JP2017508749A5 - - Google Patents
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- Publication number
- JP2017508749A5 JP2017508749A5 JP2016555554A JP2016555554A JP2017508749A5 JP 2017508749 A5 JP2017508749 A5 JP 2017508749A5 JP 2016555554 A JP2016555554 A JP 2016555554A JP 2016555554 A JP2016555554 A JP 2016555554A JP 2017508749 A5 JP2017508749 A5 JP 2017508749A5
- Authority
- JP
- Japan
- Prior art keywords
- bladder
- gemcitabine
- patient
- day
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 34
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 32
- 229960005277 gemcitabine Drugs 0.000 claims 32
- 229940079593 drug Drugs 0.000 claims 13
- 238000011200 topical administration Methods 0.000 claims 6
- 238000012377 drug delivery Methods 0.000 claims 5
- 210000002700 urine Anatomy 0.000 claims 5
- 230000002459 sustained effect Effects 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 239000002357 osmotic agent Substances 0.000 claims 3
- 239000002562 thickening agent Substances 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 210000005068 bladder tissue Anatomy 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003232 mucoadhesive effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 230000007928 solubilization Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000003708 urethra Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461949215P | 2014-03-06 | 2014-03-06 | |
| US61/949,215 | 2014-03-06 | ||
| PCT/US2015/019262 WO2015134911A1 (en) | 2014-03-06 | 2015-03-06 | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184023A Division JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508749A JP2017508749A (ja) | 2017-03-30 |
| JP2017508749A5 true JP2017508749A5 (en:Method) | 2018-03-08 |
| JP6901858B2 JP6901858B2 (ja) | 2021-07-14 |
Family
ID=52697553
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555554A Active JP6901858B2 (ja) | 2014-03-06 | 2015-03-06 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2019184023A Active JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2021183995A Active JP7383681B2 (ja) | 2014-03-06 | 2021-11-11 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2023190543A Active JP7802743B2 (ja) | 2014-03-06 | 2023-11-08 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184023A Active JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2021183995A Active JP7383681B2 (ja) | 2014-03-06 | 2021-11-11 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2023190543A Active JP7802743B2 (ja) | 2014-03-06 | 2023-11-08 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20150250717A1 (en:Method) |
| EP (2) | EP3113782B1 (en:Method) |
| JP (4) | JP6901858B2 (en:Method) |
| KR (1) | KR102338079B1 (en:Method) |
| CN (2) | CN119950539A (en:Method) |
| AU (4) | AU2015226901B2 (en:Method) |
| BR (1) | BR112016020381A8 (en:Method) |
| CA (1) | CA2939979C (en:Method) |
| DK (2) | DK3113782T3 (en:Method) |
| ES (2) | ES3051417T3 (en:Method) |
| FI (1) | FI4124339T3 (en:Method) |
| HR (2) | HRP20251264T1 (en:Method) |
| HU (1) | HUE060704T2 (en:Method) |
| IL (2) | IL247347B2 (en:Method) |
| LT (2) | LT3113782T (en:Method) |
| MX (1) | MX2016011333A (en:Method) |
| PL (2) | PL3113782T3 (en:Method) |
| PT (2) | PT3113782T (en:Method) |
| RS (2) | RS63675B1 (en:Method) |
| RU (1) | RU2694902C1 (en:Method) |
| SG (2) | SG11201607342QA (en:Method) |
| SI (1) | SI4124339T1 (en:Method) |
| SM (2) | SMT202500385T1 (en:Method) |
| WO (1) | WO2015134911A1 (en:Method) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2882575C (en) | 2012-08-31 | 2020-05-26 | Dennis GIESING | Drug delivery systems and methods for treatment of prostate |
| LT3035991T (lt) | 2013-08-19 | 2020-11-10 | Taris Biomedical Llc | Daugiablokiai vaistų vartojimo įtaisai |
| PT3113782T (pt) * | 2014-03-06 | 2023-01-05 | Taris Biomedical Llc | Sistemas e métodos de administração de fármaco para tratamento do cancro da bexiga com gemcitabina |
| SG10201913416PA (en) * | 2016-05-06 | 2020-03-30 | Taris Biomedical Llc | Method of treating lower tract urothelial cancer |
| SG10201913998YA (en) | 2017-07-25 | 2020-03-30 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| CN111787926A (zh) * | 2017-11-08 | 2020-10-16 | 塔里斯生物医药公司 | 使用吉西他滨对膀胱癌进行治疗和维持疗法的方法 |
| JP2021532155A (ja) | 2018-08-01 | 2021-11-25 | タリス バイオメディカル エルエルシー | トロスピウムを使用した過活動膀胱の治療方法 |
| JP7660066B2 (ja) * | 2019-10-03 | 2025-04-10 | 生化学工業株式会社 | 膀胱の粘膜下組織への医薬品有効成分の経粘膜的送達システム |
| RU2713443C2 (ru) * | 2019-11-01 | 2020-02-05 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ комбинированного лечения мышечно-инвазивного рака мочевого пузыря т3-т4 n0-+m0 |
| JP2023512652A (ja) * | 2020-01-27 | 2023-03-28 | アイソラ セラピューティクス，インコーポレイテッド | 管腔内局所薬剤送達のための組織内投与 |
| CN112169066B (zh) * | 2020-10-29 | 2023-05-12 | 安徽省立医院(中国科学技术大学附属第一医院) | 具有控制器的连续缓释给药留置管 |
| CN113616666A (zh) * | 2021-08-24 | 2021-11-09 | 傅广波 | 膀胱黏膜下注射吉西他滨在治疗膀胱癌中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4111203A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| US7534241B2 (en) * | 2002-09-23 | 2009-05-19 | Microchips, Inc. | Micro-reservoir osmotic release systems and microtube array device |
| US8361490B2 (en) * | 2004-09-16 | 2013-01-29 | Theracoat Ltd. | Biocompatible drug delivery apparatus and methods |
| EP1933810B1 (en) | 2005-08-11 | 2012-10-10 | Massachusetts Institute of Technology | Intravesical drug delivery device and method |
| CA2649877A1 (en) * | 2006-04-24 | 2007-12-21 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
| JP5560200B2 (ja) | 2007-12-11 | 2014-07-23 | マサチューセッツ インスチテュート オブ テクノロジー | 膀胱および他の身体の小嚢又は管腔を治療するための埋め込み型薬物供給デバイス |
| CN102176931B (zh) | 2008-08-09 | 2015-03-04 | 麻省理工学院 | 治疗男性泌尿生殖组织和外周组织的可植入药物递送设备和方法 |
| ES2401008T3 (es) | 2009-06-26 | 2013-04-16 | Taris Biomedical, Inc. | Comprimidos farmacéuticos sólidos para dispositivos implantables para la administración de fármacos |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| US8721621B2 (en) | 2009-09-10 | 2014-05-13 | Taris Biomedical, Inc. | Systems and methods for deploying devices to genitourinary sites |
| SI2512581T1 (sl) * | 2009-12-17 | 2021-09-30 | Taris Biomedical Llc | Vsadljiva naprava z intravezikalno sprejemljivostjo |
| DK2525777T3 (da) * | 2010-01-20 | 2019-07-01 | Urogen Pharma Ltd | Materiale og fremgangsmåde til at behandle interne hulrum |
| US20110218488A1 (en) | 2010-03-05 | 2011-09-08 | Taris Biomedical, Inc. | Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites |
| WO2012048114A1 (en) | 2010-10-06 | 2012-04-12 | Taris Biomedical, Inc. | Time-selective bioresorbable or collapsible drug delivery systems and methods |
| US9457176B2 (en) | 2010-10-06 | 2016-10-04 | Taris Biomedical Llc | Implantable drug delivery device with bladder retention feature |
| RU2598057C2 (ru) * | 2011-02-04 | 2016-09-20 | ТАРИС Биомедикал ЛЛК | Имплантируемое устройство для контролируемого высвобождения лекарственного средства с низкой растворимостью |
| CA2882575C (en) * | 2012-08-31 | 2020-05-26 | Dennis GIESING | Drug delivery systems and methods for treatment of prostate |
| SG11201507294WA (en) * | 2013-03-15 | 2015-10-29 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| EP2968120B1 (en) | 2013-03-15 | 2026-01-14 | TARIS Biomedical LLC | Drug delivery devices and methods for drug delivery |
| LT3035991T (lt) | 2013-08-19 | 2020-11-10 | Taris Biomedical Llc | Daugiablokiai vaistų vartojimo įtaisai |
| CN105792880A (zh) * | 2013-11-05 | 2016-07-20 | 塔里斯生物医药公司 | 渗透药物递送装置、套件以及方法 |
| PT3113782T (pt) | 2014-03-06 | 2023-01-05 | Taris Biomedical Llc | Sistemas e métodos de administração de fármaco para tratamento do cancro da bexiga com gemcitabina |
-
2015
- 2015-03-06 PT PT157113739T patent/PT3113782T/pt unknown
- 2015-03-06 ES ES22196596T patent/ES3051417T3/es active Active
- 2015-03-06 FI FIEP22196596.5T patent/FI4124339T3/fi active
- 2015-03-06 SG SG11201607342QA patent/SG11201607342QA/en unknown
- 2015-03-06 LT LTEPPCT/US2015/019262T patent/LT3113782T/lt unknown
- 2015-03-06 LT LTEP22196596.5T patent/LT4124339T/lt unknown
- 2015-03-06 EP EP15711373.9A patent/EP3113782B1/en active Active
- 2015-03-06 PT PT221965965T patent/PT4124339T/pt unknown
- 2015-03-06 PL PL15711373.9T patent/PL3113782T3/pl unknown
- 2015-03-06 SM SM20250385T patent/SMT202500385T1/it unknown
- 2015-03-06 RU RU2016136103A patent/RU2694902C1/ru active
- 2015-03-06 HR HRP20251264TT patent/HRP20251264T1/hr unknown
- 2015-03-06 CA CA2939979A patent/CA2939979C/en active Active
- 2015-03-06 SG SG10202101978SA patent/SG10202101978SA/en unknown
- 2015-03-06 CN CN202510128139.2A patent/CN119950539A/zh active Pending
- 2015-03-06 IL IL247347A patent/IL247347B2/en unknown
- 2015-03-06 ES ES15711373T patent/ES2930435T3/es active Active
- 2015-03-06 HR HRP20221252TT patent/HRP20221252T1/hr unknown
- 2015-03-06 US US14/641,009 patent/US20150250717A1/en not_active Abandoned
- 2015-03-06 RS RS20220937A patent/RS63675B1/sr unknown
- 2015-03-06 AU AU2015226901A patent/AU2015226901B2/en active Active
- 2015-03-06 CN CN201580011259.9A patent/CN106102751A/zh active Pending
- 2015-03-06 RS RS20251017A patent/RS67337B1/sr unknown
- 2015-03-06 JP JP2016555554A patent/JP6901858B2/ja active Active
- 2015-03-06 PL PL22196596.5T patent/PL4124339T3/pl unknown
- 2015-03-06 SM SM20220449T patent/SMT202200449T1/it unknown
- 2015-03-06 DK DK15711373.9T patent/DK3113782T3/da active
- 2015-03-06 WO PCT/US2015/019262 patent/WO2015134911A1/en not_active Ceased
- 2015-03-06 EP EP22196596.5A patent/EP4124339B1/en active Active
- 2015-03-06 IL IL311410A patent/IL311410B2/en unknown
- 2015-03-06 DK DK22196596.5T patent/DK4124339T3/da active
- 2015-03-06 BR BR112016020381A patent/BR112016020381A8/pt not_active Application Discontinuation
- 2015-03-06 MX MX2016011333A patent/MX2016011333A/es unknown
- 2015-03-06 SI SI201532080T patent/SI4124339T1/sl unknown
- 2015-03-06 HU HUE15711373A patent/HUE060704T2/hu unknown
- 2015-03-06 KR KR1020167027303A patent/KR102338079B1/ko active Active
-
2019
- 2019-10-04 JP JP2019184023A patent/JP7061595B2/ja active Active
-
2020
- 2020-08-12 AU AU2020217383A patent/AU2020217383B2/en active Active
-
2021
- 2021-11-11 JP JP2021183995A patent/JP7383681B2/ja active Active
- 2021-12-23 US US17/561,540 patent/US20220117886A1/en not_active Abandoned
-
2022
- 2022-08-08 AU AU2022215156A patent/AU2022215156B2/en active Active
-
2023
- 2023-11-08 JP JP2023190543A patent/JP7802743B2/ja active Active
-
2024
- 2024-11-08 AU AU2024259822A patent/AU2024259822A1/en active Pending
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