JP2017511795A5 - - Google Patents
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- Publication number
- JP2017511795A5 JP2017511795A5 JP2016551716A JP2016551716A JP2017511795A5 JP 2017511795 A5 JP2017511795 A5 JP 2017511795A5 JP 2016551716 A JP2016551716 A JP 2016551716A JP 2016551716 A JP2016551716 A JP 2016551716A JP 2017511795 A5 JP2017511795 A5 JP 2017511795A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- moiety
- compound according
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 56
- 239000003814 drug Substances 0.000 claims 19
- 229940079593 drug Drugs 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000002993 cycloalkylene group Chemical group 0.000 claims 7
- 125000004474 heteroalkylene group Chemical group 0.000 claims 7
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 7
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000000732 arylene group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000005549 heteroarylene group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 239000000589 Siderophore Substances 0.000 claims 4
- 229960005475 antiinfective agent Drugs 0.000 claims 4
- 239000004599 antimicrobial Substances 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000013643 reference control Substances 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000003929 folic acid group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003430 antimalarial agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 229940125687 antiparasitic agent Drugs 0.000 claims 1
- -1 aryl compound Chemical class 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 229940014144 folate Drugs 0.000 claims 1
- 239000011724 folic acid Chemical group 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical group C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 125000005349 heteroarylcycloalkyl group Chemical group 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 0 C*(CCO*(C)CC(NC)=O)C(NCC(N(Cc1c-2cccc1)c(cccc1)c1-c1c-2nn[n]1C)=O)=O Chemical compound C*(CCO*(C)CC(NC)=O)C(NCC(N(Cc1c-2cccc1)c(cccc1)c1-c1c-2nn[n]1C)=O)=O 0.000 description 3
- MQEDCLYHADIJDW-UHFFFAOYSA-N CCSC(CC(N1CC(CC2)CCC2C(NC)=O)=O)C1=O Chemical compound CCSC(CC(N1CC(CC2)CCC2C(NC)=O)=O)C1=O MQEDCLYHADIJDW-UHFFFAOYSA-N 0.000 description 1
- MIVCQQGVEMZWJA-OJRHAOMCSA-N CNC(CCCNC(OCC1[C@H](CC2)[C@@H]1CCc1c2nn[n]1C)=O)=O Chemical compound CNC(CCCNC(OCC1[C@H](CC2)[C@@H]1CCc1c2nn[n]1C)=O)=O MIVCQQGVEMZWJA-OJRHAOMCSA-N 0.000 description 1
- JLSKKBWFLOBSTR-JKIOLJMWSA-N O=C(CCCNC(OCC1[C@H](CC2)[C@@H]1CCc1c2nn[n]1[IH]I)=O)N[IH]I Chemical compound O=C(CCCNC(OCC1[C@H](CC2)[C@@H]1CCc1c2nn[n]1[IH]I)=O)N[IH]I JLSKKBWFLOBSTR-JKIOLJMWSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461940295P | 2014-02-14 | 2014-02-14 | |
| US61/940,295 | 2014-02-14 | ||
| PCT/US2015/015948 WO2015123595A1 (en) | 2014-02-14 | 2015-02-13 | Cyclic peroxides as prodrugs for selective delivery of agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021001260A Division JP2021080257A (ja) | 2014-02-14 | 2021-01-07 | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511795A JP2017511795A (ja) | 2017-04-27 |
| JP2017511795A5 true JP2017511795A5 (cg-RX-API-DMAC7.html) | 2018-04-05 |
| JP6889433B2 JP6889433B2 (ja) | 2021-06-18 |
Family
ID=53800676
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016551716A Active JP6889433B2 (ja) | 2014-02-14 | 2015-02-13 | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
| JP2021001260A Ceased JP2021080257A (ja) | 2014-02-14 | 2021-01-07 | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
| JP2022147665A Withdrawn JP2022191236A (ja) | 2014-02-14 | 2022-09-16 | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021001260A Ceased JP2021080257A (ja) | 2014-02-14 | 2021-01-07 | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
| JP2022147665A Withdrawn JP2022191236A (ja) | 2014-02-14 | 2022-09-16 | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10287312B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3104857A4 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6889433B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2937752C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015123595A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2937752C (en) * | 2014-02-14 | 2023-02-07 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| CN109153639B (zh) * | 2016-03-14 | 2022-07-29 | 斯法尔制药私人有限公司 | 葫芦巴碱类化合物 |
| US11072594B2 (en) | 2017-06-27 | 2021-07-27 | The Regents Of The University Of California | Trioxolane agents |
| CN117157281A (zh) * | 2021-02-01 | 2023-12-01 | 西湖大学 | 1,2,4,5-四噁烷化合物的靶向递送及其用途 |
| CN113549106B (zh) * | 2021-07-14 | 2023-05-26 | 淮阴工学院 | 一种康普瑞汀衍生物及其制备方法和应用 |
| US20250009889A1 (en) * | 2021-09-24 | 2025-01-09 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| EP4448107B1 (en) | 2021-12-16 | 2025-11-05 | Faculdade de Farmácia da Universidade de Lisboa | Drug delivery systems based on endoperoxides useful in diagnosis and therapy, and methods thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862142A (en) * | 1972-06-13 | 1975-01-21 | Research Corp | Method of reductive ozonolysis of olefins to produce carbonyl compounds and intermediate products |
| US4631190A (en) | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| US4997913A (en) | 1986-06-30 | 1991-03-05 | Oncogen | pH-sensitive immunoconjugates and methods for their use in tumor therapy |
| US5140013A (en) | 1989-11-28 | 1992-08-18 | Universite Laval | Maleic anhydride derivatives used as conjugation agents of anti-tumor agents on desired carriers |
| JPH04334377A (ja) | 1990-12-31 | 1992-11-20 | Akzo Nv | 酸−不安定性リンカー分子 |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US5578637A (en) | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
| US6486199B1 (en) * | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US20080125441A1 (en) | 2002-06-21 | 2008-05-29 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US7371778B2 (en) | 2002-06-21 | 2008-05-13 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US6825230B2 (en) | 2002-06-21 | 2004-11-30 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trixolane antimalarials |
| US6906205B2 (en) * | 2002-06-21 | 2005-06-14 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| JP2005112799A (ja) | 2003-10-08 | 2005-04-28 | Toshiaki Miura | オレイン酸アルキルエステルオゾニド |
| FR2862304A1 (fr) * | 2003-11-14 | 2005-05-20 | Centre Nat Rech Scient | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| US20050256184A1 (en) | 2004-04-12 | 2005-11-17 | O'neill Paul M | 1,2,4-Trioxanes and 1,2,4-trioxepanes |
| WO2005110396A2 (en) | 2004-04-28 | 2005-11-24 | Uab Research Foundation | Nitrated lipids and methods of making and using thereof |
| US8067620B2 (en) * | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| US8618096B2 (en) | 2008-07-21 | 2013-12-31 | The Regents Of The University Of California | Prodrug compositions and methods for using the same in treating cancer and malaria |
| US8305807B2 (en) | 2010-07-09 | 2012-11-06 | Sandisk Technologies Inc. | Detection of broken word-lines in memory arrays |
| WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
| CA2937752C (en) | 2014-02-14 | 2023-02-07 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| JP6675030B1 (ja) * | 2019-06-20 | 2020-04-01 | 株式会社フッコー | 高炉スラグ系塗料 |
-
2015
- 2015-02-13 CA CA2937752A patent/CA2937752C/en active Active
- 2015-02-13 US US15/118,268 patent/US10287312B2/en active Active
- 2015-02-13 WO PCT/US2015/015948 patent/WO2015123595A1/en not_active Ceased
- 2015-02-13 EP EP15748856.0A patent/EP3104857A4/en not_active Withdrawn
- 2015-02-13 JP JP2016551716A patent/JP6889433B2/ja active Active
-
2019
- 2019-03-26 US US16/364,577 patent/US10662215B2/en active Active
-
2020
- 2020-04-08 US US16/843,567 patent/US11014955B2/en active Active
-
2021
- 2021-01-07 JP JP2021001260A patent/JP2021080257A/ja not_active Ceased
- 2021-04-22 US US17/237,525 patent/US20220017559A1/en not_active Abandoned
-
2022
- 2022-09-16 JP JP2022147665A patent/JP2022191236A/ja not_active Withdrawn
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