/EP2015/057521 WO2015155187A1 (en) 2014-04-07 2015-04-07 Improved stem cell composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018200619A Division AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition

Publications (2)

Publication Number Publication Date
AU2015243575A1 AU2015243575A1 (en) 2016-10-13
AU2015243575B2 true AU2015243575B2 (en) 2017-11-02

Family

ID=53724311

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2015243575A Active AU2015243575B2 (en) 2014-04-07 2015-04-07 Improved stem cell composition
AU2018200619A Active AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition
AU2020202214A Active AU2020202214B2 (en) 2014-04-07 2020-03-27 Improved stem cell composition
AU2022200640A Active AU2022200640B2 (en) 2014-04-07 2022-02-01 Improved stem cell composition

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2018200619A Active AU2018200619B9 (en) 2014-04-07 2018-01-25 Improved stem cell composition
AU2020202214A Active AU2020202214B2 (en) 2014-04-07 2020-03-27 Improved stem cell composition
AU2022200640A Active AU2022200640B2 (en) 2014-04-07 2022-02-01 Improved stem cell composition

Country Status (9)

Country Link
US (4) US10400218B2 (cg-RX-API-DMAC10.html)
EP (2) EP3129468B1 (cg-RX-API-DMAC10.html)
JP (4) JP6882161B2 (cg-RX-API-DMAC10.html)
KR (2) KR102577698B1 (cg-RX-API-DMAC10.html)
CN (2) CN113337462A (cg-RX-API-DMAC10.html)
AU (4) AU2015243575B2 (cg-RX-API-DMAC10.html)
CA (1) CA2944262C (cg-RX-API-DMAC10.html)
SG (2) SG10202000644TA (cg-RX-API-DMAC10.html)
WO (1) WO2015155187A1 (cg-RX-API-DMAC10.html)

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WO2012048093A2 (en) 2010-10-08 2012-04-12 Osiris Therapeutics, Inc. Enhanced msc preparations
KR102577698B1 (ko) 2014-04-07 2023-09-12 메조블라스트 인터내셔널 에스에이알엘 개선된 줄기 세포 조성물
WO2015189063A1 (en) * 2014-06-10 2015-12-17 Mesoblast International Sàrl Treatment of immune disorders
JP6231709B1 (ja) * 2016-05-31 2017-11-15 シスメックス株式会社 蛍光画像分析装置および分析方法
EP3619294A1 (en) * 2017-05-04 2020-03-11 Mesoblast International Sàrl Mesenchymal lineage precursor or stem cells with enhanced immunosuppression
WO2019102268A1 (en) 2017-11-22 2019-05-31 Mesoblast International Sarl Cellular compositions and methods of treatment i
US12702683B2 (en) 2019-01-03 2026-08-11 Mesoblast International Sárl Method for improving visual acuity
CN113677790B (zh) * 2019-03-26 2024-05-24 普罗米瑟拉疗法公司 用于治疗慢加急性肝衰竭的成体肝祖细胞
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
WO2021176001A1 (en) 2020-03-05 2021-09-10 Mesoblast International Sàrl Method for treating inflammatory lung diseases using mesenchymal lineage precursor or stem cells
EP4181675A4 (en) 2020-07-18 2024-04-24 Ossium Health, Inc. PERMEATION OF WHOLE VERTEBRATE BODIES WITH A CRYOPRETECTIVE AGENT USING VACUUM-ASSISTED DIFFUSION
EP4229183A4 (en) 2020-10-14 2024-12-11 Ossium Health, Inc. Compositions and methods for extraction of mesenchymal stem cells
EP4228406A4 (en) 2020-10-14 2024-11-13 Ossium Health, Inc. SYSTEMS AND METHODS FOR BONE MARROW EXTRACTION AND CRYOPRESERVATION
EP4262831A4 (en) 2020-12-18 2025-01-01 Ossium Health, Inc. CELLULAR THERAPY PROCESSES
WO2022173737A1 (en) 2021-02-09 2022-08-18 Millennium Pharmaceuticals, Inc. Methods and compositions for freezing and thawing mammalian cells
JP2025538783A (ja) * 2022-12-09 2025-11-28 メゾブラスト・インターナショナル・エスアーエールエル 事前承認された組成物及び細胞培養方法
AU2023389700A1 (en) * 2022-12-09 2025-07-10 Mesoblast International Sarl Method of treating heart failure in subjects with persistent inflammation
WO2024121821A1 (en) * 2022-12-09 2024-06-13 Mesoblast International Sarl Conditioned media and use of the same

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Also Published As

Publication number Publication date
AU2022200640A1 (en) 2022-02-24
US20250136944A1 (en) 2025-05-01
JP7571109B2 (ja) 2024-10-22
US20190345452A1 (en) 2019-11-14
KR20160145066A (ko) 2016-12-19
AU2018200619B9 (en) 2020-05-07
JP2024177516A (ja) 2024-12-19
JP7196216B2 (ja) 2022-12-26
AU2018200619B2 (en) 2020-01-02
US20230030428A1 (en) 2023-02-02
CN106459913B (zh) 2021-05-18
KR20220080023A (ko) 2022-06-14
KR102405663B1 (ko) 2022-06-07
US10400218B2 (en) 2019-09-03
KR102577698B1 (ko) 2023-09-12
WO2015155187A1 (en) 2015-10-15
AU2024203197A1 (en) 2024-05-30
EP3129468A1 (en) 2017-02-15
CA2944262A1 (en) 2015-10-15
US20170107495A1 (en) 2017-04-20
AU2022200640B2 (en) 2024-02-15
CN106459913A (zh) 2017-02-22
SG10202000644TA (en) 2020-03-30
EP3129468B1 (en) 2022-09-21
SG11201607925SA (en) 2016-10-28
EP4137560A1 (en) 2023-02-22
JP2017512842A (ja) 2017-05-25
CA2944262C (en) 2023-08-01
AU2020202214B2 (en) 2021-11-18
AU2018200619A1 (en) 2018-02-15
AU2020202214A1 (en) 2020-04-16
US11312941B2 (en) 2022-04-26
JP2021080272A (ja) 2021-05-27
AU2015243575A1 (en) 2016-10-13
CN113337462A (zh) 2021-09-03
JP2023021279A (ja) 2023-02-10
JP6882161B2 (ja) 2021-06-02

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