JP2017511138A5 - - Google Patents
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- JP2017511138A5 JP2017511138A5 JP2016560431A JP2016560431A JP2017511138A5 JP 2017511138 A5 JP2017511138 A5 JP 2017511138A5 JP 2016560431 A JP2016560431 A JP 2016560431A JP 2016560431 A JP2016560431 A JP 2016560431A JP 2017511138 A5 JP2017511138 A5 JP 2017511138A5
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- 108091029430 CpG site Proteins 0.000 claims description 55
- 101150015830 nd1 gene Proteins 0.000 claims description 53
- 230000011987 methylation Effects 0.000 claims description 46
- 238000007069 methylation reaction Methods 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 38
- 108020005196 Mitochondrial DNA Proteins 0.000 claims description 27
- 208000024827 Alzheimer disease Diseases 0.000 claims description 26
- 208000018737 Parkinson disease Diseases 0.000 claims description 18
- 239000002773 nucleotide Substances 0.000 claims description 17
- 125000003729 nucleotide group Chemical group 0.000 claims description 17
- 230000006607 hypermethylation Effects 0.000 claims description 15
- 108020004707 nucleic acids Proteins 0.000 claims description 15
- 102000039446 nucleic acids Human genes 0.000 claims description 15
- 150000007523 nucleic acids Chemical class 0.000 claims description 15
- 238000000338 in vitro Methods 0.000 claims description 14
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 230000004770 neurodegeneration Effects 0.000 claims description 9
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 9
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 108091034117 Oligonucleotide Proteins 0.000 claims description 5
- 229940104302 cytosine Drugs 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 238000011321 prophylaxis Methods 0.000 claims description 4
- 229940035893 uracil Drugs 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 238000012175 pyrosequencing Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000007450 ChIP-chip Methods 0.000 claims 1
- 208000031124 Dementia Alzheimer type Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 238000001369 bisulfite sequencing Methods 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000007855 methylation-specific PCR Methods 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 claims 1
- 230000007067 DNA methylation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201430444A ES2546743B1 (es) | 2014-03-28 | 2014-03-28 | Marcadores mitocondriales de enfermedades neurodegenerativas |
| ESP201430444 | 2014-03-28 | ||
| PCT/ES2015/070230 WO2015144964A2 (es) | 2014-03-28 | 2015-03-27 | Marcadores mitocondriales de enfermedades neurodegenerativas |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511138A JP2017511138A (ja) | 2017-04-20 |
| JP2017511138A5 true JP2017511138A5 (enExample) | 2018-07-19 |
| JP6687532B2 JP6687532B2 (ja) | 2020-04-28 |
Family
ID=54150970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016560431A Active JP6687532B2 (ja) | 2014-03-28 | 2015-03-27 | 神経変性疾患のミトコンドリアマーカー |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11053549B2 (enExample) |
| EP (1) | EP3124621B9 (enExample) |
| JP (1) | JP6687532B2 (enExample) |
| AU (1) | AU2015238195C1 (enExample) |
| BR (1) | BR112016022582B1 (enExample) |
| CA (1) | CA2944281C (enExample) |
| DK (1) | DK3124621T3 (enExample) |
| ES (2) | ES2546743B1 (enExample) |
| PT (1) | PT3124621T (enExample) |
| WO (1) | WO2015144964A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107904667A (zh) * | 2018-01-02 | 2018-04-13 | 上海美吉生物医药科技有限公司 | 一种新型甲基化建库试剂盒及其应用 |
| CN108841928B (zh) * | 2018-06-11 | 2021-11-23 | 河北医科大学 | 一种人类线粒体基因组甲基化检测试剂盒及其应用 |
| CN109358194A (zh) * | 2018-09-29 | 2019-02-19 | 中国海洋大学 | 凡纳滨对虾高血糖激素间接竞争酶联免疫检测方法 |
| CN112813159B (zh) * | 2021-03-23 | 2023-05-30 | 广州金域医学检验中心有限公司 | 帕金森病的生物标志物及其应用 |
| EP4490322A1 (en) * | 2022-03-11 | 2025-01-15 | Admit Therapeutics SL | Methods of determining the risk of developing alzheimer's disease dementia |
| WO2024008759A1 (en) | 2022-07-04 | 2024-01-11 | Admit Therapeutics Sl | Method for identifying dementia with lewy bodies in a subject |
| CN119144600B (zh) * | 2024-11-20 | 2025-04-01 | 天津赛萌生物技术有限公司 | 一种含鲑鱼线粒体基因克隆载体的构建及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT975800E (pt) | 1997-02-27 | 2003-10-31 | Ingeneus Corp | Doseamento de nucleotidos em solucao usando sondas anp |
| WO2000063441A2 (en) * | 1999-04-20 | 2000-10-26 | Mitokor | Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease |
| WO2003046225A1 (en) | 2001-11-26 | 2003-06-05 | Mitokor | Mitochondrial dna polymorphisms |
| JP2005000044A (ja) | 2003-06-10 | 2005-01-06 | Masatsugu Tanaka | ヒトミトコンドリア遺伝子変異に基づく遺伝子検出法 |
| US20120232016A1 (en) | 2011-03-08 | 2012-09-13 | Coleman Paul D | Method and system to detect and diagnose alzheimer's disease |
-
2014
- 2014-03-28 ES ES201430444A patent/ES2546743B1/es not_active Expired - Fee Related
-
2015
- 2015-03-27 US US15/300,248 patent/US11053549B2/en active Active
- 2015-03-27 JP JP2016560431A patent/JP6687532B2/ja active Active
- 2015-03-27 EP EP15770042.8A patent/EP3124621B9/en active Active
- 2015-03-27 AU AU2015238195A patent/AU2015238195C1/en active Active
- 2015-03-27 BR BR112016022582-1A patent/BR112016022582B1/pt active IP Right Grant
- 2015-03-27 WO PCT/ES2015/070230 patent/WO2015144964A2/es not_active Ceased
- 2015-03-27 PT PT15770042T patent/PT3124621T/pt unknown
- 2015-03-27 DK DK15770042.8T patent/DK3124621T3/da active
- 2015-03-27 CA CA2944281A patent/CA2944281C/en active Active
- 2015-03-27 ES ES15770042T patent/ES2744592T3/es active Active
-
2021
- 2021-06-02 US US17/337,355 patent/US12065702B2/en active Active
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