JP2017506640A5 - - Google Patents
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- Publication number
- JP2017506640A5 JP2017506640A5 JP2016551824A JP2016551824A JP2017506640A5 JP 2017506640 A5 JP2017506640 A5 JP 2017506640A5 JP 2016551824 A JP2016551824 A JP 2016551824A JP 2016551824 A JP2016551824 A JP 2016551824A JP 2017506640 A5 JP2017506640 A5 JP 2017506640A5
- Authority
- JP
- Japan
- Prior art keywords
- edc
- alkyl
- present
- targeting moiety
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 229940079593 drug Drugs 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 19
- 230000008685 targeting Effects 0.000 claims description 16
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 12
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 10
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims description 10
- 150000003431 steroids Chemical class 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- QEEBRPGZBVVINN-UHFFFAOYSA-N Desacetyl-bufotalin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C1(O)CCC2C=1C=CC(=O)OC=1 QEEBRPGZBVVINN-UHFFFAOYSA-N 0.000 claims description 4
- QEEBRPGZBVVINN-BMPKRDENSA-N bufalin Chemical compound C=1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)C=CC(=O)OC=1 QEEBRPGZBVVINN-BMPKRDENSA-N 0.000 claims description 4
- 230000003177 cardiotonic effect Effects 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- TYYDXNISHGVDGA-UHFFFAOYSA-N Corotoxigenin Natural products CC12CCC3C(CCC4CC(O)CCC34C=O)C1CCC2C5=CC(=O)OC5 TYYDXNISHGVDGA-UHFFFAOYSA-N 0.000 claims description 3
- JIUWTCXNUNHEGP-GJHPUSIBSA-N cardenolide Chemical compound C1([C@H]2CC[C@@H]3[C@H]4[C@@H]([C@]5(CCCCC5CC4)C)CC[C@@]32C)=CC(=O)OC1 JIUWTCXNUNHEGP-GJHPUSIBSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- XZTUSOXSLKTKJQ-UHFFFAOYSA-N Uzarigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C1(O)CCC2C1=CC(=O)OC1 XZTUSOXSLKTKJQ-UHFFFAOYSA-N 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 230000000747 cardiac effect Effects 0.000 claims description 2
- 229960002204 daratumumab Drugs 0.000 claims description 2
- XZTUSOXSLKTKJQ-CESUGQOBSA-N digitoxigenin Chemical compound C1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)=CC(=O)OC1 XZTUSOXSLKTKJQ-CESUGQOBSA-N 0.000 claims description 2
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 208000026278 immune system disease Diseases 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461940219P | 2014-02-14 | 2014-02-14 | |
| US61/940,219 | 2014-02-14 | ||
| US201461946314P | 2014-02-28 | 2014-02-28 | |
| US61/946,314 | 2014-02-28 | ||
| PCT/US2015/016212 WO2015123687A1 (en) | 2014-02-14 | 2015-02-17 | Extracellular targeted drug conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017506640A JP2017506640A (ja) | 2017-03-09 |
| JP2017506640A5 true JP2017506640A5 (cg-RX-API-DMAC7.html) | 2018-03-08 |
Family
ID=53800709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016551824A Pending JP2017506640A (ja) | 2014-02-14 | 2015-02-17 | 細胞外標的化薬物共役体 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10675352B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3104882B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017506640A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015123687A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017023760A1 (en) | 2015-07-31 | 2017-02-09 | Prudent James R | Extracellular drug conjugates targeting cd20 |
| CA3014531A1 (en) * | 2016-02-12 | 2017-08-17 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
| CA3066547A1 (en) | 2017-06-08 | 2018-12-13 | Black Belt Therapeutics Limited | Cd38 modulating antibody |
| AU2018280871B2 (en) | 2017-06-08 | 2024-09-26 | Black Belt Therapeutics Ltd | CD38 modulating antibody |
| EP3641831B1 (en) * | 2017-06-20 | 2024-11-06 | Sorrento Therapeutics, Inc. | Cd38 antibody drug conjugate |
| AU2019403458A1 (en) | 2018-12-20 | 2021-06-10 | Kleo Pharmaceuticals, Inc. | Combination therapy of arms and natural killer cells |
| JP2022539258A (ja) * | 2019-07-03 | 2022-09-07 | クレオ ファーマシューティカルズ， インコーポレイテッド | Ｃｄ３８に結合する薬剤およびその使用 |
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| JP2003514773A (ja) | 1999-09-28 | 2003-04-22 | ウニヴェルジテート チューリッヒ | 血清及び血漿中のプリオン結合活性を有する因子並びに伝染性海綿状脳障害を検出するための薬剤 |
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| EP1174440A1 (en) * | 2000-07-19 | 2002-01-23 | U-BISys B.V. | A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment |
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| AU2010292172A1 (en) * | 2009-09-09 | 2012-05-03 | Centrose, Llc | Extracellular targeted drug conjugates |
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| KR101912957B1 (ko) * | 2010-09-27 | 2018-10-29 | 모르포시스 아게 | 다발성 골수종 및 nhl 치료를 위한 항-cd38 항체 및 레날리도마이드 또는 보르테조밉 |
| WO2012050884A2 (en) | 2010-09-28 | 2012-04-19 | President And Fellows Of Harvard College | Cardiac glycosides are potent inhibitors of interferon-beta gene expression |
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-
2015
- 2015-02-17 WO PCT/US2015/016212 patent/WO2015123687A1/en not_active Ceased
- 2015-02-17 US US15/117,672 patent/US10675352B2/en active Active
- 2015-02-17 EP EP15749237.2A patent/EP3104882B1/en active Active
- 2015-02-17 JP JP2016551824A patent/JP2017506640A/ja active Pending
-
2020
- 2020-03-25 US US16/830,049 patent/US20200384122A1/en not_active Abandoned